Method for diagnosing and / or treating acute or chronic liver disease, kidney disease or lung disease

JP2025037865A5Inactive Publication Date: 2025-10-08ASSOC CENT DE INVESTIGACION COOP & NANOCIENCIAS CIC NANOGUNE
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Patent Information

Application Number
JP2024191758
Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
Priority Date
2018-11-26
Filing Date
2024-10-31
Publication Date
2025-10-08
Estimated Expiration
Not applicable · inactive patent

AI Technical Summary

Technical Problem

The prior art is difficult to effectively diagnose and treat chronic or acute diseases of the liver, kidney and lung, especially in the early stages of the disease, with a lack of sensitive markers and effective treatments.

Method used

CNNM4 is used as a disease marker to treat these diseases by inhibiting the activity of CNNM4. Specific methods include the diagnosis of liver, renal and lung diseases using CNNM4 inhibitors and determination of CNNM4 expression levels by in vivo diagnostic methods.

Benefits of technology

CNNM4 was found to be overexpressed in a variety of human samples and animal models, and inhibiting CNNM4 could reduce the levels of disease markers, providing new methods for the treatment and diagnosis of liver, renal and lung diseases.

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Abstract

To provide a method for diagnosing and treating an acute disease or a chronic disease.SOLUTION: Provided are a CNNM4 inhibitor to be used in treatment of an acute liver disease or chronic liver disease, kidney disease and / or lung disease in a subject, and a pharmaceutical composition containing a therapeutically effective amount of CNNM4 inhibitor and a pharmaceutically acceptable filler or carrier. Furthermore, a method for diagnosing a liver disease, kidney disease or lung disease in a subject, and a method of identifying a potentially useful compound in order to alleviate CNNM4-mediated disease or pathosis induced in a cell are provided.SELECTED DRAWING: None
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