Valve assembly and radioactive microsphere infusion system

Abstract

The present application relates to the field of valve assembly and infusion system, and provides a valve assembly and a radioactive microsphere infusion system comprising the valve assembly. The valve assembly comprises a valve body, a valve core, a first needle body and a second needle body. The valve body comprises a valve main body provided with a cavity and a first opening, a second opening, a third opening and a fourth opening communicated with the cavity; the valve core is rotatably arranged in the cavity, so that a first channel, a second channel and a third channel are formed in the valve assembly; the first needle body is communicated with the third opening, and the second needle body is communicated with the fourth opening. The radioactive microsphere infusion system comprises a first pipeline, a second pipeline, a container and the valve assembly, and the container can be selectively communicated with the first pipeline and the second pipeline through the valve assembly, which is beneficial to simplify the operation steps and reduce the operation time.

Description

Technical Field

[0001] This invention relates to the field of valve assemblies and infusion systems for medical devices. Specifically, this invention relates to infusion systems for delivering insoluble materials to living organisms, and valve assemblies within such infusion systems. Background Technology

[0002] Radiopharmaceuticals are an important component of nuclear medicine, widely used in cancer diagnosis and treatment. A common type of radiopharmaceutical is the radioactive microsphere, an insoluble material, which is currently commercially available from several companies. Radioactive microspheres can be used to treat inoperable tumors, and clinical data indicates that this method is quite effective. The delivery of radioactive microspheres to the body requires the use of water for injection and contrast agents.

[0003] Figure 1 An existing infusion system 300 for delivering radioactive microspheres is shown. Its principle involves injecting physiological saline into a conical-bottom flask 331 containing radioactive microspheres, and then using pressure to infuse the microspheres into the human body. The infusion system 300 includes three syringes, two three-way valves, the conical-bottom flask 331, and several tubing lines. The three syringes are syringes 321, 322, and 323, where syringe 321 is used for injecting water for injection, syringe 322 for injecting contrast agent, and syringe 323 for injecting both water for injection and air. The two three-way valves are three-way valves 311 and 312. The tubing lines include tubing lines 301, 302, 303, and 304. The connection methods of the components in the infusion system 300 are described below. Figure 1 This will not be elaborated upon here. Because the microspheres are radioactive, the infusion system 300 also includes an infusion tank ( Figure 1 (Not shown in the diagram), where the three-way valve 311 and the conical bottom bottle 331 are located in the infusion tank, which can reduce the radiation of the microspheres to the operator.

[0004] The procedure for delivering radioactive microspheres using infusion system 300 is as follows: First, before connecting the tubing, air must be purged from each tubing. Then, manually operate the three-way valve 311 in the infusion tank to connect tubing 301 and 302. Manually adjust the three-way valve 312 to connect syringes 321 and 322 sequentially to tubing 302, thereby injecting contrast agent and water for injection sequentially into tubing 301 to determine the surgical location. Next, manually operate the three-way valve 311 to connect tubing 301 to tubing 303, injecting water for injection from syringe 323 (connected to tubing 304) into conical flask 331. The microspheres in conical flask 331, along with the water for injection, are then delivered into the organism via tubing 303 and 301. During the microsphere infusion process, contrast agent needs to be frequently injected from syringe 322, and the operating procedure is the same as before. In addition, syringe 323 needs to draw air in, injecting the air from syringe 323 into conical flask 331, thereby injecting all the microspheres in conical flask 331 into the organism. The specific operation method for syringe 323 drawing air and three-way valve 311 is as follows: open the infusion tank cap, lift the long needle connected to tubing 304 from conical flask 331 above the liquid surface, draw air in syringe 323, and then manually operate three-way valve 311 to connect tubing 301 and tubing 303, injecting the air from syringe 323 into conical flask 331. Figure 1 The transport system shown is too complicated and prone to errors when transporting radioactive microspheres. Summary of the Invention

[0005] To address the aforementioned technical problems, this disclosure provides a valve assembly for an infusion system, and a radioactive microsphere infusion system including the valve assembly.

[0006] The first aspect of this disclosure discloses a valve assembly for an infusion system, including a valve body, a valve core, a first needle body, and a second needle body. The valve body includes a valve body having a cavity and a first opening, a second opening, a third opening, and a fourth opening communicating with the cavity. The valve core is rotatably disposed within the cavity, forming a first channel, a second channel, and a third channel within the valve assembly. The first needle body communicates with the third opening, and the second needle body communicates with the fourth opening. When the valve core is in a first position, the first opening and the second opening communicate to form the first channel; when the valve core is in a second position, the first opening and the third opening communicate to form the second channel, and the second opening and the fourth opening communicate to form the third channel.

[0007] In some embodiments, the valve core includes a partition rotatably disposed within a cavity. When the valve core is in a first position, at least one surface of the partition defines a first channel. Further, the valve body includes a blocking step located within the cavity; when the valve core is in the first position, the blocking step, together with the partition, defines the first channel. Preferably, the cavity is configured as a column, coaxially disposed with the valve core, and two blocking steps are configured, one blocking step disposed near a first opening and the other blocking step disposed near a second opening.

[0008] In other embodiments, the valve core is provided with a spacer, and the spacer has a valve core channel. When the valve core is in a first position, the first channel is at least partially formed by the valve core channel. Preferably, the lateral dimensions on both sides of the spacer are greater than the lateral dimensions in the middle of the spacer.

