Phototherapy device and phototherapy method

Abstract

The invention provides a phototherapy device and a phototherapy method. The phototherapy equipment comprises a wearing part, and the wearing part is suitable for enabling the phototherapy equipment to be worn outside the brain of a human body; the light source module is embedded in the wearing part, the light source module is configured to provide a first light source with a first wavelength range and / or a second light source with a second wavelength range, the light source module is suitable for irradiating the brain of the human body through the first light source and / or the second light source, the first wavelength range comprises 790 nm to 830 nm, and the second wavelength range comprises 956 nm to 1070 nm. According to the phototherapy equipment and the phototherapy method, brain fatigue can be effectively relieved, and the attention level can be improved.

Description

Technical Field

[0001] The present application mainly relates to the field of medical equipment technology, and in particular to a phototherapy device and a phototherapy method. Background Art

[0002] With the accelerating pace of modern life, people are facing increasing mental stress, and problems such as mental fatigue and difficulty concentrating are becoming increasingly common. Traditional treatments often have certain limitations, such as the potential side effects of medications. In recent years, phototherapy, as a non-invasive and non-invasive treatment method, has received increasing attention in the medical field. Near-infrared light has excellent tissue penetrability and biocompatibility, and can penetrate deep into human tissue to produce photobiomodulation effects, thereby treating a variety of diseases and improving physiological functions. Currently, there are some near-infrared phototherapy devices on the market, but most use a single wavelength light source or a wavelength range that is poorly selected, resulting in poor efficacy. Furthermore, they are rarely used to relieve mental fatigue and improve attention. Summary of the Invention

[0003] The technical problem to be solved by this application is to provide a phototherapy device and a phototherapy method that can effectively relieve brain fatigue and improve attention levels.

[0004] To solve the above technical problems, the present application provides a phototherapy device, comprising: a wearing portion, which is suitable for allowing the phototherapy device to be worn on the outside of the human brain; and a light source module, which is embedded in the wearing portion, and the light source module is configured to provide a first light source having a first wavelength range and / or a second light source having a second wavelength range, and the light source module is suitable for irradiating the human brain through the first light source and / or the second light source, wherein the first wavelength range includes 790nm~830nm, and the second wavelength range includes 956nm~1070nm.

[0005] Optionally, the wavelength of the first light source satisfies at least one of the following wavelength values and wavelength ranges: 810 nm or within the range of 800 nm to 820 nm.

[0006] Optionally, the wavelength of the second light source satisfies at least one of the following wavelength values and wavelength ranges: 976nm, within the range of 956nm to 996nm, within the range of 966nm to 986nm, or 980nm, or within the range of 960nm to 1000nm, within the range of 970nm to 990nm, 1050nm, within the range of 1030nm to 1070nm, or within the range of 1040nm to 1060nm.

[0007] Optionally, the first light source and the second light source respectively include a near-infrared LED light source, an OLED light source or a MicroLED light source.

[0008] Optionally, a light-guiding portion is further included. When the light source module provides the first light source and / or the second light source, the light-guiding portion is suitable for converging the light of the first light source and / or the light of the second light source so that the first light source and / or the second light source illuminate the same area of the human brain.

[0009] Optionally, a control module is further included, which is connected to the light source module and is used to transmit control instructions to the light source module. The control instructions include start and stop information for controlling the first light source and / or the second light source to turn on and off, and parameter information related to the illumination parameters of the first light source and / or the second light source.

[0010] Optionally, the irradiation parameters include: an output waveform, wherein the output waveform includes a continuous wave or a pulse waveform; and / or an output frequency, wherein the output frequency is 10 Hz to 50 Hz; and / or an output power, wherein the output power is greater than 30 mW / cm 2 ; and / or irradiation duration, wherein the irradiation duration includes a single irradiation duration or an irradiation duration in a mode matching the treatment mode.

[0011] Optionally, a temperature sensing unit is further included, embedded in the wearable portion, and the temperature sensing unit is configured to monitor the skin temperature of the irradiated area of the human brain and transmit a first temperature signal containing the skin temperature to the control module, wherein the control module is configured to compare the skin temperature with a first temperature threshold, and when the skin temperature is higher than the first temperature threshold, the control module is suitable for turning off the light source module.

[0012] Optionally, the wearing portion includes a fitting portion and a heat dissipation device, wherein the fitting portion is suitable for fitting with the skin of the human brain, and the fitting portion is made of porous material; the heat dissipation device is connected to the control module, and the control module is also configured to compare the skin temperature and a second temperature threshold, and when the skin temperature is higher than the second temperature threshold, the control module is suitable for turning on the heat dissipation device and cooling the irradiated area through the porous material in the fitting portion, wherein the second temperature threshold is lower than the first temperature threshold.

[0013] Optionally, the temperature sensing unit is further configured to monitor the element temperature of the wearing part and transmit a second temperature signal containing the element temperature to the control module, wherein the control module is configured to compare the element temperature with a third temperature threshold, and when the element temperature is higher than the third temperature threshold: the control module is suitable for turning on the heat dissipation device and lowering the element temperature through the porous material in the fitting part; and / or the control module is suitable for controlling the light source module to adjust the irradiation parameters to lower the element temperature.

[0014] Optionally, a heart rate sensing unit is further included, which is configured to collect the heart rate data of the patient and transmit the heart rate data to the control module, wherein the control module is configured to calculate the heart rate variability index based on the heart rate data and adjust the irradiation parameters according to the changing trend of the heart rate variability index.

[0015] Optionally, it also includes an EEG sensing unit, which is configured to collect EEG data of the patient and transmit the EEG data to the control module, wherein the control module is configured to adjust the irradiation parameters according to the change trend of the EEG data.

[0016] Optionally, a user input unit is further included, connected to the control module, the user input unit is configured to receive input instructions and transmit the input instructions to the control module, wherein the control module is configured to generate the control instructions according to the input instructions.

[0017] Optionally, the user input unit further includes a remote control device, the control module is embedded in the remote control device, and the remote control device is located outside the wearable portion.

[0018] Optionally, a storage unit is further included, connected to the control module, and the storage unit is configured to store device operation information, wherein the device operation information at least includes information of the irradiation parameters and adjustment history records of adjusting the irradiation parameters.

[0019] Another aspect of the present application also proposes a phototherapy method, comprising the following steps: wearing a phototherapy device on the outside of a human brain through a wearing portion; starting a light source module of the phototherapy device to irradiate the human brain, wherein the light source module is embedded in the wearing portion, and the light source module is configured to provide a first light source having a first wavelength range and / or a second light source having a second wavelength range, and the light source module is suitable for irradiating the human brain through the first light source and / or the second light source, the first wavelength range includes 790nm~830nm, and the second wavelength range includes 956nm~1070nm.

[0020] Optionally, it also includes monitoring the skin temperature of the irradiated area of the human brain while starting the light source module of the phototherapy device to irradiate the human brain, and comparing the skin temperature with a first temperature threshold, and turning off the light source module when the skin temperature is higher than the first temperature threshold.

[0021] Optionally, it also includes comparing the skin temperature with a second temperature threshold, and when the skin temperature is higher than the second temperature threshold, turning on the heat dissipation device embedded in the wearable part, and ventilating and cooling the irradiated area, wherein the second temperature threshold is lower than the first temperature threshold.

[0022] Optionally, the method further includes monitoring the physiological indicators of the patient while starting the light source module of the phototherapy device to irradiate the human brain, and adjusting the irradiation parameters of the light source module according to the physiological indicators, wherein the physiological indicators include heart rate variability indicators and / or EEG data.

