Method for establishing nano-plastic induced macrophage aging model

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By establishing a nanoplastic-induced macrophage aging model, it is confirmed that nanoplastics can promote macrophage aging, revealing its mechanisms, and providing a basis for evaluating the health hazards of nanoplastics.

CN120366216APending Publication Date: 2025-07-25HEBEI MEDICAL UNIVERSITY

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Patent Information

Application Number: CN202510617314.4
Authority / Receiving Office: CN · China
Patent Type: Applications(China)
Current Assignee / Owner
Priority Date: 2024-07-10
Filing Date: 2025-05-14
Publication Date: 2025-07-25

Application Information

Patent Timeline

10 Jul 2024

Priority

14 May 2025

Application

CN202510617314.4

25 Jul 2025

Publication

CN120366216A

IPC: C12N5/0786

CPC: C12N5/0645; C12N2533/30; C12N2500/30

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Application Domain

Culture process Cell culture supports/coating

Technology Topics

Biochemistry Human health

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AI Technical Summary

Technical Problem

Existing studies have difficulty assessing the health hazards of nanoplastics to macrophages over a long period of ambient concentrations, especially whether their mechanisms can induce cellular aging are not yet clear.

Method used

By co-culturing polystyrene nanoplastics with mouse mononuclear macrophages, a nanoplastic induced macrophage senescence model was established, specifically including culturing cells with medium containing 1.6 μg/mL of polystyrene nanoplastics under 5% CO2 and 37°C and passing them to the 10th generation of cells.

Benefits of technology

It has been confirmed that nanoplastics can promote macrophage aging, reveal their rules and working mechanisms, and provides a basis for studying the impact of nanoplastics on human health.

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Abstract

The invention relates to a method for establishing a nano-plastic induced macrophage senescence model, and belongs to the technical field of medicines.The nano-plastic and mouse mononuclear macrophages are co-cultured to obtain the macrophage senescence model, the promotion effect of NPs on macrophage senescence is proved, and the rule and working mechanism of the NPs are disclosed. The insight of people on damage of NPs to human health is expanded, and a basis is provided for research of senescence macrophages.

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