Aspherical intraocular lens, method for designing aspherical intraocular lens, and method for manufacturing aspherical intraocular lens

Abstract

An intraocular lens and related technology are provided. The intraocular lens has a power distribution map V. This power distribution map V falls within a set of power distribution maps obtained by various combinations of power distribution maps Va and Vb, with the intersection point of a first region power distribution map Va and a second region power distribution map Vb as the position ra on the horizontal axis. The first region power distribution map Va is obtained by subtracting the vertical axis values ​​at each horizontal axis value of the aspherical reference power distribution map W from the base power, and multiplying it by a predetermined ratio α (α is 10%). The second region degree distribution map Vb is obtained by subtracting the horizontal axis values ​​of the aspherical reference degree distribution map W from the maximum horizontal axis value rmax of the aspherical reference degree distribution map W, multiplying the result by a predetermined ratio β (β is above 10% and below 50%), and then adding the result to the horizontal axis values ​​of the vertical axis values ​​of the aspherical reference degree distribution map W.

Description

Technical Field

[0001] This invention relates to aspheric intraocular lenses, methods for designing aspheric intraocular lenses, and methods for manufacturing aspheric intraocular lenses. Background Technology

[0002] There is a known type of intraocular lens that corrects vision after the lens has become cloudy due to cataracts. For example, when the lens becomes cloudy due to cataracts, an artificial intraocular lens is surgically implanted into the lens capsule to replace the cloudy lens, thereby restoring vision.

[0003] Patent document 1

[0007] describes the following problem: while maintaining the advantage of existing aberration-reducing intraocular lenses that appear clear, an intraocular lens is obtained that results in a small decrease in contrast even when the optical axis of the intraocular lens deviates from the optical axis of the eyeball during implantation.

[0004] To address this issue, claim 1 of Patent Document 1 describes the following: When an intraocular lens is implanted into the eye and a power distribution designed to compensate for corneal spherical aberration is used as a reference power distribution, at least one positive power offset region and one negative power offset region are respectively provided in the region near the center of the intraocular lens. The positive power offset region is a region with a power greater than that represented by the reference power distribution, and the negative power offset region is a region with a power less than that represented by the reference power distribution. By having the above power distribution, the contrast decrease caused by the optical axis of the intraocular lens implanted in the eye deviating from the optical axis of the eyeball can be suppressed.

[0005] In addition, the following intraocular lenses are also known.

[0006] For example, Patent Documents 2 and 3 propose intraocular lenses that do not add spherical aberration to the existing spherical aberration of the cornea (claim 1 of Patent Document 2 and claim 1 of Patent Document 3). In such intraocular lenses, the optical power value of the entire optical region is constant. Since no spherical aberration is added to the spherical optical system of the eye, it is not affected by image quality degradation caused by lens shift and tilt. In

[0005] of Patent Document 2, an aspherical intraocular lens is proposed, in which the amount of negative spherical aberration is less than the amount required to offset the positive spherical aberration of the cornea.

[0007] To minimize spherical aberration in the eye's optical system, Patent Document 4 proposes an aspherical intraocular lens that reduces average corneal spherical aberration (claims 1 and 13 of Patent Document 4, etc.). The optical power of this type of aspherical intraocular lens decreases as the lens radius increases. To achieve high image quality, lens shift and tilt in aphakic patients need to be kept at a low level.

[0008] Patent Document 5 proposes an aspherical intraocular lens that can balance image contrast and depth of focus within permissible limits under conditions of particularly large pupils (e.g., 4.5–5 mm) (claim 1 of Patent Document 5).

[0009] Patent document 6 discloses an aspherical intraocular lens that minimizes optical sensitivity in the event of lens convergence and lens tilt. The lens's optical power initially decreases, then increases with increasing lens radius (Patent document 6). Figure 6 (solid dots).

[0010] Existing technical documents Patent documents Patent Document 1: Japanese Patent Application Publication No. 2007-330478 Patent Document 2: US Publication No. US2005 / 0203619 Patent Document 3: WO2004 / 090611 Patent Document 4: US2004 / 0088050 Patent Document 5: WO2006 / 060477 Patent document 6: WO2007 / 128423. Summary of the Invention

[0011] The problem that the invention aims to solve After an intraocular lens is implanted, it is assumed that the optical axis of the intraocular lens will decentize from the center of the cornea, or that the optical axis of the intraocular lens will tilt relative to the direction of corneal thickness (the direction of the axial length).

[0012] Furthermore, it is assumed that the wearer of the intraocular lens implanted in the eye may work outdoors in bright light or indoors (or in a dark place) in less light. That is, it is also assumed that the wearer's pupil diameter may change.

[0013] The purpose of this invention is to provide an intraocular lens and related technologies that are robust to changes in image quality caused by the aforementioned offset, tilt, and pupil diameter variations while maintaining good image quality.

[0014] means for solving problems The first method is: An intraocular lens has at least two concentric and adjacent vision correction regions centered on a lens center O with a predetermined base power. The vision correction area is defined as a second area surrounding the first area, starting from the first area containing the lens center O and moving radially outward. In the diopter distribution diagram, the position when viewing the lens center O radially is set as the horizontal axis (unit: mm), and the diopter is set as the vertical axis (unit: D (diopter)). When the position of the first boundary between the first region and the second region when viewed radially from the lens center O is set as r1, and When the power distribution map of a virtual aspherical lens, which has a base power at the center O of the lens and completely cancels out the positive longitudinal spherical aberration caused by the cornea, is set as the aspherical reference power distribution map W, The intraocular lens has a power distribution map V, which falls within the set region of power distribution maps obtained by various combinations of power distribution maps Va and Vb when the intersection of the first region's power distribution map Va and the second region's power distribution map Vb is taken as the position ra on the horizontal axis. The degree distribution map Va for the first region is obtained as follows: the value obtained by subtracting the vertical axis values ​​at each horizontal axis value of the aspherical reference degree distribution map W from the base degree value is multiplied by a predetermined ratio α (α is more than 10% and less than 50%), and then the multiplied value is added to the vertical axis values ​​at each horizontal axis value of the aspherical reference degree distribution map W. The second region is obtained by subtracting the horizontal axis values ​​of each vertical axis value of the aspherical reference degree distribution map W from the maximum horizontal axis value rmax of the aspherical reference degree distribution map W, multiplying the result by a predetermined ratio β (β is more than 10% and less than 50%), and then adding the multiplied value to the horizontal axis values ​​of each vertical axis value of the aspherical reference degree distribution map W.

[0015] The second method is: According to the intraocular lens of the first method, r1 is a value in the range of 1.5 mm or more and 2.3 mm or less.

[0016] The third method is: According to the intraocular lens of the first method, the position where the positive maximum value occurs is position r1, which is the value obtained by subtracting the vertical axis value of the aspherical reference power distribution map W from the vertical axis value of the power distribution map V at each horizontal axis value of the power distribution map V.

[0017] The fourth method is: According to the intraocular lens of the first method, the maximum value rmax of the horizontal axis of the power distribution map V is a value in the range of 2.5 mm or more and 3.5 mm or less.

[0018] The fifth method is: According to the intraocular lens of the first embodiment, one or more additional regions are provided radially outward from the second region. The additional area surrounds the second area. At each horizontal axis value of the degree distribution map Vadd in at least one of the additional regions, the value obtained by subtracting the vertical axis value of the aspherical reference degree distribution map W from the vertical axis value of the degree distribution map Vadd is less than ±0.30D.

[0019] The sixth method is: According to the intraocular lens of the first method, the power distribution map V is represented by a polynomial.

[0020] The seventh method is: According to the intraocular lens of the first embodiment, one or more additional regions are provided radially outward from the second region. The additional area surrounds the second area. The additional area has the function of refracting the incident light beam onto the retina.

[0021] The eighth method is: An intraocular lens has at least two concentric and adjacent vision correction regions centered on a lens center O with a predetermined base power. The vision correction area is defined as a second area surrounding the first area, starting from the first area containing the lens center O and moving radially outward. In the diopter distribution diagram, the position when viewing the lens center O radially is set as the horizontal axis (unit: mm), and the diopter is set as the vertical axis (unit: D (diopter)). When the position of the first boundary between the first region and the second region when viewed radially from the lens center O is set as r1, and When the power distribution map of a virtual aspherical lens, which has a base power at the center O of the lens and completely cancels out the positive longitudinal spherical aberration caused by the cornea, is set as the aspherical reference power distribution map W, In the first region, the average value of the vertical axis of the degree distribution map V1 is greater than the average value of the vertical axis of the aspherical reference degree distribution map W. In the second region, the average value of the vertical axis of the degree distribution map V2 is greater than the average value of the vertical axis of the aspherical reference degree distribution map W. In the degree distribution map V1 for the first region, as the horizontal axis value increases, at each horizontal axis value, the value obtained by subtracting the vertical axis value of the aspherical reference degree distribution map W from the vertical axis value of degree distribution map V1 continuously increases. In the second region using the degree distribution map V2, as the horizontal axis value increases, at each horizontal axis value, the value obtained by subtracting the vertical axis value of the aspherical reference degree distribution map W from the vertical axis value of the degree distribution map V2 continuously decreases. In the degree distribution map V, the position where the positive maximum value occurs is position r1, obtained by subtracting the vertical axis value of the aspherical reference degree distribution map W from the vertical axis value of the degree distribution map V2. The value obtained by subtracting the vertical axis value of the aspherical reference degree distribution map W from the vertical axis value at the maximum horizontal axis value rmax of the degree distribution map V is less than 0.25D.

[0022] The ninth method is: According to the intraocular lens of the eighth method, the absolute value of the average slope of the tangent line of the power distribution map V2 in the second region is more than three times the absolute value of the average slope of the tangent line of the power distribution map V1 in the first region.

[0023] The tenth method is: According to the intraocular lens of the eighth method, r1 is a value in the range of 1.5 mm or more and 2.3 mm or less.

[0024] The eleventh method is: According to the intraocular lens of the eighth method, the maximum value rmax of the horizontal axis of the power distribution map V is a value in the range of 2.5 mm or more and 3.5 mm or less.

[0025] The twelfth method is: The intraocular lens according to the eighth method has a power distribution map V, which falls within the set region of power distribution maps obtained by various combinations of power distribution maps Va and Vb when the intersection of the first region power distribution map Va and the second region power distribution map Vb is taken as the position ra on the horizontal axis. The degree distribution map Va for the first region is obtained as follows: the value obtained by subtracting the vertical axis values ​​at each horizontal axis value of the aspherical reference degree distribution map W from the base degree value is multiplied by a predetermined ratio α (α is more than 10% and less than 50%), and then the multiplied value is added to the vertical axis values ​​at each horizontal axis value of the aspherical reference degree distribution map W. The second region is obtained by subtracting the horizontal axis values ​​of each vertical axis value of the aspherical reference degree distribution map W from the maximum horizontal axis value rmax of the aspherical reference degree distribution map W, multiplying the result by a predetermined ratio β (β is more than 10% and less than 50%), and then adding the multiplied value to the horizontal axis values ​​of each vertical axis value of the aspherical reference degree distribution map W.

[0026] The thirteenth method is: According to the intraocular lens of the eighth embodiment, one or more additional regions are provided radially outward from the second region. The additional area surrounds the second area. At each horizontal axis value of the degree distribution map Vadd in at least one of the additional regions, the value obtained by subtracting the vertical axis value of the aspherical reference degree distribution map W from the vertical axis value of the degree distribution map Vadd is less than ±0.30D.

[0027] The fourteenth method is: According to the intraocular lens of the eighth method, the power distribution map V is represented by a polynomial.

[0028] The fifteenth method is: According to the intraocular lens of the eighth embodiment, one or more additional regions are provided radially outward from the second region. The additional area surrounds the second area. The additional area has the function of refracting the incident light beam onto the retina.

[0029] The sixteenth method is: An intraocular lens has at least two concentric and adjacent vision correction regions centered on a lens center O with a predetermined base power. The vision correction area is defined, starting from the first area containing the lens center O and moving radially outward, as a middle area surrounding the first area and a second area surrounding the middle area. In the diopter distribution diagram, the position when viewing the lens center O radially is set as the horizontal axis (unit: mm), and the diopter is set as the vertical axis (unit: D (diopter)). When the power distribution map of a virtual aspherical lens, which has a base power at the center O of the lens and completely cancels out the positive longitudinal spherical aberration caused by the cornea, is set as the aspherical reference power distribution map W, The intraocular lens has a power distribution map V, which is composed of a power distribution map Va for a first region, a power distribution map Vb for a second region, and a power distribution map Vmid for an intermediate region. The power distribution map V falls within the set region of power distribution maps obtained by various combinations of Va, Vmid, and Vb. The degree distribution map Va for the first region is obtained as follows: the value obtained by subtracting the vertical axis values ​​at each horizontal axis value of the aspherical reference degree distribution map W from the base degree value is multiplied by a predetermined ratio α (α is more than 10% and less than 50%), and then the multiplied value is added to the vertical axis values ​​at each horizontal axis value of the aspherical reference degree distribution map W. The second region is obtained using the degree distribution map Vb as follows: The value obtained by subtracting the horizontal axis values ​​of each vertical axis value of the aspherical reference degree distribution map W from the maximum horizontal axis value rmax of the aspherical reference degree distribution map W is multiplied by a predetermined ratio β (β is greater than 10% and less than 50%), and then the resulting multiplication is added to the horizontal axis values ​​of each vertical axis value of the aspherical reference degree distribution map W. The average degree of the intermediate region, as shown in the degree distribution map Vmid, is less than the average degree of the first region but greater than the average degree of the second region.

[0030] The seventeenth method is: According to the sixteenth method of the intraocular lens, the absolute value of the average slope of the tangent line of the diopter distribution map Vmid in the intermediate region is greater than the absolute value of the average slope of the tangent line of the diopter distribution map V1 in the first region, and less than the absolute value of the average slope of the tangent line of the diopter distribution map V2 in the second region.

