Aortic valve annuloplasty system

Abstract

This application relates to the field of medical devices, and more particularly to an aortic valve annulus repair system, including a delivery device and an annulus repair device. The annulus repair device includes a repair ring, three clamping and locking devices, a repair cord, and a locking device. The repair cord is connected to each clamping and locking device. The delivery device includes a control catheter and an adjustment control element. The control catheter is used to connect to the clamping and locking devices, and the adjustment control element is used to connect to the locking device. By operating the control catheter, the clamping and locking devices capture and anchor the leaflet tissue at the leaflet junction. The locking device is used to be positioned in the central region of the aortic valve and is sleeved around the periphery of the repair cord. In this invention, the clamping and locking devices capture and anchor the leaflet tissue at the junction, causing the leaflet junction to close. Combined with the pulling action of the repair cord, the annulus circumference is effectively reduced, achieving a dual repair effect on the valve and effectively improving the aortic valve regurgitation problem.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, specifically to an aortic valve annulus repair system. Background Technology

[0002] Aortic regurgitation is a common valvular heart disease caused by incomplete closure of the aortic valve leaflets, leading to the backflow of diastolic blood from the aorta into the left ventricle. Over time, this can cause ventricular enlargement, heart failure, and even heart failure. For severe aortic regurgitation, surgical valve repair or replacement is currently the standard treatment.

[0003] In valve repair surgery, aortic annulusoplasty is one of the key techniques. Its purpose is to reduce the enlarged valve annulus and restore the effective occlusion area of ​​the valve leaflets, thereby improving valve closure function. Traditional annulusoplasty usually involves implanting an annulus ring, which is then sutured and fixed to the valve annulus to achieve annulus reduction. However, traditional annulus rings only provide a static annulus reduction effect and are difficult to dynamically adjust according to the actual occlusion state of the valve leaflets. Furthermore, the procedure is complex, relies heavily on the surgeon's experience, and carries risks such as postoperative paravalvular leakage and unsatisfactory repair results.

[0004] In recent years, transcatheter valve repair technology has gradually developed, with some systems attempting to achieve minimally invasive annulus repair by implanting angioplasty devices via transvascular routes. However, existing interventional annulus repair systems still have many design shortcomings. For example, some systems use contralateral leaflet anchoring, with the anchoring point far from the leaflet root, making it difficult to effectively control the leaflet occlusion zone; while some systems allow for postoperative adjustments, their locking mechanisms are complex and lack reliability, making it difficult to maintain ideal annulus contraction while ensuring long-term stability. Furthermore, existing systems still need improvement in the coordinated control of the anchoring device and the angioplasty cord, the release sequence between devices, and ease of operation, making it difficult to achieve precise control of the degree of annulus contraction during surgery.

[0005] Therefore, there is an urgent need to provide an aortic valve annuloplasty system with a reasonable structural design, controllable operation, and the ability to anchor the leaflet root and precisely adjust the degree of annular contraction, so as to improve the surgical outcome and safety of aortic valve regurgitation repair. Summary of the Invention

[0006] This application is made in view of the above and other ideas.

[0007] The purpose of this invention is to provide an aortic valve annulus repair system to solve the technical problems of existing annulus repair devices, such as imperfect anchoring position, poor annulus contraction adjustment accuracy, complex operation, and difficulty in achieving precise and controllable repair.

[0008] The technical solution adopted to solve the technical problem of the present invention is to provide an aortic valve annulus repair system, including a delivery device; and an annulus repair apparatus, wherein the annulus repair apparatus includes a repair ring, three clamping and locking devices, a repair cord, and a locking device, the repair cord being connected to each of the clamping and locking devices; the delivery device includes at least one control catheter and an adjustment control element, the control catheter being operably connected to the clamping and locking devices, and the adjustment control element being operably connected to the locking device; wherein the shape of the repair ring matches the aortic valve annulus; the control catheter is operated... The tube allows the clamping and locking device to grasp and anchor the leaflet tissue at the leaflet junction. The locking device is positioned in the central region of the aortic valve and sleeved around the periphery of the angioplasty cord. The angioplasty ring is configured to first release and position itself at the aortic valve annulus. The clamping and locking device is manipulated to grasp and anchor the leaflet tissue at the junction. The operating end of the angioplasty cord is manipulated to pull the clamping and locking device. When pulled to a predetermined position, the locking device is manipulated to lock the angioplasty cord, thereby maintaining the current length of the angioplasty cord to allow the aortic valve annulus to contract towards the center and repair regurgitation.