[0009] Furthermore, the distance from the center of the valve core to the free end of the first needle body is less than the distance from the center of the valve core to the free end of the second needle body. Preferably, the first needle body and the second needle body are arranged in parallel, and the interval between the free ends of the first needle body and the free ends of the second needle body is 3~12mm.

[0010] Optionally, the valve body includes a connecting body disposed on the outer periphery of the valve body. The connecting body includes a cone. The extension direction of the first needle body and the extension direction of the second needle body are both parallel to the axis of the cone. The first needle body and the second needle body extend through the cone. Most of the cone is close to the valve body.

[0011] A second aspect of this disclosure discloses a radioactive microsphere infusion system, including a first conduit, a second conduit, a container, and a valve assembly provided in the first aspect of this disclosure. A first opening of the valve assembly is connected to the first conduit, a second opening of the valve assembly is connected to the second conduit, and the container is connected to the valve assembly via a first needle body and a second needle body. When the valve core is in a first position, the container is isolated from the first and second conduits; when the valve core is in a second position, the container is in communication with both the first and second conduits.

[0012] Optionally, the infusion system further includes an actuator coupled to the valve core, the actuator being used to drive the valve core to rotate between a first position and a second position. Preferably, the valve core has a knob located outside the valve body, and the actuator is configured as an operating lever, one end of which has a coupling feature coupled to the knob, the operating lever being detachably connected to the knob.

[0013] Optionally, the infusion system further includes an infusion tank and a support. The container and valve assembly are located inside the infusion tank, and the support is connected to the valve assembly and coupled to the infusion tank. The support has a first longitudinal position and a second longitudinal position. When the support is in the first longitudinal position, the first needle body and the second needle body are located inside the container and the second needle body is in communication with the liquid inside the container; when the support is in the second longitudinal position, the first needle body and the second needle body are located outside the container.

[0014] The features and advantages of this disclosure include:

[0015] The valve assembly disclosed herein features four openings and two needles. By controlling the rotational position of the valve core, a first channel, a second channel, and a third channel can be formed within the valve assembly. When the valve core is in the first position, the first opening and the second opening communicate to form the first channel; when the valve core is in the second position, the first opening and the third opening form the second channel, and the fourth opening communicates with the second opening to form the third channel. Specifically, the distance between the free ends of the two needles can be customized according to the size of the conical flask, with an adjustable range of 3~12mm. This allows the microspheres in the conical-bottomed container to be completely delivered into the human body during infusion, simplifying the operation and reducing operation time.

[0016] The infusion system disclosed herein includes a valve assembly, an operating lever, and a support. The operating lever is coupled to a valve core of the valve assembly, allowing the valve core to rotate between a first position and a second position, thereby selectively communicating the container with a flow path. The support is connected to the valve assembly, and moving the support longitudinally moves the valve assembly to allow a first needle and a second needle to enter or exit the container. Attached Figure Description

[0017] To more clearly illustrate the technical solutions in the embodiments of this disclosure, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of this disclosure. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0018] Figure 1 A schematic diagram of an existing infusion system is shown;

[0019] Figure 2 A schematic diagram of the infusion system of this disclosure is shown;

[0020] Figure 3 It shows Figure 2 A three-dimensional schematic diagram of the valve assembly in the diagram;

[0021] Figure 4 A schematic diagram of one embodiment of the valve assembly of the present disclosure is shown, wherein the valve core of the valve assembly is in a second position;

[0022] Figure 5 A schematic diagram of one embodiment of the valve assembly of the present disclosure is shown, wherein the valve core of the valve assembly is in a first position;

[0023] Figure 6 A schematic diagram of another embodiment of the valve assembly of the present disclosure is shown, wherein the valve core of the valve assembly is in a second position;

[0024] Figure 7A schematic diagram of another embodiment of the valve assembly of the present disclosure is shown, wherein the valve core of the valve assembly is in a first position;

[0025] Figure 8 A schematic diagram of the infusion system with an infusion tank as disclosed herein is shown;

[0026] Figure 9 A schematic diagram of the infusion tank, support, operating lever, and valve assembly of the infusion system disclosed herein is shown.

[0027] Figure 10 A schematic diagram of the infusion tank of this disclosure is shown;

[0028] Figure 11 and Figure 12 A schematic diagram of the support structure of this disclosure is shown, wherein Figure 11 This shows one side of the bracket with the mating groove. Figure 12 The side of the bracket without the mating groove is shown;

[0029] Figure 13 A schematic diagram is shown of the bracket of this disclosure being moved upward and rotated before being placed on the cover of the infusion tank;

[0030] Figure 14 A schematic diagram of the operating lever and valve assembly of this disclosure is shown.

[0031] Explanation of reference numerals in the attached figures:

[0032] 100 - Valve assembly;

[0033] 10-Valve body, 11-First opening, 12-Second opening, 13-Third opening, 14-Fourth opening, 15-Blocking step, 16-Valve body, 17-Connector, 18-First pipe body, 19-Second pipe body;

[0034] 22 - First needle body, 24 - Second needle body;

[0035] 30 - Valve core, 32 - Baffle plate, 34 - Knob;

[0036] 40-Valve core, 42-Block, 44-Valve core channel, 46-Knob;

[0037] 200-Infusion system, 201-Pipeline, 202-Pipeline, 211-Three-way valve, 221-First syringe, 222-Second syringe, 231-Container;

[0038] 240-Infusion tank, 241-Tank cover, 2412-Support hole, 2414-Protrusion, 242-First side wall, 2422-First hole, 243-Second side wall, 2432-Limiting plate, 2434-Second hole, 2436-Limiting step, 2438-Limiting groove, 244-Third side wall, 2442-Third hole, 245-Fourth side wall, 246-Bottom wall;

