Compositions and therapeutic methods using glutathione

Abstract

This invention provides compositions and therapeutic methods using glutathione. [Solution] A topical composition comprising a nano-sized L-glutathione and cyclodextrin complex in a glutathione to ascorbic acid weight ratio of 7:1 to 15:1 and 1:1 to 1:15, and further compounds including ascorbic acid and dexpanthenol, thiamine, benzalkonium chloride, sodium hyaluronate or acetyl-L-cysteine, wherein the composition is administered topically to treat symptoms of viral infections including COVID-19 and influenza, as well as to treat herpes simplex, herpes zoster, postherpetic neuralgia, genital herpes, alcohol detoxification, high triglycerides, age spots or melasma and lupus.

Claims

1. Reduced, nano-sized L-glutathione that is non-esterified, non-acetylated, and non-fatty acid bound; Gamma cyclodextrin; Ascorbic acid; and One or more compounds selected from the group consisting of dexpanthenol, thiamine, benzalkonium chloride, sodium hyaluronate, and acetyl-L-cysteine; Includes, Here, the weight ratio of glutathione to ascorbic acid is between approximately 7:1 and 15:1, in a topical composition.

2. The composition according to claim 1, wherein the weight ratio is approximately 7:

1.

3. The composition according to claim 1, wherein the weight ratio is 10:

1.

4. The composition according to claim 1, wherein the weight ratio is approximately 14:

1.

5. A method for treating the subject, comprising administering a topical composition onto a region of the subject's skin, wherein the composition is Reduced, nano-sized L-glutathione that is non-esterified, non-acetylated, and non-fatty acid bound; Gamma cyclodextrin; and Ascorbic acid; Including; Here, the weight ratio of glutathione to ascorbic acid is between approximately 7:1 and 15:1; and Herein, the composition is administered once to ten times per day.

6. The method according to claim 5, wherein the composition further comprises one or more of dexpanthenol, thiamine, benzalkonium chloride, sodium hyaluronate, and acetyl-L-cysteine.

7. The method according to claim 5 or 6, wherein approximately 0.15 ml of the composition per dose is administered to the skin.

8. The method according to claim 5 or 6, wherein approximately 0.5 ml of the composition per dose is administered to the skin.

9. The method according to claim 5 or 6, wherein approximately 1.25 ml of the composition per dose is administered to the skin.

10. The method according to any one of claims 5 to 9, wherein the composition is administered in a single dose.

11. The method according to any one of claims 5 to 9, wherein the composition is administered once a day.

12. The method according to any one of claims 5 to 9, wherein the composition is administered twice a day.

13. The method according to any one of claims 5 to 9, wherein the composition is administered every four hours.

14. The method according to any one of claims 5 to 13, wherein the administration period is 1 day.

15. The method according to any one of claims 5 to 13, wherein the administration period is 2 weeks.

16. The method according to any one of claims 5 to 13, wherein the administration period is 60 days.

17. The method according to any one of claims 5 to 13, wherein the administration period is 4 months.

18. The composition is applied to the skin at a rate of approximately 0.8 cm 2 The method according to any one of claims 5 to 17, wherein the surface area is administered.

19. The method according to any one of claims 5 to 17, wherein the composition is administered to a surface area of ​​skin of about 24 square inches.

20. The method according to any one of claims 5 to 17, wherein the composition is administered to a surface area of ​​skin of about 25 square inches.

21. The method according to any one of claims 5 to 20, wherein the patient is being treated for one or more of the following conditions: influenza, COVID-19, herpes simplex, herpes zoster, postherpetic neuralgia, genital herpes, alcohol detoxification, high triglycerides, age spots or melasma, and lupus.

22. Reduced, nano-sized L-glutathione that is non-esterified, non-acetylated, and non-fatty acid bound; Gamma cyclodextrin; Ascorbic acid; and One or more compounds selected from the group consisting of dexpanthenol, thiamine, benzalkonium chloride, sodium hyaluronate, acetyl-L-cysteine, and potassium sorbate; Includes, Here, the weight ratio of glutathione to ascorbic acid is between approximately 1:1 and 1:15 in this topical composition.

23. The composition according to claim 22, wherein the weight ratio is approximately 1:

10.

24. The composition according to claim 22, wherein the weight ratio is approximately 1:

5.

25. The composition according to claim 22, wherein the weight ratio is approximately 1:

2.

26. A method for treating the subject, comprising administering a topical composition onto a region of the subject's skin, wherein the composition is Reduced, nano-sized L-glutathione that is non-esterified, non-acetylated, and non-fatty acid bound; Gamma cyclodextrin; and Ascorbic acid; Including; Here, the weight ratio of glutathione to ascorbic acid is between approximately 1:1 and 1:15; and Herein, the composition is administered once to ten times per day.

27. The method according to claim 26, wherein the composition further comprises one or more of dexpanthenol, thiamine, benzalkonium chloride, sodium hyaluronate, acetyl-L-cysteine, and potassium sorbate.

28. The method according to claim 26 or 27, wherein approximately 0.15 ml of the composition per dose is administered to the skin.

29. The method according to claim 26 or 27, wherein approximately 0.5 ml of the composition per dose is administered to the skin.

30. The method according to claim 26 or 27, wherein approximately 1.25 ml of the composition per dose is administered to the skin.

31. The method according to any one of claims 26 to 30, wherein the composition is administered in a single dose.

32. The method according to any one of claims 26 to 30, wherein the composition is administered once a day.

33. The method according to any one of claims 26 to 30, wherein the composition is administered twice a day.

34. The method according to any one of claims 26 to 30, wherein the composition is administered every four hours.

35. The method according to any one of claims 26 to 34, wherein the administration period is 1 day.

36. The method according to any one of claims 26 to 34, wherein the administration period is two weeks.

37. The method according to any one of claims 26 to 34, wherein the administration period is 60 days.

38. The method according to any one of claims 26 to 34, wherein the administration period is 4 months.

39. The composition is applied to the skin at a rate of approximately 0.8 cm 2 The method according to any one of claims 26 to 38, wherein the surface area is administered.

40. The method according to any one of claims 26 to 38, wherein the composition is administered to a surface area of ​​skin of about 24 square inches.

41. The method according to any one of claims 26 to 38, wherein the composition is administered to a surface area of ​​skin of about 25 square inches.

Images