[0023] Optionally, the step of adjusting the illumination parameters of the light source module according to the physiological indicators further includes: at the current output wavelength, judging whether the change of the physiological indicators meets the expected response; if the judgment result is no, adjusting the output frequency, output power and / or illumination duration in the illumination parameters until the change of the physiological indicators meets the expected response; if adjusting the output frequency, output power and / or illumination duration in the illumination parameters still cannot make the change of the physiological indicators meet the expected response, adjusting the output wavelength.

[0024] Compared with existing technologies, the present invention has the following advantages: The phototherapy device and method of the present invention, through the selection of specific wavelengths, can penetrate deep into brain tissue when irradiating the human brain, producing a photobiomodulation effect. This enhances the release of neurotransmitters, regulates nervous system function, improves the transmission of brain nerve signals, improves brain blood circulation, and promotes brain cell metabolism, thereby effectively alleviating symptoms of brain fatigue and improving work efficiency and quality of life. Furthermore, the phototherapy device and method of the present invention have a simple structure, are easy to operate, and can achieve good therapeutic effects using a non-invasive approach. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] The accompanying drawings are included to provide a further understanding of the present application. They are incorporated into and constitute a part of this application. The accompanying drawings illustrate embodiments of the present application and, together with this specification, serve to explain the principles of the present application. In the accompanying drawings:

[0026] Figure 1 This is a schematic diagram of the module architecture of a phototherapy device according to an embodiment of the present application;

[0027] Figure 2This is a schematic diagram of the module architecture of a phototherapy device according to another embodiment of the present application;

[0028] Figure 3 、 Figure 4 and Figure 5 This application is Figure 2 A schematic diagram of a light therapy device worn on a human brain in the illustrated embodiment;

[0029] Figure 6 This application is Figure 2 A schematic cross-sectional view of a light therapy device according to the illustrated embodiment;

[0030] Figure 7 This application is Figure 2 A schematic diagram of the principle of a light guide portion in a phototherapy device in the illustrated embodiment;

[0031] Figure 8 is a schematic cross-sectional view of a phototherapy device according to another embodiment of the present application;

[0032] Figure 9 This is a flow chart of a phototherapy method according to an embodiment of the present application;

[0033] Figure 10 is a flow chart of a phototherapy method according to another embodiment of the present application;

[0034] Figure 11 、 Figure 12 、 Figure 13 and Figure 14 This is a schematic diagram of the test results on the effect of wavelength selection in a phototherapy device and a phototherapy method according to an embodiment of the present application. DETAILED DESCRIPTION

[0035] To more clearly illustrate the technical solutions of the embodiments of this application, the following is a brief introduction to the drawings required for describing the embodiments. Obviously, the drawings described below are merely examples or embodiments of this application. Those skilled in the art can apply this application to other similar scenarios based on these drawings without inventive effort. Unless otherwise apparent from the context or otherwise noted, the same reference numerals in the figures represent the same structure or operation.

[0036] As used in this application and the claims, unless the context clearly indicates otherwise, the words "a," "an," "an," and / or "the" are not intended to refer to the singular but may include the plural. Generally speaking, the terms "comprises" and "include" only indicate the inclusion of the steps and elements specifically identified, and these steps and elements do not constitute an exclusive list. A method or apparatus may also include other steps or elements.

[0037] Unless otherwise specifically stated, the relative arrangement of the parts and steps, numerical expressions and numerical values set forth in these embodiments do not limit the scope of the present application. At the same time, it should be understood that, for ease of description, the sizes of the various parts shown in the drawings are not drawn according to actual proportional relationships. The techniques, methods and equipment known to those of ordinary skill in the relevant art may not be discussed in detail, but where appropriate, the techniques, methods and equipment should be considered as part of the authorization specification. In all examples shown and discussed here, any specific values should be interpreted as being merely exemplary and not as limitations. Therefore, other examples of the exemplary embodiments may have different values. It should be noted that similar numbers and letters represent similar items in the following figures, and therefore, once an item is defined in one figure, it does not need to be further discussed in subsequent figures.

[0038] In the description of this application, it should be understood that the directions or positional relationships indicated by directional words such as "front, back, up, down, left, right", "horizontal, vertical, vertical, horizontal" and "top, bottom" are usually based on the directions or positional relationships shown in the accompanying drawings. They are only for the convenience of describing this application and simplifying the description. Unless otherwise specified, these directional words do not indicate or imply that the device or element referred to must have a specific direction or be constructed and operated in a specific direction. Therefore, they cannot be understood as limiting the scope of protection of this application; the directional words "inside and outside" refer to the inside and outside relative to the outline of each component itself.

[0039] For ease of description, spatially relative terms such as "above", "above", "on the upper surface of", "above", etc. may be used herein to describe the spatial positional relationship of a device or feature to other devices or features as shown in the figures. It should be understood that spatially relative terms are intended to include different orientations of the device in use or operation in addition to the orientation described in the figures. For example, if the device in the drawings is inverted, the device described as "above other devices or structures" or "above other devices or structures" will be positioned as "below other devices or structures" or "below other devices or structures". Thus, the exemplary term "above" can include both "above" and "below". The device can also be positioned in other different ways (rotated 90 degrees or in other orientations), and the spatially relative descriptions used here are interpreted accordingly.

[0040] Furthermore, it should be noted that the use of terms such as "first" and "second" to define components is solely for the purpose of distinguishing the corresponding components. Unless otherwise stated, these terms have no special meaning and therefore should not be construed as limiting the scope of protection of this application. Furthermore, while the terms used in this application are selected from commonly known and commonly used terms, some terms mentioned in this specification may have been selected by the applicant at his or her discretion, and their detailed meanings are explained in the relevant sections of this description. Furthermore, this application should be understood not only by the actual terms used, but also by the meaning implied by each term.

[0041] It should be understood that when a component is referred to as being “on another component,” “connected to another component,” “coupled to another component,” or “contacting another component,” it can be directly on, connected to, coupled to, or contacting the other component, or intervening components may be present. In contrast, when a component is referred to as being “directly on another component,” “directly connected to,” “directly coupled to,” or “directly contacting” another component, there are no intervening components. Similarly, when a first component is referred to as being “electrically in contact with” or “electrically coupled to” a second component, an electrical path exists between the first and second components that allows current to flow. This electrical path may include capacitors, coupled inductors, and / or other components that allow current to flow, even without direct contact between the conductive components.

[0042] An embodiment of this application refers to Figure 1 A phototherapy device 10 is proposed, which includes a wearing portion 11, and the wearing portion 11 is suitable for allowing the phototherapy device 10 to be worn on the outside of the human brain. Furthermore, the phototherapy device also includes a light source module 12, which is embedded in the wearing portion 11, and the light source module 12 is configured to provide a first light source 121 with a first wavelength range and a second light source 122 with a second wavelength range. The light source module 12 is suitable for irradiating the human brain through the first light source 121 and the second light source 122, wherein the first wavelength range includes 790nm~830nm, and the second wavelength range includes 956nm~1070nm. Figure 1 In the illustrated embodiment, the light source module 12 in the phototherapy device 10 simultaneously provides a first light source 121 and a second light source 122 having the above-mentioned two wavelength ranges. The light source module 12 is further configured to switch between the first light source 121 and the second light source 122, or to simultaneously provide the first light source 121 and the second light source 122 to irradiate the human body when the phototherapy device 10 is working. It should be noted that this application does not Figure 1 The embodiments shown are limited to the embodiments shown. In other embodiments of the present application, some light therapy devices may only provide Figure 1As shown, one of the first light source 121 and the second light source 122. Since the above two wavelength ranges have improved effects on relieving brain fatigue and improving attention level, such an embodiment with a single light source setting can still achieve the technical effects to be achieved by the present application.