[0039] 250-Bracket, 251-Bracket body, 2512-Matching groove, 2514-Accommodation part, 2516-Plate, 252-Valve body connection part, 2522-Accommodation groove, 2524-Clamping rod, 2526-Clamping plate, 2528-Limiting protrusion, 253-Stop block, 255-Handheld part;

[0040] 260-Operating lever, 261-Lever body, 262-Connecting part, 2622-Connecting groove, 263-Limiting block, 264-Handle, 265-Baffle;

[0041] 300 - Infusion system; 301, 302, 303, 304 - Piping; 311, 312 - Three-way valves; 321, 322, 323 - Syringes; 331 - Conical flask. Detailed Implementation

[0042] The technical solutions of the embodiments of this disclosure will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of this disclosure, and not all of them. Based on the embodiments of this disclosure, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of this disclosure.

[0043] See Figure 2 This invention provides an infusion system 200 for delivering insoluble materials, including a flow channel, a container 231, and a valve assembly 100 disposed in the flow channel. The insoluble material is stored in the container 231, and the valve assembly 100 selectively connects the container 231 to the flow channel, thereby injecting the insoluble material into the flow channel. The infusion system 200 is used to deliver the insoluble material to an organism, wherein the organism can be a human or other animal, and the insoluble material can specifically be radioactive microspheres or other insoluble materials used for treatment. The following description uses a human body and radioactive microspheres as examples. In some embodiments, the container 231 may also store water for injection, and the valve assembly 100 selectively connects the container 231 to the flow channel to facilitate the removal of air from the flow channel. It should be noted that the container 231 storing the radioactive microspheres and the container 231 storing the water for injection may not be the same container.

[0044] Specifically, the infusion system 200 includes conduits 201 and 202, with a valve assembly 100 disposed between conduits 201 and 202. The valve assembly 100 has four openings and two needles. The first opening communicates with conduit 201, the second opening with conduit 202, the third opening with the first needle 22, and the fourth opening with the second needle 24. In some cases, the valve assembly 100 can be operated to connect the first and second openings, and the third and fourth openings, or not. In other cases, the valve assembly 100 can be operated to connect the first and third openings, while simultaneously connecting the fourth opening with the second opening. Both the first needle 22 and the second needle 24 can be connected to a container 231, allowing the container 231 to be selectively connected to the infusion channel. One end of conduit 201 is connected to the human body, allowing the medium in the infusion channel to enter the human body.

[0045] The infusion system 200 also includes a three-way valve 211, a first syringe 221, and a second syringe 222. The three ends of the three-way valve 211 are respectively connected to the first syringe 221, the second syringe 222, and the tubing 202. By operating the three-way valve 211, the first syringe 221 and the second syringe 222 can be selectively connected to the tubing 202 (i.e., connected to the flow channel). In some embodiments, the first syringe 221 is used to store water for injection or air, and the second syringe 222 is used to store contrast agent.

[0046] The operation of delivering radioactive microspheres using infusion system 200 includes six steps, in sequence: purging air from the tubing, injecting microspheres, injecting contrast agent, injecting water for injection, continuing to inject microspheres with air, and continuing to inject water for injection. Steps two through four are repeated multiple times during the delivery process until the microsphere delivery is nearly complete before proceeding to step five. Infusion system 200 includes two containers 231: one for storing water for injection and one for storing radioactive microspheres. The container 231 for storing water for injection is used only in step one; the containers used in the remaining steps are all the same as the container 231 for storing radioactive microspheres.

[0047] In step one, the free ends of the first needle body 22 and the second needle body 24 of the valve assembly 100 are inserted below the liquid surface of the container 231 for storing water for injection, and the valve assembly 100 is operated to connect the container 231 with the flow channel; the three-way valve 211 is adjusted to connect the syringe 221 with the tubing 202, and the syringe 221 containing water for injection is pushed in until all the air in the tubing is expelled. At this time, the inside of the valve assembly 100 and the first needle body 22 and the second needle body 24 are filled with water for injection. In step two, the free ends of the first needle body 22 and the second needle body 24 are inserted below the liquid surface of the container 231 containing the microsphere mixture, the tubing 201 is connected to the tubing inside the human body, and the water for injection in the syringe 221 is slowly pushed in to allow the microspheres to enter the human body. During the pushing of the microspheres, contrast agent needs to be injected intermittently to observe the position of the microspheres. In step three, the three-way valve 211 and valve assembly 100 are operated to connect syringe 222 to the tubing, disconnecting the first needle body 22 and the second needle body 24 from the tubing, and pushing the contrast agent. In step four, the three-way valve 211 is operated to connect syringe 221 to the tubing, and injecting water to completely introduce the contrast agent into the body; then the valve assembly 100 is operated to connect the first needle body 22 and the second needle body 24 to the tubing. Steps two to four are repeated until the microspheres are almost completely pushed into step five. In step five, the valve assembly 100 is operated to isolate tubing 202 from syringes 221 and 222, and air is drawn into syringe 221; then the valve assembly 100 is operated to reconnect tubing 202 and syringe 221, and air is injected into container 231 storing the microsphere mixture until all the microspheres are pushed into tubing 201. In step six, the valve assembly 100 is operated to isolate the tubing 202 from the syringes 221 and 222, and the syringe 221 is filled with water for injection; the valve assembly 100 is operated to disconnect the first needle body 22 and the second needle body 24 from the tubing, and the syringe 221 is used to push the water for injection until the microspheres in the tubing 221 are completely pushed into the human body.

