Methods and Compositions Related to Adenosine Receptors
JP2024504384A5Active Publication Date: 2025-03-18TWIST BIOSCIENCE CORP
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Patent Information
- Application Number
- JP2023544418
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2021-09-16
- Filing Date
- 2022-01-20
- Publication Date
- 2025-03-18
- Estimated Expiration
- 2042-01-20
AI Technical Summary
Technical Problem
The low expression and instability of G protein-coupled receptors (GPCRs), such as adenosine receptors, during purification make it difficult to generate effective antibodies for therapeutic intervention.
Method used
Development of antibodies or antibody fragments with specific sequences that bind to adenosine 2A receptors with high affinity, including monoclonal, polyclonal, and humanized antibodies, designed to activate T cells and enhance therapeutic targeting.
Benefits of technology
The antibodies achieve high binding affinity and low dissociation constants, effectively activating T cells and providing a basis for therapeutic interventions targeting adenosine receptors.
✦ Generated by Eureka AI based on patent content.
Abstract
Provided herein are methods and compositions relating to an adenosine A2A receptor library having nucleic acids encoding scaffolds comprising adenosine A2A binding domains. The adenosine A2A receptor library described herein encodes immunoglobulins such as antibodies.
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