Micro-nano bubble reinforced ultrasonic tumor ablation device

Abstract

This invention discloses a micro / nano bubble-enhanced ultrasound tumor ablation device, belonging to the field of medical device technology. The device includes an ultrasound unit, an imaging system, and a bubble generating unit. The bubble generating unit prepares and delivers micro / nano bubbles to the tumor region. The ultrasound unit emits ultrasonic waves to cause the bubbles to collapse, generating cavitation and thermal ablation to destroy the tumor. The imaging system observes the process in real time. The bubble generating unit includes a shell containing a microfluidic chip with microchannels, a liquid outlet tube, a support component, a detachable receiving component and a liquid collection component, and a transmission mechanism to drive the reciprocating motion of the support component. This device can achieve fully automated switching between the initial folding and storage of the receiving component and the liquid collection component, the intermediate receiving and detection, and the final liquid collection, completing the key processes of bubble preparation, solving problems such as manpower occupation and sample waste, and improving overall work efficiency.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, and in particular to a micro-nano bubble enhanced ultrasound tumor ablation device. Background Technology

[0002] The micro-nano bubble enhanced ultrasound tumor ablation device is a novel tumor treatment device that integrates micro-nano bubble and high-intensity focused ultrasound (HIFU) technology, aiming to significantly improve the efficiency, accuracy and safety of ultrasound ablation.

[0003] Existing systems typically include: a HIFU treatment head for emitting focused ultrasound waves and precisely locating the tumor region; a bubble infusion module for delivering micro- and nano-bubbles to the target area via intravenous or local injection; an imaging unit for real-time guidance of focusing, monitoring of the treatment process, and evaluation of efficacy; and an intelligent control system for coordinating and controlling ultrasound parameters (such as frequency, power, and pulse mode) with the timing of bubble release. Furthermore, they are equipped with microfluidic chip-based bubble preparation systems (such as microfluidic generators) that can precisely control the flow, mixing, reaction, and separation of nanoliter to picoliter liquids in microchannels to generate uniformly sized and stable micro- and nano-bubbles.

[0004] However, there is still a significant operational bottleneck in the current bubble preparation process: before collecting bubbles, various solvents need to be installed on the instrument holder and introduced into the microchannels of the microfluidic chip for mixing via a gas source. To remove residual gas from the microchannels and tubing, some of the mixture needs to be discharged first (this process usually takes several minutes, limited by the generation and discharge speed of micron-sized bubbles).

[0005] Subsequently, the operator must manually hold the slide at the outlet to collect a drop of the mixture for microscopic observation; then manually replace it with a collection container to receive subsequent products. During this process, due to the delay in the drainage interval (for example, it may take nearly a minute from the drop of one liquid to the drop of the next), the operator must wait at the outlet close to the dripping time (e.g., 20 seconds in advance) to prevent the solution from dripping and causing waste or contamination.

[0006] This operating method not only consumes manpower and restricts the freedom of staff to perform other tasks, but also easily leads to sample loss, environmental pollution or experimental delays due to negligence, seriously affecting preparation efficiency and experimental repeatability. Summary of the Invention

[0007] This invention provides a micro-nano bubble enhanced ultrasound tumor ablation device to overcome the above-mentioned problems.

[0008] To achieve the above objectives, the technical solution of the present invention is as follows: A micro-nano bubble-enhanced ultrasound tumor ablation device includes an ultrasound device, an imaging system, and a bubble generating device; The bubble generator is used to prepare micro- and nano-bubbles, and the bubble delivery module delivers the micro- and nano-bubbles to the tumor area; the ultrasound device can emit ultrasound waves of specific frequencies and powers, causing the micro- and nano-bubbles to vibrate, expand, and collapse, resulting in cavitation and thermal ablation effects, destroying and ablating tumor tissue; the imaging system is used to observe the tumor location, the distribution of micro- and nano-bubbles, and the tumor ablation process in real time. The bubble generating device includes: The outer shell of the bubble generator contains a microfluidic chip. The microfluidic chip has a microchannel, and the two ends of the microchannel are respectively provided with an inlet for introducing solvent and an outlet for discharging bubble liquid. The liquid outlet tube is connected to the liquid outlet end of the microchannel and is used to discharge the bubble liquid; A support assembly is disposed on one side of the outer shell of the bubble generator; A receiving component, detachably mounted on the support component, is used to receive the test droplets flowing out of the outlet pipe; The liquid collection component is detachably installed on the support component and is used to collect the liquid bubbles flowing out of the liquid outlet pipe after the receiving component has received the droplets to be tested. A transmission mechanism, disposed on the housing of the bubble generator, is used to drive the support assembly to reciprocate outside the housing of the bubble generator, such that the support assembly drives the receiving assembly to a folded position that fits against the side wall of the housing of the bubble generator or to a receiving position located below the outlet of the liquid outlet pipe, and causes the support assembly to drive the liquid collecting assembly to a folded position that fits against the side wall of the housing of the bubble generator or to a liquid collecting position located below the outlet of the liquid outlet pipe.

[0009] Furthermore, the support assembly includes a support plate; The support plate is provided with a receiving part, a liquid collecting part, and an installation channel penetrating one side of the receiving part and the liquid collecting part; the receiving component is detachably installed in the receiving part, and the liquid collecting component is detachably installed in the liquid collecting part; the outer wall of the support plate near the installation channel includes an arc surface and a limiting plate connected to the arc surface and set at a right angle to the support plate; The transmission mechanism includes a lead screw, which is rotatably mounted on the housing of the bubble generator, and the mounting channel is mounted on the lead screw through an internal threaded structure. The outer casing of the bubble generator is equipped with a first plate that restricts the rotation of the support plate; When the lead screw rotates continuously toward the outer shell of the bubble generator, it can drive the support plate to flip from the folded vertical state when it is in the retracted position on the outer shell of the bubble generator to the horizontal state, and drive the receiving component on the support plate to flip away from the outer shell of the bubble generator to the receiving position. At this time, the arc surface can rotate around the axis of the lead screw until the side wall of the limiting plate abuts against the vertical side wall of the outer shell of the bubble generator. After the receiving component finishes receiving the liquid, the lead screw continues to rotate toward the outer shell of the bubble generator. At the same time, under the action of the limiting plate abutting against the vertical side wall of the outer shell of the bubble generator, the support plate can move toward the first plate on the lead screw until the receiving component moves to the bottom of the first plate and the liquid collecting component moves to the liquid collecting position to collect the liquid. After the liquid collection assembly finishes collecting the liquid, the lead screw can rotate continuously in a direction away from the outer shell of the bubble generator, and cooperate with the first plate to drive the support plate to move back to the receiving position along the lead screw in a direction away from the first plate, and can continue to drive the support plate to flip to the retracted position.

