Application of PIEZO1 gene mutation in selection of lambing number of Mancheng black goats

By detecting the SNP marker sites of the PIEZO1 gene, the problem of slow genetic progress in lambing number in Macheng black goat breeding was solved, achieving efficient and accurate breeding selection and increasing lambing number.

CN121975950APending Publication Date: 2026-05-05HUAZHONG AGRI UNIV +1
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Patent Information

Application Number
CN202610316247.7
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-03-16
Publication Date
2026-05-05

AI Technical Summary

Technical Problem

Traditional methods are ineffective in improving the genetic progress of the lambing number trait in the breeding of Macheng black goats. The selection effect is unstable and the heritability is low. Existing molecular marker-assisted selection has limited effect.

Method used

By utilizing the SNP marker sites of the PIEZO1 gene, particularly the differences between the CC and AC genotypes and the AA genotype located at position 236 of the nucleotide sequence, specific primers were designed to amplify and sequence the genotypes of individual goats, thereby enabling the prediction and selection of lambing numbers.

Benefits of technology

This improves the selection efficiency and accuracy in the breeding process, effectively screening out goat individuals with high lambing rates and gradually increasing the number of lambs produced in the herd.

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Abstract

The invention discloses application of an SNP (Single Nucleotide Polymorphism) marker influencing the lambing number of goats. The marker is located on a PIEZO1 gene on a capa circus 18 # chromosome, the specific SNP marker site is A / C base mutation at the 236bp position of SEQ ID NO: 1 in a sequence table, and the lambing number of CC genotype and AC genotype goat individuals at the site is remarkably higher than that of AA genotype individuals. According to the present invention, the Musheng black goats are adopted as the research object, the DNA sequence of the 33rd exon of the PIEZO1 gene is subjected to PCR amplification, the sequence has an SNP variation site, the influence of the site polymorphism on the goat lambing number is analyzed, the individual Musheng black goat breeding is performed according to the influence, and the method can be used for improving the Musheng black goat lambing number so as to provide the basis for the breeding of the Musheng black goats. The breeding of a new variety (strain) taking the Muscheng black goat as a breeding material is accelerated, and a marker resource is provided for marker-assisted selective breeding of goat lambing number traits.
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