Oral mucosal treatment system including an adhesive layer
By adopting a multi-layer membrane structure in the oral mucosal treatment system, combining water-insoluble and water-soluble polymers, and adding binders, the problems of uneven drug release and drug entry into the gastrointestinal tract are solved, and long-term stable release and efficient drug delivery are achieved.
Patent Information
- Application Number
- JP2024553768
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2022-03-11
- Filing Date
- 2023-03-08
- Publication Date
- 2025-03-21
AI Technical Summary
When the existing oral mucosal treatment system remains in the oral cavity for a long time, the adhesion between the backing layer and the agent layer is not firm enough, resulting in uneven drug release and it is difficult to avoid drug entering the gastrointestinal tract through saliva, resulting in reduced efficiency.
A multilayer film structure containing polymer is adopted, wherein the backing layer consists of a water-insoluble polymer, the agent layer contains a water-soluble polymer, and an adhesive is added to the intermediate layer to enhance interlayer adhesion.
It achieves a long-term stable release of drugs on the oral mucosa, reduces the risk of drugs entering the gastrointestinal tract through saliva, and improves the bioaccessibility and efficacy of drugs.