[0010] Furthermore, the support assembly also includes a limiting component; the limiting component is disposed on the receiving portion of the support plate, and when the receiving component is installed on the support plate, the receiving component can restrict the liquid collecting component from moving out of the liquid collecting portion through the limiting component.

[0011] Furthermore, the inner wall of the receiving part is provided with a slot for receiving the insertion and removal of the component and having an opening on one side. The slot includes a first slot, a second slot and a third slot that are sequentially connected from the direction near the liquid collection part to the direction away from the liquid collection part. The depth of the first groove is greater than the depth of the second and third grooves. The first groove is provided with an elastic element mounting groove and a snap-fit ​​groove. The limiting component includes an elastic element and a limiting block; the limiting block is disposed in the first groove, the elastic element is installed in the elastic element mounting groove and one end of the elastic element is fixed to the elastic element mounting groove, and the other end of the elastic element is fixedly connected to the side of the limiting block near the elastic element mounting groove. The liquid collecting part has a liquid collecting component placement cavity, and the liquid collecting component has a locking block on its side. When the liquid collecting component is installed in the liquid collecting component placement cavity, the part of the locking block near the receiving part is located in the locking groove and is located on the lower side of the limiting block. When the receiving component is inserted into the slot, it can drive the limiting block to move towards the elastic element mounting groove until the side wall of the limiting block near the elastic element mounting groove contacts the side wall of the locking block away from the elastic element, thus preventing the locking block from disengaging from the locking groove.

[0012] Furthermore, the inner side wall of the liquid collection component placement cavity is provided with a sliding groove that extends obliquely and whose bottom is connected to the locking groove; the liquid collection component placement cavity is provided with a recessed locking platform limiting groove with a diameter larger than the diameter of the liquid collection component placement cavity; the liquid collection component includes a liquid collection cylinder and a locking platform disposed on the liquid collection cylinder; the locking block extends obliquely along the outer wall of the liquid collection cylinder, the locking block can slide along the sliding groove and slide into the bottom of the sliding groove, and the side of the locking block near the receiving part enters the locking groove and is pressed down and fixed in the locking groove by the limiting block, at which time the locking platform is disposed in the locking platform limiting groove.

[0013] Furthermore, the receiving component includes a connecting piece and a glass slide. The side of the glass slide away from the lead screw is fixedly connected to the connecting piece. Both sides of the glass slide can be inserted into or pulled out of the receiving area along the first groove and the third groove, respectively. The outer wall of the glass slide near the elastic element abuts against the side wall of the limiting block away from the elastic element. Furthermore, the top surface of the limiting block near the opening and one end of the groove wall of the third groove near the opening are both provided with inclined surfaces for guiding the insertion of the glass slide.

[0014] Furthermore, the transmission mechanism also includes a motor, a first support block, and a second support block; the first support block and the second support block are fixed on the outer shell of the bubble generator, and the two ends of the lead screw are rotatably connected to the first support block and the second support block respectively; the motor is fixed on the outer shell of the bubble generator, and its output end is connected to the lead screw.

[0015] Furthermore, the motor is provided with a protective shell, the protective shell is provided with a heat dissipation vent, and the heat dissipation vent is provided with a dustproof net.

[0016] Furthermore, it also includes a monitoring sensor for receiving the droplets to be detected on the component.

[0017] The beneficial effects of this invention are: This invention discloses a micro / nano bubble-enhanced ultrasound tumor ablation device. Through the coordinated operation of a support component, a receiving component, a liquid collection component, and a transmission mechanism, it effectively solves the problems of heavy manpower requirements, continuous operator monitoring, sample waste, and environmental pollution in existing bubble preparation processes. The support component provides a stable mounting carrier for the receiving and liquid collection components. The receiving component conveniently receives the droplets to be tested flowing from the outlet tube, while the liquid collection component efficiently collects subsequent bubble liquid after receiving. Both components are detachable for easy cleaning and replacement. The transmission mechanism, located on the outer shell of the bubble generator, drives the support component to reciprocate, switching the receiving and liquid collection components to a folded position that fits snugly against the outer shell and a receiving / collecting position below the outlet tube. This eliminates the need for manual monitoring of the outlet tube and manual replacement of the receiving and collecting components, achieving fully automated switching from initial folding and storage to mid-stage receiving and detection and subsequent liquid collection. This completes the key bubble preparation process, freeing up operator time for other tasks while ensuring the continuity and consistency of the bubble preparation process and improving overall work efficiency. Attached Figure Description To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0018] Figure 1 This is a schematic diagram of the structure of a micro-nano bubble enhanced ultrasound tumor ablation device disclosed in an embodiment of the present invention. Figure 1 ; Figure 2 This is a schematic diagram of the structure of a micro-nano bubble enhanced ultrasound tumor ablation device disclosed in an embodiment of the present invention. Figure 2 ; Figure 3 This is a schematic diagram of the structure of the support component, liquid collection component, receiving component, and transmission mechanism of a micro-nano bubble enhanced ultrasound tumor ablation device disclosed in an embodiment of the present invention. Figure 4 This is a schematic diagram of the transmission mechanism of a micro-nano bubble enhanced ultrasound tumor ablation device disclosed in an embodiment of the present invention; Figure 5 This is a schematic diagram of the structure of the support component, liquid collection component, and receiving component of a micro-nano bubble enhanced ultrasound tumor ablation device disclosed in an embodiment of the present invention; Figure 6 This is a schematic diagram of the structure of a support component for a micro-nano bubble-enhanced ultrasound tumor ablation device disclosed in an embodiment of the present invention. Figure 1 ; Figure 7This is a schematic diagram of the structure of a support component for a micro-nano bubble-enhanced ultrasound tumor ablation device disclosed in an embodiment of the present invention. Figure 2 ; Figure 8 This is a schematic diagram of the structure of a support component for a micro-nano bubble-enhanced ultrasound tumor ablation device disclosed in an embodiment of the present invention. Figure 3 ; Figure 9 This is a schematic diagram of the liquid collection component of a micro-nano bubble enhanced ultrasound tumor ablation device disclosed in an embodiment of the present invention.

