Production process of water-soluble thiophanate-methyl preparation

By preparing porous drug-loaded microspheres, the problems of insufficient water solubility and wettability of thiophanate-methyl have been solved, realizing efficient and environmentally friendly pesticide utilization, which is suitable for modern agriculture.

CN120898809APending Publication Date: 2025-11-07ANHUI GUANGXIN AGROCHEM
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Patent Information

Application Number
CN202510986427.1
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-07-17
Publication Date
2025-11-07

AI Technical Summary

Technical Problem

Existing thiophanate-methyl formulations have low solubility in water, resulting in uneven efficacy, and traditional preparation methods have potential negative impacts on the soil environment.

Method used

A polyethylene glycol-modified chitosan was formed by combining chitosan and polyethylene glycol monomethyl ether under the action of a crosslinking agent. Porous drug-loaded microspheres were then prepared by spray drying. Combined with a pore-forming agent and a surfactant, a methyl thiophanate formulation with high wettability and water solubility was formed.

Benefits of technology

It improves the water solubility and wettability of thiophanate-methyl, enhances efficacy, reduces pesticide runoff and residue, is suitable for modern agricultural spraying, and is environmentally friendly.

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Abstract

The invention discloses a production process of a water-soluble thiophanate-methyl preparation, and belongs to the technical field of pesticide preparations, the production process comprises the following steps: preparing porous drug-loaded microspheres by a spray drying method, crosslinking chitosan and methoxypolyethylene glycol under the action of a crosslinking agent to form polyethylene glycol modified chitosan, and coating thiophanate-methyl by using the polyethylene glycol modified chitosan as a loading material to prepare the water-soluble thiophanate-methyl preparation. Under the synergistic effect of the pore-forming agent, the granulation and pore-forming of the microspheres can be realized in one step. The thiophanate-methyl preparation prepared by taking the porous drug-loaded microspheres as the raw material not only has excellent water solubility and wettability, but also has the functions of slow release and pyrolysis resistance due to the combination of coating and micropores, the utilization rate of thiophanate-methyl is increased, and the raw material components have excellent biocompatibility and environmental friendliness, so that the thiophanate-methyl preparation has good application prospects. The sustainable development of agriculture is facilitated.
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