Preparation method of trigonelline inner salt and application of trigonelline inner salt in inhibition of algae growth

By improving the preparation method of trigonelline inner salt, using inexpensive and readily available ethyl nicotinate and dimethyl sulfate, the problems of high preparation cost and poor environmental performance in the existing technology are solved, realizing the effective application of trigonelline inner salt in inhibiting algal growth, with a concentration-dependent inhibition effect.

CN121800718APending Publication Date: 2026-04-07苏州满元生物科技有限公司
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Patent Information

Application Number
CN202511720631.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-11-21
Publication Date
2026-04-07

AI Technical Summary

Technical Problem

Existing methods for preparing trigonelline are costly, complex, and environmentally unfriendly, and there is limited research on its application in inhibiting algal growth.

Method used

The inner salt of trigonelline was obtained by reacting ethyl nicotinate with dimethyl sulfate in methanol, followed by reaction with alkali and thiourea in water, and by adjusting the pH and solvent extraction. This method avoids the use of highly toxic reagents, reduces synthesis costs, and improves the environmental friendliness of the process.

Benefits of technology

The efficient preparation of trigonelline inner salt and its application in inhibiting algal growth were achieved, demonstrating a concentration-dependent inhibitory effect, suitable for large-scale industrial production and reducing environmental risks.

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Abstract

The invention discloses a preparation method of trigonelline inner salt and application of the trigonelline inner salt in inhibition of algae growth, the preparation method comprises the following steps: S1, ethyl nicotinate reacts with dimethyl sulfate in methanol to obtain N-methyl ethyl nicotinate monomethyl sulfate salt; s2, stirring and reacting with alkali and thiourea in deionized water while heating to obtain a trigonelline inner salt crude product; and S3, adding an acid to adjust the pH value, adding methanol, filtering, concentrating the solvent, and pulping by using isopropanol to obtain a pure product of the trigonelline inner salt. The method provided by the invention effectively reduces the synthesis cost, avoids the use of a large amount of dangerous reagents, eliminates the residue of toxic reagents, effectively reduces the generation of industrial three wastes, and has the advantages of simple process, convenient operation, cheap and easily available raw materials, high yield, and facilitation of large-scale industrial production. Experimental studies show that the trigonelline inner salt has obvious effects of inhibiting algae growth and killing algae, and can be applied to algicides or inhibiting algal blooms in water.
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