[0019] In the picture: 100. Outer casing of the bubble generator; 200. Discharge pipe; 300. Monitoring sensors; 500. Support component; 501. Support plate; 502. Receiving part; 503. Liquid collection part; 504. Installation channel; 505. Curved surface; 506. Limiting plate; 507. Opening; 508. Slot; 509. First slot; 510. Second slot; 511. Third slot; 512. Elastic element; 513. Limiting block; 514. Liquid collection component placement cavity; 515. Slide groove; 516. Carding platform limiting groove; 517. Inclined surface; 518. Snap-fit ​​groove; 519. Elastic element mounting groove; 600. Liquid collection assembly; 601. Card block; 602. Liquid collection cylinder; 603. Carding platform; 700. Receiving component; 701. Connecting piece; 702. Glass slide; 800, First Board; 900. Transmission mechanism; 901. Lead screw; 902. Motor; 903. First support block; 904. Second support block; 905. Protective shell. Detailed Implementation

[0020] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0021] Example: like Figures 1-2 The image shows a micro-nano bubble enhanced ultrasound tumor ablation device provided in this embodiment, including an ultrasound device, an imaging system, and a bubble generating device; The bubble generator is used to prepare micro- and nano-bubbles, which are then delivered to the tumor area (target area) via intravenous or local injection through the bubble delivery module. The ultrasound device can emit ultrasound waves of specific frequencies and powers, causing the micro- and nano-bubbles to vibrate, expand, and collapse, resulting in cavitation and thermal ablation effects, thereby destroying and ablating tumor tissue. The imaging system is used to observe the tumor location, micro- and nano-bubble distribution, bubble rupture degree, and tumor ablation process in real time, while also facilitating the adjustment of the ultrasound device's ultrasound power.

[0022] The bubble generating device includes: The bubble generator housing 100 has a microfluidic chip inside, and the microfluidic chip has a microchannel. The two ends of the microchannel are respectively provided with an inlet for introducing solvent and an outlet for discharging bubble liquid. The liquid outlet pipe 200 is connected to the liquid outlet end of the microchannel and is used to discharge the bubble liquid and transport it to the bubble delivery module. A support assembly 500 is disposed on one side of the housing 100 of the bubble generator; The receiving component 700 is detachably installed on the support component 500 and is used to receive the test droplets flowing out from the liquid outlet pipe 200; The liquid collection component 600 is detachably installed on the support component 500 and is used to collect the bubble liquid flowing out of the liquid outlet pipe 200 after the receiving component 700 has received the droplet to be tested. A transmission mechanism 900 is disposed on the housing 100 of the bubble generator and is used to drive the support assembly 500 to reciprocate outside the housing 100 of the bubble generator, so that the support assembly drives the receiving assembly 700 to a folded position that fits against the side wall of the housing 100 of the bubble generator or to a receiving position located below the outlet of the liquid outlet pipe 200, and so that the support assembly drives the liquid collecting assembly 600 to a folded position that fits against the side wall of the housing 100 of the bubble generator or to a liquid collecting position located below the outlet of the liquid outlet pipe 200.

[0023] This application utilizes a bubble preparation module comprised of a bubble generator housing 100 and a liquid outlet pipe 200. Its purpose is to generate, optimize, and deliver micro / nano bubbles with specific properties to meet the requirements of ultrasonic ablation, thereby enhancing the ablation effect of ultrasound on tumors. Its function extends beyond simply creating bubbles; combined with the cavitation effect and thermal ablation effect of the ultrasound device, it can effectively destroy tumor tissue. Simultaneously, the imaging system enables real-time monitoring throughout the process, improving the accuracy and safety of treatment. The bubble preparation process of the bubble generator consists of three stages: In the initial stage, when solvent is introduced and gas is discharged, the transmission mechanism 900 folds and attaches the receiving component 700 and the liquid collection component 600 to the side wall of the bubble generator housing 100 (e.g., ...). Figure 2(as shown in the storage position) to avoid obstructing the discharge of air and unmixed waste liquid from the microchannels of the microfluidic chip; after the intermediate waste liquid is discharged, the transmission mechanism 900 will rotate the receiving component 700 and the liquid collection component 600 back to their original positions (as shown in the storage position). Figure 1 As shown in the diagram, the receiving component 700 is positioned directly below the outlet end of the outlet pipe 200, receiving one or more drops of bubble liquid dripping from the outlet pipe 200. No real-time monitoring by personnel is required. The bubble liquid on the receiving component 700 can then be sent to an external microscope for observation and data recording. After the receiving component 700 completes its receiving process, the transmission mechanism 900 drives the receiving component 700 and the liquid collecting component 600 to move synchronously, moving the liquid collecting component 600 to below the outlet end of the outlet pipe 200 (the liquid collecting position) to collect the remaining bubble liquid. The collection process requires no operator intervention, automating the detection and collection of bubble liquid, significantly reducing manual labor intensity, and avoiding bubble liquid contamination or operational errors caused by human intervention.

