Automated reconstitution dilution and supplementation device for vaccine lyophilized formulations

Abstract

The utility model relates to the field of veterinary instruments for aquatic animal disease prevention, and particularly discloses an automatic redissolving, diluting and supplementing device for vaccine freeze-dried preparations, which comprises: a feeding mechanism including a limiting cylinder vertically arranged on a workbench, a centrifugal disc rotatably arranged in the limiting cylinder and a first motor, and a discharge port is formed in the cylinder wall of the limiting cylinder; a first conveying belt, an input end of the first conveying belt is aligned with the discharge port; a positioning mechanism including a work turntable rotatably mounted on the workbench and a second motor, and an outer edge of the work turntable forms a receiving notch; a bottle opening mechanism mounted on the workbench and arranged on the middle stream side of the work turntable; a second conveying belt, an input end of the second conveying belt is aligned with the downstream side of the work turntable; a bearing platform mounted on the workbench; a vaccine pool mounted on the workbench; and an electric liquid suction needle tube mounted on the workbench through a mechanical arm. The utility model solves the time-consuming and labor-consuming problem existing in the manual redissolving, diluting and supplementing operation of vaccine freeze-dried preparations in the existing fish vaccine soaking and inoculation process.

Description

Technical Field

[0001] This utility model relates to the field of veterinary instruments and tools, specifically to an automated reconstitution, dilution and replenishment device for freeze-dried formulations of fish vaccines. Background Technology

[0002] In existing fish vaccine soaking and inoculation processes, especially when using freeze-dried vaccine formulations for immunization, it is necessary to frequently add diluted solution of the reconstituted freeze-dried vaccine formulation to the vaccine soaking and inoculation device. However, the existing reconstitution and dilution replenishment operations for freeze-dried vaccines are mostly done manually. For fish vaccine soaking and inoculation devices, the demand for reconstitution and replenishment of vaccine soaking solution is large, and the concentration of the vaccine soaking solution needs frequent adjustment. Manual replenishment is not only time-consuming and labor-intensive, but also makes it difficult to ensure the accuracy and consistency of each replenishment operation. Therefore, there is an urgent need for an automated device with optimized structure and stable operation to solve the above problems. Utility Model Content

[0003] To overcome the shortcomings of existing technologies, an automated reconstitution, dilution and replenishment device for freeze-dried vaccine preparations is provided to solve the time-consuming and labor-intensive problem of manually completing the reconstitution and dilution replenishment of freeze-dried vaccine preparations during the current process of soaking and inoculating fish vaccines.

[0004] To achieve the above objectives, an automated reconstitution, dilution, and replenishment device for lyophilized vaccine formulations is provided, comprising:

[0005] The feeding mechanism includes a limiting cylinder erected on the workbench, a centrifugal disc for holding vials and rotatably disposed in the limiting cylinder, and a first motor for driving the centrifugal disc. The cylinder wall of the limiting cylinder has a discharge port facing the top of the centrifugal disc.

[0006] A first conveyor belt, the input end of which is aligned with the discharge port;

[0007] The positioning mechanism includes a working turntable rotatably mounted on the worktable and a second motor for driving the working turntable. The upstream side of the working turntable is aligned with the output end of the first conveyor belt, and the outer edge of the working turntable forms a receiving notch for inserting the vial.

[0008] A bottle-opening mechanism for removing the stopper of a vial from the receiving notch of the working turntable is installed on the workbench and located on the middle side of the working turntable.

[0009] A second conveyor belt, the input end of which is aligned with the downstream side of the work turntable;

[0010] A support platform for placing diluent bottles and positioned opposite the second conveyor belt is installed on the workbench;

[0011] The vaccine pool is installed on the workbench;

[0012] An electric aspiration needle, used to extract vaccine reconstituted solution from vials on the second conveyor belt and diluent from dilution bottles and input it into the vaccine pool, is mounted on the workbench via a robotic arm.

[0013] Furthermore, the inner wall of the limiting cylinder is lined with a silicone pad.

[0014] Furthermore, two guide ribs are installed on the frame of the first conveyor belt, which are positioned above the synchronous belt of the first conveyor belt. The guide ribs are arranged along the length of the synchronous belt, and the distance between the two guide ribs is adapted to the outer diameter of the vial.

[0015] Furthermore, a first flow limiter is installed on the workbench to limit the conveying speed of vials on the first conveyor belt.

[0016] Furthermore, the inner wall of the accommodating notch is lined with a rubber anti-slip layer.