[0009] Furthermore, the clamping and locking device is anchored at the leaflet root, and the forming cable is configured to move the clamping and locking device and the leaflet root toward the valve center when pulled.

[0010] Furthermore, the adjustment control component includes a control tube, a lasso, and an adjustment member; the lasso is disposed at the distal end of the control tube, and the adjustment member is connected to the lasso; the lasso has a one-way locking structure and is configured to tighten and ultimately fix to the forming cable when the adjustment member is pulled; the adjustment member includes an adjustment wire and a limiting sleeve sleeved on the adjustment wire; when the adjustment wire is pulled, the one-way locking structure and the distal end of the limiting sleeve form a limit.

[0011] Furthermore, the control conduit includes a guide tube, a guide wire, and a push tube. The guide tube is sleeved on the push tube, and the clamping and locking device is installed inside the guide tube. The guide wire is detachably connected to the forming ring. The guide tube is provided with a connection hole, and the guide wire passes through the connection hole so that the guide tube can move along the guide wire to the forming ring.

[0012] Furthermore, each of the clamping and locking devices includes a first clamping arm and a second clamping arm arranged opposite to each other, and at least two locking lines. The at least two locking lines pass through the first clamping arm and the second clamping arm, and their ends are intertwined to form a fisherman's knot. When the clamping and locking device is released from the guide tube and captures the adjacent leaflet tissue, the fisherman's knot can be tightened and locked by pulling the tail end of the locking line, thereby driving the first clamping arm and the second clamping arm to come closer to each other and clamp and fix them on the leaflet tissue to close the junction of the adjacent leaflets.

[0013] Furthermore, the clamping and locking device has a V-shaped structure, with opposing proximal and distal ends. The distal opening of the clamping and locking device is configured to capture adjacent leaflet tissue from the outer surface of the leaflet after the guide tube reaches the target leaflet junction along the guide line.

[0014] Furthermore, the locking line passes through the inner side of the clamping and locking device and connects the first clamping arm and the second clamping arm. The clamping and locking device has an open, natural state in which the distal ends of the first clamping arm and the second clamping arm are separated from each other. The clamping and locking device is configured to capture adjacent leaflet tissue located at the leaflet junction in the open, natural state after being released from the guide tube. In response to the operation of pulling the tail end of the locking line, the first clamping arm and the second clamping arm move closer to each other until the captured leaflet tissue is locked and anchored.

[0015] Furthermore, the distal end of the clamping and locking device is provided with anti-dislodgement barbs; the anti-dislodgement barbs are configured such that when the clamping and locking device retracts and locks in response to pulling the locking line, the anti-dislodgement barbs penetrate into the clamped leaflet tissue to increase the anchoring force between the clamping and locking device and the leaflet tissue and prevent dislodgement.

[0016] Furthermore, a control wire is slidably threaded through the push tube, and the distal end of the control wire is detachably connected to the fisherman's knot; and the radial dimension of the fisherman's knot is larger than the diameter of the distal end of the push tube; wherein, pulling the control wire causes the fisherman's knot to be tightened, and drives the locking line to close the clamping and locking device.

[0017] Furthermore, the clamping and locking device is made of a flexible metal or polymer material; the first clamping arm and the second clamping arm are in a natural state with an opening angle α, the range of which is 15° to 45°; the opening angle α is configured such that when the clamping and locking device is released from the guide tube, it can automatically spring open to the opening angle α to fully expose the capture space.

[0018] Compared with the prior art, the advantages of the technical solution of this application include at least the following: According to a concept of this application, the angioplasty ring is preferentially released and positioned on the aortic valve annulus. The clamping and locking device is quickly and accurately delivered to the leaflet junction through a preset guide path, and captures and anchors on the leaflet tissue at the junction, so that the leaflet junction closes. In addition, combined with the pulling action of the angioplasty cable, it can directly drive the leaflet root to move towards the center, effectively reducing the annulus circumference and achieving a dual repair effect on the valve, effectively improving the aortic valve regurgitation problem.

[0019] According to one concept of this application, the clamping and locking device is anchored in the root region of the leaflet, so that the clamping and locking device can effectively drive the root of the leaflet to move towards the center, thereby reducing the circumference of the leaflet ring, and without affecting the shape of the leaflet.

[0020] According to one concept of this application, the clamping and locking device releases from the outer side of the leaflet and captures the leaflet, which enables the clamping and locking device to effectively clamp adjacent leaflet tissue and achieve effective fixation.