[0043] exist Figure 1 In the illustrated embodiment, the phototherapy device 10 utilizes a first light source 121 and a second light source 122 with different wavelength ranges. In this embodiment, the first light source 121 and the second light source 122 can be implemented as near-infrared LEDs, OLEDs, or MicroLEDs, respectively, though this application is not limited thereto. Near-infrared LEDs are millimeter-level LEDs with mature, efficient, and low-cost manufacturing technology, making them suitable for the phototherapy scenarios described herein. Furthermore, preferably, MicroLEDs can achieve high power density, are smaller than 100 microns, and offer extremely high brightness and strong focusing capabilities. OLEDs are flexible, large-area, uniform light sources suitable for patch-type treatments. In this embodiment, the first wavelength range of the first light source 121 is set to 790nm to 830nm, and the second wavelength range of the second light source 122 is set to 956nm to 1070nm. Near-infrared light in these two wavelength ranges has excellent tissue penetration and bioactivity, penetrating deep into brain tissue to produce photobiomodulation, promoting brain cell metabolism and improving cerebral blood circulation, thereby relieving mental fatigue and enhancing attention. More specifically, according to the research conducted by the inventors of this application, photobiomodulation has the following principle mechanisms in alleviating brain fatigue and enhancing attention: (1) Activating cytochrome C oxidase and promoting cellular energy production. After irradiation with near-infrared light, a photochemical reaction occurs with the target cells, activating respiratory chain complex IV (cytochrome C oxidase, CCO) in the mitochondria, further activating the electron transport chain of the mitochondria → the proton gradient on both sides of the mitochondrial membrane increases, further increasing the membrane potential, and subsequently producing ATP and reactive oxygen species required for normal cellular respiration, increasing cellular energy consumption, relieving mental fatigue, and promoting enhanced attention. (2) After irradiation with a light source with a specific wavelength (such as near-infrared light), N-methyl-D-aspartate receptors are activated, cell membranes are depolarized, and the permeability of neurons to calcium ions is increased, locally acting on large signal transduction complexes associated with synapses, promoting synaptic signal conduction, activating neuronal activity, and promoting enhanced attention. (3) It promotes increased cerebral blood flow and accelerates blood flow velocity. Irradiation with a light source with a specific wavelength (such as near-infrared light) can change the spatial structure of the extracellular space of the brain, reduce the tortuosity of the extracellular space of the brain, increase the diffusion coefficient of molecules in the extracellular space of the brain, accelerate the drainage of interstitial fluid in the brain tissue, cause an increase in cerebral blood flow and blood flow velocity, and promote the clearance of metabolic substances in the brain.

[0044] Specifically, the wavelength range of about 810nm corresponding to the first light source 121 is the wavelength band corresponding to the peak of light absorption by cytochrome C oxidase; and the wavelength band of about 1050nm corresponding to the second light source 122 corresponds to the wavelength band where the peak of light absorption by water is located. Through the research and experimental verification of the inventors of this application, the selection of the above two wavelength ranges has a significant improvement in the therapeutic effect on the brain. Furthermore, in an actual experimental scenario, the inventors of this application found that for different therapists, due to the different responses of individuals to light irradiation, when the phototherapy device 10 is simultaneously provided with the first light source 121 and the second light source 122 having different wavelength ranges, the phototherapy device 10 can have better universality for different therapists with individual differences. On the other hand, during actual treatment, if the therapist responds poorly to a light source with a single wavelength range, turning on the first light source 121 and the second light source 122 at the same time can also improve the therapeutic effect of the therapist. Therefore, on the whole, even if Figure 1 The phototherapy device 10 shown is provided with a first light source 121 and a second light source 122 . In actual use, only one of the light sources may be turned on for treatment, or both light sources may be turned on for irradiation.

[0045] exist Figure 1 On the basis of the illustrated embodiment, the wavelength of the first light source 121 is preferably set to 810nm, or within the range of 790nm to 810nm. Further, the wavelength of the second light source 122 is preferably set to meet at least one of the following wavelength values and wavelength ranges: 976nm, within the range of 956nm to 996nm, within the range of 966nm to 986nm, 980nm, within the range of 960nm to 1000nm, within the range of 970nm to 990nm, 1050nm, within the range of 1030nm to 1070nm, or within the range of 1040nm to 1060nm. The following will further explain the effects that can be achieved by the selection of the above-mentioned wavelength values and wavelength ranges, and further explain the preferred variant embodiment of the phototherapy device 10 from the perspective of structure.

[0046] refer to Figure 2 , Figure 2 The module structure diagram of a light therapy device 20 in another embodiment of the present application is shown. Figure 1 Based on the light therapy device 10 shown in FIG. 1 , a preferred embodiment is realized, so the same component modules are marked with the same reference numerals. Figure 2 , in addition to being embedded in the wearing portion 11 ( Figure 2In addition to the light source module 12 in the image processing apparatus 20 (not shown), the light therapy device 20 also includes a control module 14 and a sensor module 13, a user input unit 15 and a memory 16 that interact with the control module 14. Furthermore, the light source module 12 also has communication interaction with the control module 14. The control module 14 is used to transmit control instructions to the light source module 12. The control instructions include start and stop information for controlling the first light source 121 and / or the second light source 122 to turn on and off, and parameter information related to the irradiation parameters of the first light source 121 and / or the second light source 122. Preferably, in different embodiments of the present application, the irradiation parameters include: output waveform, wherein the output waveform includes a continuous wave or a pulse waveform; output frequency, wherein the output frequency is 10Hz to 50Hz; output power, wherein the output power is greater than 30mW / cm 2 ; Irradiation time, wherein the irradiation time includes the single irradiation time or the irradiation time in a mode matching the treatment mode.

[0047] It should be emphasized that the phototherapy device 20 preferably adopts a pulse waveform, and the selected output frequency is between 10Hz and 50Hz, preferably between 10Hz and 40Hz. Through the research and experiments of the inventors of this application, it was found that the use of the above-mentioned pulse waveform and output frequency range can better stimulate brain cells when light is irradiated to the brain, regulate the function of the nervous system, and enhance the phototherapy effect. According to the understanding of the inventors of this application, pulsed light of different frequencies has different stimulating effects on brain cells. The frequency range of 10Hz to 50Hz, especially 10Hz to 40Hz, can effectively activate brain cells, promote the release of neurotransmitters, improve the transmission of brain nerve signals, thereby improving attention levels and alleviating brain fatigue symptoms. In addition, the phototherapy device 20 can also adopt continuous waves, which can also achieve the purpose of treating the human brain, but after experimental verification, the effect of the above-mentioned pulse waveform is better than that of continuous waves. On the other hand, the output power determines the light intensity of the first light source 121 and the second light source 122 during irradiation. It depends on the safety of use of the equipment, the effectiveness of the treatment and the upper limit selection corresponding to the light source module 12. It is preferred to set some output power values, such as 40mW / cm 2 , 15mW / cm 2 and 200mW / cm 2 etc., and is further preferably set to 30 mW / cm 2 ~200mW / cm 2 Within the range of 30mW / cm 2 ~150mW / cm 2 within the range of 40mW / cm 2 ~150mW / cm 2In addition, the control module 14 can also control the irradiation time of the first light source 121 and / or the second light source 122. For example, for a single treatment, the single irradiation time can be set after each activation of the light source module 12. In addition, the control module 14 can also automatically control the irradiation time of the first light source 121 and the second light source 122 according to the set treatment mode and other information.

