Dendritic mesoporous silica loaded with alkannin on surface and used for demineralization reduction and remineralization promotion of tooth enamel
By loading dendritic mesoporous silica material with shikonin onto the enamel surface and modifying it with polydopamine and polyethylene glycol, MSPP material is formed. This solves the problem of existing anti-caries materials inhibiting demineralization and promoting remineralization in acidic environments, and achieves stable protection and remineralization of enamel.
Patent Information
- Application Number
- CN202610674837.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-05-15
- Publication Date
- 2026-07-24
AI Technical Summary
Existing anti-caries materials are difficult to effectively inhibit demineralization and promote remineralization in acidic environments, and they also have problems with insufficient targeting and retention.
Dendritic mesoporous silica loaded with shikonin is used to form MSPP material by coating its surface with a polydopamine coating and a polyethylene glycol modification layer. This material forms a stable interface layer on the enamel surface, inhibits the growth of cariogenic bacteria and acid metabolism, and actively induces mineralization.
MSPP material significantly alleviates enamel demineralization, inhibits cariogenic bacteria and biofilm acid formation, slows down mineral dissolution, remains stable in acidic environments, promotes remineralization, improves enamel hardness and Ca/P ratio, and achieves continuous tooth surface protection.