[0021] According to a concept of this application, the clamping and locking device adopts a V-shaped structure, which, together with the fisherman's knot formed by the locking line, allows the clamping arm to be retracted and locked by pulling the locking line. It is convenient to operate and has a simple and stable structure. At the same time, the anti-detachment barbs and anti-slip structure further enhance the stability of the clamping, effectively preventing the clamping and locking device from falling off and ensuring the durability of the repair effect.

[0022] The embodiments of this application can achieve other advantageous technical effects not listed one by one. These other technical effects may be partially described below and can be expected and understood by those skilled in the art after reading this application. Attached Figure Description

[0023] The above-described features and advantages, as well as other features and advantages, and the ways in which they are implemented, of these embodiments will become more apparent and the embodiments of this application will be better understood by referring to the following description in conjunction with the accompanying drawings, in which: Figure 1 This is a schematic diagram of the aortic valve annulus repair system of the present invention.

[0024] Figure 2 This is a diagram showing the effect of implantation after the invention.

[0025] Figure 3 This is a schematic diagram illustrating the configuration of the adjustment control component of the present invention.

[0026] Figure 4 This is a schematic diagram of the control catheter of the present invention.

[0027] Figure 5 This is a schematic diagram of the guide wire of the present invention.

[0028] Figure 6 This is a schematic diagram of the valve ring forming device of the present invention.

[0029] The features represented by the numbers in the attached diagram are as follows: 1-Delivery device, 11-Control catheter, 111-Guide tube, 112-Guide wire, 113-Push tube, 114-Control wire, 12-Adjustment control element, 121-Control tube, 122-Sleeve, 123-Adjustment element, 2-Valve ring forming device, 21-Forming ring, 22-Clamping and locking device, 221-First clamping arm, 222-Second clamping arm, 223-Locking line, 224-Fisherman's knot, 225-Anti-detachment barb, 23-Forming cord, 24-Locking device. Detailed Implementation

[0030] The details of one or more embodiments of this application will be set forth in the following description of the accompanying drawings and specific embodiments. Other features, objects, and advantages of this application will become clear from these descriptions, drawings, and claims.

[0031] It should be understood that the illustrated and described embodiments are not limited in application to the details of the construction and arrangement of the components set forth in the following description or illustrated in the accompanying drawings. The illustrated embodiments may be other embodiments and can be implemented or performed in various ways. The examples are provided by way of explanation rather than limitation of the disclosed embodiments. In fact, it will be apparent to those skilled in the art that various modifications and variations can be made to the embodiments of this application without departing from the scope or spirit of this disclosure. For example, features illustrated or described as part of one embodiment may be used with another embodiment to still produce another embodiment. Therefore, this disclosure covers such modifications and variations that fall within the scope of the appended claims and their equivalents.

[0032] Similarly, it is understood that the phrases and terms used in this document are for descriptive purposes and should not be considered restrictive. The use of “including,” “contains,” or “has,” and their variations, in this document is intended to include, in an open-ended manner, the items listed thereafter, their equivalents, and any additional items.

[0033] The present application will now be described in more detail with reference to various embodiments and examples of several aspects thereof.

[0034] One of the objectives of the embodiments described below is to address the aforementioned deficiencies, as well as other problems.

[0035] Example 1: This example describes the repair of mitral regurgitation using aortic annulus angioplasty. A system for aortic annulus angioplasty includes a delivery device 1 and an annulus angioplasty device 2. The annulus angioplasty device 2 includes an annulus angioplasty ring 21, three clamping and locking devices 22, an annulus angioplasty cord 23, and a locking device 24. The annulus angioplasty cord 23 is connected to each of the clamping and locking devices 22, as shown below. Figure 1 As shown; the delivery device 1 includes at least one manipulating catheter 11 and an adjusting control 12. The manipulating catheter 11 is operably connected to the clamping and locking device 22, and the adjusting control 12 is operably connected to the locking device 24. The morphology of the angioplast 21 matches the aortic valve annulus. Operating the manipulating catheter 11 causes the clamping and locking device 22 to grasp and anchor the leaflet tissue at the leaflet junction. The locking device 24 is positioned in the central region of the aortic valve and sleeved around the angioplast 23. The angioplast 21 is configured to be released first and positioned on the aortic valve. At the junction, the clamping and locking device 22 is manipulated to capture and anchor the leaflet tissue at the junction. The operating end of the shaping cord 23 is manipulated to pull the clamping and locking device 22. When pulled to a predetermined position, the locking device 24 is manipulated to lock the shaping cord 23, thereby maintaining the current length of the shaping cord 23, so that the aortic valve annulus contracts towards the center to repair regurgitation. By closing the leaflet junction through the clamping and locking device 22 and combining the pulling action of the shaping cord 23, the leaflet root can be directly driven to move towards the center, effectively reducing the annulus circumference and achieving a dual repair effect on the valve, effectively improving the aortic valve regurgitation problem. Figure 2 As shown.