[0048] Using the infusion system 200 of this disclosure simplifies the operation of infusing radioactive microspheres into the human body. For example, in step one, it is easier to purge air from the tubing by using the valve assembly 100. In steps two through six, by manipulating the valve assembly 100, the first needle 22 and the second needle 24 can be selectively connected to the tubing. Since the first needle 22 and the second needle 24 are located in the container 231, and the second needle 24 is below the liquid surface, the microsphere mixture in the container 231 can be selectively connected to the tubing, simplifying the operation.

[0049] The following reference Figures 3 to 7 The valve assembly 100 disclosed herein is described in detail, wherein, Figure 3 A perspective view of the valve assembly 100 of this disclosure is shown. See also Figure 3The valve assembly 100 includes a valve body 10, a valve core 30 or 40, a first needle body 22, and a second needle body 24. See also... Figures 3 to 5 The valve body 10 includes a valve body 16 with a cavity and a first opening 11, a second opening 12, a third opening 13, and a fourth opening 14 communicating with the cavity. A first needle body 22 communicates with the third opening 13, and a second needle body 24 communicates with the fourth opening 14. The valve core 30 is rotatably disposed in the cavity of the valve body 16, so that a first channel, a second channel, and a third channel are formed within the valve assembly 100. When the valve core 30 is in the first position, the first opening 11 and the second opening 12 communicate to form the first channel; when the valve core 30 is in the second position, the first opening 11 and the third opening 13 form the second channel, and the fourth opening 14 communicates with the second opening 12 to form the third channel.

[0050] Specifically, see Figures 3 to 5 This illustrates one embodiment of the valve assembly 100 of this disclosure. Specifically, see [link to relevant documentation]. Figure 4 and Figure 5 The cavity of the valve body 16 disclosed herein can be constructed in any shape, as long as it can accommodate the valve core 30 and form the aforementioned three channels. Specifically, the cavity of the valve body 16 can be constructed as a sphere, cylinder, cone, or other three-dimensional shape. In some embodiments, the four openings are directly disposed in the valve body 16; in other embodiments, some or all of the openings are disposed in a component of the valve body, which communicates with the cavity of the valve body 16. See also Figure 3 The valve body 10 also includes a hollow first tube 18 and a hollow second tube 19. One end of the first tube 18 forms a first opening 11, and the other end of the first tube 18 is connected to the valve body 16. One end of the second tube 19 forms a second opening, and the other end of the second tube 19 is connected to the valve body 16. The first tube 18 and the second tube 19 facilitate connection to the first conduit 201 and the second conduit 202.

[0051] Specifically, the valve core 30 is provided with a partition 32, which is rotatably disposed in the cavity of the valve body 16. When the valve core is in the first position, at least one surface of the partition 32 defines a first channel. See also Figure 5 When the valve core is in the first position, the partition 32 divides the cavity into two independent parts, one of which connects the first opening 11 and the second opening 12. At this time, the third opening 13 and the fourth opening 14 are connected to the other part, thus isolating the third opening 13 and the fourth opening 14 by the partition 32, thereby isolating the container 231 from the flow channel. See also Figure 4 When the valve core is in the second position, the valve core still divides the cavity into two parts, one part connecting the first opening 11 with the third opening 13, and the other part connecting the fourth opening 14 with the second opening 12.

[0052] Specifically, the cavity of the valve body 16 is coaxially arranged with the valve core 30. In some embodiments, the cavity is configured as a sphere, the partition 32 is configured as a generally circular plate, and the two opposite sidewalls of the partition 32 are configured as curved surfaces, which contact the inner sidewall of the valve body 16. In other embodiments, the cavity is configured as a column, the partition 32 is configured as a generally rectangular plate, and the two opposite sidewalls of the partition 32 are configured as arcuate shapes, which are used to contact the inner sidewall of the valve body 16. The following description uses a columnar cavity.

[0053] In some embodiments, the valve body 10 has a blocking step located in a cavity of the valve body 16. When the valve core 30 is in the first position, the blocking step, together with the partition 32, defines a first channel. Providing the blocking step facilitates a reduction in the thickness of the partition 32. See also Figure 5 The valve body 10 is provided with two blocking steps 15, one blocking step 15 is located near the first opening, and the other blocking step 15 is located near the second opening. Specifically, one blocking step 15 is located between the first pipe body 18 and the valve body 16, and the other blocking step 15 is located between the second pipe body 19 and the valve body 16. Preferably, the side of the blocking step 15 near the baffle 32 is constructed to be arc-shaped, so that this sidewall of the blocking step 15 can contact the baffle 32.

[0054] Specifically, see Figure 3 , Figure 4 In some embodiments, the valve body 16 is constructed as a cylindrical tube closed at both ends, and the valve core 30 extends through one end sidewall of the valve body 16 and enters the valve body 16. A third opening 13 and a fourth opening 14 are provided near the lower part of the valve body 16, and a first needle body 22 and a second needle body 24 are arranged in parallel and connected to the third opening 13 and the fourth opening 14, respectively. A first tube body 18 and a second tube body 19 are respectively provided on opposite sides of the outer periphery of the valve body 16. When the valve body 30 is in the first position, the partition 32 is in a horizontal position; when the valve body is in the second position, the partition 32 is in a vertical position.