[0024] In a specific embodiment, such as Figures 5-8 As shown, the support assembly 500 includes a support plate 501; The support plate 501 is provided with a receiving part 502, a liquid collecting part 503, and an installation channel 504 penetrating one side of the receiving part and the liquid collecting part; the receiving component 700 is detachably installed in the receiving part, and the liquid collecting component 600 is detachably installed in the liquid collecting part; the outer wall of the support plate 501 near the installation channel 504 includes an arc surface 505 and a limiting plate 506 connected to the arc surface and set at a right angle to the support plate; like Figures 3-4 As shown, the transmission mechanism 900 includes a lead screw 901, which is rotatably mounted on the housing 100 of the bubble generator. The mounting channel 504 is mounted on the lead screw through an internal threaded structure. The outer casing 100 of the bubble generator is provided with a first plate 800 that restricts the rotation of the support plate; When the lead screw 901 rotates continuously toward the bubble generator housing 100, it can drive the support plate 501 to flip from the folded vertical state when it is in the retracted position on the bubble generator housing 100 to the horizontal state, and drive the receiving component 700 on the support plate 501 to flip away from the bubble generator housing 100 to the receiving position (below the liquid outlet). At this time, the arc surface can rotate around the axis of the lead screw 901 until the side wall of the limiting plate 506 abuts against the vertical side wall of the bubble generator housing 100. After the receiving component 700 has received the liquid, the lead screw 901 continues to rotate toward the bubble generator housing 100. At the same time, under the action of the limiting plate 506 abutting against the vertical side wall of the bubble generator housing 100, the support plate 501 can move toward the first plate 800 on the lead screw until the receiving component 700 moves to below the first plate 800 and the liquid collecting component 600 moves to the liquid collecting position below the liquid outlet pipe 200 to collect the liquid. After the liquid collection assembly 600 has finished collecting the liquid, the lead screw can continuously rotate in a direction away from the housing 100 of the bubble generator (from... Figure 1 (Looking at the direction of the middle arrow, the lead screw rotates clockwise), and in conjunction with the first plate 800, it drives the support plate 501 to move back to the receiving position along the lead screw 901 in a direction away from the first plate 800, and can continue to drive the support plate 501 to flip to the retracted position.

[0025] The support plate 501 provides a stable mounting and support carrier for the receiving component 700 and the liquid collecting component 600. The partitioned arrangement of the receiving part 502 and the liquid collecting part 503 allows for independent installation and disassembly of the receiving component 700 and the liquid collecting component 600, facilitating later cleaning and replacement and improving the ease of maintenance of the device. The threaded engagement between the installation channel 504 and the lead screw 901, combined with the rotational characteristics of the arc surface 505 and the limiting function of the limiting plate 506, enables the switching between flipping and translating of the support plate 501. Specifically, when the lead screw 901 rotates towards the housing 100 of the bubble generator... The arc surface 505 rotates slowly away from the bubble generator housing 100 with the axis of the lead screw 901 as its center, causing the support plate 501 to gradually flip from the vertical folded state until the limiting plate 506 abuts against the vertical side wall of the bubble generator housing 100. At this time, the arc surface 505 stops rotating, and the support plate 501 remains in the horizontal state. When the liquid collection is completed and the lead screw 901 rotates in the reverse direction, the arc surface 505 rotates towards the bubble generator housing 100 with the axis of the lead screw 901 as its center, causing the support plate 501 to gradually flip back from the horizontal state to the vertical folded state. The first plate 800 effectively limits the rotation range of the support plate 501, ensuring the accuracy of the support plate 501's position and guaranteeing the smooth operation of receiving and collecting liquid. The rotation drive method of the lead screw 901 has high transmission accuracy and strong stability. It can work together with the first plate 800 and the limit plate 506 to control the flipping angle and moving distance of the support plate 501, realizing real-time switching between receiving position, liquid collecting position and retracting position, further improving the automation level and operational reliability of the device.

[0026] In a specific embodiment, the support component 500 further includes a limiting component; the limiting component is disposed on the receiving portion of the support plate 501, and when the receiving component 700 is installed on the support plate 501, the receiving component 700 can limit the liquid collecting component 600 from moving out of the liquid collecting portion 503 through the limiting component.

[0027] When the receiving component 700 is not separated from the support plate 501, the limiting component can prevent the liquid collecting component 600 from separating from the support plate 501. This prevents the liquid collecting component 600 from falling off the liquid collecting part 503 due to vibration, equipment shaking, or other factors during the rotation and movement of the receiving component 700 and the liquid collecting component 600 driven by the transmission mechanism 900, thus preventing the leakage of bubble liquid and causing waste and pollution. At the same time, it can ensure that the liquid collecting component 600 will not be accidentally removed before the staff has tested the bubble liquid to be tested on the receiving component 700 and obtained relevant data. This avoids the inability to collect subsequent bubble liquid due to the premature removal of the liquid collecting component 600, ensuring the continuity and integrity of the entire bubble liquid testing and collection process, and reducing the impact of human error. Specifically, when the receiving component 700 is installed onto the receiving part 502 of the support plate 501, the receiving component 700 triggers the action of the limiting component, causing the limiting component to limit the liquid collecting component 600 on the liquid collecting part 503, preventing the liquid collecting component 600 from moving out of the liquid collecting part 503; when the staff completes the bubble liquid test and pulls the receiving component 700 out of the receiving part 502, the limiting effect of the limiting component is released, and the liquid collecting component 600 can be easily removed from the liquid collecting part 503 for subsequent bubble liquid treatment or component cleaning.