[0036] In this embodiment, the clamping and locking device 22 is anchored to the leaflet root, and the forming cable 23 is configured to move the clamping and locking device 22 and the leaflet root toward the valve center when pulled. The clamping and locking device 22 is anchored to the leaflet root so that when the forming cable 23 is pulled, its tension mainly acts on the leaflet root region, which can effectively reduce the diameter of the valve annulus and will not affect the shape of the leaflet.

[0037] In this embodiment, the adjustment control element 12 includes a control tube 121, a sleeve 122, and an adjustment element 123, such as... Figure 3 As shown; the lasso is located at the distal end of the control tube 121, and the adjusting member 123 is connected to the lasso; the lasso has a one-way locking structure, such as a cable tie-like structure, and is configured to tighten and eventually fix to the forming cable 23 when the adjusting member 123 is pushed; the adjusting member 123 includes an adjusting wire and a limiting sleeve 122 sleeved on the adjusting wire; when the adjusting wire is pulled, the one-way locking structure and the distal end of the limiting sleeve 122 form a limit.

[0038] In this embodiment, the control tube 121 has three metal wires at its distal end. The three metal wires are detachably connected to the lasso, and the metal wires are flexible wires that will not interfere with the contraction of the lasso.

[0039] In this embodiment, the control catheter 11 includes a guide tube 111, a guide wire 112, and a push tube 113, such as Figure 4 As shown, the guide tube 111 is sleeved on the push tube 113, the clamping and locking device 22 is installed inside the guide tube 111, the guide wire 112 is detachably connected to the forming ring 21, the guide tube 111 is provided with a connecting hole, and the guide wire 112 passes through the connecting hole so that the guide tube 111 can move along the guide wire 112 to the forming ring 21, as shown. Figure 5 As shown.

[0040] In this embodiment, each of the clamping and locking devices 22 includes a first clamping arm 221 and a second clamping arm 222 disposed opposite to each other, and at least two locking lines 223, such as Figure 6 As shown, at least two locking wires 223 are threaded through the first clamping arm 221 and the second clamping arm 222, and their ends are intertwined to form a fisherman's knot 224. It is worth noting that the fisherman's knot 224 has a self-locking characteristic: when the clamping locking device 22 is subjected to an outward expanding force from the leaflet tissue (i.e., a force attempting to reopen the clamping arms), this expanding force is transmitted to the fisherman's knot 224 through the locking wires 223, making the intertwining between the two locking wires 223 tighter, thereby further tightening the fisherman's knot 224; in other words, the outward expanding force acting on the clamping arms... The outward expansion force will not cause the fisherman's knot 224 to loosen, but will instead enhance its locking effect, ensuring that the clamping and locking device 22 maintains a reliable anchoring state during long-term implantation, effectively preventing the risk of incomplete leaflet closure or clamping device detachment after surgery; when the clamping and locking device 22 is released from the guide tube 111 and captures the adjacent leaflet tissue, the fisherman's knot 224 can be tightened and locked by pulling the tail end of the locking line 223, thereby driving the first clamping arm 221 and the second clamping arm 222 to come closer to each other and clamp and fix them on the leaflet tissue to close the junction of adjacent leaflets.

[0041] In this embodiment, the clamping and locking device 22 has a V-shaped structure and has a proximal end and a distal end. The distal opening of the clamping and locking device 22 is configured to capture adjacent leaflet tissue from the outer side of the leaflet (i.e., the side facing the aortic vessel wall) after the guide tube 111 reaches the target leaflet junction along the guide line 112, ensuring the accuracy of capture and avoiding damage to the functional surface of the inner side of the leaflet. Furthermore, the clamping and locking device 22 is not subjected to the impact of blood flow when the aortic valve opens and closes. On the one hand, this can avoid hemolysis caused by blood flow impact on the clamping and locking device 22, and on the other hand, it can effectively prevent the clamping and locking device 22 from falling off due to excessive impact force.

