Method for producing bubbles having a polymer shell using acoustic waves to generate bubbles - Patents.com
Micro bubbles with polyimide shells are generated and formed through sonic wave technology, which solves the problem of long generation time and uneven shapes of micro bubbles in the prior art, and achieves higher stability and reduced immune reactivity.
JP2025507631APending Publication Date: 2025-03-21INST NAT DE LA SANTE & DE LA RECHERCHE MEDICALE (INSERM) +2
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Patent Information
- Application Number
- JP2024549526
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- Filing Date
- 2022-02-21
- Publication Date
- 2025-03-21
AI Technical Summary
Technical Problem
The prior art is difficult to produce uniformly shaped, more spherical polyimide microbubbles in a short time, which are inadequate in stability and immunoreactivity in biomedical applications.
Method used
By applying acoustic wave technology to generate bubbles, and the pH value and sound wave duration are controlled when contacting the polyimide monomer to form micro bubbles of polyimide shells.
Benefits of technology
The rapid generation of polyimide microbubbles is achieved, with more uniform shape and spherical shape, and has higher stability and reduced immune response in biomedical applications.
✦ Generated by Eureka AI based on patent content.
Abstract
The present invention relates to an improved method for producing bubbles with a polycyanoacrylate shell using sonication to generate the bubbles. It has been found that application of sonication for at least 6 minutes in combination with a specific pH selection is critical to produce stable bubbles in high yield. The bubbles produced by the method of the present invention have improved sphericity and are obtained in a shorter time compared to bubbles obtained by the prior art methods. Using the method of the present invention, the bubbles can be functionalized with fluorescent probes or with polysaccharides, giving them targeting properties. Such bubbles can be used as contrast agents for ultrasound imaging or for sonothrombolysis.
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