[0028] In a specific embodiment, the inner wall of the receiving part 502 is provided with a slot 508 for receiving the insertion and removal of components and having an opening 507 on one side. The slot 508 includes a first groove 509, a second groove 510 and a third groove 511 that are sequentially connected from near the liquid collection part to away from the liquid collection part. The depth of the first groove 509 is greater than the depth of the second groove 510 and the third groove 511 (the depth is the dimension in the direction perpendicular to the support plate). The first groove 509 is provided with an elastic element mounting groove 519 and a snap-fit ​​groove 518. The limiting component includes an elastic element 512 and a limiting block 513; the limiting block 513 is disposed in the first groove 509, the elastic element 512 is installed in the elastic element mounting groove 519 and one end of the elastic element is fixed to the elastic element mounting groove 519, and the other end of the elastic element 512 is fixedly connected to the side of the limiting block 513 near the elastic element mounting groove 519. The liquid collection part 503 has a liquid collection component placement cavity 514. The liquid collection component 600 has a locking block 601 on its side. When the liquid collection component 600 is installed in the liquid collection component placement cavity 514, the part of the locking block 601 near the receiving part is located in the locking groove 518 and is located on the lower side of the limiting block 513. When the receiving component 700 is inserted into the slot 508, the limiting block 513 can be driven to move downward towards the elastic element mounting groove 519 until the side wall of the limiting block 513 near the elastic element mounting groove 519 contacts the side wall of the locking block 601 away from the elastic element, thus preventing the locking block 601 from disengaging from the locking groove 518 (sliding groove).

[0029] The slot 508 provides guidance and installation space for the insertion and removal of the receiving component 700. The partitioned design of the first slot 509, the second slot 510, and the third slot 511 can limit the receiving component 700 at multiple points, ensuring that the receiving component 700 will not shift after installation and guaranteeing the stability of the bubble liquid receiving. The depth of the first slot 509 is greater than the depth of the second slot 510 and the third slot 511, providing sufficient space for the installation of the limiting component and the lifting and lowering of the limiting block 513, and avoiding obstruction when the limiting block 513 is lifted or lowered. The elastic element 512 allows the limiting block 513 to remain in the upper position under elastic force when not under pressure from the receiving component 700, preventing compression of the locking block 601 of the liquid collection component 600 and facilitating the installation and removal of the liquid collection component 600. When the limiting block 513 is under pressure from the receiving component 700, it can adapt to the descent of the limiting block 513, ensuring that the receiving component 700 can be smoothly inserted into the slot 508 and trigger the limiting action. The locking groove 518 cooperates with the locking block 601 of the liquid collection component 600 to initially limit the liquid collection component 600, preventing lateral displacement of the liquid collection component 600 within the liquid collection component placement cavity 514. The cooperation between the limiting block 513 and the locking block 601 further strengthens the limiting of the liquid collection component 600, ensuring that the liquid collection component 600 cannot detach from the liquid collection part 503 when the receiving component 700 is not pulled out, thus ensuring the stability of the device. Specifically, during installation, the liquid collection component 600 is first placed into the liquid collection component placement cavity 514, so that the portion of the locking block 601 near the receiving part is embedded in the locking groove 518. At this time, the limiting block 513 is positioned above under the action of the elastic element 512, which does not affect the embedding of the locking block 601. Then, the receiving component 700 is inserted into the slot 508 through the opening 507. The receiving component 700 presses against the limiting block 513, causing the limiting block 513 to compress the elastic element 512 downwards until the side wall of the limiting block 513 near the elastic element mounting groove 519 contacts the side wall of the locking block 601 away from the elastic element, thereby limiting the locking block 601. During disassembly, the receiving component 700 is pulled out, and the limiting block 513 resets under the elastic force of the elastic element 512, releasing the limitation on the locking block 601, and the liquid collection component 600 can then be removed from the liquid collection component placement cavity 514. In this embodiment, the elastic element is a spring.

[0030] In a specific embodiment, the inner sidewall of the liquid collection component placement cavity 514 is provided with a sliding groove 515 that extends obliquely and whose bottom is connected to the snap-fit ​​groove 518; the liquid collection component placement cavity 514 is provided with a recessed snap-fit ​​limiting groove 516 with a diameter larger than the diameter of the liquid collection component placement cavity 514; such as Figure 9 As shown, the liquid collection assembly also includes a liquid collection cylinder 602 and a locking platform 603 disposed on the liquid collection cylinder 602; the locking block 601 extends obliquely along the outer wall of the liquid collection cylinder 602. When the liquid collection cylinder 602 is placed in the liquid collection assembly placement cavity 514, the locking block 601 can slide along the slide groove 515 and slide into the bottom of the slide groove 515. The side of the locking block 601 near the receiving part enters the locking groove 518 and is pressed down and fixed in the locking groove 518 by the limiting block 513. At this time, the locking platform is disposed in the locking platform limiting groove 516.

[0031] In this embodiment, two chute 515s are symmetrically arranged on the inner wall of the liquid collection component placement cavity 514. This ensures balanced support force for the liquid collection component, uniform force distribution when the liquid collection cylinder 602 is placed in the liquid collection component placement cavity 514, and guarantees stability during bubble liquid collection, preventing bubble liquid leakage. The chute 515 extends obliquely and communicates with the locking groove 518. Combined with the oblique angle of the locking block 601, it provides guidance for the installation of the liquid collection cylinder 602, facilitating quick sliding of the locking block 601 into the locking groove 518, improving installation efficiency. Simultaneously, the chute 515 provides initial positioning of the locking block 601. The liquid collection cylinder 602 has an upward-opening cavity. When the liquid collection cylinder 602 moves below the liquid outlet pipe 200, the cavity and opening stably collect the bubble liquid dripping from the liquid outlet pipe 200, ensuring the integrity of the collection. The mounting plate 603, in conjunction with the recessed mounting plate limiting groove 516, can be stored within the mounting plate limiting groove 516, effectively reducing the external space occupied by the mounting plate 603 and making the overall structure of the device more compact and aesthetically pleasing. At the same time, the mounting plate 603 can cover the top opening of the slide 515, preventing dust and debris from falling into the slide 515 and causing blockages during use, ensuring the smooth use of the slide 515 and reducing the maintenance cost of the device. When installing the liquid collecting cylinder 602, align the locking block 601 of the liquid collecting cylinder 602 with the slide groove 515 and slide it diagonally downward along the slide groove 515 until the locking block 601 slides into the bottom of the slide groove 515. At this time, the side of the locking block 601 near the receiving part enters the locking groove 518, and the locking platform 603 is embedded in the locking platform limiting groove 516, completing the initial fixation of the liquid collecting cylinder 602. Then, insert the receiving component 700 and press down the limiting block 513 to fix the locking block 601 in the locking groove 518, realizing the firm installation of the liquid collecting cylinder 602. When disassembling, pull out the receiving component 700, the limiting block 513 resets, and pull the liquid collecting cylinder 602 upward along the slide groove 515 to remove the liquid collecting cylinder 602 from the liquid collecting component placement cavity 514.

