Eccdna associated with cirrhosis transformation into hepatocellular carcinoma and obtaining method and application thereof
By obtaining and synthesizing eccDNA of HBV-related cirrhosis transforming into hepatocellular carcinoma, the problem of lacking specific molecular markers for dynamic monitoring in existing technologies has been solved, realizing stable and non-invasive early molecular marker monitoring and diagnosis, and enabling risk assessment and auxiliary diagnosis of cirrhosis transforming into hepatocellular carcinoma.
CN122405623APending Publication Date: 2026-07-17SHENZHEN PEOPLES HOSPITAL
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Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- SHENZHEN PEOPLES HOSPITAL
- Filing Date
- 2026-04-23
- Publication Date
- 2026-07-17
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Figure CN122405623A_ABST
Abstract
本发明涉及一种肝硬化向肝细胞癌转化相关的eccDNA及其获取方法和应用，eccDNA的核苷酸序列如SEQ ID NO：1所示；同时公开了该eccDNA的获取方法和应用。该发明获取的eccDNA是稳定、无创、可动态监测并具有机制解释能力的早期分子标志物，为肝硬化向肝细胞癌转化的风险评估、辅助诊断、预后分析以及潜在靶向干预提供新的技术路径。
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