[0055] The valve body 10 also includes a connector 17 disposed on the outer periphery of the valve body, through which the first needle 22 and the second needle 24 extend. The connector 17 is configured to connect to the opening of the container 231. Specifically, the connector 17 is connected to the lower part of the valve body 16, and the connector 17 includes a cone, the extension directions of the first needle and the second needle are both parallel to the axis of the cone, and the majority of the cone is close to the valve body 16. The majority of the cone refers to the portion with a large cross-section. The first needle 22 and the second needle 24 each include a free end and a fixed end, wherein the free end refers to the end away from the valve body 16, and the fixed end refers to the end fixed to the valve body 16. Preferably, the distance from the center of the valve core 30 to the free end of the first needle 22 is less than the distance from the center of the valve core 30 to the free end of the second needle 24. In some embodiments, the first needle 22 and the second needle 24 are arranged in parallel, and the portion of the first needle 22 protruding from the valve assembly 100 is less than the portion of the second needle 24 protruding from the valve assembly 100.

[0056] Specifically, the distance between the free ends of the first needle body 22 and the second needle body 24 needs to be customized according to the specific requirements of the conical flask size, with an adjustable range of 3~12mm. Here, the distance refers to the interval between the free ends of the first needle body 22 and the second needle body 24. The distance between the free ends of the first needle body 22 and the second needle body 24 is obtained through fluid dynamics simulation and verification, ensuring that the microspheres in the conical-bottomed container 231 can be completely delivered into the human body, which helps simplify the operation steps and reduce surgical time.

[0057] The valve core 30 can be rotated automatically or manually. The infusion system 200 includes an actuator coupled to the valve core 30 for driving the valve core 30 to rotate between a first position and a second position. Optionally, the valve core 30 also has a knob 34 located outside the valve body 16. The knob 34 facilitates the rotation of the valve core 30. See schematically. Figure 2 The knob 34 is constructed with a cylindrical middle section and straight sides. Optionally, the knob 34 is aligned with the partition 32, and the position of the knob 34 corresponds to the position of the partition 32.

[0058] See Figure 5 When the valve core 30 is in the first position (i.e., the partition 32 is in the horizontal position), it forms a first channel due to the isolation effect of the partition 32 and the blocking step 15. The medium in the channel flows from the first opening 11 to the second opening 12, and the container 231 is isolated from the channel. See also Figure 4When the valve core 30 is in the second position (i.e., the partition 32 is in the vertical position), the partition forms the second and third channels, and the container 231 is connected to the flow channel. The medium in the flow channel flows from the first opening 11 to the third opening 13, enters the container 231 through the first needle body 22, mixes with the medium in the container, and then enters the cavity of the valve body 16 through the second needle body 24, flowing from the fourth opening 14 to the second opening 12.

[0059] Figure 6 , Figure 7 Another embodiment of the valve assembly 100 of this disclosure is shown, wherein, with Figure 4 , Figure 5 The valve assembly differs in that valve core 30 is replaced with valve core 40. See details below. Figure 7 The valve core 40 is provided with a spacer 42, and the spacer 42 is provided with a valve core channel 44. When the valve core 40 is in the first position, the first channel is at least partially formed by the valve core channel 44. Specifically, when the cavity is constructed as a cylinder, the spacer 42 is constructed with a cross-sectional shape as shown in the figure. Figure 6 The column shown has two opposite sidewalls with a central recess in the partition 42, meaning the lateral dimensions on either side of the partition 42 are larger than the lateral dimension at the center of the partition 42. (See also...) Figure 7 When the partition 42 is in the first position, the lateral dimensions on both sides of the partition 42 are relatively large, which can effectively separate the first opening 11, the second opening 12 from the third opening 13 and the fourth opening 14; see also Figure 6 When the partition 42 is in the second position, the lateral dimension of the middle part of the partition 42 is smaller, which is conducive to the smooth flow of the medium in the second and third channels. Optionally, the valve core 40 is also provided with a knob 46 located on the outside of the valve body 16. Optionally, the knob 46 is aligned with the valve core channel 44, and the position of the knob 46 corresponds to the position of the valve core channel 44.

[0060] In some embodiments, except for the valve core, the first needle body, and the second needle body, the remaining components of the valve assembly 100 are integrally formed. In some embodiments, except for the valve core, the remaining components of the valve assembly 100 are integrally formed.

[0061] In particular, the microspheres are radioactive. See also Figure 9 The infusion system 200 includes a radiation shield 204, within which a container 231 for storing the microspheres is placed. Optionally, the container 231 for storing the microspheres is configured as a transparent V-shaped bottle (conical bottom flask). See also Figure 8 , Figure 9The infusion system 200 also includes an infusion tank 240, a container 231, a radiation shielding device 204, and a valve assembly 100, all housed within the infusion tank 240. Pipelines 201 and 202, connected to the valve assembly 100, extend through the infusion tank 240. The infusion tank 240, the container 231 for storing the microspheres, the radiation shielding device 204, and the pipelines are all transparent, allowing medical personnel to easily monitor the microsphere delivery process during surgery.

[0062] Specifically, the infusion tank 240 includes a tank cover 241, a base plate 246, and side walls located between the tank cover 241 and the base plate 246. More specifically, the infusion tank 240 is constructed as a cuboid, and the side walls include a first side wall 242, a second side wall 243, a third side wall 244, and a fourth side wall 245. In a top view, the first side wall 242, the second side wall 243, the third side wall 244, and the fourth side wall 245 are arranged counterclockwise. The first side wall 242 has a first hole 2422 through which the pipe 201 extends; the third side wall 244 has a third hole 2442 through which the pipe 202 extends.