[0017] Furthermore, an arc-shaped anti-detachment strip is installed on the worktable. The anti-detachment strip is fitted to the circumferential surface of the work turntable, and the curvature of the anti-detachment strip is adapted to the curvature of the circumferential surface of the work turntable. The anti-detachment strip is located between the upstream and downstream sides of the work turntable.

[0018] Furthermore, the bottle opening mechanism includes a first bracket mounted on the workbench and an electric gripper that is vertically mounted on the first bracket.

[0019] Furthermore, a flow guide ramp is installed on the workbench, with the upper end of the flow guide ramp positioned below the electric gripper. A first collection bucket is installed below the workbench, and the lower end of the flow guide ramp is positioned above the opening of the first collection bucket.

[0020] Furthermore, the robotic arm includes a rotary table rotatably mounted on the worktable, a third motor for driving the rotary table, a second bracket mounted on the rotary table, a horizontal linear module mounted on the second bracket, and a vertical linear module mounted on a slide of the horizontal linear module. The electric aspiration needle is mounted on the slide of the vertical linear module.

[0021] The beneficial effects of this invention are that the automated reconstitution, dilution, and replenishment device for freeze-dried vaccine formulations achieves automated operation of the entire process, from automatic vial feeding, stable transportation, precise cap opening, efficient liquid extraction to accurate dilution, and collection of waste vials and caps. This greatly improves the efficiency and accuracy of vaccine reconstitution, dilution, and replenishment. This automated reconstitution, dilution, and replenishment device for freeze-dried vaccine formulations not only supports continuous operation but also demonstrates excellent efficiency in vial opening and liquid extraction, ensuring that each step is completed accurately. By introducing intelligent automation technology, this automated reconstitution, dilution, and replenishment device for freeze-dried vaccine formulations eliminates the traditional method of manually opening vials and manually extracting vaccine reconstitution solution, saving labor costs and improving work efficiency, and possesses significant market application potential and a promising commercial prospect. Attached Figure Description

[0022] Other features, objects, and advantages of this application will become more apparent from the following detailed description of non-limiting embodiments with reference to the accompanying drawings:

[0023] Figure 1 This is a schematic diagram of the structure of an automated reconstitution, dilution, and replenishment device for freeze-dried vaccine formulations according to an embodiment of the present invention.

[0024] Figure 2 This is a schematic diagram of the feeding mechanism according to an embodiment of the present utility model.

[0025] Figure 3 This is a schematic diagram of the structure of the first conveyor belt in an embodiment of the present utility model.

[0026] Figure 4 This is a schematic diagram of the positioning mechanism structure according to an embodiment of the present utility model.

[0027] Figure 5 This is a schematic diagram of the bottle opening mechanism according to an embodiment of the present invention.

[0028] Figure 6 This is a schematic diagram of the structure of the second conveyor belt in an embodiment of the present invention.

[0029] Figure 7 This is a schematic diagram of the structure of the robotic arm according to an embodiment of the present invention.

[0030] Figure 8 This is a schematic diagram of the structure of the first current limiter according to an embodiment of the present utility model. Detailed Implementation

[0031] The present application will now be described in further detail with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the relevant utility model and not intended to limit the scope of the utility model. Furthermore, it should be noted that, for ease of description, only the parts relevant to the utility model are shown in the accompanying drawings.

[0032] It should be noted that, unless otherwise specified, the embodiments and features described in this application can be combined with each other. This application will now be described in detail with reference to the accompanying drawings and embodiments.

[0033] Reference Figures 1 to 8 As shown, this utility model provides an automated reconstitution, dilution and replenishment device for freeze-dried vaccine preparations, including: a feeding mechanism 1, a first conveyor belt 2, a positioning mechanism 3, a bottle opening mechanism 4, a second conveyor belt 5, a support platform 6, a vaccine pool 7 and an electric aspiration needle 8.

[0034] In this embodiment, the automated reconstitution, dilution and replenishment device for freeze-dried vaccine formulations of this invention also includes a workbench 9.

[0035] Preferably, the workbench is a movable workbench. The workbench includes a frame and a tabletop. The tabletop is mounted on the frame. Casters are installed at the bottom of the frame. The casters are omnidirectional casters. The tabletop is used to install components such as the feeding mechanism 1, the first conveyor belt 2, the positioning mechanism 3, the bottle opening mechanism 4, the second conveyor belt 5, the support platform 6, the vaccine pool 7, and the electric aspiration needle 8.