[0048] More specifically, according to Figure 2 The sensor module 13 includes a temperature sensor unit 131, a heart rate sensor unit 132, and an electroencephalogram sensor unit 133. The sensor module 13 can provide a feedback mechanism for the phototherapy device 20 during operation through communication interaction with the control module 14, thereby improving the treatment effect. First, the temperature sensor unit 131 is embedded in the wearing part 11. The temperature sensor unit 131 is configured to monitor the skin temperature of the irradiated area of the human brain and transmit a first temperature signal containing the skin temperature to the control module 14. For example, according to Figure 3 The EEG sensor unit 133 can be configured to fit the frontal lobe of the human brain, for example Figure 3 On this basis, the control module 14 is correspondingly configured to compare the skin temperature with a first temperature threshold, and when the skin temperature is higher than the first temperature threshold, the control module 14 is adapted to turn off the light source module 12, i.e., interrupt the treatment process of the phototherapy device 20.

[0049] In this embodiment, preferably, further preferred settings can be made to realize the temperature feedback condition function. Figures 3 to 5 , these drawings show how the present application Figure 2 Schematic diagram of the light therapy device 20 in the embodiment shown being worn outside the human brain. Figure 3 The wearing portion 11 is further provided with a fitting portion 111. The fitting portion 111 may be made of a flexible material, so as to better fit the skin of the human head, and a porous material may be used at least in a local area 1110 on the fitting portion 111. Exemplarily, the flexible material may include a flexible thermoplastic polyurethane (TPU) substrate. Further preferably, the fitting portion 111 adopts a stretchable, head-fitting annular structure, and the weight is preferably set to less than 150g. The above design is superior to the rigid frame design of traditional helmets in terms of comfort and wearing weight. Figure 4The light source module 12 is also shown to have a protective mirror 123, which is mainly used to block dust and avoid the generation of air static electricity. In addition, in other embodiments of the present application, an indicator light source, such as a near-infrared LED light source, can also be provided in the light source module 12 to warn the user to avoid visually viewing the near-infrared light source during operation. This is because near-infrared light is invisible and cannot be naturally avoided by the human body. When viewed directly, it may cause damage to the eyes. Therefore, by adding corresponding warnings in the above manner, the safety of the phototherapy device 20 can be further enhanced.

[0050] On this basis, Figure 4 and Figure 5 It is also shown that the wearing portion 11 is provided with a heat dissipation device 112. For example, the heat dissipation device 112 can be implemented as a turbo cooling fan. Figure 2 and Figure 4 as well as Figure 5 , the heat dissipation device 112 is connected to the control module 14, and the control module 14 is further configured to compare the skin temperature and a second temperature threshold, and when the skin temperature is higher than the second temperature threshold, the control module 14 is suitable for turning on the heat dissipation device 112 and cooling the irradiated area through the porous material in the fitting portion 111, wherein the second temperature threshold is less than the first temperature threshold. In this way, during the actual treatment process, when the temperature of the phototherapy device 20 rises slightly, the temperature can be first lowered by heat dissipation within the device, and the light source module 12 can be turned off when the temperature further rises to the first temperature threshold, thereby optimizing the temperature regulation mechanism. In addition, the temperature sensing unit 131 is also configured to monitor the temperature of the components of the wearing portion 11, and transmit a second temperature signal containing the component temperature to the control module 14. In such a case, the control module 14 is also configured to compare the component temperature with a third temperature threshold, and when the component temperature is higher than the third temperature threshold, the control module 14 can adopt any one of the following methods, or two of them simultaneously, to control and adjust the component temperature: first, the control module 14 is suitable for turning on the heat dissipation device 112, and reducing the temperature of the component equipped with the heat dissipation device 112 through the porous material in the bonding portion 111; second, the control module 14 is suitable for controlling the light source module 12 to adjust the irradiation parameters to reduce the component temperature.

[0051] Continue to refer Figure 2, the phototherapy device 20 preferably also includes a heart rate sensing unit 132, the heart rate sensing unit 132 is configured to collect the heart rate data of the patient and transmit the heart rate data to the control module 14, wherein the control module 14 is configured to calculate the heart rate variability index based on the heart rate data, and adjust the irradiation parameters of the light source module 12 according to the changing trend of the heart rate variability index. Specifically, the heart rate data of the patient is collected in real time by the built-in heart rate sensor of the heart rate sensing unit 132, and the control module 14 calculates the heart rate variability index HRV based on the heart rate data, such as the standard deviation of adjacent normal heartbeat intervals (SDNN), the root mean square of the difference between adjacent heartbeat intervals (RMSSD), etc. These indicators can reflect the activity and balance state of the autonomic nervous system. Usually, HRV will change when fatigue occurs. By timely adjusting the irradiation parameters of the light source module 12 according to the changing trend of this parameter, the treatment effect can be further intelligently improved. For example, Figure 3 The figure shows one implementation of the heart rate sensor unit 132, employing an ear clip sensor. This approach reduces the overall weight of the wearable portion 11 of the phototherapy device 20 and facilitates independent sensing and measurement, improving the accuracy and reliability of heart rate data. Furthermore, the heart rate sensor unit 132 can be further expanded to include blood oxygen detection, thereby enriching the range of physiological indicators detected.

[0052] besides, Figure 2 It is also shown that the phototherapy device 20 includes an EEG sensing unit 133, which is configured to collect EEG data of the patient and transmit the EEG data to the control module 14, wherein the control module 14 is configured to adjust the irradiation parameters according to the changing trend of the EEG data. Specifically, the EEG sensing unit 133 can use EEG electrodes to collect EEG data (such as EEG signals) of the patient. Preferably, the control module 14 focuses on the α wave (8Hz-13Hz), β wave (13Hz-30Hz) and θ wave (4Hz-8Hz) frequency bands. Alpha waves are usually associated with a relaxed and awake state, β waves are associated with alertness and tension, and θ waves increase when tired and sleepy. Exemplarily, the control module 14 can perform pre-processing such as filtering and denoising on the collected EEG signals to improve the signal quality, so as to better adjust the irradiation parameters corresponding to the light source module 12 according to the changes in the EEG data.

[0053] Continue to refer Figure 2The phototherapy device 20 also includes a user input unit 15 connected to the control module 14. The user input unit 15 is configured to receive input instructions and transmit the input instructions to the control module 14. Based on this, the control module 14 is configured to generate control instructions based on the input instructions. The design of the user input unit 15 allows the therapist to better control the use of the phototherapy device 20. In this embodiment, the user input unit 15 includes a remote control device 151, a mobile phone 152, and other input devices 153. Figures 3 to 5 Both show a remote control device 151, combined with Figure 4 The control module 14 is embedded in the wearable portion 11 and is connected to the remote control device 151 via a data line 140. For example, the control module 14 can be implemented as a PCB control board. However, this application does not Figure 4 The illustrations are limited. In other embodiments of the present application, the control module 14 can be embedded in the remote control device 151, and the remote control device 151 is located outside the wearable portion 11. In this way, the weight of the wearable portion 11 can be further reduced. In addition, in such an embodiment, the power module of the phototherapy device 20 can also be set in the external remote control device 151, thereby further improving the portability of the phototherapy device 20. It should be noted that Figures 3 to 5 As a schematic illustration only, the remote control device 151 can actually communicate and interact with the phototherapy equipment 20 through wired or wireless communication, and does not need to be worn as an accessory on the human brain. Even if it is a wired communication method, the length of the connecting line can be adjusted so that the therapist can hold the remote control device 151 for operation.