[0031] The eighteenth method is: According to the sixteenth embodiment of the intraocular lens, the average value obtained by subtracting the vertical axis value of the aspherical reference power distribution map W from the horizontal axis value of the power distribution map Vmid in the intermediate region is taken at each horizontal axis value. The average of the values ​​obtained by subtracting the vertical axis value of the aspherical reference degree distribution map W from the horizontal axis value of the degree distribution map V1 in the first region, where each horizontal axis value is greater than the horizontal axis value of the degree distribution map V1 in the first region, and The average of the values ​​obtained by subtracting the vertical axis value of the aspherical reference degree distribution map W from the horizontal axis value of the degree distribution map V2 in the second region at each horizontal axis value greater than the horizontal axis value of the degree distribution map V2 in the second region.

[0032] The nineteenth method is: According to the sixteenth method, the intraocular lens has a transverse axis value in the intermediate region that falls within the range of 1.3 mm or more and 2.5 mm or less.

[0033] The twentieth method is: According to the sixteenth method, the intraocular lens has a maximum horizontal axis value rmax of the power distribution map V that is within the range of 2.5 mm or more and 3.5 mm or less.

[0034] The twenty-first method is: According to the sixteenth method of the intraocular lens, the absolute value of the average slope of the tangent line of the power distribution map V2 in the second region is more than three times the absolute value of the average slope of the tangent line of the power distribution map V1 in the first region.

[0035] The twenty-second method is: According to the sixteenth embodiment of the intraocular lens, one or more additional regions are provided radially outward from the second region. The additional area surrounds the second area. At each horizontal axis value of the degree distribution map Vadd in at least one of the additional regions, the value obtained by subtracting the vertical axis value of the aspherical reference degree distribution map W from the vertical axis value of the degree distribution map Vadd is less than ±0.30D.

[0036] The twenty-third method is: According to the sixteenth method, the intraocular lens, wherein the power distribution map V is represented by a polynomial.

[0037] The twenty-fourth method is: According to the sixteenth embodiment of the intraocular lens, one or more additional regions are provided radially outward from the second region. The additional area surrounds the second area. The additional area has the function of refracting the incident light beam onto the retina.

[0038] The twenty-fifth method is: An intraocular lens has at least two concentric and adjacent vision correction regions centered on a lens center O with a predetermined base power. The vision correction area is defined as a second area surrounding the first area, starting from the first area containing the lens center O and moving radially outward. When the power distribution map of a virtual aspherical lens, which has a base power at the center O of the lens and completely cancels out the positive longitudinal spherical aberration caused by the cornea, is set as the aspherical reference power distribution map W, In the total power distribution diagram, where the position observed radially from the lens center O is set as the horizontal axis (unit: mm), and the total power T (combining the refractive power of the cornea and the power of the intraocular lens) is set as the vertical axis (unit: D (diopter)), and the position of the first boundary between the first and second regions when observed radially from the lens center O is set as r1, The intraocular lens has a total power distribution map TV, which falls within the set region of total power distribution maps obtained by various combinations of total power distribution maps TVa and TVb when the intersection of the first region using total power distribution map TVa and the second region using total power distribution map TVb is taken as the position ra on the horizontal axis. The first region is obtained using the total power distribution map TVa as follows: the value obtained by subtracting the vertical axis values ​​of each horizontal axis value of the aspheric reference total power distribution map TW after adding corneal refractive power from the baseline power is multiplied by a predetermined ratio α (α is greater than 10% and less than 50%), and then the multiplied value is added to the vertical axis values ​​of each horizontal axis value of the aspheric reference total power distribution map TW. The second region is obtained using the total power distribution map TVb as follows: the value obtained by subtracting the horizontal axis value of each vertical axis value of the aspheric reference total power distribution map TW after adding the corneal refractive power from the maximum horizontal axis value rmax of the aspheric reference total power distribution map TW, multiplying the result by a predetermined ratio β (β is more than 10% and less than 50%), and then adding the multiplied value to the horizontal axis value of each vertical axis value of the aspheric reference total power distribution map TW.

[0039] The twenty-sixth method is: According to the intraocular lens of the twenty-fifth embodiment, in the total power distribution map TV1 of the first region, the vertical axis value increases continuously with the increase of the horizontal axis value. In the second region using the total degree distribution map TV2, the vertical axis value decreases continuously as the horizontal axis value increases.

[0040] The twenty-seventh method is: According to the intraocular lens described in method 25, wherein... The absolute value of the average slope of the tangent line to the total degree distribution map TV1 near the origin in the first region is less than the absolute value of the average slope of the tangent line to the total degree distribution map TV1 near the middle position in the first region. The absolute value of the average slope of the tangent line of the total degree distribution map TV1 near the middle position in the first region is greater than the absolute value of the average slope of the tangent line of the total degree distribution map TV1 near position r1 in the first region. The absolute value of the average slope of the tangent line of the total degree distribution map TV1 near position r1 in the first region is less than the absolute value of the average slope of the tangent line of the total degree distribution map TV2 near the middle position in the second region.

[0041] The twenty-eighth method is: According to the intraocular lens of the twenty-fifth method, in the total power distribution map TV, the maximum positive value is obtained by subtracting the vertical axis value at r=0 from the vertical axis value at position r1. r1 is a value within the range of 1.5 mm to 2.3 mm.

[0042] The twenty-ninth method is: According to the 25th method, the intraocular lens, wherein the value obtained by subtracting the vertical axis value at r=0 from the vertical axis value at the maximum horizontal axis value rmax of the total power distribution map TV is less than ±0.30D.

[0043] The thirtieth method is: According to the intraocular lens of the twenty-fifth method, the maximum value rmax of the horizontal axis of the total power distribution map TV is a value in the range of 2.5 mm or more and 3.5 mm or less.

[0044] The thirty-first method is: According to the intraocular lens described in method 25, wherein... One or more additional regions are set out radially outward from the second region. The additional area surrounds the second area. The additional area has the function of refracting the incident light beam onto the retina.

[0045] The thirty-second method is: An intraocular lens has at least two concentric and adjacent vision correction regions centered on a lens center O with a predetermined base power. The vision correction area is defined as the second area surrounding the first area, starting from the first area containing the lens center O and moving radially outward. In the diopter distribution diagram, the position when viewing the lens center O radially is set as the horizontal axis (unit: mm), and the diopter is set as the vertical axis (unit: D (diopter)). The power distribution map of a virtual aspherical lens, which has a base power at the center O of the lens and completely cancels out the positive longitudinal spherical aberration caused by the cornea, is set as the aspherical reference power distribution map W. The degree distribution map obtained as follows is set as the degree distribution map Va for the first region: The value obtained by subtracting the vertical axis values ​​at each horizontal axis value of the aspherical reference degree distribution map W from the base degree is multiplied by a predetermined ratio α (α is greater than 10% and less than 50%), and then the multiplied value is added to the vertical axis values ​​at each horizontal axis value of the aspherical reference degree distribution map W. The degree distribution map obtained in the following manner is set as the degree distribution map Vb for the second region: The value obtained by subtracting the horizontal axis values ​​of each vertical axis value of the aspherical reference degree distribution map W from the maximum horizontal axis value rmax of the aspherical reference degree distribution map W is multiplied by a predetermined ratio β (β is above 10% and below 50%), and then the multiplied value is added to the horizontal axis values ​​of each vertical axis value of the aspherical reference degree distribution map W. At this point, The first region includes an inner first region, which has a degree distribution map obtained by adding positive degrees to the degree distribution map Va of the first region. The second region has a degree distribution map Vb. The area of ​​the inner first region is less than 50% of the total area of ​​the first region.

[0046] The thirty-third method is: According to the intraocular lens described in method thirty-two, wherein... The first region, when viewed radially from the center O of the lens, comprises an inner first region and an outer first region surrounding the inner first region. The outer first region has a degree distribution map Va, and it connects with the second region at the intersection of degree distribution maps Va and Vb.

[0047] The thirty-fourth method is: According to the thirty-second embodiment of the intraocular lens, an inner first region is provided on the anterior surface, posterior surface, or both surfaces of the lens body of the intraocular lens having two opposing surfaces.

[0048] The thirty-fifth method is: According to the 32nd embodiment of the intraocular lens, the first region includes regions other than the inner first region, whose average power is equal to the average power of the power distribution map Va, and the average power of the inner first region is 0.75D to 4.0D greater than the average power of the regions other than the inner first region.

[0049] The thirty-sixth method is: According to the 33rd embodiment of the intraocular lens, the first region has an outer transition region for connecting the inner first region to the outer first region.

[0050] The thirty-seventh method is: According to the intraocular lens of the thirty-second embodiment, the inner first region has a fixed-power supplementary region, which has a power distribution map obtained by adding a positive fixed power to the power distribution map Va of the first region. When viewed radially from the center O of the lens, the radial distance of the fixed-degree additional region is 33% to 67% of the radial distance of the inner first region.

[0051] The thirty-eighth method is: According to the thirty-second method, the intraocular lens includes a lens center O in the inner first region.

[0052] The thirty-ninth method is: According to the intraocular lens of the thirty-third embodiment, the first region includes an innermost region, which has a power distribution map Va of the first region and includes a lens center O. The innermost region is surrounded by the first innermost region.

[0053] The fortieth method is: According to the thirty-ninth embodiment of the intraocular lens, the first region has an inner transition region for connecting the inner first region to the innermost region.

[0054] The forty-first method is: According to the thirty-second embodiment of the intraocular lens, the anterior surface, posterior surface, or both surfaces of the lens body of the intraocular lens having two opposing surfaces are aspherical.

[0055] The forty-second method is: According to the thirty-second method, the intraocular lens has a tortuous surface on the anterior surface, posterior surface, or both surfaces of the lens body having two opposing surfaces, the tortuous surface having a cylindrical power for correcting astigmatism in patients with aphakic eyes.

[0056] In order to achieve (produce) the degree distribution pattern taught by the contents of this application (this application specification), the lens surface that is machined (formed) into an aspherical surface by a lathe may be only the front surface, only the rear surface, or both the front and rear surfaces (both surfaces).

[0057] The forty-third method is: The intraocular lens according to any one of the first to forty-second embodiments, wherein the intraocular lens is composed of at least one of silicone, hydrophobic acrylic resin, hydrophilic acrylic resin, hydrogel, PMMA, PMMA copolymer, and HEMA (hydroxyethyl methacrylate) copolymer containing collagen.

[0058] The forty-fourth method is: A method for designing an intraocular lens, used to design an intraocular lens as described in any of the first to forty-second methods.

[0059] The forty-fifth method is: A method for manufacturing an intraocular lens, comprising manufacturing an intraocular lens designed by the intraocular lens design method described in the forty-fourth method by at least one of lathe machining, molding, or 3D printing.

[0060] In addition, the present invention may also be described in the following other ways.

[0061] The area ratio of the first region to the second region from a planar perspective can be set between 25:75 and 75:25.

[0062] The preferred degree decreases continuously in the first region and in the second region.

[0063] Within the interval from the lens center O to the first boundary position r1, the total power T of the cornea after superimposing the refractive power of the intraocular lens is preferably continuously increased.

[0064] The technical concept of this invention can also be applied to the design or manufacturing methods of intraocular lenses.

[0065] Invention Effects According to the present invention, while maintaining good imaging quality, it is possible to make the imaging quality robust to the aforementioned offset, tilt and pupil diameter changes. Attached Figure Description

[0066] Figure 1 This is a planar schematic diagram illustrating an intraocular lens according to an embodiment of the present invention.

[0067] Figure 2 It is a power distribution diagram with the position when viewed radially from the center O of the lens set as the horizontal axis (unit: mm) and the power set as the vertical axis (unit: D (diopter)).

[0068] Figure 3 It is a power distribution diagram showing the refractive power (vertical axis) brought about by the optical part of the intraocular lens relative to the distance from the center O of the lens (horizontal axis), and it is a diagram showing the power distribution diagram Va. The power distribution diagram Va is obtained as follows: the value obtained by subtracting the reference power from the vertical axis value of each horizontal axis value of the aspherical reference power distribution diagram W, multiplying it by a preset ratio α (10% of the value between 10% and 50% is I10, 35% is I35, and 50% is I50), and then adding the value to the vertical axis value of each horizontal axis value of the aspherical reference power distribution diagram W.

[0069] Figure 4 It is a power distribution diagram showing the refractive power (vertical axis) brought about by the optical part of the intraocular lens relative to the distance from the center O of the lens (horizontal axis), and it is a diagram showing the power distribution diagram Vb. The power distribution diagram Vb is obtained as follows: the horizontal axis value of each vertical axis value of the aspherical reference power distribution diagram W is subtracted from the maximum value rmax of the horizontal axis of the aspherical reference power distribution diagram W, multiplied by a preset ratio β (β is 10% of the value between 10% and 50%, which is O10, 25% is O25, and 50% is O50), and then added to the horizontal axis value of each vertical axis value of the aspherical reference power distribution diagram W.

[0070] Figure 5 It is Figure 3 I35 and Figure 4 An explanatory diagram of O25 superposition.

[0071] Figure 6 It means to Figure 5 The degree distribution map V is obtained by stitching together the degree distribution map Va (I35) of the first region and the degree distribution map Vb (O25) of the second region.

[0072] Figure 7 This is a diagram representing I10-O10, I40-O20, and I50-O50.

[0073] Figure 8It is a graph representing the region (shaded area) formed by the degree distribution map of the first region (where α is above 10% and below 50%) and the second region (where β is above 10% and below 50%), with the intersection of the degree distribution map Va (where α is above 10% and below 50%) and the degree distribution map Vb (where β is above 10% and below 50%) as the position ra on the horizontal axis.

[0074] Figure 9 This refers to a degree distribution map V (solid line) in an embodiment of the present invention where different degree distribution maps are not directly spliced ​​together, but a distribution map that imitates the spliced ​​map is used.

[0075] Figure 10 This is a graph showing the degree distribution V (solid line, I35-O25, optical diameter 6.50mm) when an additional area is set.

[0076] Figure 11 It is a graph representing I10-O10 and I50-O50, and for each degree distribution graph V, it simultaneously shows the absolute value of the average slope of the tangent line of the degree distribution graph V1 in the first region and the average slope of the tangent line of the degree distribution graph V2 in the second region.