[0036] The feeding mechanism 1 includes a limiting cylinder 11, a centrifugal disc 12, and a first motor 13.

[0037] Specifically, in combination Figure 2 As shown, the limiting cylinder 11 is vertically mounted on the workbench 9. A centrifuge disc 12 is rotatably mounted within the limiting cylinder 11. The centrifuge disc and the limiting cylinder are coaxially aligned. The outer diameter of the centrifuge disc is adapted to the inner diameter of the limiting cylinder. The centrifuge disc is used to hold vials. A first motor 13 is mounted on the workbench and is used to drive the centrifuge disc 12. In this embodiment, the first motor 13 is vertically mounted on the workbench. The output end of the first motor is coaxially connected to the centrifuge disc. The limiting cylinder 11 has a discharge port a on its wall. The discharge port a faces the top of the centrifuge disc 12.

[0038] In this embodiment, the height of the discharge port a is adapted to the height of the vial, and the width of the discharge port is slightly larger than the outer diameter of the vial. The bottom of the discharge port is flush with the upper surface of the centrifuge disc.

[0039] The vials placed on the centrifuge disc slide toward the inner wall of the limiting cylinder under the centrifugal force generated by the rotation of the centrifuge disc driven by the first motor, and are finally output in a single row through the discharge port.

[0040] As a preferred embodiment, the inner wall of the limiting cylinder 11 is lined with a silicone pad.

[0041] The first motor is a stepper motor. The limiting cylinder is made of ABS engineering plastic, with a 3mm thick silicone pad (Shore hardness 30A) attached to the inner wall to effectively buffer the impact of the bottle.

[0042] Combination Figure 3 As shown, the first conveyor belt 2 has an input end and an output end. The input end of the first conveyor belt 2 is aligned with the discharge port a. The discharge port of the limiting cylinder is equipped with a guide ramp, so that the bottle body smoothly enters the input end of the first conveyor belt at a linear velocity of 0.5-1.2 m / s.

[0043] In this embodiment, two guide ribs 21 are mounted on the frame of the first conveyor belt 2, arranged opposite each other. The two guide ribs 21 are positioned above the synchronous belt of the first conveyor belt 2. The guide ribs 21 are arranged along the length of the synchronous belt. The distance between the two guide ribs 21 is adapted to the outer diameter of the vial.

[0044] A first flow limiter 91 is installed on the workbench 9 to limit the conveying speed of vials on the first conveyor belt 2.

[0045] Specifically, in combination Figure 8 As shown, the first flow limiter includes a base 913, a column 912, and a chuck 911. The base is mounted on a workbench. The column is erected vertically on the base. The chuck is rotatably mounted on the upper end of the column. Multiple slots are formed on the outer edge of the chuck. The size of the slots is adapted to the outer diameter of the vials. A drive motor for driving the chuck is mounted on the column. The drive motor controls the rotational speed of the chuck. One side of the chuck is positioned above the middle of the synchronous belt of the first conveyor belt. With the rotation of the chuck, the upper part of the vials on the synchronous belt is engaged in the slots of the chuck. The conveying speed of the vials on the first conveyor belt is adjusted by the chuck.

[0046] When the bottle density on the second conveyor belt exceeds the set threshold, the chuck speed is adjusted, and subsequent bottles remain in the area at the junction of the centrifugal disc and the input end of the first conveyor belt until the density returns to normal. The base is fixed to the workbench surface with M6 hex socket screws for easy disassembly and maintenance.

[0047] The second conveyor belt is a polyurethane synchronous belt with evenly spaced teeth (2mm module, 120 teeth) on the inner ring, which meshes with the sprocket of the drive wheel. Guide ribs are provided on the upper surface of the synchronous belt to ensure the vials are transported upright. A photoelectric encoder is installed on the drive wheel shaft to provide real-time feedback of the rotational speed to the control system.

[0048] The positioning mechanism is located at the output end of the first conveyor belt. Specifically, in conjunction with... Figure 4 As shown, the positioning mechanism 3 includes a working turntable 31 and a second motor.

[0049] The work turntable 31 is rotatably mounted on the worktable 9. Specifically, the second motor is fixed to the surface of the worktable. The work turntable is coaxially connected to the output shaft of the second motor. The second motor drives the work turntable to rotate.

[0050] The outer edge of the working turntable 31 forms a receiving notch b for inserting vials. In this embodiment, there are multiple receiving notches. The multiple receiving notches are evenly spaced along the circumference of the working turntable. The size of the receiving notches is adapted to the outer diameter of the vials.