[0054] according to Figure 2 , the phototherapy device 20 also includes a storage unit 16, which is connected to the control module 14, and the storage unit 16 is configured to store device operation information, and the device operation information at least includes information on the irradiation parameters of the light source module 12 and the adjustment history of the irradiation parameters. Combined with the above description of the sensor module 13, the phototherapy device 20 can regularly (for example, every 5 minutes) conduct a comprehensive evaluation of the HRV and EEG data, and decide whether to adjust the irradiation parameters of the light source module 12 based on the changes in the two. If the change trends of the HRV and EEG signals are consistent, and both show that the treatment effect is good or poor, the parameters are adjusted according to the corresponding feedback logic. The storage unit 16 records the irradiation parameters and adjustment history of each therapist at different treatment stages, as well as the corresponding HRV and EEG change data, so that a personalized treatment parameter model for the therapist can be established. As the number of treatments increases, by setting Figure 2With the modular architecture shown, the phototherapy device 20 can continuously learn and adapt to each patient's physiological characteristics and response patterns, continuously optimizing light therapy parameters and achieving more personalized adaptive adjustment. Furthermore, Bluetooth 5.0 transmission and cloud-based analysis capabilities can be considered to synchronize treatment parameters (such as wavelength, dosage, duration, etc.) with physiological data (such as blood oxygen, HRV, etc.) to a host computer, thereby establishing a group-specific efficacy prediction model.

[0055] More preferably, referring to Figure 6 , Figure 6 Schematic diagram of a cross-section of the light therapy device 20 is shown. Figure 6 The light therapy device 20 further includes a light guide 124. When the light source module 12 provides the first light source 121 and / or the second light source 122, the light guide 124 is adapted to converge the light of the first light source 121 and / or the light of the second light source 122 so that the first light source 121 and / or the second light source 122 illuminate the same area of the human brain. Figure 6 It can be seen from the partially enlarged schematic diagram of the cross-section that the phototherapy device 20 uses multiple groups of dual-wavelength LED light sources, each group of LED light sources includes a first light source 121 and a second light source 122, which are installed on the LED frame 120. The phototherapy device 20 preferably provides a light guide portion 124 for each group of LED light sources. For more specific reference Figure 7 As shown, when the light source module 12 provides the first light source 121 and the second light source 122 at the same time, the light guide portion 124 can make the light of the first light source 121 and the second light source 122 in each group of LED light sources converge and illuminate the same area of the human brain. In this way, the phototherapy device 20 can further enhance the treatment effect when implementing light source irradiation in a single wavelength range or two wavelength ranges. Due to the diversity of human body dimensions of the foreheads of different patients, there is a size tolerance between the LED lamp beads and the skin. Therefore, in this embodiment, it is preferred to use the light guide portion 124 to avoid effect deviation caused by light attenuation. According to Figure 7 The LED light sources of the two wavelength ranges can emit light separately or in combination, so the LED lamp beads of each group of LED light sources (for example, one 1050nm and one 810nm wavelength LED) share a light guide 124. The light is reflected by the reflective outer wall of the light guide and can illuminate the skin with almost no attenuation, thereby improving the treatment effect.

[0056] On this basis, Figure 8 Another variation based on the light therapy device 20 is shown. Figure 8The light source module 12 in the light therapy device 30 is implemented as an integrated light source 31, which includes an OLED as a light source or a MicroLED light source as a light source. This light source design can provide two wavelength ranges of illumination light after starting up, including a first wavelength range of 790nm to 830nm and a second wavelength range of 956nm to 1070nm. Figure 8 The integrated light source 31 is set on the light row support plate bracket 32, and can illuminate the irradiation area 33 of the human brain after starting up.

[0057] The above-mentioned phototherapy device 20 of the present application can relieve brain fatigue. Through irradiation with near-infrared light of a specific wavelength and, for example, a pulse waveform, it can penetrate deep into brain tissue, improve brain blood circulation, promote the metabolism of brain cells, effectively relieve symptoms of brain fatigue, and improve work efficiency and quality of life. On this basis, the level of attention can be effectively improved. The phototherapy device 20 can regulate the function of the nervous system, enhance the release of neurotransmitters, and improve the transmission of brain nerve signals, thereby improving the level of attention and improving learning and work efficiency. The following will provide experimental data to demonstrate this. Finally, the phototherapy device 20 can be safe and non-invasive. It adopts a non-invasive phototherapy method that is non-invasive, painless, and has no side effects. It is suitable for people of all ages and has good safety and tolerability. In addition, the phototherapy device 20 is easy to operate, its device structure is simple, easy to operate, and parameters can be adjusted according to different treatment needs. The therapist can use it at home by himself, which has good convenience and practicality.

[0058] Another embodiment of this application refers to Figure 9 A method of phototherapy 40 is proposed. The accompanying drawings in this application use flowcharts to illustrate the operations performed by the system according to the embodiments of the present application. It should be understood that the previous or following operations are not necessarily performed in exact order. Instead, various steps can be processed in reverse order or simultaneously. At the same time, other operations can be added to these processes, or one or more operations can be removed from these processes. Figure 9, the phototherapy method 40 includes the following steps. Step 41 is to wear the phototherapy device on the outside of the human brain through the wearing part. Step 42 is to start the light source module of the phototherapy device to irradiate the human brain. Among them, the light source module is embedded in the wearing part, and the light source module is configured to provide a first light source with a first wavelength range and / or a second light source with a second wavelength range. The light source module is suitable for irradiating the human brain through the first light source and / or the second light source. The first wavelength range includes 790nm~830nm, and the second wavelength range includes 956nm~1070nm. Preferably, the wavelength of the first light source is preferably set to 810nm or in the range of 790nm~810nm. Furthermore, the wavelength of the second light source is preferably set to satisfy at least one of the following wavelength values and wavelength ranges: 976nm, within the range of 956nm to 996nm, within the range of 966nm to 986nm, 980nm, within the range of 960nm to 1000nm, within the range of 970nm to 990nm, 1050nm, within the range of 1030nm to 1070nm, and within the range of 1040nm to 1060nm. Exemplarily, the phototherapy method of any embodiment proposed in the present application can be applied to the phototherapy device proposed in any embodiment of the present application, so some details about the phototherapy method can also refer to the previous description of the phototherapy device, which will not be repeated here.

[0059] exist Figure 4 Based on the light therapy method 40 shown, the present application can also be modified as follows. First, a temperature adjustment mechanism is set. Figure 4 On the basis of the light therapy method 40, while executing step 42, the skin temperature of the irradiated area of the human brain can also be monitored. According to the temperature feedback regulation mechanism, the skin temperature and the first temperature threshold are compared, and when the skin temperature is higher than the first temperature threshold, the light source module is turned off. In addition, before comparing the skin temperature with the first temperature threshold, the skin temperature and the second temperature threshold can be compared, and when the skin temperature is higher than the second temperature threshold, the heat dissipation device (such as a heat dissipation fan) embedded in the wearing part is turned on, and the irradiated area is ventilated and cooled, wherein the second temperature threshold is less than the first temperature threshold.

