METHOD FOR MS / MS MASS SPECTROMETRY
Patent Information
- Application Number
- DE602013086624
- Authority / Receiving Office
- DE · DE
- Patent Type
- Patents
- Current Assignee / Owner
- Priority Date
- 2012-10-16
- Filing Date
- 2013-05-16
- Publication Date
- 2025-03-26
- Estimated Expiration
- 2033-05-16
AI Technical Summary
Existing atmospheric pressure Electron Capture Dissociation (AP-ECD) mass spectrometers face challenges in associating parent ions with their fragment ions due to the high-pressure environment, leading to complex spectra and limited analytical utility, especially when analyzing mixtures.
The method involves performing ECD and/or ETD reactions at atmospheric pressure, using an RF ion guide or ion trap to interact electrons or reagent anions with parent ions, and continuously associating fragment ions with their parent ions through simultaneous mass analysis, leveraging liquid chromatography or ion mobility separation to correlate elution or drift times.
This approach enables effective fragmentation and association of parent ions with their fragment ions, simplifying data processing and improving the analytical utility of AP-ECD mass spectrometry by correlating ions based on their elution or drift times, enhancing the identification of biomolecules and disulphide linked species.