[0051] As a preferred embodiment, the inner wall of the receiving notch b is lined with a rubber anti-slip layer. After the vial is inserted into the receiving notch, the presence of the rubber anti-slip layer prevents the vial from falling out.

[0052] The working turntable is a 600mm diameter aluminum alloy disc with 16 circumferentially distributed receiving notches (notch depth 25mm, chamfer R2mm), and the receiving notches are inlaid with rubber anti-slip strips. The working turntable is driven by a servo motor (rated power 100W, accuracy ±0.1°) through a drive shaft 25, and the rotation speed is synchronized with the first conveyor belt (typical value 4r / min).

[0053] In a preferred embodiment, an arc-shaped anti-slip strip 32 is installed on the worktable 9. The anti-slip strip 32 conforms to the circumferential surface of the work turntable. The curvature of the anti-slip strip 32 matches the curvature of the circumferential surface of the work turntable. The anti-slip strip 32 is positioned between the upstream and downstream sides of the work turntable. The distance from the inner arc surface of the anti-slip strip to the inner side of the receiving notch of the work turntable is adapted to the outer diameter of the vial. The anti-slip strip restricts and constrains the vial, preventing it from slipping out of the receiving notch.

[0054] In this embodiment, the working turntable is divided into an upstream side, a midstream side, and a downstream side along its rotation direction. The upstream side of the working turntable 31 is aligned with the output end of the first conveyor belt 2. Vials on the first conveyor belt are input into a receiving notch on the working turntable via the output end. Driven by the second motor, the working turntable rotates, causing the vials on the upstream side of the working turntable to move towards the midstream side.

[0055] The bottle opening mechanism 4 is mounted on the worktable 9. The bottle opening mechanism 4 is located on the middle side of the working turntable 31. The bottle opening mechanism 4 is used to remove the stopper of the vial from the receiving notch b of the working turntable 31.

[0056] For details, please refer to Figure 5 As shown, the bottle opening mechanism 4 includes a first support 41 and an electric gripper 42.

[0057] The first bracket 41 is mounted on the worktable 9. The electric gripper 42 is mounted on the first bracket 41 in a height-adjustable manner.

[0058] In a preferred embodiment, an upper plate is mounted on the top of the first support, and multiple guide rods are mounted on the bottom of the upper plate. A lifting motor is mounted on the upper plate. The lifting motor is vertically oriented. A lead screw is coaxially connected to the output end of the lifting motor. A lower plate slides along the multiple guide rods. The lower plate has multiple vertical through holes. The guide rods slide within these vertical through holes. An electric gripper is mounted on the bottom of the lower plate. A threaded hole is provided on the lower plate. The lead screw engages with the threaded hole in the lower plate. Driven by the lifting motor, the lead screw rotates, causing the lower plate and the electric gripper to move up and down.

[0059] Continue reading Figure 5 As shown, a flow guide ramp 92 is installed on the workbench 9. The upper end of the flow guide ramp 92 is located below the electric gripper 42. A first collection bucket is installed below the workbench 9. The lower end of the flow guide ramp 92 is located above the opening of the first collection bucket 93.

[0060] In this embodiment, an elastic baffle is connected to the upper end of the flow ramp. The elastic baffle is positioned between the electric gripper and the working turntable. When the electric gripper descends and passes over the elastic baffle, it grips the stopper of the vial on the middle side of the working turntable. Driven by the lifting motor, it rises to remove the stopper and then passes over the elastic baffle in the opposite direction. The electric gripper then releases the stopper, causing it to fall onto the elastic baffle. The stopper then slides into the first collection bucket under its own weight and the action of the flow ramp.

[0061] Preferably, the inner wall of the guide ramp is coated with Teflon to reduce friction.

[0062] Combination Figure 1 and Figure 6 As shown, the second conveyor belt 5 is positioned between the downstream side of the working turntable and the support platform. The input end of the second conveyor belt 5 is aligned with the downstream side of the working turntable 31. After the vials with their stoppers removed on the working turntable are transferred to the downstream side of the working turntable, they are fed into the input end of the second conveyor belt. The second conveyor belt then moves the vials toward its output end.

[0063] The support platform 6 is installed on the workbench 9. The vaccine pool 7 is installed on the workbench 9. The support platform is located on the first side of the second conveyor belt, and the vaccine pool is located on the second side of the second conveyor belt.