[0063] See also Figure 9 Specifically, to facilitate operation by medical personnel, the infusion system 200 also includes a bracket 250 for connecting the valve assembly 100. The bracket 250 is coupled to the infusion tank 240 and can move up and down relative to the infusion tank 240. Moving the bracket 250 up and down can cause the valve assembly 100 to move up and down, thereby positioning the free ends of the first needle body 22 and the second needle body 24 above or below the surface of the microsphere mixture in the container 231. In some embodiments, the actuator of the infusion system 200 for controlling the valve core 30 is configured as a servo motor coupled to the valve core 30. In other embodiments, the actuator is configured as an operating lever 260, which can rotate the valve core 30 between a first position and a second position, thereby selectively communicating the container 231 with the flow channel.

[0064] See Figure 10 The infusion tank 240 has a support hole 2412 on its cover 241. A support 250 extends through the support hole 2412 and is supported by contacting a portion of the support hole 2412 on the cover 241, thereby holding the support 250 in a fixed longitudinal position. Specifically, the support 250 has a first longitudinal position (see...). Figure 9 ) and second longitudinal position (see Figure 13 When the support 250 is in either the first longitudinal position or the second longitudinal position, it can be supported by the infusion tank 240, thereby keeping the support 250 in the first or second longitudinal position. See also Figure 9When the support 250 is in the first longitudinal position, the free ends of both the first needle body 22 and the second needle body 24 are located inside the container 231, and the free end of the second needle body 24 is below the liquid surface of the container 231; see also Figure 13 When the support 250 is in the second longitudinal position, the free ends of the first needle body 22 and the first needle body 24 are both located outside the container 231.

[0065] Preferably, the cover 241 further includes a protrusion 2414 disposed within the bracket hole 2412, wherein when the bracket 250 is in a first longitudinal position or a second longitudinal position, the bracket 250 is in contact with at least the upper surface of the protrusion 2414. Optionally, the bracket hole 2412 is configured to be circular. The protrusion 2414 extends inwardly from the hole wall of the bracket hole 2412. Optionally, the protrusion has two mutually perpendicular sidewalls located within the bracket hole 2412. Optionally, the protrusion 2414 is detachably connected to the cover 241 for easy installation of the bracket 250.

[0066] Specifically, see Figure 11 , Figure 12 The bracket 250 includes a bracket body 251 and a valve body connecting portion 252 disposed at one end of the bracket body 251. The valve body connecting portion 252 is provided with a receiving groove 2522 for connecting the valve assembly 100. The valve assembly 100 can be placed in the receiving groove 2522, so that the valve assembly 100 can move with the bracket 250. More specifically, the valve body connecting portion 252 is provided with two clamping rods 2524 extending longitudinally and a clamping plate 2526. The two clamping rods 2524 are located on the same side and arranged in parallel with a gap, and the two clamping rods 2524 and the clamping plate 2526 are arranged opposite to each other to form the receiving groove 2522. The first tube 18 and the second tube 19 of the valve assembly 100 extend in the same direction as the extending direction of the receiving groove 2522. The two clamping rods 2524 are spaced apart, so that the knob 46 of the valve core 40 can extend through the gap between the two clamping rods 2524. The clamping rod 2524 and clamping plate 2526 are also provided with an inwardly protruding limiting protrusion 2528 to prevent the valve assembly 100 from separating from the valve body connection portion 252. In some embodiments, the limiting protrusion 2528 is detachably connected to the clamping rod 2524 and clamping plate 2526. During installation, the valve assembly 100 can be placed into the receiving groove 2522, and then the limiting protrusion 2528 can be fixed to the clamping rod 2524 and clamping plate 2526. In another embodiment, the limiting protrusion 2528 is formed directly at the end of the clamping rod 2524 and clamping plate 2526. During installation, because the clamping rod 2524 and clamping plate 2526 are elastic, the valve assembly 100 can be pushed into the receiving groove 2522.

[0067] The support body 251 extends longitudinally and has a longitudinally extending receiving portion 2514 adapted to receive the tank cover protrusion 2414. When the receiving portion 2514 is aligned with the protrusion 2414 (i.e., the protrusion 2414 is located within the receiving portion 2514), the support body 251 can move longitudinally relative to the infusion tank 240, allowing the support 250 to move between a first longitudinal position and a second longitudinal position. The support 250 also includes a handle 255, which is located at the end of the support body 251 away from the valve body connection portion 252. The handle 255 not only facilitates the operator's grip but also provides a limit for the longitudinal movement of the support body 251. In addition, when the support 250 is in the first longitudinal position, the handle 255 at least abuts against the protrusion 2414, keeping the support 250 in the first longitudinal position. Specifically, the handle 255 is constructed as a circular flat plate.

[0068] See Figure 11 The support body 251 is also provided with a connecting groove 2512 that is offset from and communicates with the receiving portion 2514 in its circumferential direction. The connecting groove 2512 is suitable for engaging with the protrusion 2414. When the receiving portion 2514 is aligned with the protrusion 2414, the support 250 can be moved to the second longitudinal position, and the support 250 can be rotated to allow the protrusion 2414 to enter the connecting groove 2512. At this time, the upper sidewall of the connecting groove 2512 contacts the upper surface of the protrusion 2414, thereby supporting the support 250 and keeping the support 250 in the second longitudinal position. In addition, when the protrusion 2414 is located in the connecting groove 2512, the upper and lower sidewalls of the connecting groove 2512 can also limit the longitudinal movement of the support 250.