[0077] Figure 12A This is a graph showing the degree distribution V (solid line, I35-O25) when the intermediate area is set.

[0078] Figure 12B It is Figure 12A The diagram shows the enlarged central region.

[0079] Figure 12C It is a graph showing the degree distribution V (solid line, I40-O40) when the intermediate area is set.

[0080] Figure 13 This is a table showing the conditions used in the total degree distribution map according to the embodiments of the present invention.

[0081] Figure 14 This is a total power distribution diagram TV, which represents the total power T (vertical axis) of the cornea, which is the sum of the refractive power of the cornea and the power of the intraocular lens, relative to the distance from the center O of the lens (horizontal axis).

[0082] Figure 15 It is a graph of the total degree distribution (TV) when the horizontal axis value rmax = 3.0 mm is the same as the vertical axis value when the horizontal axis value is zero.

[0083] Figure 16It is a graph representing the region (shaded area) formed by the total degree distribution map, which is a graph with the position ra on the horizontal axis at the intersection of the first region with the total degree distribution map TVa (α is above 10% and below 50%) and the second region with the total degree distribution map TVb (β is above 10% and below 50%).

[0084] Figure 17A This is a graph showing the MTF value (vertical axis) representing contrast relative to the object distance (horizontal axis) from the corneal apex (aperture diameter (pupil diameter)) (with no offset or tilt). Figures 17-30 show MTF values ​​at a spatial frequency of 100 lines / mm. The spatial frequency of the MTF value (vertical axis) is 100 lines / mm.

[0085] Figure 17B Is Figure 17A The image shows the aperture diameter set to 3.5mm.

[0086] Figure 17C Is Figure 17A The image shows the aperture diameter set to 4.0mm.

[0087] Figure 17D Is Figure 17A The image shows the aperture diameter set to 4.5mm.

[0088] Figure 18A It is a graph representing the MTF value (vertical axis) that represents contrast relative to the object distance (horizontal axis) from the corneal vertex (aperture diameter (pupil diameter) is set to 3.0mm, with an offset of 0.3mm and no tilt).

[0089] Figure 18B Is Figure 18A The image shows the aperture diameter set to 3.5mm.

[0090] Figure 18C Is Figure 18A The image shows the aperture diameter set to 4.0mm.

[0091] Figure 18D Is Figure 18A The image shows the aperture diameter set to 4.5mm.

[0092] Figure 19A It is a graph representing the MTF value (vertical axis) that represents contrast relative to the object distance (horizontal axis) from the corneal vertex (aperture diameter (pupil diameter) is set to 3.0mm, with an offset of 0.5mm and no tilt).

[0093] Figure 19B Is Figure 19AThe image shows the aperture diameter set to 3.5mm.

[0094] Figure 19C Is Figure 19A The image shows the aperture diameter set to 4.0mm.

[0095] Figure 19D Is Figure 19A The image shows the aperture diameter set to 4.5mm.

[0096] Figure 20A It is a graph representing the MTF value (vertical axis) that represents contrast relative to the object distance (horizontal axis) from the corneal vertex (aperture diameter (pupil diameter) is set to 3.0mm, with no offset and a tilt of 3 degrees).

[0097] Figure 20B Is Figure 20A The image shows the aperture diameter set to 3.5mm.

[0098] Figure 20C Is Figure 20A The image shows the aperture diameter set to 4.0mm.

[0099] Figure 20D Is Figure 20A The image shows the aperture diameter set to 4.5mm.

[0100] Figure 21A It is a graph representing the MTF value (vertical axis) that represents contrast relative to the object distance (horizontal axis) from the corneal vertex (aperture diameter (pupil diameter) is set to 3.0mm, with no offset and a tilt of 5 degrees).

[0101] Figure 21B Is Figure 21A The image shows the aperture diameter set to 3.5mm.

[0102] Figure 21C Is Figure 21A The image shows the aperture diameter set to 4.0mm.

[0103] Figure 21D Is Figure 21A The image shows the aperture diameter set to 4.5mm.

[0104] Figure 22A It is a graph representing the MTF value (vertical axis) that represents contrast relative to the object distance (horizontal axis) from the corneal apex (aperture diameter (pupil diameter) is set to 3.0 mm, with an offset of 0.3 mm and a tilt of 3 degrees).

[0105] Figure 22B Is Figure 22AThe image shows the aperture diameter set to 3.5mm.

[0106] Figure 22C Is Figure 22A The image shows the aperture diameter set to 4.0mm.

[0107] Figure 22D Is Figure 22A The image shows the aperture diameter set to 4.5mm.

[0108] Figure 23A It is a graph representing the MTF value (vertical axis) that represents contrast relative to the object distance (horizontal axis) from the corneal apex (aperture diameter (pupil diameter) is set to 3.0 mm, with an offset of 0.4 mm and a tilt of 4 degrees).

[0109] Figure 23B Is Figure 23A The image shows the aperture diameter set to 3.5mm.

[0110] Figure 23C Is Figure 23A The image shows the aperture diameter set to 4.0mm.

[0111] Figure 23D Is Figure 23A The image shows the aperture diameter set to 4.5mm.

[0112] Figure 24A It is a graph representing the MTF value (vertical axis) that represents contrast relative to the object distance (horizontal axis) from the corneal vertex (aperture diameter (pupil diameter) is set to 3.0 mm, with an offset of 0.5 mm and a tilt of 5 degrees).

[0113] Figure 24B Is Figure 24A The image shows the aperture diameter set to 3.5mm.

[0114] Figure 24C Is Figure 24A The image shows the aperture diameter set to 4.0mm.

[0115] Figure 24D Is Figure 24A The image shows the aperture diameter set to 4.5mm.

[0116] Figure 25A It is a graph showing the MTF value (vertical axis) representing contrast, opposite to the offset (horizontal axis) (object distance set to 2.0m, aperture diameter (pupil diameter) set to 3.0mm, and no tilt).

[0117] Figure 25B Is Figure 25AThe figure is tilted at 3 degrees.

[0118] Figure 25C Is Figure 25A The image is tilted at 5 degrees.

[0119] Figure 25D Is Figure 25A The image shows the aperture diameter set to 4.0mm and without tilt.

[0120] Figure 25E Is Figure 25A The image shows the aperture diameter set to 4.0mm and the tilt set to 3 degrees.

[0121] Figure 25F Is Figure 25A The image shows the aperture diameter set to 4.0mm and the tilt set to 5 degrees.

[0122] Figure 26A It is a graph representing the MTF value (vertical axis) that represents contrast, opposite to the offset (horizontal axis) (object distance set to 3.0m, aperture diameter (pupil diameter) set to 3.0mm, and no tilt).

[0123] Figure 26B Is Figure 26A The figure is tilted at 3 degrees.

[0124] Figure 26C Is Figure 26A The image is tilted at 5 degrees.

[0125] Figure 26D Is Figure 26A The image shows the aperture diameter set to 4.0mm and without tilt.

[0126] Figure 26E Is Figure 26A The image shows the aperture diameter set to 4.0mm and the tilt set to 3 degrees.

[0127] Figure 26F Is Figure 26A The image shows the aperture diameter set to 4.0mm and the tilt set to 5 degrees.

[0128] Figure 27A It is a graph showing the MTF value (vertical axis) representing contrast, opposite to the offset (horizontal axis) (object distance set to 4.0m, aperture diameter (pupil diameter) set to 3.0mm, and no tilt).

[0129] Figure 27B Is Figure 27A The figure is tilted at 3 degrees.

[0130] Figure 27C Is Figure 27A The image is tilted at 5 degrees.

[0131] Figure 27D Is Figure 27A The image shows the aperture diameter set to 4.0mm and without tilt.

[0132] Figure 27E Is Figure 27A The image shows the aperture diameter set to 4.0mm and the tilt set to 3 degrees.

[0133] Figure 27F Is Figure 27A The image shows the aperture diameter set to 4.0mm and the tilt set to 5 degrees.

[0134] Figure 28A It is a graph showing the MTF value (vertical axis) representing contrast, opposite to the tilt (horizontal axis) (object distance set to 2.0m, aperture diameter (pupil diameter) set to 3.0mm, and no offset).

[0135] Figure 28B Is Figure 28A The image shows the offset set to 0.3mm.

[0136] Figure 28C Is Figure 28A The image shows the offset set to 0.5mm.

[0137] Figure 28D Is Figure 28A The image shows the aperture diameter set to 4.0mm with no offset.

[0138] Figure 28E Is Figure 28A The image shows the aperture diameter set to 4.0mm and the offset set to 0.3mm.

[0139] Figure 28F Is Figure 28A The image shows the aperture diameter set to 4.0mm and the offset set to 0.5mm.

[0140] Figure 29A It is a graph showing the MTF value (vertical axis) representing contrast, opposite to the tilt (horizontal axis) (object distance set to 3.0m, aperture diameter (pupil diameter) set to 3.0mm, and no offset).

[0141] Figure 29B Is Figure 29A The image shows the offset set to 0.3mm.

[0142] Figure 29C Is Figure 29A The image shows the offset set to 0.5mm.

[0143] Figure 29D Is Figure 29A The image shows the aperture diameter set to 4.0mm with no offset.

[0144] Figure 29E Is Figure 29A The image shows the aperture diameter set to 4.0mm and the offset set to 0.3mm.

[0145] Figure 29F Is Figure 29A The image shows the aperture diameter set to 4.0mm and the offset set to 0.5mm.

[0146] Figure 30A It is a graph showing the MTF value (vertical axis) representing contrast, opposite to the tilt (horizontal axis) (object distance set to 4.0m, aperture diameter (pupil diameter) set to 3.0mm, and no offset).

[0147] Figure 30B Is Figure 30A The image shows the offset set to 0.3mm.

[0148] Figure 30C Is Figure 30A The image shows the offset set to 0.5mm.

[0149] Figure 30D Is Figure 30A The image shows the aperture diameter set to 4.0mm with no offset.

[0150] Figure 30E Is Figure 30A The image shows the aperture diameter set to 4.0mm and the offset set to 0.3mm.

[0151] Figure 30F Is Figure 30A The image shows the aperture diameter set to 4.0mm and the offset set to 0.5mm.

[0152] Figure 31A This is a planar schematic diagram showing the intraocular lens of Embodiment 5A of the present invention.

[0153] Figure 31B This is a planar schematic diagram showing the intraocular lens of Embodiment 5B of the present invention.

[0154] Figure 32A This is a power distribution diagram in the intraocular lens of Embodiment 5A of the present invention, in which the position when viewed radially from the center O of the lens is set as the horizontal axis (unit: mm) and the power is set as the vertical axis (unit: D (diopter)).

[0155] Figure 32BThis is a power distribution diagram in the intraocular lens of Embodiment 5B of the present invention, in which the position when viewed radially from the center O of the lens is set as the horizontal axis (unit: mm) and the power is set as the vertical axis (unit: D (diopter)).

[0156] Figure 33A This is a planar schematic diagram (upper side) showing the intraocular lens of Embodiment 5A of the present invention having an outer transition region, and a power distribution diagram (lower side) showing the position when viewed radially from the center O of the lens as the horizontal axis (unit: mm) and the power as the vertical axis (unit: D (diopter)).

[0157] Figure 33B This is a planar schematic diagram (upper side) showing the intraocular lens of Embodiment 5B of the present invention having an outer transition region and an inner transition region, and a power distribution diagram (lower side) with the position when viewed radially from the center O of the lens set as the horizontal axis (unit: mm) and the power set as the vertical axis (unit: D (diopter)).

[0158] Figure 34 This is a power distribution diagram in the intraocular lens of Embodiment 5A of the present invention, with the position when viewing from the center O of the lens radially set as the horizontal axis (unit: mm) and the power set as the vertical axis (unit: D (diopter)). It is also a diagram used to illustrate the ratio of the radial distance of the fixed power additional region to the radial distance of the inner first region. Detailed Implementation

[0159] [Definitions, etc.] For structures not described below, known structures may be appropriately adopted. In particular, the contents described in the inventor's published document (WO2009 / 153873, especially the support portion) may be applied to this embodiment.

[0160] In addition, the symbol “~” in this specification indicates above and below the predetermined value.

[0161] The intraocular lens described in this specification has two opposing surfaces. When the intraocular lens is implanted into the lens capsule, the surface of the lens body that contacts the posterior capsule can be referred to as the posterior surface, the retinal-side surface, or the retinal-side surface in the optical axis direction; this specification primarily uses the term "posterior surface." The other surface can be referred to as the anterior surface, the corneal-side surface, or the corneal-side surface in the optical axis direction; this specification primarily uses the term "anterior surface." The optical axis direction is the direction of lens thickness, which is the direction from the posterior surface towards the anterior surface or vice versa; the optical axis direction is defined as the z-axis direction.

[0162] The lens center O refers to the geometric or optical center of the intraocular lens. This instruction manual uses the case where the geometric center coincides with the optical center as an example. Furthermore, the refractive power at the lens center O is called the base power. This base power refers to the refractive power required for distance vision with conventional intraocular lenses.

[0163] [Common Implementation Method] Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings. First, the common content and core inventive concept of Embodiment 1 and subsequent embodiments will be described as common embodiments.

[0164] Figure 1 This is a planar schematic diagram showing an intraocular lens of a common embodiment.

[0165] like Figure 1 As shown, the intraocular lens involved in the common embodiment (and other methods described in this specification) is the same as that of conventional intraocular lenses, including a lens body with lens function and a support portion that supports the lens body within the lens capsule.

[0166] The material of the intraocular lens is not limited, and it may be composed of at least one of silicone, hydrophobic acrylic resin, hydrophilic acrylic resin, hydrogel, PMMA, and PMMA copolymers, or HEMA (hydroxyethyl methacrylate) copolymer containing collagen (e.g., Collamer (registered trademark)).

[0167] like Figure 1 As shown, in the common embodiment (and other embodiments described in this specification), the lens body as an entire optical unit with lens function will be used as an example for explanation. Here, "lens function" refers to the function of refracting an incident light beam onto the retina.

