T cell recruiting polypeptides based on CD3 reactivity
Multispecific polypeptides with high affinity for CD3 and target antigens address manufacturing and stability issues of existing bispecific antibodies, achieving robust T cell activation and cytotoxic activity against target cells.
JP2025186357APending Publication Date: 2025-12-23ABLYNX NV
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Patent Information
- Application Number
- JP2025151363
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2015-05-13
- Filing Date
- 2025-09-11
- Publication Date
- 2025-12-23
AI Technical Summary
Technical Problem
Current bispecific antibody formats for recruiting cytotoxic T cells to tumor sites face manufacturing challenges, stability issues, and clinical efficacy limitations, particularly in smaller formats like BiTE molecules and DARTs, which lack stability and require continuous infusion.
Method used
Development of multispecific polypeptides with high affinity for CD3 on T cells and a target antigen, independent of MHC recognition, to activate cytotoxic T cell activity against target cells.
Benefits of technology
The multispecific polypeptides effectively activate T cells to induce cytotoxic activity against target cells, achieving significant inhibition, up to 100% in some cases, and overcoming the limitations of existing bispecific antibody formats.
✦ Generated by Eureka AI based on patent content.
Abstract
To provide T cell recruiting polypeptides binding CD3 on a T cell, which can be used in methods for treating cancers.SOLUTION: Provided is a polypeptide comprising a first and a second immunoglobulin single variable domain (ISV), the first ISV having high affinity for / binding to cluster of differentiation 3 (CD3) present on a T cell, the second ISV having high affinity for / binding to a first antigen on a target cell, the first antigen being different from the CD3, and the target cell being different from the T cell.SELECTED DRAWING: None
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