[0032] In a specific embodiment, the receiving component 700 includes a connecting piece 701 and a glass slide 702. The side of the glass slide 702 away from the lead screw is fixedly connected to the connecting piece 701. Both sides of the glass slide 702 can be inserted into or pulled out of the receiving area along the first groove 509 and the third groove 511, respectively. When the glass slide 702 is inserted into the slot 508, the outer wall of the glass slide 702 near the elastic member 512 abuts against the side wall of the limiting block 513 away from the elastic member 512. In this embodiment, the slide 702 is made of transparent glass. When the bubble liquid dripping from the outlet tube 200 lands on the surface of the slide 702, it facilitates the subsequent observation of relevant parameters of the bubble liquid under an external microscope without the need to transfer the bubble liquid, thus avoiding contamination and leakage during the transfer process and ensuring the accuracy of the test data. The connecting piece 701 can be made of transparent glass, non-transparent plastic plate, or metal plate. Its main function is to facilitate the handling of the slide 702 by the operator. The protruding area formed by the connecting piece 701 can prevent the operator from directly contacting the surface of the slide 702 when handling it, preventing contamination of the slide 702 and the bubble liquid to be tested, further ensuring the reliability of the test data. The two sides of the slide 702 respectively cooperate with the first groove 509 and the third groove 511, ensuring accurate positioning of the slide 702 after it is inserted into the slot 508, ensuring the stability of the droplet receiving. At the same time, the slide 702 abuts against the limiting block 513, which can trigger the limiting component to limit the liquid, ensuring reliable limiting effect. The working process of the receiving component 700 is as follows: Before the use of the bubble generator housing 100 or during the initial air venting stage, the connecting piece 701 and the glass slide 702 are in an upright position along with the support plate 501, i.e., the retracted position (e.g., Figure 2 As shown), this will not occupy much external space, nor will it obstruct the discharge of air and waste liquid; when it is necessary to receive the bubble liquid to be tested, the transmission mechanism 900 drives the support plate 501 to flip, so that the connecting piece 701 and the glass slide 702 are rotated to the horizontal position (as shown). Figure 1 As shown in the diagram, this is the receiving position. At this time, the slide 702 is located directly below the outlet of the liquid outlet tube 200, and the bubble liquid can drip directly onto the surface of the slide 702 without the need for staff to monitor it in real time, which is convenient and quick. After the slide 702 receives one or more drops of bubble liquid, the transmission mechanism 900 drives the support plate 501 to move, removing the slide 702 from under the liquid outlet tube 200 to avoid receiving subsequent drops of bubble liquid. When convenient, the staff can pull out the slide 702 through the connecting piece 701 to detect the bubble liquid.

[0033] In a specific embodiment, the top surface of the limiting block 513 near the opening 507 and the end of the third groove 511 near the opening 507 are both provided with inclined surfaces 517 for guiding the insertion of the slide 702. The inclined surfaces 517 can correct the insertion direction of the slide 702, ensuring that the slide 702 can be accurately inserted into the first groove 509 and the third groove 511. This improves the installation efficiency of the slide 702 and also ensures the limiting function of the trigger limiting component, preventing the limiting from failing due to installation misalignment of the slide 702.

[0034] In a specific embodiment, the transmission mechanism 900 further includes a motor 902, a first support block 903, and a second support block 904; the first support block 903 and the second support block 904 are fixed on the housing 100 of the bubble generator, and the two ends of the lead screw 901 are rotatably connected to the first support block 903 and the second support block 904 respectively through bearings; the motor 902 is fixed on the housing 100 of the bubble generator, and its output end is connected to the lead screw.

[0035] The first support block 903 and the second support block 904 provide stable support for the lead screw 901. By connecting the two ends of the lead screw 901 to the first and second support blocks 903 and 904 respectively via bearings, the friction during the rotation of the lead screw 901 is reduced, ensuring smooth and stable rotation and improving transmission accuracy. Simultaneously, the two support blocks can be fixed to the outer shell 100 of the bubble generator, further strengthening the connection stability between the support assembly 500, the liquid collection assembly 600, and the outer shell 100 of the bubble generator, preventing loosening or displacement of components during transmission and ensuring the overall reliability of the device. The motor 902 provides a stable power source for the rotation of the lead screw 901, eliminating the need for manual driving and automating the flipping and movement of the support assembly 500, significantly reducing manual labor intensity. Furthermore, the speed of the motor 902 can be precisely controlled, enabling precise adjustment of the rotation angle and speed of the lead screw 901, thereby precisely controlling the flipping angle and moving distance of the support plate 501, ensuring precise switching between the receiving position, liquid collection position, and retraction position. The first plate 800 is fixed on top of the second support block 904, which makes reasonable use of space and makes the device structure more compact. At the same time, it can precisely limit the rotation range of the support plate 501, avoiding damage to components or positional displacement caused by excessive rotation of the support plate 501, and further improving the safety and stability of the device operation. After the motor 902 starts, the output end drives the lead screw 901 to rotate. The lead screw 901 rotates smoothly under the support of the first support block 903 and the second support block 904, and drives the support plate 501 to flip or move through the threaded engagement. When the lead screw 901 rotates forward (towards the bubble generator housing 100), it drives the support plate 501 to flip to the side and move to the receiving position and liquid collection position. When the lead screw 901 rotates in the opposite direction (away from the bubble generator housing 100), it drives the support plate 501 to move back to the receiving position and flip to the retracted position. The entire position change process does not require manual intervention and has a high degree of automation.