[0168] The lens body described in this specification is exemplified by a configuration consisting of a first region (zone 1) and a second region (zone 2) as described below. In other configurations described in this specification, an intermediate region surrounding the first region is provided between the first and second regions, or an additional region surrounding the second region is provided radially outside the second region.

[0169] In the common embodiment, the intraocular lens is defined according to the refractive power (optical power, diopter) corresponding to the distance traveled radially away from the lens center O. In this specification, "the direction of radial movement away from the lens center O" is defined as "outer side".

[0170] The intraocular lens according to the common embodiment (and other embodiments described in this specification) firstly includes at least two concentric and adjacent vision correction regions centered on a lens center O with a predetermined base power. These vision correction regions are sequentially defined as second regions surrounding the first region, extending radially outward from the first region containing the lens center O. Furthermore, the position of the first boundary (boundary 1) between the first and second regions when viewed radially from the lens center O is defined as r1.

[0171] like Figure 1 As shown, from a planar perspective, the first region is circular, and the second region is annular. In other embodiments described in this specification, the intermediate region is a small annular ring, and the additional region is a large annular ring. Alternatively, an ellipse and / or an elliptical ring can be used instead of a circle and / or annular ring. If it is an ellipse, the position r1 of the first boundary can be either the major or minor axis.

[0172] Figure 2 This is a power distribution diagram with the position viewed radially from the center O of the lens as the horizontal axis (unit: mm) and the power as the vertical axis (unit: D (diopter)). The distance from the center O of the lens is also called the radius.

[0173] The solid line represents the power distribution of the intraocular lens (and other methods described in this specification) according to the common embodiments.

[0174] The dotted line represents the power distribution of a virtual spherical lens (also referred to as a "spherical IOL" in this specification) with a base power (dashed line) at the lens center O. Additionally, known products include intraocular lenses whose power remains constant regardless of the radius value (the horizontal axis) (e.g., SofPort AO IOL). These intraocular lenses are also referred to as "zero-aberration IOLs" in this specification. However, the zero-aberration IOL differs from the aspherical reference power distribution map W described later in that it does not consider the cornea. That is, the power distribution map of the zero-aberration IOL does not include the positive longitudinal spherical aberration and refractive power generated by the cornea.

[0175] The dotted line represents the power distribution of a virtual aspherical lens with a base power at the lens center O that completely cancels out the positive longitudinal spherical aberration produced by the cornea. This power distribution is also called the aspherical reference power distribution map W.

[0176] Longitudinal spherical aberration refers to the spherical aberration that extends radially when viewed from the lens center O, i.e., in the radial direction. In this case, the spherical aberration in the circumferential direction, which is perpendicular to the radial direction, is called transverse spherical aberration.

[0177] The cornea has positive refractive power. Furthermore, spherical aberration increases with distance from the corneal center. In other words, the curve representing a virtual aspherical lens that theoretically completely cancels out the positive longitudinal spherical aberration produced by the cornea is the dashed line representing the aspherical reference power distribution map W.

[0178] From then on, all types of lines had the same meaning.

[0179] An aspherical optical design unit (IOL) with an aspherical reference power distribution map W is designed to correct or reduce all or part of the spherical aberration of the cornea. The extent of spherical aberration reduction varies depending on the manufacturer of the IOL. Each manufacturer's IOL is designed to reduce the spherical aberration of the cornea by a specific amount (numerical value). In the design process of this aspherical IOL, a corneal model with the same spherical aberration value as the specific amount of spherical aberration to be reduced is pre-set. By selecting the optical parameters of this corneal model, the specific amount of spherical aberration to be reduced by the aspherical IOL can be determined. During the optical design process, the total spherical aberration of the optical system (optical system) formed by the pre-determined corneal model and the designed aspherical IOL is zero (i.e., there is no spherical aberration).

[0180] The spherical aberration value of the predetermined corneal model is determined as follows: assuming that the spherical aberration value of the predetermined corneal model used in the optical design of the aspherical IOL is the same as the average spherical aberration value of the group of patients with eye diseases wearing the IOL; or, by setting a spherical aberration value that can partially reduce the corneal spherical aberration of the group of patients with eye diseases, the spherical aberration value of the predetermined corneal model is determined.

[0181] The aspherical reference power distribution map W represents the power distribution of an aspherical IOL. This power distribution possesses characteristics that can completely or partially reduce the average corneal spherical aberration (statistical corneal optical parameters) of the aphakic patient population. In this specification, the spherical aberration value of the predetermined corneal model is set to 0.27 μm. Figure 2 This is also an example of an aspherical IOL power distribution that can completely compensate for spherical aberration in a corneal model with a value of 0.27 μm. 0.27 μm can also be expressed as +0.27 μm. Furthermore, the present invention is not strictly limited to 0.27 μm, and values ​​in the range of +0.24 to +0.30 μm, for example, can also be used.

[0182] The inventive concept common to Embodiment 1 and subsequent embodiments will be described below.

[0183] To reiterate, the purpose of this invention is to provide an intraocular lens and related technology that are robust to changes in image quality caused by the aforementioned offsets, tilts, and pupil diameter changes (hereinafter collectively referred to as "variable changes"). "Robustness" as used herein can also be understood as being less susceptible to influence and having low sensitivity.

[0184] The aforementioned aspherical IOLs can correct or reduce all or part of the spherical aberrations of the cornea and can meet the prescribed values. However, on the other hand, their image quality is quite sensitive to the aforementioned changes.

[0185] Compared to aspherical IOLs, spherical IOLs are more robust to the aforementioned variations in image quality. However, in the absence of these variations, the image quality of spherical IOLs is inferior to that of aspherical IOLs. This difference in image quality becomes particularly pronounced when an increase in pupil diameter occurs among the aforementioned variations.

[0186] Compared to aspherical IOLs, the image quality of the aforementioned zero-aberration IOLs is robust to the changes described above. However, the power distribution map of the zero-aberration IOL does not incorporate the positive longitudinal spherical aberration and refractive power generated by the cornea. As a result, in the absence of the aforementioned changes, the image quality of the zero-aberration IOL is slightly better than that of the spherical IOL, but still inferior to that of the aspherical IOL.

[0187] This invention is based on the aspherical reference power distribution diagram W of the aspherical IOL. In the aspherical reference power distribution diagram W, the larger the horizontal axis value in the radial direction from the lens center O, the smaller the vertical axis value representing the power.

[0188] Here, the aspherical reference power distribution map W is divided into at least two regions. The side closer to the lens center O is designated as the first region, and the outer side is designated as the second region. The aspherical reference power distribution map W is then deformed within each region.

[0189] In the first region, even as the horizontal axis value increases, the rate of decrease in the vertical axis value slows down compared to the aspherical reference degree distribution map W. To compensate for this difference, in the second region, as the horizontal axis value increases, the rate of decrease in the vertical axis value accelerates compared to the aspherical reference degree distribution map W.

[0190] As shown in the data below, an intraocular lens that uses a power distribution map obtained by deforming the aspheric reference power distribution map W according to the above concept can maintain the same excellent imaging quality as an aspheric IOL while making the imaging quality robust to the above-mentioned changes.

[0191] In other words, the present invention does not employ a single degree distribution map, such as an aspherical reference degree distribution map W, but rather combines two or more distinct degree distribution maps. Furthermore, the combination process involves: in the first region, the rate of decrease in the vertical axis value is slower compared to the aspherical reference degree distribution map W from an overall perspective; and in the second region, the rate of decrease in the vertical axis value is faster compared to the aspherical reference degree distribution map W from an overall perspective.

[0192] Furthermore, according to the concept of this invention, it also has the advantage of reducing the thickness of the intraocular lens. For example, under the following parameter conditions, it is applicable to spherical IOLs, zero-aberration IOLs, aspherical IOLs, and IOLs employing the concept of this invention (hereinafter). Figure 2 The center thickness of the front surface is measured; this parameter is also known as condition 1. The radius of curvature of the rear surface is negative because the front surface is convex, and the bending direction of the convex surface is set to positive.

[0193] Lens optical diameter: 6mm Refractive index at 35℃: 1.520 The outermost edge thickness of the lens body: 0.18mm Rear surface curvature radius: -20.0 mm The measurement results are as follows: Spherical IOL: 0.674mm Zero aberration IOL: 0.669mm Aspherical IOL: 0.626mm The IOL of this invention is 0.632 mm. The IOL using the concept of this invention can reduce the thickness of the intraocular lens. This facilitates the folding of the intraocular lens and its repositioning after implantation, while also reducing the size of the surgical incision.

[0194] The embodiments 1 to 4 described below are all specific methods based on the above concept.

[0195] Implementation method 1 is based on the above concept, and the range of convergence of the power distribution map V of the intraocular lens is characterized by the deformation range of the aspherical reference power distribution map W in the first region and the deformation range of the aspherical reference power distribution map W in the second region.

[0196] Implementation method 2 is to characterize the above concept by subtracting the vertical axis value of the aspherical reference degree distribution map W from the vertical axis values ​​of degree distribution maps V1 and V2.

[0197] Implementation method 3 is a method of adding an intermediate region between the first region and the second region in implementation method 1.

[0198] Implementation method 4 is the method of converting the diopter distribution map in implementation method 1 into a total diopter distribution map after superimposing corneal refractive power.

[0199] Furthermore, the intraocular lenses described in Embodiments 1 to 4 below are aspheric intraocular lenses. In order to realize (produce) the power distribution pattern taught by the contents of this application (this application specification), the surface of the intraocular lens that is machined (formed) into an aspheric surface on a lathe may be only the anterior surface, only the posterior surface, or both the anterior and posterior surfaces (both surfaces).

[0200] [Implementation Method 1] The intraocular lens involved in Embodiment 1 is described below. Embodiment 1 and subsequent embodiments can be freely combined with any other embodiment (including common embodiments). Furthermore, the content described in Embodiment 1 is applicable to other embodiments (including common embodiments).

[0201] "An intraocular lens has a power distribution map V, which falls within the set region of power distribution maps obtained by various combinations of power distribution maps Va and Vb when the intersection point of a first region using a power distribution map Va and a second region using a power distribution map Vb is taken as the position ra on the horizontal axis." The first region degree distribution map Va is obtained by subtracting the vertical axis values ​​of each horizontal axis value of the aspherical reference degree distribution map W from the base degree value, multiplying the result by a predetermined ratio α (α is more than 10% and less than 50%), and then adding the multiplied value to the vertical axis values ​​of each horizontal axis value of the aspherical reference degree distribution map W. The second region's degree distribution map Vb is obtained by subtracting the horizontal axis values ​​of each vertical axis value of the aspherical reference degree distribution map W from the maximum horizontal axis value rmax of the aspherical reference degree distribution map W, multiplying the result by a predetermined ratio β (β is above 10% and below 50%), and then adding the multiplied value to the horizontal axis values ​​of each vertical axis value of the aspherical reference degree distribution map W. "The region (hereinafter also called the set region) formed by the degree distribution maps with the intersection of the first region's degree distribution map Va and the second region's degree distribution map Vb as the position ra on the horizontal axis" refers to... Figure 8 The shaded area in the diagram. The degree distribution plots Va and Vb intersect. From this intersection point (horizontal axis position ra), the degree distribution plot Va is used as the first region along the negative horizontal axis. From this intersection point (horizontal axis position ra), the degree distribution plot Vb is used as the second region along the positive horizontal axis. Simultaneously, the set of degree distribution plots obtained from various combinations where α is above 10% and below 50%, and β is above 10% and below 50%, is... Figure 8 The shaded area.

[0202] The maximum value rmax on the horizontal axis of the aspherical reference power distribution diagram W refers to the outermost edge of the lens body, that is, the optical part that has the function of a lens.

[0203] The content related to "multiplying by a predetermined ratio α, β" can also be expressed as follows.

[0204] "An intraocular lens has a power distribution map V, which falls within the set region of power distribution maps obtained by various combinations of power distribution maps Va and Vb when the intersection point of a first region using a power distribution map Va and a second region using a power distribution map Vb is taken as the position ra on the horizontal axis." The first region uses the degree distribution map Va, which is obtained by reducing the aspherical reference degree distribution map W from the negative direction of the vertical axis to the positive direction by a certain factor α (α is more than 10% and less than 50%) while keeping the vertical axis value (the vertical axis value when the horizontal axis value is zero) unchanged. The second region uses the degree distribution map Vb, which is obtained by reducing the aspherical reference degree distribution map W from the negative direction of the horizontal axis to the positive direction by a certain factor β (β is more than 10% and less than 50%) (keeping the part of the horizontal axis value rmax unchanged).

[0205] For example, the value of r1 is above 1.5mm and below 2.3mm.

[0206] For example, at each horizontal axis value of the degree distribution map V, the position where the positive maximum value appears is the value obtained by subtracting the vertical axis value of the aspherical reference degree distribution map W from the vertical axis value of the degree distribution map V. Position r1 is also the stitching point between different degree distribution maps.

[0207] For example, the maximum value rmax of the horizontal axis of the degree distribution plot V ranges from 2.5 mm to 3.5 mm. Unless otherwise specified, the following explanation will use rmax as an example of 3.0 mm.

[0208] The intraocular lens of this embodiment may have one or more additional regions arranged radially from the second region, the additional regions surrounding the second region. Preferably, the additional regions have the function of refracting the incident light beam onto the retina, and preferably perform the functions of the optical part.

[0209] At each horizontal axis value of the degree distribution map Vadd in at least one of the additional regions, the value obtained by subtracting the vertical axis value of the aspherical reference degree distribution map W from the vertical axis value of the degree distribution map Vadd can be less than ±0.30D (preferably less than ±0.15D, the same below). That is, at least one region in the additional regions located outside the second region (preferably the outermost additional region, or the only additional region), even if it is consistent with or inconsistent with the aspherical reference degree distribution map W, its vertical axis deviation can be less than ±0.30D.

[0210] As mentioned earlier, aspherical IOLs exhibit good image quality even when none of the aforementioned variations exist. This robustness in image quality against these variations is primarily achieved by the first and second regions. Consequently, even when an additional region is added outside the second region, a power distribution map that closely resembles the aspherical reference power distribution map W is preferred. A curve deviating from the aspherical reference power distribution implies the development of longitudinal spherical aberration, which in turn compromises vision correction. To avoid this, a power distribution map that closely resembles the aspherical reference power distribution map W is also preferred.