[0060] In addition, further preferably, based on the phototherapy method 40, a preferred embodiment also includes monitoring the physiological indicators of the patient while executing step 42, and adjusting the irradiation parameters of the light source module according to the physiological indicators, wherein the physiological indicators include heart rate variability indicators HRV and / or EEG data. More specifically, the step of adjusting the irradiation parameters of the light source module according to the physiological indicators further includes: at the current output wavelength, judging whether the change of the physiological indicators meets the expected response; if the judgment result is no, adjusting the output frequency, output power and / or irradiation duration in the irradiation parameters until the change of the physiological indicators meets the expected response; if the output frequency, output power and / or irradiation duration in the irradiation parameters still cannot make the change of the physiological indicators meet the expected response, then adjusting the output wavelength. When adjusting, different ranges can be adjusted for the same light source, or the light source can be directly changed to select different wavelength ranges. Figure 10 A flow chart of a preferred embodiment according to the above-mentioned phototherapy method 40 is shown. First, after the program is started, the baseline data is measured, and the maximum phototherapy frequency F_max, power P_max, and the maximum treatment dose J_max of each course of treatment are preset. Whether the treatment response meets expectations is evaluated based on physiological indicators such as HRV and EEG signals. If it does not meet expectations, the treatment parameters need to be adjusted. Specifically, after the program starts, a baseline indicator measurement (such as 1 minute) is first performed, and the output wavelength of the current treatment is set accordingly. If the change in the physiological indicator meets the expected response, the current parameters are maintained and the data is recorded. If the physiological indicator does not change or the response is weak, the output frequency, output power and treatment duration can be adjusted in turn. The upper limit of the treatment duration in the current cycle depends on the preset maximum treatment dose J_max until the change in the physiological indicator meets the expected response. Of course, this application is not based on Figure 10 The examples shown are limited. In other embodiments of the present application, when the physiological indicators show a weak response, the parameters of output frequency, output power and treatment duration can also be adjusted in other orders. In particular, in order to better achieve the treatment effect and effectively record the data, the wavelength is not adjusted during each treatment, and the irradiation parameters of each wavelength are referenced. Figure 10 After optimizing the treatment parameters, the next wavelength can be further adjusted to suit the optimal treatment parameters for different patients. Figure 10 The personalized parameters are optimized through multiple treatments, and this information can be stored in the storage unit corresponding to the phototherapy device, so that it can complete the pattern recording and adaptive conditions during each treatment process.

[0061] Specifically, from the perspective of HRV regulation, if HRV indicators such as SDNN and RMSSD gradually increase during the treatment process, it means that the activity and balance of the autonomic nervous system have improved, which may indicate that the current light therapy parameters have a positive effect on relieving fatigue. The output power of the light source module can be appropriately increased (for example, by 5 mW / cm each time). 2 ) or extend the treatment time (for example, add 5 minutes each time) to further enhance the treatment effect. If the HRV index decreases or does not change significantly, it may mean that the current irradiation parameters are inappropriate. On the other hand, from the perspective of EEG feedback, when the power spectral density of the alpha wave in the EEG data gradually increases during the treatment process, the power spectral density of the beta wave decreases relatively, and the power spectral density of the theta wave decreases, it indicates that the brain gradually enters a state of relaxation and wakefulness, indicating that the current light irradiation parameters are effective. The output frequency of the light can be appropriately increased. If the power spectral density of the alpha wave decreases and the power spectral density of the theta wave increases, it indicates that the brain may be more tired or not adapted to the current parameters. At this time, reduce the output power of the light (such as reducing it by 5mW / cm each time). 2 ), and check whether the wavelength or output frequency needs to be adjusted. On this basis, a comprehensive evaluation of HRV and EEG data is conducted regularly (for example, every 5 minutes), and the changes in the two are combined to decide whether to adjust the light irradiation parameters for the patient. If the changing trends of HRV and EEG signals are consistent, and both show that the treatment effect is good or poor, the parameters are adjusted according to the corresponding feedback logic. The storage unit records the parameter adjustment history of each user at different treatment stages and the corresponding HRV and EEG change data, and establishes a user-personalized treatment parameter model. As the number of treatments increases, the system continuously learns and adapts to the physiological characteristics and response patterns of each user, continuously optimizes the light therapy parameters, and achieves more personalized adaptive adjustment.

[0062] The focus of the phototherapy device and phototherapy method of the present application is that, based on the research and experiments of the inventor of the present application, two wavelength ranges that can significantly improve the brain treatment effect are selected, and on this basis, an adaptive feedback adjustment mechanism is set to enhance the actual use effect and experience of the phototherapy device and phototherapy method. Based on the technical solution of the present application, according to the research and experiments of the inventor, when the wavelength is around 810nm, the human brain can respond to light to achieve the purpose of treatment. On this basis, a human skull model is used to perform a penetration test at a wavelength value of 810nm and a wavelength value of 1050nm, and an optical power meter is used to directly test the power density of the lamp beads and the prefrontal skull, and calculate the penetration rate. The results are as follows: Figure 11 As shown. Figure 11, the test results show that the penetration rate of 1050nm is higher than that of 810nm. It can be seen that for the wavelength range of about 810nm and the wavelength range of about 1050nm, good therapeutic effects on the human brain can be achieved. The inventors also conducted research and experiments on other wavelengths near the above-mentioned wavelength numerical range, and concluded that when the wavelength is set to the following values or ranges, the therapeutic effect on the human brain is better: 810nm, 790nm~810nm; 976nm, 956nm~996nm, 966nm~986nm, 980nm, 960nm~1000nm, 970nm~990nm, 1050nm, 1030nm~1070nm or 1040nm~1060nm.

[0063] Based on this, the inventors also conducted animal and human trials. The following discusses the experimental effects using two wavelengths, 810nm and 1050nm, as examples. First, 54 healthy adults were recruited and randomly divided into a control group, a 1050nm group, and an 810nm group, stratified by gender. During the trial, subjects continuously performed an N-back task, which required comparing a letter or number displayed on a screen to the Nth preceding letter or number. If they matched, they pressed the matching key; if they differed, they pressed the non-matching key. In-task feedback was provided using a keyboard or mouse. Each 10-minute block consisted of a single block, with subjective and objective fatigue assessments conducted after each block. The trial lasted for 12 blocks. The intervention began one hour into the task, while the control group only turned on the power without irradiation. After the intervention, the intervention effect was continuously evaluated, with no break between tasks. Subjects performed the N-back task continuously until the end of the trial. Subjective fatigue was assessed using a subjective fatigue scale, while objective assessments included task performance indicators, eye movement tasks, electrocardiogram (ECG) assessments, and EEG data.

[0064] The fatigue-inducing device uses a display and a 2-Back test as the fatigue-inducing paradigm. In the specific test, the subjects are required to compare the letter or number presented on the screen with the second letter or number before it (i.e., one letter or number in between): if they are the same, press the matching key; if they are different, press the non-matching key. Feedback during the task can be obtained with the help of a keyboard or mouse.

[0065] Accuracy rate: refers to the number of correct choices made by the participant divided by the total number of stimuli (number of correct choices / total number of choices) * 100%. Average recall: The number of recalls refers to the number of stimuli that the participant correctly recalled as matching. The total number of trials equals the number of matching stimuli. The calculation formula is recall rate = (number of recalls / total number of trials) * 100%.