[0036] In a specific embodiment, the motor is provided with a protective shell 905, the protective shell is provided with a heat dissipation vent, and the heat dissipation vent is provided with a dustproof net.

[0037] The protective shell is fixed to the outer casing 100 of the bubble generator. This shell effectively protects the motor 902 from damage caused by external impacts, dust, liquids, etc., reducing the probability of damage, extending its service life, ensuring the stable operation of the transmission mechanism 900, and thus ensuring the normal operation of the entire device. The heat dissipation vents on the protective shell allow for timely dissipation of heat generated by the motor 902 during operation, preventing performance degradation and damage due to overheating, ensuring stable long-term operation and meeting the continuous working requirements of the device. The dustproof mesh at the heat dissipation vents effectively prevents dust and debris from entering the motor 902, preventing dust accumulation that could cause wear and short circuits in internal parts, further protecting the motor 902. Simultaneously, it does not obstruct normal heat dissipation, achieving a dual effect of protection and heat dissipation.

[0038] In a specific embodiment, a monitoring sensor 300 for receiving the droplet to be detected on the component 700 is also included.

[0039] The monitoring sensor is located on the housing 100 of the bubble generator, corresponding to the outlet position of the liquid outlet pipe.

[0040] The monitoring sensor 300 activates the transmission mechanism 900 after detecting that the receiving component 700 has received the liquid to be tested. The monitoring sensor 300 automatically detects whether the receiving component 700 is receiving the bubble-filled liquid, eliminating the need for real-time observation by personnel. This further enhances the automation level of the device, reduces manual operation, and prevents waste of bubble-filled liquid due to over-collection or failure to switch to collection mode in time. The monitoring sensor 300 is positioned at the outlet of the liquid outlet pipe 200, accurately detecting the dripping of bubble-filled liquid and ensuring the accuracy of the test results. The monitoring sensor 300 uses a TT Electronics OPB9000 reflective photoelectric sensor, which detects the liquid by receiving the light signal reflected from the droplets. It does not directly contact the droplets, thus preventing contamination of the bubble-filled liquid and ensuring the purity of the liquid and the accuracy of the test data. When the liquid outlet 200 drips bubble-forming liquid into the receiving component 700, the monitoring sensor 300 detects the droplet and immediately transmits a signal to the controller (existing technology). The controller then automatically activates the transmission mechanism, driving the support component to move, causing the receiving component to move away and the liquid collection component to quickly switch to below the outlet pipe to complete liquid collection. This achieves fully automated switching of the receiving and collection process, thus solving problems such as manual operation, sample waste, and environmental pollution. It significantly improves the automation level and working efficiency of the device, avoids losses caused by droplet overflow or switching lag, and ensures a continuous and stable bubble preparation process. The controller and monitoring sensor mentioned above are all conventional components, and their more specific principles will not be elaborated here.

[0041] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and not to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features; and these modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A micro / nano bubble-enhanced ultrasound tumor ablation device, characterized in that, Includes ultrasonic devices, imaging systems, and bubble generators; The bubble generator is used to prepare micro- and nano-bubbles, and the bubble delivery module delivers the micro- and nano-bubbles to the tumor area; the ultrasound device can emit ultrasound waves of specific frequencies and powers, causing the micro- and nano-bubbles to vibrate, expand, and collapse, resulting in cavitation and thermal ablation effects, destroying and ablating tumor tissue; the imaging system is used to observe the tumor location, the distribution of micro- and nano-bubbles, and the tumor ablation process in real time. The bubble generating device includes: The outer shell (100) of the bubble generator is provided with a microfluidic chip inside. The microfluidic chip is provided with a microchannel. The two ends of the microchannel are respectively provided with an inlet for introducing solvent and an outlet for discharging bubble liquid. The liquid outlet tube (200) is connected to the liquid outlet end of the microchannel and is used to discharge the bubble liquid; A support assembly (500) is disposed on one side of the housing (100) of the bubble generator; A receiving component (700) is detachably mounted on the support component (500) for receiving the test droplets flowing out of the outlet pipe (200); The liquid collection assembly (600) is detachably mounted on the support assembly (500) and is used to collect the liquid bubbles flowing out of the liquid outlet pipe (200) after the receiving assembly (700) has received the droplets to be tested. A transmission mechanism (900) is disposed on the housing (100) of the bubble generator and is used to drive the support assembly (500) to reciprocate outside the housing (100) of the bubble generator, so that the support assembly drives the receiving assembly (700) to a folded position that is folded against the side wall of the housing (100) of the bubble generator or to a receiving position located below the outlet of the liquid outlet pipe (200), and so that the support assembly drives the liquid collecting assembly (600) to a folded position that is folded against the side wall of the housing (100) of the bubble generator or to a liquid collecting position located below the outlet of the liquid outlet pipe (200).

