Drug coating balloon capable of realizing sequential drug release through double-drug synergism and preparation method and application of drug coating balloon

By designing a three-layer drug-coated balloon, sequential drug release is achieved, solving the problem that existing drug-coated balloons cannot meet the multi-stage needs of vascular repair, reducing restenosis rate and foreign body residue risk, and improving treatment efficacy and safety.

CN122440906APending Publication Date: 2026-07-24ZHENGZHOU UNIV +1
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Patent Information

Application Number
CN202610805186.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-06-05
Publication Date
2026-07-24

AI Technical Summary

Technical Problem

Existing drug-coated balloons cannot meet the multi-stage needs of vascular repair through dual-drug synergy. Drug release is not sequential, and the coating carrier is non-degradable, resulting in high restenosis rates and the risk of foreign body residue.

Method used

The drug-coated balloon employs a three-layer structure: the inner drug coating contains inhibitors loaded on a biodegradable carrier, the middle adhesive layer contains hydrophilic polymers, and the outer drug coating contains anti-inflammatory agents loaded on a biodegradable carrier. By controlling the drug combination and the selection of carrier materials, the sequential release of drugs can be achieved, adapting to different physiological stages of vascular repair.

Benefits of technology

It achieves precise timing of drug release, with rapid anti-inflammatory effects from the outer layer and slow release from the inner layer. The coating carrier is biodegradable, and the degradation products are non-toxic, reducing the risk of restenosis and improving treatment efficacy and safety.

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Abstract

The invention belongs to the technical field of implantation intervention medical apparatuses and instruments, and relates to a drug coating balloon for realizing sequential drug release through double-drug synergism and a preparation method and application thereof. The invention aims to overcome the defects of an existing drug coating balloon. According to the drug coating balloon, a three-layer structure of an inner layer drug coating, a middle bonding layer and an outer layer drug coating is sequentially arranged on a balloon base body from inside to outside, double drugs of an inhibitor and an anti-inflammatory agent cooperate, and time sequence accurate release is achieved. Rapamycin / everolimus is used for inhibiting smooth muscle proliferation in a long-acting manner to realize long-term restenosis prevention; through the design of the degradable carrier and the bonding layer, quick release of the outer layer and slow release of the inner layer are achieved, the coating is firm and degradable in the whole process, and the effectiveness and safety of vascular interventional therapy are improved from the source.
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