[0211] The degree distribution map V can be represented by a polynomial. For example, the degree distribution maps of the first region, the second region, the intermediate region described later, and the additional region can all be expressed by the following polynomials.

[0212] P(r) = a n r n +a n-1 r n-1 +a n-2 r n-2 +a n-3 r n-3 +...+a3r 3 +a2r 2 +a1r 1 +a0···(Equation 1) P(r): The degree measure corresponding to the radius of the lens. a: coefficient r: Lens radius position n: degree of the polynomial The following polynomials are for each region when position r1 is 1.92mm, the horizontal axis value is 3.00mm (the boundary between the second region and the additional region (only one)), and rmax is 3.25mm (see [reference]). Figure 10 Additionally, P in the following text I35 In this context, I35 refers to the case where the predetermined proportion α in the degree distribution plot Va is 35% (e.g., as shown in the example). Figure 2 As shown, when α is 10%, it is denoted as Va(I10)), P O25 O25 in the text refers to the case where the predetermined proportion β in the degree distribution plot Vb is 25% (e.g., as shown in the example). Figure 2 As shown, when β is 10%, it is denoted as Vb(O10)).

[0213] First area: P I35 (r)=-2.87802590e-03r 4 -4.84408818e-04r 3-2.39306469e-01r 2 -1.30725682e-04r+20.000009 Second area: P O25 (r)=-4.38903190e-04r 4 -7.72003537e-02r 3 -3.13958521e-01r 2 +4.43293306e-01r+19.934990 Additional area: P add (r)=1.75786855r 4 -2.21096892e+01r 3 +1.03671760e+02r 2 -2.17611350e+02r+190.681131 In this embodiment, such as Figure 2 As shown, P I50 With P O50 Let the x-axis value of the intersection point be rah, P O10 With P I10 Let the x-axis value of the intersection point be ral. That is, as shown... Figure 2 As shown, the degree distribution map V falls within the range of P. I50 ,rah,P O50 P O10 ,ral,P I10 The area enclosed in a clockwise direction ( Figure 8 (within the shaded area).

[0214] However, the present invention is not limited to the degree distribution map V falling within the above-mentioned region ( Figure 8 Within the shaded area. For example, even when the horizontal axis value of the power distribution map V is zero or close to the value of rmax, its vertical axis value is slightly lower than that of the aspherical reference power distribution map W, and the impact on the optical performance of the intraocular lens (IOL) is small, and the characteristic of robustness of image quality to the above-mentioned changes remains unchanged. In view of this, the following embodiment 2 more fully reflects the provisions of the above-mentioned inventive concept.

[0215] [Implementation Method 2] The intraocular lens involved in Implementation Method 2 is as follows.

[0216] "An intraocular lens, wherein..." In the first region, the average value of the vertical axis of the degree distribution map V1 is greater than the average value of the vertical axis of the aspherical reference degree distribution map W. In the second region, the average value of the vertical axis of the degree distribution map V2 is greater than the average value of the vertical axis of the aspherical reference degree distribution map W. In the degree distribution map V1 for the first region, as the horizontal axis value increases, at each horizontal axis value, the value obtained by subtracting the vertical axis value of the aspherical reference degree distribution map W from the vertical axis value of degree distribution map V1 continuously increases. In the second region using the degree distribution map V2, as the horizontal axis value increases, at each horizontal axis value, the value obtained by subtracting the vertical axis value of the aspherical reference degree distribution map W from the vertical axis value of the degree distribution map V2 continuously decreases. In the degree distribution map V, the position where the positive maximum value occurs is position r1, obtained by subtracting the vertical axis value of the aspherical reference degree distribution map W from the vertical axis value of the degree distribution map V2. The value obtained by subtracting the vertical axis value of the aspherical reference degree distribution map W from the vertical axis value at the maximum value rmax on the horizontal axis of the degree distribution map V is less than 0.25D. For example, the absolute value of the average slope of the tangent line in the second region's power distribution map V2 is more than three times the absolute value of the average slope of the tangent line in the first region's power distribution map V1. In other words, in the power distribution map V of the intraocular lens according to this embodiment, power distribution maps with such different absolute values ​​of the average slope of the tangent line are spliced ​​together at position r1.

[0217] The statement "In the first region, the average value of the vertical axis of the power distribution map V1 is greater than the average value of the vertical axis of the aspherical reference power distribution map W" means that the average power of the intraocular lens in the first region according to this embodiment is greater than the average power of the aspherical reference power distribution map W in the first region. Similarly, the statement "In the second region, the average value of the vertical axis of the power distribution map V2 is greater than the average value of the vertical axis of the aspherical reference power distribution map W" means that the average power of the intraocular lens in the second region according to this embodiment is greater than the average power of the aspherical reference power distribution map W in the second region.

[0218] Furthermore, "the value after subtraction in the first region increases continuously" and "the value after subtraction in the second region decreases continuously" are preferred examples and can be excluded from the specifications. Even if there are only a very small number of locations in the first or second region that do not meet these requirements, the impact on the effectiveness of the invention is minor.

[0219] Furthermore, in the above-described configuration of the intraocular lens according to Embodiment 2, the following provisions can be adopted as the provisions for the intraocular lens according to Embodiment 2: "In the first region, the average value of the vertical axis of the degree distribution map V1 is greater than the average value of the vertical axis of the aspherical reference degree distribution map W." In the second region, the average value of the vertical axis of the degree distribution map V2 is greater than the average value of the vertical axis of the aspherical reference degree distribution map W; and "The absolute value of the average slope of the tangent line in the degree distribution map V2 in the second region is greater than the absolute value of the average slope of the tangent line in the degree distribution map V1 in the first region." "In the degree distribution map V, the position where the positive maximum value appears is position r1, obtained by subtracting the vertical axis value of the aspherical reference degree distribution map W from the vertical axis value of the degree distribution map V2." "r1 is a value in the range of 1.5mm or more and 2.3mm or less".

[0220] For example, r1 is a value within the range of 1.5 mm to 2.3 mm. Additionally, the maximum value rmax on the horizontal axis of the degree distribution plot V is a value within the range of 2.5 mm to 3.5 mm.

[0221] For this embodiment, the following provisions adopted in Embodiment 1 may also be used.

[0222] "Having a degree distribution map V, which falls within the set of degree distribution maps obtained by various combinations of degree distribution maps Va and Vb when the intersection point of the first region's degree distribution map Va and the second region's degree distribution map Vb is taken as the position ra on the horizontal axis." The first region degree distribution map Va is obtained by subtracting the vertical axis values ​​of each horizontal axis value of the aspherical reference degree distribution map W from the base degree value, multiplying the result by a predetermined ratio α (α is more than 10% and less than 50%), and then adding the multiplied value to the vertical axis values ​​of each horizontal axis value of the aspherical reference degree distribution map W. The second region's degree distribution map Vb is obtained by subtracting the horizontal axis values ​​of each vertical axis value of the aspherical reference degree distribution map W from the maximum horizontal axis value rmax of the aspherical reference degree distribution map W, multiplying the result by a predetermined ratio β (β is above 10% and below 50%), and then adding the multiplied value to the horizontal axis values ​​of each vertical axis value of the aspherical reference degree distribution map W. One or more additional regions can be provided radially outward from the second region, the additional regions surrounding the second region. At each horizontal axis value of the degree distribution map Vadd in at least one of the additional regions, the value obtained by subtracting the vertical axis value of the aspherical reference degree distribution map W from the vertical axis value of the degree distribution map Vadd can be less than ±0.30D. The additional regions can have the function of refracting the incident light beam onto the retina.

[0223] The degree distribution plot V can be represented by the polynomial mentioned above.

[0224] [Implementation Method 3] The intraocular lens involved in Implementation Method 3 is as follows.

[0225] "An intraocular lens has a power distribution map V, which is composed of a power distribution map Va for a first region, a power distribution map Vb for a second region, and a power distribution map Vmid for an intermediate region, and falls within the set region of power distribution maps obtained by various combinations of power distribution maps Va, Vmid, and Vb." The first region uses a degree distribution map Va, which is obtained by subtracting the vertical axis values ​​of each horizontal axis value of the aspherical reference degree distribution map W from the base degree, multiplying the result by a predetermined ratio α (α is more than 10% and less than 50%), and then adding the multiplied value to the vertical axis values ​​of each horizontal axis value of the aspherical reference degree distribution map W. The second region uses a degree distribution map Vb, which is obtained by subtracting the horizontal axis values ​​of each vertical axis value of the aspherical reference degree distribution map W from the maximum horizontal axis value rmax of the aspherical reference degree distribution map W, multiplying the result by a predetermined ratio β (β is above 10% and below 50%), and then adding the multiplied value to the horizontal axis values ​​of each vertical axis value of the aspherical reference degree distribution map W. The middle region, represented by the degree distribution map Vmid, has an average degree that is less than the average degree of the first region but greater than the average degree of the second region. In this embodiment, the intermediate region serves to connect the first region and the second region. Alternatively, the intermediate region can act as a transitional area that smoothly connects the first and second regions along the vertical axis. In other words, in this embodiment, when stitching together different degree distribution maps, these maps are not directly stitched together; instead, another degree distribution map is inserted between them before stitching the three degree distribution maps together.

[0226] For example, the absolute value of the average slope of the tangent line of the degree distribution map Vmid in the middle region is greater than the absolute value of the average slope of the tangent line of the degree distribution map V1 in the first region, and less than the absolute value of the average slope of the tangent line of the degree distribution map V2 in the second region.

[0227] For example, at each horizontal axis value of the degree distribution map Vmid in the middle region, the average value is obtained by subtracting the vertical axis value of the aspherical reference degree distribution map W from the vertical axis value of the degree distribution map Vmid. The average of the values ​​obtained by subtracting the vertical axis value of the aspherical reference degree distribution map W from the horizontal axis value of the degree distribution map V1 in the first region, where each horizontal axis value is greater than the horizontal axis value of the degree distribution map V1 in the first region, and The average of the values ​​obtained by subtracting the vertical axis value of the aspherical reference degree distribution map W from the horizontal axis value of the degree distribution map V2 in the second region at each horizontal axis value greater than the horizontal axis value of the degree distribution map V2 in the second region.

[0228] For example, the horizontal axis value in the middle region falls within the range of 1.3mm or more and 2.5mm or less.

[0229] For example, the maximum value rmax of the horizontal axis of the degree distribution plot V is a value within the range of 2.5 mm or more and 3.5 mm or less.

[0230] For example, the absolute value of the average slope of the tangent line of the degree distribution map V2 in the second region is more than three times the absolute value of the average slope of the tangent line of the degree distribution map V1 in the first region.

[0231] For example, one or more additional regions are provided radially outward from the second region, and the additional regions surround the second region. At each horizontal axis value of the degree distribution map Vadd in at least one of the additional regions, the value obtained by subtracting the vertical axis value of the aspherical reference degree distribution map W from the vertical axis value of the degree distribution map Vadd is less than ±0.30D. The additional regions have the function of refracting the incident light beam onto the retina.

[0232] For example, the degree distribution plot V is represented by a polynomial.

[0233] The following polynomials are the polynomials in each region when the boundary position between the first region and the middle region is 1.625 mm, the boundary position between the middle region and the second region is 2.485 mm, and rmax is 3.000 mm (see [reference]). Figure 12B ).

[0234] First area: P I35 (r)=-2.87802590e-03r 4 -4.84408818e-04r 3 -2.39306469e-01r 2 -1.30725682e-04r+20.000009 Middle area: P mid (r)=-3.75928693e-03r 4 -3.53365485e-03r 3 -3.65323646e-01r 2 +1.15043830e-03r+20.347617 Second area: P O25(r)=-4.38903190e-04r 4 -7.72003537e-02r 3 -3.13958521e-01r 2 +4.43293306e-01r+19.934990 [Implementation Method 4] The intraocular lens involved in Implementation Method 4 is as follows.

[0235] "In a total power distribution diagram of an intraocular lens, where the position when viewing radially from the lens center O is set as the horizontal axis (unit: mm), and the total power T (combining the refractive power of the cornea and the power of the intraocular lens) is set as the vertical axis (unit: D (diopter)), and the position of the first boundary between the first and second regions when viewing radially from the lens center O is set as r1,..." The system possesses a total degree distribution map TV, which falls within the set region of total degree distribution maps obtained by various combinations of total degree distribution maps TVa and TVb when the intersection point of the first region's total degree distribution map TVa and the second region's total degree distribution map TVb is taken as the position ra on the horizontal axis. The first region uses the total power distribution map TVa, which is obtained by subtracting the vertical axis values ​​of each horizontal axis value of the aspheric reference total power distribution map TW after adding the corneal refractive power from the baseline power, multiplying the result by a predetermined ratio α (α is more than 10% and less than 50%), and then adding the multiplied value to the vertical axis values ​​of each horizontal axis value of the aspheric reference total power distribution map TW. The second region uses the total power distribution map TVb, which is obtained by subtracting the horizontal axis values ​​of the aspheric reference total power distribution map TW (after adding corneal refractive power) from the maximum horizontal axis value rmax of the aspheric reference total power distribution map TW, multiplying the result by a predetermined ratio β (β is above 10% and below 50%), and then adding the multiplied value to the horizontal axis values ​​of the vertical axis values ​​of the aspheric reference total power distribution map TW. In the total degree distribution map TV1 of the first region, the vertical axis value can increase continuously as the horizontal axis value increases; In the second region using the total degree distribution map TV2, the vertical axis value can decrease continuously as the horizontal axis value increases.

[0236] The absolute value of the average slope of the tangent line of the total degree distribution map TV1 near the origin in the first region can be less than the absolute value of the average slope of the tangent line of the total degree distribution map TV1 near the middle position in the first region. The absolute value of the average slope of the tangent line of the total degree distribution map TV1 near the middle position in the first region can be greater than the absolute value of the average slope of the tangent line of the total degree distribution map TV1 near position r1 in the first region. The absolute value of the average slope of the tangent line of the total degree distribution map TV1 near position r1 in the first region can be less than the absolute value of the average slope of the tangent line of the total degree distribution map TV2 near the middle position in the second region.