[0069] Specifically, the support body 251 is configured with a cross-shaped cross-section, meaning the support body 251 includes four plates 2516 arranged along its axis, and the four plates 2516 are evenly spaced circumferentially. A receiving portion 2514 is formed between two adjacent plates 2516 of the support body 251. A connecting groove 2512 is provided on the side of the support body 251 near the two clamping rods 2524; more specifically, the connecting groove 2512 is formed by removing a portion of one of the plates near the valve body connecting portion 252. Preferably, the support 250 also includes a stop 253, which is disposed between two adjacent plates 2516 and located longitudinally between the handle portion 255 and the valve body connecting portion 252. A stop 253 is provided between the two plates, allowing the bracket 250 to stop at a third longitudinal position between the first and second longitudinal positions. The bracket 250 can only move from the first longitudinal position to the second longitudinal position after rotating to the corresponding position (i.e., rotating until the receiving portion 2514 aligns with the protrusion 2414). Specifically, the stop 253 and the receiving portion 2514 are respectively provided on both sides of the plate with the connecting groove 2512. The stop 253 also enhances the overall strength of the bracket 250. Specifically, the receiving portion 2514 is only provided on one side of the plate with the connecting groove 2512. The bracket 250 also includes two reinforcing plates 254, which are respectively provided between the remaining plates, such as... Figure 12 As shown.

[0070] See Figure 13 The protrusion 2414 is located within the mating groove 2512, keeping the bracket 250 in the second longitudinal position. At this time, the first needle body 24 is separated from the container 231.

[0071] See Figure 14 The operating lever 260 includes a lever body 261 and a connecting portion 262, with the connecting portion 262 located at one end of the lever body 261. The connecting portion 262 has a coupling feature for coupling with a knob 34. See also... Figure 9 The connecting part 262 is located inside the infusion tank 240; see also Figure 10 The infusion tank 240 has a second hole 2434 on its second side wall 243, through which the rod 261 can extend. Medical personnel can manually rotate the operating rod 260 to rotate the valve core 30. Optionally, the connecting part 262 cannot pass through the second hole 2434, thus limiting the range of axial movement of the operating rod 260. The operating rod 260 is detachably connected to the knob 34.

[0072] Specifically, the coupling feature of the connecting portion 262 is configured as a connecting groove 2622, with the connecting portion 262 having a connecting groove 2622 suitable for accommodating the knob 34 at one end away from the rod body 261. Optionally, the connecting portion 262 is detachably connected to the rod body 261. Specifically, the rod body 261 is configured as a cylinder, the second hole 2434 is configured as a circular hole, the connecting portion 262 is configured as a cylinder, and the radius of the connecting portion 262 is larger than the radius of the second hole 2434.

[0073] In some embodiments, the operating lever 260 includes a limiting block 263, and the infusion tank 240 is provided with a limiting groove 2438. When the connecting part 262 is engaged with the knob 34, the limiting block 263 is located within the limiting groove 2438 and restricts the rotation range of the operating lever 260. The limiting groove 2438 can restrict the operating lever 260 to rotate between a first rotation position and a second rotation position, thereby causing the valve core 30 to rotate between a first position and a second position. That is, when the operating lever 260 is in the first rotation position, the valve core 30 is in the first position; when the operating lever 260 is in the second rotation position, the valve core 30 is in the second position. Preferably, the limiting block 263 is located outside the infusion tank 240, and the limiting groove 2438 can also restrict the axial movement of the operating lever 260.

[0074] Specifically, in some embodiments, the second sidewall 243 is provided with two stops, forming a limiting groove 2438 between the stops. In some embodiments, the limiting groove 243 is formed by removing a portion of the second sidewall 243 adjacent to the second hole 2434. See also Figure 10 In some embodiments, the second sidewall 243 is provided with a limiting disc 2432, and the second hole 2434 is disposed in the middle of the limiting disc 2432. The limiting disc 2432 has a limiting groove 2438 communicating with the operating rod hole on one side of its outer surface. The limiting groove 2438 is defined by two sidewalls and a bottom wall located between the two sidewalls. See also Figure 10 The limiting plate 3432 is provided with a limiting step 2436 protruding from the outer surface of the second sidewall 243, and a limiting groove 2438 communicating with the second hole 2434 is formed between the two opposite sides of the limiting step 2436. Alternatively, the limiting step 2436 of the limiting plate 3432 may also be flush with or lower than the outer surface of the second sidewall 243. When the bottom wall of the limiting groove 2438 contacts the limiting block 263, it can restrict the continued movement of the operating rod 260 toward the valve assembly 100. Optionally, when the connecting part 262 is engaged with the knob 34, the bottom of the limiting groove 2438 contacts the limiting block 263.

[0075] Specifically, the operating lever 260 includes a handle 264 disposed at the other end of the lever body 261. The handle 264 has anti-slip features, making the operating lever 260 easy to hold and rotate. Specifically, the anti-slip features are anti-slip stripes disposed circumferentially on the handle. Optionally, the operating lever 260 also has a baffle 265 located on the lever body 261 for convenient gripping and operation. Specifically, the baffle 265 is disposed on the side of the handle 264 near the connecting portion 262.