[0066] (1) In terms of subjective fatigue, compared with the control group, the intervention group had a significant effect on relieving subjective fatigue within 30 minutes after the start of the intervention, and the mean change was significantly lower than that of the control group (P < 0.05, Table 1).

[0067] Table 1 Changes in subjective fatigue

[0068]

[0069] Change = Current subjective fatigue score minus pre-intervention subjective fatigue score. A result > 0 indicates an increase in subjective fatigue; a result < 0 indicates a decrease. As shown in Table 1, both experimental groups were more effective in alleviating mental fatigue than the control group.

[0070] (2) In terms of performance indicators, the two intervention groups achieved 100% accuracy ≥ 85% and recall ≥ 60% at all time points, while the control group showed large fluctuations in performance. Figure 12 , referring to the boxed part, it can be clearly seen that for different intervention time stages, 4 stages did not meet this standard.

[0071] (3) In terms of ECG indices, the frequency domain indices of the 1050nm*10Hz group decreased significantly at all stages after intervention, with statistically significant differences at 10min, 20min, 40min, and 60min after intervention (P<0.05); while there was no significant change in the control group.

[0072] (4) In terms of eye movement indicators, except for 30 minutes after intervention, the pupil diameter of the control group was significantly reduced in all other stages (P < 0.05), and the pupil diameter was reduced by a large margin, and the fatigue level continued to increase. In the intervention group, there was no statistical difference in the overall pupil diameter reduction in the 1050nm*10Hz group, and the mean change was very close to 0. It was relatively stable overall, and the pupil diameter showed an increasing trend 30 minutes after intervention; there was no statistical difference in the pupil change in the 810nm*40Hz group at each stage after intervention, and it was relatively stable. There was an increasing trend in the pupil diameter 40 minutes after intervention. At 20 minutes, 50 minutes, and 60 minutes after intervention, the mean pupil diameter change was very close to 0 ( Figure 13 ).

[0073] Through the above experimental comparison, it can be seen that after adopting the phototherapy equipment of the present application, performance indicators and eye movement indicators have been improved. For example, for performance indicators, the accuracy rates of the two intervention groups are higher, which means that the subjects have a higher accuracy in completing the task, lower brain fatigue, and higher attention; on the other hand, the pupil diameter of the intervention group tends to be stable for a longer period of time after the intervention than that of the control group, which also means that the attention is more focused and the brain is less fatigued than the control group. Accordingly, after adopting the phototherapy equipment with specific wavelength selection of the present application, various physiological indicators, performance indicators for reflecting the degree of attention and brain fatigue, eye movement indicators, etc. have been significantly improved, which means that the phototherapy equipment of the present application is more helpful in regulating the function of the nervous system, enhancing the release of neurotransmitters, and improving the transmission of brain nerve signals, thereby improving the level of attention and reducing the degree of brain fatigue.

[0074] In addition, for animal experiments, 6-8 week old C57BL / 6J mice were selected for the experiment and randomly divided into 810nm group, 1050nm group and control group SD for behavioral experiments. The mice were sleep deprived for 6 hours after adapting for about a week. After the sleep deprivation, the mice in the control group were placed in the phototherapy device but the device was not started; the mice in the 810nm group and the 1050nm group were intervened respectively, and the new object recognition experiment was performed immediately after the intervention. The results of the new object recognition experiment showed that compared with the control group, the new object preference scores of the mice in the 810nm and 1050nm groups were significantly increased (P < 0.01), and the exploration time of the new objects was increased, indicating that the cognitive function of the mice was effectively improved after the intervention ( Figure 14 ).

[0075] Results of mouse brain tissue marker test: Tissues were collected from 35 8-week-old C57BL / 6J mice and randomly divided into 810nm group, 1050nm group and control group. After the intervention, the mice were killed and the prefrontal lobe tissues were immediately taken on ice. The activity of mouse cytochrome C oxidase (CCO) was detected by colorimetry. The results showed that after the intervention, the CCO activity of the 1050nm group was 8.0U / gprot higher than that of the control group (P < 0.01), and the average CCO activity of the 810nm group was 29.9U / gprot higher than that of the control group (P < 0.001), among which the 810nm group was more obvious.

[0076] It can be seen from the above test results that the wavelength range values selected in the phototherapy equipment and phototherapy method of the present application have obvious therapeutic improvement functions in the range of 790nm~830nm and 956nm~1070nm. The other wavelength numerical parameters within the above wavelength range have similar treatment verification results to the above 810nm and 1050nm, which will not be repeated here.

[0077] The basic concepts have been described above. It will be apparent to those skilled in the art that the above disclosures are merely examples and do not limit the present application. Although not explicitly stated herein, those skilled in the art may make various modifications, improvements, and revisions to the present application. Such modifications, improvements, and revisions are suggested in the present application and remain within the spirit and scope of the exemplary embodiments of the present application.

[0078] At the same time, this application uses specific terms to describe the embodiments of this application. For example, "one embodiment," "an embodiment," and / or "some embodiments" refer to a certain feature, structure, or characteristic related to at least one embodiment of this application. Therefore, it should be emphasized and noted that "one embodiment," "an embodiment," or "an alternative embodiment" mentioned twice or multiple times in different locations in this specification does not necessarily refer to the same embodiment. In addition, certain features, structures, or characteristics in one or more embodiments of this application may be appropriately combined.

[0079] Some aspects of the present application can be performed entirely by hardware, entirely by software (including firmware, resident software, microcode, etc.), or by a combination of hardware and software. The above hardware or software can be referred to as "data blocks", "modules", "engines", "units", "components" or "systems". The processor can be one or more application-specific integrated circuits (ASICs), digital signal processors (DSPs), digital signal processing devices (DAPDs), programmable logic devices (PLDs), field programmable gate arrays (FPGAs), processors, controllers, microcontrollers, microprocessors or combinations thereof. In addition, various aspects of the present application may be expressed as computer products located in one or more computer-readable media, which include computer-readable program code. For example, computer-readable media may include, but are not limited to, magnetic storage devices (e.g., hard disks, floppy disks, tapes...), optical disks (e.g., compact disks CDs, digital versatile disks DVDs...), smart cards, and flash memory devices (e.g., cards, sticks, key drives...).

[0080] A computer-readable medium may include a propagated data signal embodying computer program code, for example, in baseband or as part of a carrier wave. The propagated signal may be in a variety of forms, including electromagnetic, optical, etc., or a suitable combination thereof. A computer-readable medium may be any computer-readable medium other than a computer-readable storage medium that can be connected to an instruction execution system, apparatus, or device to communicate, propagate, or transmit the program for use. The program code on the computer-readable medium may be transmitted via any suitable medium, including radio, cable, fiber optic cable, radio frequency signal, or similar medium, or any combination of the above.

[0081] Similarly, it should be noted that, in order to simplify the description of this application and thus facilitate understanding of one or more embodiments of the application, the foregoing description of the embodiments of this application sometimes combines multiple features into a single embodiment, figure, or description thereof. However, this disclosure method does not mean that the subject matter of this application requires more features than those recited in the claims. In fact, the features of an embodiment may be fewer than all the features of the individual embodiments disclosed above.

[0082] In some embodiments, numbers are used to describe the quantity of components and attributes. It should be understood that such numbers used in the description of the embodiments are modified by the modifiers "about", "approximately" or "substantially" in some examples. Unless otherwise stated, "about", "approximately" or "substantially" indicate that the numbers are allowed to vary by ±20%. Accordingly, in some embodiments, the numerical parameters used in the description and claims are approximate values, which may change according to the required features of individual embodiments. In some embodiments, the numerical parameters should take into account the specified significant digits and adopt the general method of retaining digits. Although the numerical domains and parameters used to confirm the breadth of their range in some embodiments of the present application are approximate values, in specific embodiments, the settings of such numerical values are as accurate as possible within the feasible range.