[0237] The term "nearby" as used here, for example, in the case of the middle position, refers to the range within ±0.20mm (or 0.10mm) from that middle position.

[0238] For example, in the total degree distribution chart TV, the maximum positive value is obtained by subtracting the vertical axis value at r=0 from the vertical axis value at position r1. r1 is a value within the range of 1.5 mm to 2.3 mm.

[0239] For example, the value obtained by subtracting the vertical axis value at r=0 from the vertical axis value at the maximum horizontal axis value rmax of the total degree distribution chart TV is less than ±0.30D.

[0240] For example, the maximum value rmax of the horizontal axis of the total degree distribution chart (TV) is a value within the range of 2.5 mm or more and 3.5 mm or less.

[0241] For example, one or more additional regions are provided radially outward from the second region, the additional regions surrounding the second region, and the additional regions have the function of refracting the incident light beam onto the retina.

[0242] [other] The intraocular lens of this embodiment is not limited to the above-described embodiment, but also includes various modifications and improvements made within the scope of the specific effects obtained by deriving the constituent elements of the invention and their combination.

[0243] When viewed from above, the area ratio of the first region to the second region can be set between 25:75 and 75:25.

[0244] In the first region, the preferred degree decreases continuously.

[0245] In the second region, the preferred degree decreases continuously.

[0246] From the center O of the lens to the position r1 of the first boundary, the total power T of the cornea combined with the power of the intraocular lens preferably increases continuously.

[0247] Alternatively, instead of directly stitching together dissimilar degree distribution maps, a distribution map derived by mimicking this stitched curve can be used. The polynomial representing this degree distribution map is as follows.

[0248] P Np (r)=-8.31778546e-02r 8 +9.97022762e-01r 7 -4.79532863e+00r 6 +1.18428403e+01r 5 -1.60518818e+01r 4 +1.18152492e+01r 3 -4.57931927e+00r 2 +6.59257903e-01r+19.976408 Furthermore, while intraocular lenses have been described using examples in each embodiment, the technical concept of the present invention can also be applied to the design method of intraocular lenses. The technical concept of the present invention can also be applied to the manufacturing method of intraocular lenses, i.e., manufacturing an intraocular lens designed by the intraocular lens design method by at least one of lathe machining, molding, or 3D printing.

[0249] [Specific example] The intraocular lens of this embodiment is not limited to the above-described embodiment, but also includes various modifications and improvements made within the scope of the specific effects obtained by deriving the constituent elements of the invention and their combination.

[0250] The following are specific examples of degree distribution charts. In these examples, the parameters of condition 1 above were used.

[0251] Figure 2 This is a power distribution diagram showing the refractive power (vertical axis) of the optical portion of the intraocular lens relative to the distance from the lens center O in the embodiments of the present invention.

[0252] Figure 2 In the diagram, the degree distribution of a spherical IOL is represented by a dotted line, the degree distribution of a zero-aberration IOL is represented by a dashed line, the degree distribution of an aspherical IOL (aspherical reference degree distribution diagram W) is represented by a dotted-dashed line, and the IOL of this invention is represented by a solid line. Figure 2 In the middle, the degree distribution plot V falls into the area defined by P. I50 P O50 P O10 P I10 Within the area enclosed in a clockwise direction (shaded area).

[0253] Figure 3It is a power distribution diagram showing the refractive power (vertical axis) brought about by the optical part of the intraocular lens relative to the distance from the center O of the lens (horizontal axis), and it is a diagram showing the power distribution diagram Va. The power distribution diagram Va is obtained by subtracting the vertical axis value of each horizontal axis value of the aspherical reference power distribution diagram W from the reference power, and multiplying it by a preset ratio α (α is 10% of the value between 10% and 50%, which is I10, 35% is I35, and 50% is I50).

[0254] Figure 4 It is a power distribution diagram showing the refractive power (vertical axis) brought about by the optical part of the intraocular lens relative to the distance from the center O of the lens (horizontal axis), and it is a diagram showing the power distribution diagram Vb. The power distribution diagram Vb is obtained as follows: the horizontal axis value of each vertical axis value of the aspherical reference power distribution diagram W is subtracted from the maximum value rmax of the horizontal axis of the aspherical reference power distribution diagram W, multiplied by a preset ratio β (β is 10% of the value between 10% and 50%, which is O10, 25% is O25, and 50% is O50), and then added to the horizontal axis value of each vertical axis value of the aspherical reference power distribution diagram W.

[0255] Figure 5 It is Figure 3 I35 and Figure 4 An explanatory diagram of O25 superposition.

[0256] Figure 6 It means to Figure 5 The degree distribution map V is obtained by stitching together the degree distribution map Va (I35) of the first region and the degree distribution map Vb (O25) of the second region.

[0257] Hereafter, the degree distribution map V will be denoted as "I35-O25". The degree distribution map V will be recorded in the same manner below.

[0258] exist Figure 5 and Figure 6 In the diagram, the aspherical reference degree distribution map W is represented by a dotted line. The aspherical reference degree distribution map W is also appropriately shown in the subsequent appendices.

[0259] Figure 7 This is a diagram representing I10-O10, I40-O20, and I50-O50.

[0260] Figure 7 In the diagram, the distribution of aspherical reference degree W is represented by a solid line.

[0261] Figure 8It is a graph representing the region (shaded area) formed by the degree distribution map of the first region (where α is above 10% and below 50%) and the second region (where β is above 10% and below 50%), with the intersection of the degree distribution map Va (where α is above 10% and below 50%) and the degree distribution map Vb (where β is above 10% and below 50%) as the position ra on the horizontal axis.

[0262] Figure 9 This refers to a diagram showing a degree distribution diagram V (solid line) in one of the other embodiments of the present invention, where different degree distribution diagrams are not directly spliced ​​together, but a distribution diagram that imitates the spliced ​​diagram is used. The aspherical reference degree distribution diagrams W (dotted line), I10-O10 (dashed line), and I50-O50 (dotted line) are also described.

[0263] Figure 10 This is a graph showing the degree distribution V (solid line, I35-O25, optical diameter 6.50mm) when an additional area is set.

[0264] The following specific examples mainly relate to implementation method 2.

[0265] Figure 11 It is a graph representing I10-O10 and I50-O50, and for each degree distribution graph V, it simultaneously shows the absolute value of the average slope of the tangent line of the degree distribution graph V1 in the first region and the average slope of the tangent line of the degree distribution graph V2 in the second region.

[0266] Figure 11 In I10-O10 and I50-O50, In the degree distribution map V1 of the first region, as the horizontal axis value increases, at each horizontal axis value, the value obtained by subtracting the vertical axis value of the aspherical reference degree distribution map W from the vertical axis value of the degree distribution map V1 continuously increases; In the second region using the degree distribution map V2, as the horizontal axis value increases, at each horizontal axis value, the value obtained by subtracting the vertical axis value of the aspherical reference degree distribution map W from the vertical axis value of the degree distribution map V2 continuously decreases; In the degree distribution map V, the position where the positive maximum value appears is position r1, which is the value obtained by subtracting the value of the vertical axis of the aspherical reference degree distribution map W from the value of the vertical axis of the degree distribution map V2. The value obtained by subtracting the vertical axis value of the aspherical reference degree distribution map W from the vertical axis value at the maximum horizontal axis value rmax of the degree distribution map V is less than 0.25D.

[0267] also, The absolute value of the average slope of the tangent line of the degree distribution map V2 in the second region is more than three times the absolute value of the average slope of the tangent line of the degree distribution map V1 in the first region.

[0268] Furthermore, at each horizontal axis value of the degree distribution map Vadd in the additional region, the value obtained by subtracting the vertical axis value of the aspherical reference degree distribution map W from the vertical axis value of the degree distribution map Vadd is less than ±0.30D.

[0269] The numerical range of the absolute value of the average slope of the tangent line of the degree distribution map V1 in the first region, for example, the upper limit is 0.73D / mm and the lower limit is 0.46D / mm.

[0270] The numerical range of the absolute value of the average slope of the tangent line of the degree distribution map V2 in the second region, for example, the upper limit is 3.94D / mm and the lower limit is 2.36D / mm.

[0271] The following specific examples mainly involve implementation method 3.

[0272] Figure 12A This is a graph showing the degree distribution V (solid line, I35-O25) when the intermediate area is set.

[0273] Figure 12B It is Figure 12A The diagram shows the enlarged central region.

[0274] Figure 12C It is a graph showing the degree distribution V (solid line, I40-O40) when the intermediate area is set.

[0275] The following specific examples mainly involve implementation method 4.

[0276] Figure 13 This is a table showing the conditions used in the total degree distribution map according to the embodiments of the present invention.

[0277] Figure 14 This is a total power distribution diagram TV, which represents the total power T (vertical axis) of the cornea, which is the sum of the refractive power of the cornea and the power of the intraocular lens, relative to the distance from the center O of the lens (horizontal axis).

[0278] Figure 14 The total power distribution map was designed using the well-known optical design software ZEMAX (registered trademark) (manufactured by ZEMAX Development Corporation of the United States), which modeled the optical system of the cornea and IOL and designed the aspherical front surface of the IOL.

[0279] Figure 14In the diagrams, the power distribution of spherical IOLs is represented by dotted lines, the power distribution of zero-aberration IOLs is represented by broken lines, and the IOLs of this invention are represented by solid lines. Furthermore, regarding the total power distribution of aspherical IOLs, the total power distribution when the spherical aberration value of the corneal model (recorded as negative values ​​in each figure) is 0.07 μm is represented by a wide dotted line, the total power distribution when it is 0.20 μm is represented by a narrow dotted line, and the total power distribution when it is 0.27 μm is represented by a dashed-dot line.

[0280] Figure 15 This is a graph (TV) showing the total degree distribution when the horizontal axis value (rmax) is 3.0 mm and the vertical axis value is the same as when the horizontal axis value is zero.

[0281] Figure 16 It is a graph representing the region (shaded area) formed by the total degree distribution map, which is a graph with the position ra on the horizontal axis at the intersection of the first region with the total degree distribution map TVa (α is above 10% and below 50%) and the second region with the total degree distribution map TVb (β is above 10% and below 50%).

[0282] The following specific examples of the present invention demonstrate the following effects: while maintaining good image quality, the image quality is robust to changes in the aforementioned offset, tilt, and pupil diameter. At least one of I40-O40 and I35-O25 in the following specific examples, while achieving an MTF value comparable to that of an aspherical IOL, exhibits robustness to changes in image quality even with the aforementioned variations. This robustness is comparable to that of a spherical IOL or a zero-aberration IOL. In other words, according to the present invention, the advantages of a spherical IOL, a zero-aberration IOL, and an aspherical IOL can be obtained simultaneously.

[0283] Prior to this, the MTF values ​​of the spherical IOL (dotted line), the zero-aberration IOL (dashed line), the aspherical IOL (narrow dotted line), and the IOL of this invention (I40-O40 are solid lines, I35-O25 are dotted lines) will be explained in the absence of the aforementioned changes. This explanation also applies to the following figures.

[0284] Figure 17 is a graph showing the MTF value (vertical axis) representing contrast relative to the object distance (horizontal axis) from the corneal vertex (aperture diameter (pupil diameter) set to 3.0–4.5 mm, with no offset or tilt).

[0285] The above graphs were obtained using the aforementioned ZEMAX. Furthermore, the specific details of the experiment may be appropriately adapted from the applicant's WO2008 / 078804 publication.

[0286] The MTF (Modulation Transfer Function) value is one of the metrics for evaluating lens performance. It represents the degree of fidelity with which the contrast of a visual object can be reproduced on the image plane, expressed as a spatial frequency characteristic. A high MTF value means that the wearer perceives a high contrast when viewing an object through the lens.

[0287] Figure 18 is a graph showing the MTF value (vertical axis) representing contrast relative to the object distance (horizontal axis) from the corneal vertex (aperture diameter (pupil diameter) set to 3.0–4.5 mm, with an offset of 0.3 mm and no tilt).

[0288] Figure 19 is a graph showing the MTF value (vertical axis) representing contrast relative to the object distance (horizontal axis) from the corneal vertex (aperture diameter (pupil diameter) set to 3.0mm to 4.5mm, with an offset of 0.5mm and no tilt).

[0289] Figure 20 is a graph showing the MTF value (vertical axis) representing contrast relative to the object distance (horizontal axis) from the corneal vertex (aperture diameter (pupil diameter) set to 3.0–4.5 mm, with no offset and a tilt of 3 degrees).

[0290] Figure 21 is a graph showing the MTF value (vertical axis) representing contrast relative to the object distance (horizontal axis) from the corneal vertex (aperture diameter (pupil diameter) set to 3.0–4.5 mm, with no offset and a tilt of 5 degrees).

[0291] Figure 22 is a graph showing the MTF value (vertical axis) representing contrast relative to the object distance (horizontal axis) from the corneal vertex (aperture diameter (pupil diameter) set to 3.0–4.5 mm, with an offset of 0.3 mm and a tilt of 3 degrees).

[0292] Figure 23 is a graph showing the MTF value (vertical axis) representing contrast relative to the object distance (horizontal axis) from the corneal vertex (aperture diameter (pupil diameter) set to 3.0–4.5 mm, with an offset of 0.4 mm and a tilt of 4 degrees).

[0293] Figure 24 is a graph showing the MTF value (vertical axis) representing contrast relative to the object distance (horizontal axis) from the corneal vertex (aperture diameter (pupil diameter) set to 3.0–4.5 mm, with an offset of 0.5 mm and a tilt of 5 degrees).

[0294] Figure 25 is a graph showing the MTF value (vertical axis) representing contrast, opposite to the offset (horizontal axis) (object distance set to 2.0m, aperture diameter (pupil diameter) set to 3.0mm and 4.0mm, tilt set to 0-5 degrees).