[0076] The following is combined Figure 8 , Figure 9 , Figure 13 , Figure 14 The following details the relevant operating steps of the entire infusion system. Connect all tubing and operate valve assembly 100 to position valve core 30 in the first position, i.e., the needles (first needle 22, second needle 24) are connected to the tubing. First, move support 250 to the third longitudinal position, ensuring the free ends (tips) of the first needle 22 and second needle 24 are below the liquid surface of the container 231 containing water for injection. Following the steps described in step one above, inject water for injection into the tubing to expel air. After the air is expelled, move support 250 to the second longitudinal position and stop it in the infusion tank 240. Place the container 231 containing radioactive microspheres in the designated position within the infusion tank 240. Move support 250 to the first longitudinal position so that both needles pierce the container 231 containing radioactive microspheres, with the second needle 24 below the liquid surface of the microsphere mixture solution. At this point, the support 250 rests against the infusion tank 240 and remains in the first longitudinal position. In steps two through four, water for injection and contrast agent are intermittently pushed into the tubing. In step five, the microspheres are continued to be injected with air, and in step six, water for injection continues to be injected. The detailed steps are as described above. When it is necessary to connect the needle to the tubing, the operating lever 260 can be used to rotate the knob 34 to position the valve core 30 in the second position; when it is necessary to isolate the needle from the tubing, the operating lever 260 can be used to rotate the knob 34 to position the valve core 30 in the first position. Once all the microspheres have been inserted into the body, the tubing is closed, and the syringe, tubing, valve assembly 100, etc., are placed together into the nuclear waste disposal container.

[0077] In some implementations, continuing to inject the microspheres with air is not necessary. When using water for injection to deliver all the microspheres into the body, step five can be omitted.

[0078] Using the infusion system disclosed herein, during the infusion process, once the two needles are inserted into the container 23 containing radioactive microspheres, there is no need to change the longitudinal position of the two needles or frequently modify the tubing connection method, making the operation simple and quick. This reduces surgical time, lowers the risk of radiation exposure for operators, and also reduces the time operators are exposed to radiation.

[0079] The above descriptions are merely a few embodiments of this disclosure. Those skilled in the art can make various modifications or variations to the embodiments of this disclosure based on the content disclosed in the application documents without departing from the spirit and scope of this disclosure.

Claims

1. A valve assembly for an infusion system, the infusion system comprising a container, characterized in that, include: The valve body includes a valve body having a cavity and a first opening, a second opening, a third opening, and a fourth opening communicating with the cavity; A valve core is rotatably disposed in the cavity, thereby forming a first channel, a second channel, and a third channel within the valve assembly; A first needle body and a second needle body, wherein the first needle body is connected to the third opening and the second needle body is connected to the fourth opening; The valve assembly can be connected to the container via the first needle body and the second needle body; When the valve core is in the first position, the first opening and the second opening communicate to form a first channel, and the first channel is isolated from the container; When the valve core is in the second position, the first opening and the third opening communicate to form a second channel, and the second opening and the fourth opening communicate to form a third channel. The second channel and the third channel are connected to the container.

2. The valve assembly according to claim 1, characterized in that, The valve core is provided with a partition plate, which is rotatably disposed in the cavity; When the valve core is in the first position, the surface of at least one side of the partition defines the first channel.

3. The valve assembly according to claim 2, characterized in that, The valve body is provided with a blocking step located in the cavity. When the valve core is in the first position, the blocking step and the partition together define the first channel.

4. The valve assembly according to claim 3, characterized in that, The cavity is constructed in a columnar shape and is coaxially arranged with the valve core. Two blocking steps are constructed, one of which is located near the first opening and the other is located near the second opening.

5. The valve assembly according to claim 1, characterized in that, The valve core is provided with a partition, and the partition is provided with a valve core channel; When the valve core is in the first position, the first channel is at least partially formed by the valve core channel.

6. The valve assembly according to claim 5, characterized in that, The lateral dimensions on both sides of the partition are greater than the lateral dimensions in the middle of the partition.

7. The valve assembly according to any one of claims 1 to 6, characterized in that, The distance from the center of the valve core to the free end of the first needle is less than the distance from the center of the valve core to the free end of the second needle.

8. The valve assembly according to claim 7, characterized in that, The first needle body and the second needle body are arranged in parallel, and the distance between the free end of the first needle body and the free end of the second needle body is 3~12mm.

9. The valve assembly according to claim 7, characterized in that, The valve body includes a connecting body disposed on the outer periphery of the valve body. The connecting body includes a cone portion. The extension directions of the first needle body and the second needle body are both parallel to the axis of the cone portion, and the first needle body and the second needle body extend through the cone portion. Most of the cone portion is close to the valve body.

10. A radioactive microsphere delivery system, characterized in that, It includes a first pipeline, a second pipeline, a container, and a valve assembly as described in any one of claims 1 to 8; The first opening of the valve assembly is connected to the first pipeline, the second opening of the valve assembly is connected to the second pipeline, and the container is connected to the valve assembly through the first needle and the second needle. When the valve core is in the first position, the container is isolated from the first and second pipelines; when the valve core is in the second position, the container is connected to the first and second pipelines.

11. The infusion system according to claim 10, characterized in that, The infusion system further includes an actuator coupled to the valve core, the actuator being used to drive the valve core to rotate between a first position and a second position.

12. The infusion system according to claim 11, characterized in that, The valve core has a knob located outside the valve body, and the actuator is configured as an operating lever. One end of the operating lever has a coupling feature that is coupled to the knob, and the operating lever is detachably connected to the knob.

13. The infusion system according to claim 10, characterized in that, The infusion system also includes an infusion tank and a support, the container and the valve assembly are located inside the infusion tank, the support is connected to the valve assembly, and the support is coupled to the infusion tank; The support has a first longitudinal position and a second longitudinal position. When the support is in the first longitudinal position, the first needle and the second needle are located inside the container and the second needle is in communication with the microsphere mixture inside the container. When the support is in the second longitudinal position, the first needle and the second needle are located outside the container.

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