Delivery system comprising lipid or polymeric nanoparticles comprising thyroid hormones
EP4746923A2Pending Publication Date: 2026-05-27FONDAZIONE RICCARDO TERZI E SILVIO ALBINI +2
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Patent Information
- Authority / Receiving Office
- EP · EP
- Patent Type
- Applications
- Current Assignee / Owner
- FONDAZIONE RICCARDO TERZI E SILVIO ALBINI
- Filing Date
- 2024-07-18
- Publication Date
- 2026-05-27
AI Technical Summary
Technical Problem
Current treatments for diabetic cardiomyopathy and diabetic nephropathy lack effective methods to selectively deliver thyroid hormones to stressed cells, leading to adverse effects from high doses and inadequate targeting.
Method used
A delivery system comprising lipid or polymeric nanoparticles loaded with thyroid hormones, specifically targeting the TRPC6 receptor overexpressed in stressed podocytes and cardiomyocytes, to minimize systemic distribution and reduce toxicity.
Benefits of technology
The nanoparticle-based delivery system effectively increases intracellular T3 levels in targeted cells, enhancing their repairing and regenerating abilities while minimizing adverse effects, thereby treating diabetic cardiomyopathy and nephropathy effectively.
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Smart Images
Figure IB2024000416_23012025_PF_FP_ABST
Abstract
The present invention relates to a delivery system of thyroid hormones comprising lipid or polymeric nanoparticles, preferably comprising a targeting agent for the TRCP6 receptor. Such a delivery system can be used in the treatment of diabetic cardiomyopathy or diabetic nephropathy.
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