[0295] Figure 26 is a graph showing the MTF value (vertical axis) representing contrast, opposite to the offset (horizontal axis) (object distance set to 3.0m, aperture diameter (pupil diameter) set to 3.0mm and 4.0mm, tilt set to 0-5 degrees).

[0296] Figure 27 is a graph showing the MTF value (vertical axis) representing contrast, opposite to the offset (horizontal axis) (object distance set at 4.0m, aperture diameter (pupil diameter) set at 3.0mm and 4.0mm, tilt at 0-5 degrees).

[0297] Figure 28 is a graph showing the MTF value (vertical axis) representing contrast, opposite to the offset (horizontal axis) (object distance set to 2.0m, aperture diameter (pupil diameter) set to 3.0mm and 4.0mm, and offset to 0-0.5mm).

[0298] Figure 29 is a graph showing the MTF value (vertical axis) representing contrast, opposite to the tilt (horizontal axis) (object distance set to 3.0m, aperture diameter (pupil diameter) set to 3.0mm and 4.0mm, with an offset of 0 to 0.5mm).

[0299] Figure 30 is a graph showing the MTF value (vertical axis) representing contrast, opposite to the tilt (horizontal axis) (object distance set at 4.0m, aperture diameter (pupil diameter) set at 3.0mm and 4.0mm, with an offset of 0 to 0.5mm).

[0300] [Implementation Method 5] At least a portion of the power distribution map in the first region of this embodiment can also be applied to intraocular lenses with added positive power to correct near vision and / or intermediate vision in patients with aphakia.

[0301] The technical concept in Embodiment 5 can also be applied to monofocal lenses. For example, an enhanced monofocal intraocular lens (EM-IOL) with an additional positive power (e.g., one or more positive fixed powers) of 0.75D or more and 1.75D or less can be listed. In addition, the technical concept in Embodiment 5 can also be applied to multifocal lenses (e.g., with an additional positive power of 2.5D or more and 4.0D or less), and can also be applied to intermediate lenses between multifocal lenses and EM-IOLs, namely extended depth-of-focus intraocular lenses (EDOF) (e.g., with an additional positive power greater than 1.75D and less than 2.5D).

[0302] The region with the added positive degree is called the Inner First Region. The region outside of this region (located in the direction away from the lens center O) that has the same degree distribution pattern Va as the aforementioned first region is called the Outer First Region. Regarding this example, as embodiment 5, Figures 31 to 32 are used below. Figure 34 Please provide an explanation.

[0303] The intraocular lens involved in Implementation 5 is as follows.

[0304] "An intraocular lens comprising at least two concentric and adjacent vision correction regions centered on a lens center O with a predetermined base power, wherein..." The vision correction area is defined as the second area surrounding the first area, starting from the first area containing the lens center O and moving radially outward. In the diopter distribution diagram, the position when viewing the lens center O radially is set as the horizontal axis (unit: mm), and the diopter is set as the vertical axis (unit: D (diopter)). The power distribution map of a virtual aspherical lens, which has a base power at the center O of the lens and completely cancels out the positive longitudinal spherical aberration caused by the cornea, is set as the aspherical reference power distribution map W. The degree distribution map obtained as follows is set as the degree distribution map Va for the first region: The value obtained by subtracting the vertical axis values ​​at each horizontal axis value of the aspherical reference degree distribution map W from the base degree is multiplied by a predetermined ratio α (α is greater than 10% and less than 50%), and then the multiplied value is added to the vertical axis values ​​at each horizontal axis value of the aspherical reference degree distribution map W. The degree distribution map obtained in the following manner is set as the degree distribution map Vb for the second region: The value obtained by subtracting the horizontal axis values ​​of each vertical axis value of the aspherical reference degree distribution map W from the maximum horizontal axis value rmax of the aspherical reference degree distribution map W, multiplying the result by a predetermined ratio β (β is above 10% and below 50%), and then adding the multiplied value to the horizontal axis values ​​of each vertical axis value of the aspherical reference degree distribution map W. At this point, The first region includes an inner first region, which has a degree distribution map obtained by adding positive degrees to the degree distribution map Va of the first region. The second region has a degree distribution map Vb. The area of ​​the inner first region is less than 50% of the total area of ​​the first region. For ease of explanation, the case where the lens center O is contained in the inner first region is taken as Embodiment 5A, and the case where the lens center O is contained in the innermost region of the degree distribution map that is the same as the degree distribution map Va (described later) is taken as Embodiment 5B.

[0305] That is to say, in implementation method 5A, such as Figures 31A to 33A and Figure 34 As shown, the inner first region may include the lens center O.

[0306] Additionally, in implementation method 5B, such as Figures 31B to 33B As shown, the first region includes the innermost region, which has the same degree distribution map Va as the outer first region and includes the lens center O. The inner first region can surround the innermost region.

[0307] Figure 31~ Figure 34 The symbols A and B in the text correspond to 5A and 5B in this embodiment. Figure 34 This belongs to Implementation Method 5A. Furthermore, the two implementation methods are collectively referred to as Implementation Method 5.

[0308] Similar to the embodiments described above, the first region connects to the second region at the intersection point ra of the degree distribution maps Va and Vb. As a specific example, the outermost first region of the first region connects to the second region at this intersection point ra.

[0309] To correct near and / or intermediate vision in patients with aphakia, such as Figure 31A , Figure 31B , Figure 32A , Figure 32B As shown, the spectacle lens may have an inner first region comprised of one or more regions within the optical portion of the IOL of the present invention. The area of ​​this inner first region is less than 50% of the area of ​​the first region.

[0310] The inner first region may have a fixed degree additional region, which has a degree distribution map obtained by adding a positive fixed degree to the degree distribution map Va of the outer first region.

[0311] "The degree obtained by adding a positive fixed degree to the degree distribution map Va" means that at a predetermined distance from the center O of the lens, the deviation between the curve after adding a positive fixed degree to the degree distribution map Va and the curve is less than ±0.30D (preferably less than ±0.15D).

[0312] The added value is not necessarily a positive fixed degree. It is also possible to set both a portion with added positive fixed degrees and a portion with added non-positive fixed degrees. Figure 32A This example is illustrated. Specifically, the power distribution map from approximately 0mm (the horizontal axis representing the lens center O) to around 0.30mm includes a non-positive constant power. Furthermore, this added power is greater than the positive constant power; in other words, it introduces a positive power deviation relative to the positive constant power. This region is referred to as the Positive Power Deviation Region. A positive constant power is added from approximately 0.30mm to around 0.80mm. This region is referred to as the Constant Power Addition Region.

[0313] Positive degree deviation area such as Figure 32A , Figure 33A , Figure 34 The diagram shown can be a convex (upward) degree distribution map, or conversely, a convex (downward) degree distribution map. The larger the average absolute value of the difference between the degree distribution map in the positive degree deviation region and the degree distribution map obtained by adding a positive fixed degree to the degree distribution map Va, the better. In other words, the positive degree deviation region is preferably a convex degree distribution map.

[0314] The shape of the degree distribution map in each region that constitutes the inner first region can be different. Its shape can be continuous, discontinuous (stepped), or a combination of different shapes. Figure 32A and Figure 32B This illustrates adjacent combinations of degree distribution maps that are different from each other, such as positive degree deviation regions and fixed degree additional regions.

[0315] When viewed radially from the center O of the lens, the radial distance of the fixed diopter additional region can be 33% to 67% of the radial distance of the inner first region. Figure 34When the first region includes areas other than the medial first region whose average power is equal to the average power of the power distribution map Va, the average power of the medial first region can be 0.75 to 4.0D greater than the average power of the areas other than the medial first region. This structure enables patients with aphakic eyes to receive clear images of objects at specific near or intermediate distances. Examples of areas whose average power is equal to the average power of the power distribution map Va include, for example, the lateral first region and / or the medial region. In the case of this paragraph, even if the lateral first region and / or the medial region does not perfectly coincide with the power distribution map Va, as long as the average power maintains the aforementioned relationship, it is acceptable. "Areas other than the medial first region" can further refer to areas excluding the transitional regions described later, in addition to the medial first region. While adhering to this definition, the average power of the medial first region can be 0.75 to 4.0D greater than the average power of the areas other than the medial first region.

[0316] An inner first region may be provided on the anterior surface, posterior surface, or both surfaces of an intraocular lens that has two opposing surfaces.

[0317] like Figure 33A As shown, in embodiment 5A, the first region may include an outer transition region for smoothly connecting the inner first region to the outer first region. Furthermore, as... Figure 33B As shown, in embodiment 5B, the first region may include an inner transition region for smoothly connecting the inner first region to the innermost region. The degree of each transition region decreases toward the degree distribution map Va, in other words, it introduces a negative degree deviation relative to the aforementioned positive fixed degree.

[0318] Any transition region such as Figure 33A , Figure 33B The diagram can be a downward-convex degree distribution map, or conversely, an upward-convex degree distribution map. The smaller the average absolute value of the difference between the degree distribution map in the positive degree deviation region and the degree distribution map obtained by adding a positive fixed degree to the degree distribution map Va, the better. In other words, the positive degree deviation region is preferably a downward-convex degree distribution map.

[0319] In this invention, it is also permissible not to provide an outer first region. That is, an inner first region (e.g., a fixed-diopter supplementary region) or an outer transition region can be provided, such that it connects to the intersection point ra of the diopter distribution maps Va and Vb. In this case, the average diopter in the first region becomes higher, thus enhancing near and intermediate vision.

[0320] The anterior surface, posterior surface, or both surfaces of an intraocular lens that has two opposing surfaces can be aspherical.

[0321] The anterior surface, posterior surface, or both surfaces of an intraocular lens having two opposing surfaces may have a tortuous surface, which has a cylindrical power for correcting astigmatism in patients with aphakic eyes.

Claims

1. An intraocular lens comprising at least two concentric and adjacent vision correction regions centered on a lens center O with a predetermined base power. The vision correction area is defined as a second area surrounding the first area, starting from the first area containing the lens center O and moving radially outward. In the diopter distribution diagram, the position when viewing the lens center O radially is set as the horizontal axis (unit: mm), and the diopter is set as the vertical axis (unit: D (diopter)). When the position of the first boundary between the first region and the second region when viewed radially from the lens center O is set as r1, and When the power distribution map of a virtual aspherical lens, which has a base power at the center O of the lens and completely cancels out the positive longitudinal spherical aberration caused by the cornea, is set as the aspherical reference power distribution map W, The intraocular lens has a power distribution map V, which falls within the set region of power distribution maps obtained by various combinations of power distribution maps Va and Vb when the intersection of the first region's power distribution map Va and the second region's power distribution map Vb is taken as the position ra on the horizontal axis. The degree distribution map Va for the first region is obtained as follows: the value obtained by subtracting the vertical axis values ​​at each horizontal axis value of the aspherical reference degree distribution map W from the base degree value is multiplied by a predetermined ratio α (α is more than 10% and less than 50%), and then the multiplied value is added to the vertical axis values ​​at each horizontal axis value of the aspherical reference degree distribution map W. The second region is obtained by subtracting the horizontal axis values ​​of each vertical axis value of the aspherical reference degree distribution map W from the maximum horizontal axis value rmax of the aspherical reference degree distribution map W, multiplying the result by a predetermined ratio β (β is more than 10% and less than 50%), and then adding the multiplied value to the horizontal axis values ​​of each vertical axis value of the aspherical reference degree distribution map W.

2. The intraocular lens according to claim 1, wherein, r1 is a value within the range of 1.5 mm to 2.3 mm.

3. The intraocular lens according to claim 1, wherein, At each horizontal axis value of the degree distribution map V, the position where the positive maximum value appears is position r1, which is the value obtained by subtracting the vertical axis value of the aspherical reference degree distribution map W from the vertical axis value of the degree distribution map V.

4. The intraocular lens according to claim 1, wherein, The maximum value rmax of the horizontal axis of the degree distribution plot V is a value within the range of 2.5 mm above and 3.5 mm below.

5. The intraocular lens according to claim 1, wherein, One or more additional regions are set out radially outward from the second region. The additional area surrounds the second area. At each horizontal axis value of the degree distribution map Vadd in at least one of the additional regions, the value obtained by subtracting the vertical axis value of the aspherical reference degree distribution map W from the vertical axis value of the degree distribution map Vadd is less than ±0.30D.

6. The intraocular lens according to claim 1, wherein, The degree distribution plot V is represented by a polynomial.

7. The intraocular lens according to claim 1, wherein, One or more additional regions are set out radially outward from the second region. The additional area surrounds the second area. The additional area has the function of refracting the incident light beam onto the retina.

8. An intraocular lens comprising at least two concentric and adjacent vision correction regions centered on a lens center O with a predetermined base power. The vision correction area is defined as a second area surrounding the first area, starting from the first area containing the lens center O and moving radially outward. In the diopter distribution diagram, the position when viewing the lens center O radially is set as the horizontal axis (unit: mm), and the diopter is set as the vertical axis (unit: D (diopter)). When the position of the first boundary between the first region and the second region when viewed radially from the lens center O is set as r1, and When the power distribution map of a virtual aspherical lens, which has a base power at the center O of the lens and completely cancels out the positive longitudinal spherical aberration caused by the cornea, is set as the aspherical reference power distribution map W, In the first region, the average value of the vertical axis of the degree distribution map V1 is greater than the average value of the vertical axis of the aspherical reference degree distribution map W. In the second region, the average value of the vertical axis of the degree distribution map V2 is greater than the average value of the vertical axis of the aspherical reference degree distribution map W. In the degree distribution map V1 for the first region, as the horizontal axis value increases, at each horizontal axis value, the value obtained by subtracting the vertical axis value of the aspherical reference degree distribution map W from the vertical axis value of degree distribution map V1 continuously increases. In the second region using the degree distribution map V2, as the horizontal axis value increases, at each horizontal axis value, the value obtained by subtracting the vertical axis value of the aspherical reference degree distribution map W from the vertical axis value of the degree distribution map V2 continuously decreases. In the degree distribution map V, the position where the positive maximum value occurs is position r1, obtained by subtracting the vertical axis value of the aspherical reference degree distribution map W from the vertical axis value of the degree distribution map V2. The value obtained by subtracting the vertical axis value of the aspherical reference degree distribution map W from the vertical axis value at the maximum horizontal axis value rmax of the degree distribution map V is less than 0.25D.