2. The micro-nano bubble enhanced ultrasound tumor ablation device according to claim 1, characterized in that, The support assembly (500) includes a support plate (501); The support plate (501) is provided with a receiving part (502), a liquid collecting part (503), and an installation channel (504) penetrating one side of the receiving part and the liquid collecting part; the receiving component (700) is detachably installed in the receiving part, and the liquid collecting component (600) is detachably installed in the liquid collecting part; the outer wall of the support plate (501) near the installation channel (504) includes an arc surface (505) and a limiting plate (506) connected to the arc surface and set at a right angle to the support plate. The transmission mechanism (900) includes a lead screw (901), which is rotatably mounted on the housing (100) of the bubble generator. The mounting channel (504) is mounted on the lead screw through an internal threaded structure. The outer casing (100) of the bubble generator is provided with a first plate (800) that restricts the rotation of the support plate. When the lead screw (901) rotates continuously toward the bubble generator housing (100), it can drive the support plate (501) to flip from the folded vertical state when it is in the retracted position on the bubble generator housing (100) to the horizontal state, and drive the receiving component (700) on the support plate (501) to flip away from the bubble generator housing (100) to the receiving position. At this time, the arc surface can rotate around the axis of the lead screw (901) until the side wall of the limiting plate (506) abuts against the vertical side wall of the bubble generator housing (100). After the receiving component (700) has finished receiving the liquid, the lead screw (901) continues to rotate toward the housing (100) of the bubble generator. At the same time, under the action of the limiting plate (506) and the vertical side wall of the housing (100) of the bubble generator, the support plate (501) can move toward the first plate (800) on the lead screw until the receiving component (700) moves to below the first plate (800) and the liquid collecting component (600) moves to the liquid collecting position to collect the liquid. After the liquid collection assembly (600) finishes collecting the liquid, the lead screw (901) can rotate continuously in a direction away from the housing (100) of the bubble generator, and cooperate with the first plate (800) to drive the support plate (501) to move back to the receiving position along the lead screw (901) in a direction away from the first plate (800), and can continue to drive the support plate (501) to flip to the retracted position.

3. The micro-nano bubble enhanced ultrasound tumor ablation device according to claim 2, characterized in that, The support assembly (500) further includes a limiting assembly; the limiting assembly is disposed on the receiving portion of the support plate (501), and when the receiving assembly (700) is installed on the support plate (501), the receiving assembly (700) can restrict the liquid collecting assembly (600) from moving out of the liquid collecting portion (503) by the limiting assembly.

4. The micro-nano bubble enhanced ultrasound tumor ablation device according to claim 3, characterized in that, The inner wall of the receiving part (502) is provided with a slot (508) for receiving the insertion and removal of the component and having an opening (507) on one side. The slot (508) includes a first groove (509), a second groove (510) and a third groove (511) that are sequentially connected from near the liquid collection part to away from the liquid collection part. The depth of the first groove (509) is greater than the depth of the second groove (510) and the third groove (511). The first groove (509) is provided with an elastic element mounting groove (519) and a snap-fit ​​groove (518). The limiting component includes an elastic element (512) and a limiting block (513); the limiting block (513) is disposed in the first groove (509), the elastic element (512) is installed in the elastic element mounting groove (519) and one end of the elastic element is fixed to the elastic element mounting groove (519), and the other end of the elastic element (512) is fixedly connected to the side of the limiting block (513) near the elastic element mounting groove (519); The liquid collection part (503) is provided with a liquid collection component placement cavity (514). The liquid collection component (600) is provided with a locking block (601) on its side. When the liquid collection component (600) is installed in the liquid collection component placement cavity (514), the part of the locking block (601) near the receiving part is located in the locking groove (518) and is located on the lower side of the limiting block (513). When the receiving component (700) is inserted into the slot (508), the limiting block (513) can be driven to move towards the elastic element mounting groove (519) until the side wall of the limiting block (513) near the elastic element mounting groove (519) contacts the side wall of the locking block (601) away from the elastic element, thus restricting the locking block (601) from detaching from the locking groove (518).

5. The micro-nano bubble enhanced ultrasound tumor ablation device according to claim 4, characterized in that, The inner side wall of the liquid collection component placement cavity (514) is provided with a sliding groove (515) that extends obliquely and is connected to the bottom of the locking groove (518); the liquid collection component placement cavity (514) is provided with a recessed locking platform limiting groove (516) with a diameter larger than the diameter of the liquid collection component placement cavity (514); the liquid collection component includes a liquid collection cylinder (602) and a locking platform (603) provided on the liquid collection cylinder (602); the locking block (601) extends obliquely along the outer wall of the liquid collection cylinder (602), the locking block (601) can slide along the sliding groove (515) and slide into the bottom of the sliding groove (515), and the side of the locking block (601) near the receiving part enters the locking groove (518) and is pressed down and fixed in the locking groove (518) by the limiting block (513). At this time, the locking platform (603) is provided in the locking platform limiting groove (516).

6. The micro-nano bubble enhanced ultrasound tumor ablation device according to claim 4, characterized in that, The receiving component (700) includes a connecting piece (701) and a glass slide (702). The side of the glass slide (702) away from the lead screw is fixedly connected to the connecting piece (701). The two sides of the glass slide (702) can be inserted into the receiving area or pulled out from the receiving area along the first groove (509) and the third groove (511) respectively. The glass slide (702) near the outer wall of the elastic member (512) abuts against the side wall of the limiting block (513) away from the elastic member (512).

7. The micro-nano bubble enhanced ultrasound tumor ablation device according to claim 6, characterized in that, The top surface of the limiting block (513) near the opening (507) and the end of the groove wall of the third groove (511) near the opening (507) are both provided with inclined surfaces (517) for guiding the insertion of the glass slide (702).

8. The micro-nano bubble enhanced ultrasound tumor ablation device according to claim 2, characterized in that, The transmission mechanism (900) also includes a motor (902), a first support block (903), and a second support block (904); the first support block (903) and the second support block (904) are fixed on the housing (100) of the bubble generator, and the two ends of the lead screw (901) are rotatably connected to the first support block (903) and the second support block (904) respectively. The motor (902) is fixed on the housing (100) of the bubble generator, and its output end is connected to the lead screw.

9. The micro-nano bubble enhanced ultrasound tumor ablation device according to claim 8, characterized in that, The motor (902) is provided with a protective shell (905) on the outside, and the protective shell (905) is provided with a heat dissipation port, and a dustproof net is provided at the heat dissipation port.

10. The micro-nano bubble enhanced ultrasound tumor ablation device according to claim 1, characterized in that, It also includes a monitoring sensor (300) for receiving the droplets to be detected on the component (700).

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