[0042] In this embodiment, the locking line 223 passes through the inner side of the clamping and locking device 22 and connects the first clamping arm 221 and the second clamping arm 222. The clamping and locking device 22 has an open natural state in which the distal ends of the first clamping arm 221 and the second clamping arm 222 are separated from each other. The clamping and locking device 22 is configured to capture adjacent leaflet tissue located at the leaflet junction in the open natural state after being released from the guide tube 111. In response to the operation of pulling the tail end of the locking line 223, the first clamping arm 221 and the second clamping arm 222 move closer to each other until the captured leaflet tissue is locked and anchored.

[0043] In this embodiment, the distal end of the clamping and locking device 22 is provided with an anti-dislodgement barb 225; the anti-dislodgement barb 225 is configured such that when the clamping and locking device 22 retracts and locks in response to pulling the locking line 223, the anti-dislodgement barb 225 pierces into the clamped leaflet tissue to increase the anchoring force between the clamping and locking device 22 and the leaflet tissue and prevent dislodgement.

[0044] In this embodiment, a control wire 114 is slidably threaded through the push tube 113, and the distal end of the control wire 114 is detachably connected to the fisherman's knot 224; and the radial dimension of the fisherman's knot 224 is larger than the diameter of the distal end of the push tube 113; wherein, pulling the control wire 114 causes the fisherman's knot 224 to be tightened, and drives the locking line 223 to close the clamping locking device 22.

[0045] In this embodiment, the clamping and locking device 22 is made of an elastic metal or polymer material; the first clamping arm 221 and the second clamping arm 222 are in a natural state with an opening angle α, the range of which is 15° to 45°; the opening angle α is configured such that when the clamping and locking device 22 is released from the guide tube 111, it can automatically spring open to the opening angle α to fully expose the capture space.

[0046] In this embodiment, the forming ring 21 is made of metal elastic wire and has a circular ring structure; the diameter of the circular ring structure is configured to be 28 mm to match the original aortic valve annulus size of different patients.

[0047] The procedure for implanting an aortic valve annuloplasty system into the heart according to the present invention is as follows: Preoperative preparation: Based on the patient's aortic valve annulus size, select an angioplasty ring 21 with a suitable diameter (since patients with aortic regurgitation have larger annulus dilation, the angioplasty ring 21 selected in this embodiment is 28mm in size). Install the angioplasty ring 21 at the distal end of the delivery device 1. Connect the proximal ends of the three guide wires 112 to the three circumferential connection points of the angioplasty ring 21, and connect the distal ends to the guide tube 111. Load the three clamping and locking devices 22 into the guide tube 111; 2. Angioplasty ring 21 implantation: Through interventional means, guide the delivery device 1 to the aortic valve annulus, release the angioplasty ring 21, and the angioplasty ring 21 fits the original aortic valve annulus with its own elasticity to achieve precise positioning; 3. Guide tube 111 guides: Guide tube 111 along guide line 112 to the target leaflet junction (the three guide lines 112 correspond to the three leaflet junctions respectively, and can guide simultaneously or separately), ensuring that the distal opening of clamping and locking device 22 is aligned with the junction of adjacent leaflets; 4. Clamping and locking device 22 release and clamping: retract guide tube 111, release clamping and locking device 22 in guide tube 111, clamping and locking device 22 automatically springs open to an opening angle of 45°, capturing adjacent leaflet tissue from the outer side of the leaflet; pull the proximal end of locking line 223 to drive fisherman's knot 224 to tighten, after fisherman's knot 224 is locked, it drives the first clamping arm 221 and the second clamping arm 222 to move closer to each other until the leaflet tissue is firmly clamped; at this time, anti-dislodgement barb 225 pierces the leaflet tissue; 5. pull the adjusting wire, so that when the forming cord 23 drives the clamping and locking device 22 to move the leaflet root area closer to the valve center to the target position, the lasso fixes and locks the forming cord 23, and then releases the connection with the lasso; 5. withdraw delivery device 1 to complete the operation.

[0048] The foregoing description of the embodiments described above is provided for illustrative purposes. This foregoing description is not intended to be exhaustive, nor is it intended to limit the application to the precise configurations, constructions, and / or steps disclosed. Clearly, many modifications and variations can be made in light of the teachings above. The scope of the invention and all its equivalents are intended to be defined by the appended claims.