[0064] The support platform 6 is used to hold the diluent bottles. The support platform 6 is positioned opposite to the second conveyor belt 5. The support platform 6 is mounted on the worktable via a rotary motor.

[0065] The electrically operated aspirating syringe 8 is mounted on the workbench 9 via a robotic arm. The electrically operated aspirating syringe 8 is used to draw vaccine reconstituted solution from vials and diluent from dilution bottles on the second conveyor belt 5 and input them into the vaccine pool 7.

[0066] After the electric aspiration syringe transfers the vaccine reconstituted solution from the vial on the second conveyor belt to the vaccine pool, the empty vial is fed into the second collection bucket through the output end of the second conveyor belt.

[0067] Specifically, the electric aspiration syringe first draws diluent from the diluent bottle and injects it into the vial opened on the positioning mechanism to reconstitute the lyophilized vaccine powder. After the lyophilized vaccine powder in the vial is reconstituted, the electric aspiration syringe draws vaccine reconstituted solution and injects it into the vaccine pool. Simultaneously, diluent in the vaccine pool is drawn and injected into the vaccine pool via the electric aspiration syringe to mix and replenish the diluent, thus completing the dilution process.

[0068] Combination Figure 7 As shown, the robotic arm includes a rotary table 81, a third motor, a second support 82, a horizontal linear module 83, and a vertical linear module 84. An electrically operated aspiration needle 8 is mounted on the slide of the vertical linear module 84.

[0069] A rotary table 81 is rotatably mounted on a worktable 9. A third motor drives the rotary table 81. The third motor is mounted on the worktable. A second bracket 82 is mounted on the rotary table 81. A horizontal linear module 83 is mounted on top of the second bracket 41. A vertical linear module 84 is mounted on the slide of the horizontal linear module 83. An electric aspiration needle 8 is mounted on the slide of the vertical linear module 84. The horizontal linear module 83 is positioned horizontally, and the vertical linear module 84 is positioned vertically, allowing the electric aspiration needle 8 to move freely up and down and left and right.

[0070] In this embodiment, the sliders of the horizontal and vertical linear modules are driven by synchronous belts. Specifically, two opposing synchronous pulleys are mounted on the linear module (i.e., the horizontal or vertical linear module), and the synchronous belt is fitted over the two pulleys. One side of the synchronous belt is connected to the slide of the linear module. The synchronous pulleys are driven by a sliding motor, which in turn drives the slider to move via the synchronous belt.

[0071] In a preferred embodiment, the second conveyor belt employs a double-row roller chain drive (12.7mm pitch), controlled by a stepper motor (1600 pulses / revolution for microstepping drive precision). A V-shaped guide rail, 10mm deep, is installed on the surface of the second conveyor belt to ensure stable transport of the bottle to the dispensing station after opening. A baffle is installed at the output end of the second conveyor belt. The height of the baffle is adjustable (range 50-100mm), and a corrugated hose is installed on the outer side of the baffle. The corrugated hose is connected to the second collection tank. After the baffle 11 triggers a microswitch, the robotic arm pushes the empty bottle into the slide.

[0072] The electric aspiration needle includes a base, an aspiration needle, and a drive mechanism. The base is mounted on a slide of a vertical linear module. The drive mechanism is mounted on the base. The drive mechanism drives the piston rod connected to the aspiration needle via gears and a rack. After the aspiration needle completes aspiration, a third motor drives a robotic arm to rotate 90°, injecting the vaccine solution into the vaccine pool (5L volume, equipped with a level sensor).

[0073] In this embodiment, the workbench includes a frame. The frame is made of 40mm × 40mm aluminum profile. The internal compartment of the frame houses pull-out collection tanks (a first collection tank and a second collection tank, each with a volume of 20L). The bottom of the frame is equipped with casters with brakes and height-adjustable screws (adjustment range ±10mm). Various electrical components on the workbench are controlled by a PLC integrated module to control the coordinated operation of each motor. Parameters (such as pumping volume and rotation speed) are set via a touchscreen, and abnormal conditions are indicated by audible and visual alarms.

