Odor molecule detection method and system
By forming bio-nanochannels in a phospholipid bilayer using insect olfactory receptor proteins, the problems of chemical modification and low sensitivity of electrochemical sensors have been solved, enabling high-sensitivity, rapid, and accurate detection of odor molecules.
CN120870294AActive Publication Date: 2025-10-31NORTHWEST UNIV
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Patent Information
- Application Number
- CN202511365896.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-09-24
- Publication Date
- 2025-10-31
- Estimated Expiration
- 2045-09-24
AI Technical Summary
Technical Problem
Existing electrochemical sensors require chemical modification, have low sensitivity and selectivity, and require complex pretreatment steps before detection, which are time-consuming and costly.
Method used
A biological nanochannel is formed in a phospholipid bilayer using insect olfactory receptor proteins. It recognizes and binds to odor molecules through an electric field, generating an electric current signal for detection. This simplifies the detection method to one that requires no pretreatment or chemical modification.
Benefits of technology
It achieves highly sensitive detection of low concentrations of odor molecules, with a detection limit at the picomolar level. It is easy to operate and suitable for rapid and accurate detection of a variety of odor molecules.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention relates to the technical field of odor molecule detection, in particular to an odor molecule detection method and system. According to the invention, a diaphragm with holes is arranged in an electrolytic tank, and the electrolytic tank is divided into a clockwise chamber and a counterclockwise chamber; a circle of hydrophobic organic solvent layer is arranged along the periphery of the hole; adding an electrolyte into the cis-chamber cavity and the reverse-chamber cavity, adding a phospholipid solution above the electrolyte, and forming a phospholipid bilayer on the hole; adding insect olfactory receptor protein into the cis-chamber, and inserting the insect olfactory receptor protein into the phospholipid bilayer to form a closed channel; a sample containing target odorant molecules is added into the chamber, the insect olfactory receptor protein recognizes the target odorant molecules and is combined with the target odorant molecules to form an opened channel, and under the action of electric field force, electrolyte ions penetrate through the opened channel to generate a current signal for detecting the target odorant molecules. The problems that an electrochemical sensor constructed in the prior art needs chemical modification and is low in sensitivity and selectivity are solved.
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