9. The intraocular lens according to claim 8, wherein, The absolute value of the average slope of the tangent line of the degree distribution map V2 in the second region is more than three times the absolute value of the average slope of the tangent line of the degree distribution map V1 in the first region.

10. The intraocular lens according to claim 8, wherein, r1 is a value within the range of 1.5 mm to 2.3 mm.

11. The intraocular lens according to claim 8, wherein, The maximum value rmax of the horizontal axis of the degree distribution plot V is a value within the range of 2.5 mm above and 3.5 mm below.

12. The intraocular lens according to claim 8, comprising a power distribution map V, wherein the power distribution map V falls within the set region of power distribution maps obtained by various combinations of power distribution maps Va and Vb when the intersection point of the first region power distribution map Va and the second region power distribution map Vb is taken as the position ra on the horizontal axis. The degree distribution map Va for the first region is obtained as follows: the value obtained by subtracting the vertical axis values ​​at each horizontal axis value of the aspherical reference degree distribution map W from the base degree value is multiplied by a predetermined ratio α (α is more than 10% and less than 50%), and then the multiplied value is added to the vertical axis values ​​at each horizontal axis value of the aspherical reference degree distribution map W. The second region is obtained by subtracting the horizontal axis values ​​of each vertical axis value of the aspherical reference degree distribution map W from the maximum horizontal axis value rmax of the aspherical reference degree distribution map W, multiplying the result by a predetermined ratio β (β is more than 10% and less than 50%), and then adding the multiplied value to the horizontal axis values ​​of each vertical axis value of the aspherical reference degree distribution map W.

13. The intraocular lens according to claim 8, wherein, One or more additional regions are set out radially outward from the second region. The additional area surrounds the second area. At each horizontal axis value of the degree distribution map Vadd in at least one of the additional regions, the value obtained by subtracting the vertical axis value of the aspherical reference degree distribution map W from the vertical axis value of the degree distribution map Vadd is less than ±0.30D.

14. The intraocular lens according to claim 8, wherein, The degree distribution plot V is represented by a polynomial.

15. The intraocular lens according to claim 8, wherein, One or more additional regions are set out radially outward from the second region. The additional area surrounds the second area. The additional area has the function of refracting the incident light beam onto the retina.

16. An intraocular lens comprising at least two concentric and adjacent vision correction regions centered on a lens center O with a predetermined base power. The vision correction area is defined, starting from the first area containing the lens center O and moving radially outward, as a middle area surrounding the first area and a second area surrounding the middle area. In the diopter distribution diagram, the position when viewing the lens center O radially is set as the horizontal axis (unit: mm), and the diopter is set as the vertical axis (unit: D (diopter)). When the power distribution map of a virtual aspherical lens, which has a base power at the center O of the lens and completely cancels out the positive longitudinal spherical aberration caused by the cornea, is set as the aspherical reference power distribution map W, The intraocular lens has a power distribution map V, which is composed of a power distribution map Va for a first region, a power distribution map Vb for a second region, and a power distribution map Vmid for an intermediate region. The power distribution map V falls within the set region of power distribution maps obtained by various combinations of Va, Vmid, and Vb. The degree distribution map Va for the first region is obtained as follows: the value obtained by subtracting the vertical axis values ​​at each horizontal axis value of the aspherical reference degree distribution map W from the base degree value is multiplied by a predetermined ratio α (α is more than 10% and less than 50%), and then the multiplied value is added to the vertical axis values ​​at each horizontal axis value of the aspherical reference degree distribution map W. The second region is obtained using the degree distribution map Vb as follows: The value obtained by subtracting the horizontal axis values ​​of each vertical axis value of the aspherical reference degree distribution map W from the maximum horizontal axis value rmax of the aspherical reference degree distribution map W is multiplied by a predetermined ratio β (β is greater than 10% and less than 50%), and then the resulting multiplication is added to the horizontal axis values ​​of each vertical axis value of the aspherical reference degree distribution map W. The average degree of the intermediate region, as shown in the degree distribution map Vmid, is less than the average degree of the first region but greater than the average degree of the second region.

17. The intraocular lens according to claim 16, wherein, The absolute value of the average slope of the tangent line of the degree distribution map Vmid in the middle region is greater than the absolute value of the average slope of the tangent line of the degree distribution map V1 in the first region, and less than the absolute value of the average slope of the tangent line of the degree distribution map V2 in the second region.

18. The intraocular lens according to claim 16, wherein, At each horizontal axis value of the degree distribution plot Vmid in the middle region, the average value is obtained by subtracting the vertical axis value of the aspherical reference degree distribution plot W from the vertical axis value of the degree distribution plot Vmid. The average of the values ​​obtained by subtracting the vertical axis value of the aspherical reference degree distribution map W from the horizontal axis value of the degree distribution map V1 in the first region, where each horizontal axis value is greater than the horizontal axis value of the degree distribution map V1 in the first region, and The average of the values ​​obtained by subtracting the vertical axis value of the aspherical reference degree distribution map W from the horizontal axis value of the degree distribution map V2 in the second region at each horizontal axis value greater than the horizontal axis value of the degree distribution map V2 in the second region.

19. The intraocular lens according to claim 16, wherein, The horizontal axis value in the middle region falls within the range of 1.3mm or more and 2.5mm or less.

20. The intraocular lens according to claim 16, wherein, The maximum value rmax of the horizontal axis of the degree distribution plot V is a value within the range of 2.5 mm above and 3.5 mm below.

21. The intraocular lens according to claim 16, wherein, The absolute value of the average slope of the tangent line of the degree distribution map V2 in the second region is more than three times the absolute value of the average slope of the tangent line of the degree distribution map V1 in the first region.

22. The intraocular lens according to claim 16, wherein, One or more additional regions are set out radially outward from the second region. The additional area surrounds the second area. At each horizontal axis value of the degree distribution map Vadd in at least one of the additional regions, the value obtained by subtracting the vertical axis value of the aspherical reference degree distribution map W from the vertical axis value of the degree distribution map Vadd is less than ±0.30D.

23. The intraocular lens according to claim 16, wherein, The degree distribution plot V is represented by a polynomial.

24. The intraocular lens according to claim 16, wherein, One or more additional regions are set out radially outward from the second region. The additional area surrounds the second area. The additional area has the function of refracting the incident light beam onto the retina.

25. An intraocular lens comprising at least two concentric and adjacent vision correction regions centered on a lens center O with a predetermined base power. The vision correction area is defined as a second area surrounding the first area, starting from the first area containing the lens center O and moving radially outward. When the power distribution map of a virtual aspherical lens, which has a base power at the center O of the lens and completely cancels out the positive longitudinal spherical aberration caused by the cornea, is set as the aspherical reference power distribution map W, In the total power distribution diagram, where the position observed radially from the lens center O is set as the horizontal axis (unit: mm), and the total power T (combining the refractive power of the cornea and the power of the intraocular lens) is set as the vertical axis (unit: D (diopter)), and the position of the first boundary between the first and second regions when observed radially from the lens center O is set as r1, The intraocular lens has a total power distribution map TV, which falls within the set region of total power distribution maps obtained by various combinations of total power distribution maps TVa and TVb when the intersection of the first region using total power distribution map TVa and the second region using total power distribution map TVb is taken as the position ra on the horizontal axis. The first region is obtained using the total power distribution map TVa as follows: the value obtained by subtracting the vertical axis values ​​of each horizontal axis value of the aspheric reference total power distribution map TW after adding corneal refractive power from the baseline power is multiplied by a predetermined ratio α (α is greater than 10% and less than 50%), and then the multiplied value is added to the vertical axis values ​​of each horizontal axis value of the aspheric reference total power distribution map TW. The second region is obtained using the total power distribution map TVb as follows: the value obtained by subtracting the horizontal axis value of each vertical axis value of the aspheric reference total power distribution map TW after adding the corneal refractive power from the maximum horizontal axis value rmax of the aspheric reference total power distribution map TW, multiplying the result by a predetermined ratio β (β is more than 10% and less than 50%), and then adding the multiplied value to the horizontal axis value of each vertical axis value of the aspheric reference total power distribution map TW.

26. The intraocular lens according to claim 25, wherein, In the total degree distribution map TV1 for the first region, the vertical axis value increases continuously as the horizontal axis value increases. In the second region using the total degree distribution map TV2, the vertical axis value decreases continuously as the horizontal axis value increases.

27. The intraocular lens according to claim 25, wherein, The absolute value of the average slope of the tangent line to the total degree distribution map TV1 near the origin in the first region is less than the absolute value of the average slope of the tangent line to the total degree distribution map TV1 near the middle position in the first region. The absolute value of the average slope of the tangent line of the total degree distribution map TV1 near the middle position in the first region is greater than the absolute value of the average slope of the tangent line of the total degree distribution map TV1 near position r1 in the first region. The absolute value of the average slope of the tangent line of the total degree distribution map TV1 near position r1 in the first region is less than the absolute value of the average slope of the tangent line of the total degree distribution map TV2 near the middle position in the second region.

28. The intraocular lens according to claim 25, wherein, In the total degree distribution chart TV, the maximum positive value is obtained by subtracting the vertical axis value at r=0 from the vertical axis value at position r1. r1 is a value within the range of 1.5 mm to 2.3 mm.

29. The intraocular lens according to claim 25, wherein, The value obtained by subtracting the vertical axis value at r=0 from the vertical axis value at the maximum horizontal axis value rmax of the total degree distribution chart TV is less than ±0.30D.

30. The intraocular lens according to claim 25, wherein, The maximum value rmax of the horizontal axis of the total degree distribution chart TV is a value within the range of 2.5mm or more and 3.5mm or less.

31. The intraocular lens according to claim 25, wherein, One or more additional regions are set out radially outward from the second region. The additional area surrounds the second area. The additional area has the function of refracting the incident light beam onto the retina.

32. An intraocular lens comprising at least two concentric and adjacent vision correction regions centered on a lens center O with a predetermined base power. The vision correction area is defined as the second area surrounding the first area, starting from the first area containing the lens center O and moving radially outward. In the diopter distribution diagram, the position when viewing the lens center O radially is set as the horizontal axis (unit: mm), and the diopter is set as the vertical axis (unit: D (diopter)). The power distribution map of a virtual aspherical lens, which has a base power at the center O of the lens and completely cancels out the positive longitudinal spherical aberration caused by the cornea, is set as the aspherical reference power distribution map W. The degree distribution map obtained as follows is set as the degree distribution map Va for the first region: The value obtained by subtracting the vertical axis values ​​at each horizontal axis value of the aspherical reference degree distribution map W from the base degree is multiplied by a predetermined ratio α (α is greater than 10% and less than 50%), and then the multiplied value is added to the vertical axis values ​​at each horizontal axis value of the aspherical reference degree distribution map W. The degree distribution map obtained in the following manner is set as the degree distribution map Vb for the second region: The value obtained by subtracting the horizontal axis values ​​of each vertical axis value of the aspherical reference degree distribution map W from the maximum horizontal axis value rmax of the aspherical reference degree distribution map W is multiplied by a predetermined ratio β (β is above 10% and below 50%), and then the multiplied value is added to the horizontal axis values ​​of each vertical axis value of the aspherical reference degree distribution map W. At this point, The first region includes an inner first region, which has a degree distribution map obtained by adding positive degrees to the degree distribution map Va of the first region. The second region has a degree distribution map Vb. The area of ​​the inner first region is less than 50% of the total area of ​​the first region.

33. The intraocular lens according to claim 32, wherein, The first region, when viewed radially from the center O of the lens, comprises an inner first region and an outer first region surrounding the inner first region. The outer first region has a degree distribution map Va, and it connects with the second region at the intersection of degree distribution maps Va and Vb.

34. The intraocular lens according to claim 32, wherein, An inner first region is provided on the anterior surface, posterior surface, or both surfaces of an intraocular lens having two opposing surfaces.

35. The intraocular lens according to claim 32, wherein, The first region includes regions other than the inner first region, whose average degree is equal to the average degree of the degree distribution map Va, and the average degree of the inner first region is 0.75D to 4.0D greater than the average degree of the regions other than the inner first region.

36. The intraocular lens according to claim 33, wherein, The first region has an outer transition region for connecting the inner first region to the outer first region.

37. The intraocular lens according to claim 32, wherein, The inner first region has a fixed-degree supplementary region, which is a degree distribution map obtained by adding a positive fixed degree to the degree distribution map Va of the first region. When viewed radially from the center O of the lens, the radial distance of the fixed-degree additional region is 33% to 67% of the radial distance of the inner first region.

38. The intraocular lens according to claim 32, wherein, The inner first region contains the lens center O.

39. The intraocular lens according to claim 33, wherein, The first region includes the innermost region, which has a degree distribution map Va of the first region and includes the lens center O. The innermost region is surrounded by the first innermost region.

40. The intraocular lens according to claim 39, wherein, The first region has an inner transition region for connecting the inner first region to the innermost region.

41. The intraocular lens according to claim 32, wherein, An intraocular lens having two opposing surfaces has an aspherical shape in its front and rear surfaces.

42. The intraocular lens according to claim 32, wherein, The lens body of an intraocular lens having two opposing surfaces has a tortuous surface on its anterior surface, posterior surface, or both surfaces, which has a cylindrical power for correcting astigmatism in patients with aphakic eyes.

43. The intraocular lens according to any one of claims 1 to 42, wherein, The intraocular lens is composed of at least one of silicone, hydrophobic acrylic resin, hydrophilic acrylic resin, hydrogel, PMMA, PMMA copolymer, and HEMA (hydroxyethyl methacrylate) copolymer containing collagen.

44. A method for designing an intraocular lens, used to design an intraocular lens according to any one of claims 1 to 42.

45. A method for manufacturing an intraocular lens, comprising manufacturing an intraocular lens designed by the intraocular lens design method of claim 44 by at least one of lathe machining, molding, or 3D printing.

Images