Claims

1. An aortic valve annulus repair system, characterized in that: Includes a delivery device; and a petiole forming device, the petiole forming device comprising a forming ring, three clamping and locking devices, a forming cord, and a locking device, the forming cord being connected to each of the clamping and locking devices; The delivery device includes at least one control conduit and an adjustment control element, the control conduit being operably connected to the clamping and locking device, and the adjustment control element being operably connected to the locking device. The angioplasty ring is shaped to match the aortic valve annulus. The manipulating catheter causes the clamping and locking device to capture and anchor the leaflet tissue at the leaflet junction. The locking device is positioned in the central region of the aortic valve and sleeved around the angioplasty cord. The angioplasty ring is configured to first release and position itself at the aortic valve annulus. The clamping and locking device is manipulated to capture and anchor the leaflet tissue at the junction. The manipulating end of the angioplasty cord is manipulated to pull the clamping and locking device. When pulled to a predetermined position, the locking device is manipulated to lock the angioplasty cord, thereby maintaining its current length to allow the aortic valve annulus to contract towards the center and repair regurgitation. The adjustment control component includes a control tube, a lasso, and an adjustment member; the lasso is disposed at the distal end of the control tube, and the adjustment member is connected to the lasso; the lasso has a one-way locking structure and is configured to tighten and ultimately fix to the forming cable when the adjustment member is pulled; the adjustment member includes an adjustment wire and a limiting sleeve sleeved on the adjustment wire; when the adjustment wire is pulled, the one-way locking structure and the distal end of the limiting sleeve form a limit. The control conduit includes a guide tube, a guide wire, and a push tube. The guide tube is sleeved on the push tube. The clamping and locking device is installed inside the guide tube. The guide wire is detachably connected to the forming ring. The guide tube is provided with a connection hole. The guide wire passes through the connection hole so that the guide tube can move along the guide wire to the forming ring. Each of the clamping and locking devices includes a first clamping arm and a second clamping arm arranged opposite each other, and at least two locking wires. The at least two locking wires pass through the first clamping arm and the second clamping arm, and their ends are intertwined to form a fisherman's knot. When the clamping and locking device is released from the guide tube and captures adjacent leaflet tissue, the fisherman's knot can be tightened and locked by pulling the tail end of the locking wire, thereby driving the first clamping arm and the second clamping arm to come closer to each other and clamp and fix them on the leaflet tissue to close the junction of adjacent leaflets.

2. The aortic valve annulus repair system according to claim 1, characterized in that: The clamping and locking device is anchored at the leaflet root, and the forming cable is configured to move the clamping and locking device and the leaflet root toward the valve center when pulled.

3. The aortic valve annulus repair system according to claim 1, characterized in that: The clamping and locking device has a V-shaped structure and has opposing proximal and distal ends. The distal opening of the clamping and locking device is configured to capture adjacent leaflet tissue from the outer surface of the leaflet after the guide tube reaches the target leaflet junction along the guide line.

4. The aortic valve annulus repair system according to claim 3, characterized in that: The locking line passes through the inside of the clamping and locking device and connects the first clamping arm and the second clamping arm. The clamping and locking device has an open, natural state in which the distal ends of the first clamping arm and the second clamping arm are separated from each other. The clamping and locking device is configured to capture adjacent leaflet tissue located at the leaflet junction in the open, natural state after being released from the guide tube. In response to pulling the tail end of the locking line, the first clamping arm and the second clamping arm move closer together until the captured leaflet tissue is locked and anchored.

5. The aortic valve annulus repair system according to claim 4, characterized in that: The distal end of the clamping and locking device is provided with anti-dislodgement barbs; the anti-dislodgement barbs are configured such that when the clamping and locking device retracts and locks in response to pulling the locking line, the anti-dislodgement barbs penetrate into the clamped leaflet tissue to increase the anchoring force between the clamping and locking device and the leaflet tissue and prevent dislodgement.

6. The aortic valve annulus repair system according to claim 5, characterized in that: A control wire is slidably threaded through the push tube, and the distal end of the control wire is detachably connected to the fisherman's knot; and the radial dimension of the fisherman's knot is larger than the diameter of the distal end of the push tube; wherein, pulling the control wire causes the fisherman's knot to be tightened, and drives the locking line to close the clamping locking device.

7. The aortic valve annulus repair system according to claim 6, characterized in that: The clamping and locking device is made of elastic metal or polymer material; the first clamping arm and the second clamping arm are in a natural state with an opening angle α, the range of which is 15° to 45°; the opening angle α is configured such that when the clamping and locking device is released from the guide tube, it can automatically spring open to the opening angle α to fully expose the capture space.

Images