[0083] Although the present application has been described with reference to the current specific embodiments, ordinary technicians in this technical field should recognize that the above embodiments are only used to illustrate the present application, and various equivalent changes or substitutions can be made without departing from the spirit of the present application. Therefore, as long as the changes and modifications to the above embodiments are within the scope of the essential spirit of the present application, they will fall within the scope of the claims of the present application.

Claims

1. A phototherapy device, characterized in that include: a wearing portion, the wearing portion being adapted to allow the phototherapy device to be worn outside the human brain; as well as A light source module is embedded in the wearable portion, and the light source module is configured to provide a first light source having a first wavelength range and / or a second light source having a second wavelength range. The light source module is suitable for irradiating the human brain through the first light source and / or the second light source, wherein the first wavelength range includes 790nm~830nm, and the second wavelength range includes 956nm~1070nm.

2. The phototherapy device according to claim 1, wherein The wavelength of the first light source satisfies at least one of the following wavelength values and wavelength ranges: 810nm or within the range of 800nm to 820nm.

3. The phototherapy device according to claim 1, wherein The wavelength of the second light source satisfies at least one of the following wavelength values and wavelength ranges: 976 nm, within the range of 956 nm to 996 nm, within the range of 966 nm to 986 nm, 980 nm, within the range of 960 nm to 1000 nm, within the range of 970 nm to 990 nm, 1050 nm, within the range of 1030 nm to 1070 nm, or within the range of 1040 nm to 1060 nm.

4. The light therapy device according to claim 1, wherein The first light source and the second light source respectively include a near-infrared LED light source, an OLED light source or a MicroLED light source.

5. The light therapy device according to claim 1, wherein It also includes a light-guiding portion. When the light source module provides the first light source and / or the second light source, the light-guiding portion is suitable for converging the light of the first light source and / or the light of the second light source so that the first light source and / or the second light source illuminate the same area of the human brain.

6. The phototherapy device according to any one of claims 1 to 5, characterized in that: It also includes a control module, which is connected to the light source module and is used to transmit control instructions to the light source module. The control instructions include start and stop information for controlling the first light source and / or the second light source to turn on and off, as well as parameter information related to the illumination parameters of the first light source and / or the second light source.

7. The light therapy device according to claim 6, wherein The irradiation parameters include: output waveform, wherein the output waveform comprises a continuous wave or a pulse waveform; and / or Output frequency, wherein the output frequency is 10 Hz to 50 Hz; and / or Output power, wherein the output power is greater than 30mW / cm 2 and / or Irradiation duration, wherein the irradiation duration includes a single irradiation duration or an irradiation duration in a mode matching the treatment mode.

8. The light therapy device according to claim 7, wherein The device further comprises a temperature sensing unit embedded in the wearable portion, wherein the temperature sensing unit is configured to monitor the skin temperature of the irradiated area of the human brain and transmit a first temperature signal containing the skin temperature to the control module. The control module is configured to compare the skin temperature with a first temperature threshold, and when the skin temperature is higher than the first temperature threshold, the control module is adapted to turn off the light source module.

9. The light therapy device according to claim 8, wherein The wearing portion includes a fitting portion and a heat dissipation device, wherein: The fitting portion is suitable for fitting with the skin of the human brain, and the fitting portion is made of porous material; The heat dissipation device is connected to the control module, and the control module is further configured to compare the skin temperature and a second temperature threshold. When the skin temperature is higher than the second temperature threshold, the control module is suitable for turning on the heat dissipation device and cooling the irradiated area through the porous material in the bonding portion, wherein the second temperature threshold is lower than the first temperature threshold.

10. The light therapy device according to claim 9, wherein The temperature sensing unit is further configured to monitor the temperature of a component of the wearable portion and transmit a second temperature signal containing the component temperature to the control module, wherein the control module is configured to compare the component temperature with a third temperature threshold, and when the component temperature is higher than the third temperature threshold: The control module is adapted to activate the heat dissipation device and reduce the temperature of the component through the porous material in the fitting portion; and / or The control module is adapted to control the light source module to adjust the illumination parameters to reduce the temperature of the component.

11. The light therapy device according to claim 6, wherein The system further comprises a heart rate sensing unit configured to collect heart rate data of the patient and transmit the heart rate data to the control module. The control module is configured to calculate a heart rate variability index based on the heart rate data, and adjust the irradiation parameters according to a change trend of the heart rate variability index.

12. The light therapy device according to claim 6, wherein It also includes an electroencephalogram (EEG) sensing unit configured to collect EEG data of the patient and transmit the EEG data to the control module. Wherein, the control module is configured to adjust the irradiation parameters according to the change trend of the EEG data.

13. The light therapy device according to claim 6, wherein It also includes a user input unit connected to the control module, wherein the user input unit is configured to receive an input instruction and transmit the input instruction to the control module, wherein the control module is configured to generate the control instruction according to the input instruction.

14. The light therapy device according to claim 13, wherein The user input unit further includes a remote control device, the control module is embedded in the remote control device, and the remote control device is located outside the wearing portion.

15. The light therapy device according to claim 7, wherein The device further includes a storage unit connected to the control module, wherein the storage unit is configured to store device operation information, wherein the device operation information at least includes information of the irradiation parameters and an adjustment history record of adjusting the irradiation parameters.

16. A phototherapy method, characterized in that: The steps include: The light therapy device is worn on the outside of the human brain through the wearing part; Starting the light source module of the phototherapy device to irradiate the human brain, In which, the light source module is embedded in the wearing part, and the light source module is configured to provide a first light source having a first wavelength range and / or a second light source having a second wavelength range. The light source module is suitable for irradiating the human brain through the first light source and / or the second light source. The first wavelength range includes 790nm~830nm, and the second wavelength range includes 956nm~1070nm.

17. The phototherapy method according to claim 16, wherein: It also includes monitoring the skin temperature of the irradiated area of the human brain while starting the light source module of the phototherapy device to irradiate the human brain, comparing the skin temperature with a first temperature threshold, and turning off the light source module when the skin temperature is higher than the first temperature threshold.

18. The phototherapy method according to claim 17, wherein: It also includes comparing the skin temperature with a second temperature threshold, and when the skin temperature is higher than the second temperature threshold, turning on the heat dissipation device embedded in the wearing part and ventilating and cooling the irradiated area, wherein the second temperature threshold is lower than the first temperature threshold.

19. The phototherapy method according to claim 16, wherein: It also includes monitoring the physiological indicators of the patient while starting the light source module of the phototherapy device to irradiate the human brain, and adjusting the irradiation parameters of the light source module according to the physiological indicators, wherein the physiological indicators include heart rate variability indicators and / or EEG data.

20. The phototherapy method according to claim 19, wherein: The step of adjusting the illumination parameters of the light source module according to the physiological indicators further includes: At the current output wavelength, determining whether the change in the physiological indicator meets the expected response; if not, adjusting the output frequency, output power, and / or irradiation duration in the irradiation parameters until the change in the physiological indicator meets the expected response; If the change in the physiological indicator still cannot meet the expected response after adjusting the output frequency, output power and / or irradiation duration in the irradiation parameters, the output wavelength is adjusted.

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