[0074] This invention relates to an automated reconstitution, dilution, and replenishment device for freeze-dried vaccine formulations. The entire process is automated, from automatic vial feeding, stable transport, precise cap opening, efficient liquid extraction, accurate dilution, to the collection of waste vials and caps. This significantly improves the efficiency and accuracy of reconstitution, dilution, and replenishment of effluent for fishery vaccines. This automated reconstitution, dilution, and replenishment device not only supports continuous operation but also demonstrates superior efficiency in vial opening and liquid extraction, ensuring that each step is completed accurately. By introducing intelligent automation technology, this automated reconstitution, dilution, and replenishment device eliminates the traditional method of manually opening vials and manually extracting vaccine reconstitution solution, saving labor costs and improving work efficiency. It is suitable for scenarios with stringent aseptic requirements, such as those involving vaccines and biological agents.

[0075] The above description is merely a preferred embodiment of this application and an explanation of the technical principles employed. Those skilled in the art should understand that the scope of the utility model involved in this application is not limited to the technical solutions formed by specific combinations of the above-described technical features, but should also cover other technical solutions formed by arbitrary combinations of the above-described technical features or their equivalents without departing from the inventive concept. For example, technical solutions formed by substituting the above features with (but not limited to) technical features with similar functions disclosed in this application.

Claims

1. An automated reconstitution dilution and make-up device for vaccine lyophilized formulations, characterized in that, include: The feeding mechanism includes a limiting cylinder erected on the workbench, a centrifugal disc for holding vials and rotatably disposed in the limiting cylinder, and a first motor for driving the centrifugal disc. The cylinder wall of the limiting cylinder has a discharge port facing the top of the centrifugal disc. A first conveyor belt, the input end of which is aligned with the discharge port; The positioning mechanism includes a working turntable rotatably mounted on the worktable and a second motor for driving the working turntable. The upstream side of the working turntable is aligned with the output end of the first conveyor belt, and the outer edge of the working turntable forms a receiving notch for inserting the vial. A bottle-opening mechanism for removing the stopper of a vial from the receiving notch of the working turntable is installed on the workbench and located on the middle side of the working turntable. A second conveyor belt, the input end of which is aligned with the downstream side of the work turntable; A support platform for placing diluent bottles and positioned opposite the second conveyor belt is installed on the workbench; The vaccine pool is installed on the workbench; An electric aspiration needle, used to extract vaccine reconstituted solution from vials on the second conveyor belt and diluent from vials and input it into the vaccine pool, is mounted on the workbench via a robotic arm.

2. The automated reconstitution, dilution and supplementation device for vaccine lyophilisates according to claim 1, characterized in that The inner wall of the limiting cylinder is lined with a silicone pad.

3. The automated reconstitution, dilution and supplementation device for vaccine lyophilized formulations according to claim 1, characterized in that, Two guide ribs are installed on the frame of the first conveyor belt, which are positioned above the synchronous belt of the first conveyor belt. The guide ribs are arranged along the length of the synchronous belt, and the distance between the two guide ribs is adapted to the outer diameter of the vial.

4. The automated reconstitution, dilution and supplementation device for vaccine lyophilisates according to claim 3, characterized in that The workbench is equipped with a first flow limiter for limiting the conveying speed of vials on the first conveyor belt.

5. The automated reconstitution, dilution and supplementation device for vaccine lyophilized formulations according to claim 1, characterized in that, The inner wall of the accommodating notch is lined with a rubber anti-slip layer.

6. The automated reconstitution, dilution and supplementation device for vaccine lyophilisates according to claim 5, characterized in that An arc-shaped anti-detachment strip is installed on the workbench. The anti-detachment strip is fitted to the circumferential surface of the work turntable, and the curvature of the anti-detachment strip is adapted to the curvature of the circumferential surface of the work turntable. The anti-detachment strip is located between the upstream and downstream sides of the work turntable.

7. The automated reconstitution, dilution and supplementation device for vaccine lyophilized formulations according to claim 1, characterized in that, The bottle opening mechanism includes a first bracket mounted on a workbench and an electric gripper that is vertically mounted on the first bracket.

8. The automated reconstitution, dilution and supplementation device for vaccine lyophilisates according to claim 7, characterized in that A flow guide ramp is installed on the workbench, with the upper end of the flow guide ramp positioned below the electric gripper. A first collection bucket is installed below the workbench, and the lower end of the flow guide ramp is positioned above the opening of the first collection bucket.

9. The automated reconstitution, dilution, and replenishment device for freeze-dried vaccine formulations according to claim 1, characterized in that, The robotic arm includes a rotary table rotatably mounted on the worktable, a third motor for driving the rotary table, a second bracket mounted on the rotary table, a horizontal linear module mounted on the second bracket, and a vertical linear module mounted on a slide of the horizontal linear module. The electric aspirator is mounted on the slide of the vertical linear module.

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