Nasal spray devices and nasal sprays

Abstract

To provide a nasal drip device which has a simple configuration without using a pump mechanism and allows a liquid medicine to be easily administered to the mucous membrane of the nasal cavity with one hand. [Solution] The nasal drip device 2A includes a flexible container body 4, a nozzle part 6, and a piercing member 24 attached to the nozzle part 6. The container body 4 includes a first container part 8 and a second container part 10. The second container part 10 contains stem cell supernatant K and is sealed with a second sealing member 12. After the second container part 10 is joined to the bottom side of the first container part 8, the first container part 8 contains physiological saline S and is sealed with a first sealing member 14. When the nozzle part 6 is fitted into the opening 8a, the piercing member 24 breaks through the first sealing member 14 and the second sealing member 12, and the first container part 8 and the second container part 10 communicate with each other, and the two liquids are mixed. The mixed liquid is discharged from the nozzle part 6 by pressing the first container part 8 with a finger.

Description

[Technical field]

[0001] The present invention relates to a nasal drop device for administering a liquid preparation such as a cosmetic essence to the mucous membrane of the nasal cavity, and a nasal drop preparation provided with the same. [Background technology]

[0002] In the field of beauty, therapies using stem cell culture supernatants containing cytokines and exosomes are being carried out with the aim of preventing and improving wrinkles and blemishes, promoting skin cell turnover and smoothing the skin surface, etc. Specifically, stem cell culture supernatants contained in vials are extracted with a syringe and mixed with saline or the like to be administered transdermally or by drip infusion.

[0003] When injecting (administering or ingesting) liquid preparations such as beauty serums or medicinal solutions (hereinafter referred to as "liquid preparations" or "nasal drops", etc.) into the body, it is believed that mucosal absorption is more efficient than transdermal administration or injection. In particular, if it were possible to easily administer liquid preparations to the mucous membranes of the nasal cavity, the efficiency of injecting the drug into the body would be very good.

[0004] It is also known that if a cosmetic solution is prepared in advance by mixing stem cell culture supernatant with physiological saline, etc., the functions of cytokines, etc. are lost over time, and so the stem cell culture supernatant is extracted with a syringe immediately before use and mixed with physiological saline, etc. However, mixing with a syringe immediately before use is very time-consuming and tedious.

[0005] In this regard, Patent Document 1 discloses a spray container that is dissolved when used, which contains a liquid drug and a solid drug separately and mixes them by a simple operation when used to produce a mixed drug solution. [Prior art documents] [Patent documents]

[0006] [Patent Document 1] Japanese Patent Application Publication No. 8-280807 Summary of the Invention [Problem to be solved by the invention]

[0007] The configuration described in Patent Document 1 suggests a nasal administration configuration that mixes two liquids with a simple operation without using a syringe, but it employs a pump mechanism similar to commonly known medicinal liquid sprays for hay fever, etc. For this reason, it is cumbersome to operate by pressing with both hands, and the configuration is inevitably complicated.

[0008] The present invention has been made in consideration of the above-mentioned points, and its object is to provide a nasal drop device which has a relatively simple configuration that does not employ a pump mechanism, yet can easily administer a liquid agent such as a cosmetic serum to the nasal mucosa with one hand. [Means for solving the problem]

[0009] In order to achieve the above-mentioned object, the nasal drip device (2A, 2B) of the present invention is characterized by comprising: a container body (4) formed of a flexible synthetic resin and capable of storing a first liquid agent (S) and a second liquid agent (K) of different types in a separated state in a first chamber and a second chamber, respectively; a mixing mechanism (20) that mixes the first liquid agent (S) in the first chamber and the second liquid agent (K) in the second chamber by a predetermined operation to generate a mixed liquid (M); and a nozzle portion (6) that is fitted and fixed to the opening (8a) side of the container body (4) and sprays the mixed liquid (M) generated by the mixing mechanism (20).

[0010] According to the nasal drip device of the present invention, a first liquid agent and a second liquid agent of different types that are separately contained in one unit can be mixed without using an external device, so that a mixed liquid such as a fresh beauty essence that has been suppressed from deteriorating over time can be dispensed with one hand by utilizing the flexibility of the container body and administered to the nasal mucosa, improving usability. In addition, since a pump mechanism is not used, the configuration can be simplified and the manufacturing cost can be reduced.

[0011] In the above-mentioned nasal drip instrument (2A), the container body (4) may include a first container part (8) having an opening (8a) and a through hole (8c) on the side opposite the opening (8a), and a second container part (10) having one end open and joined to the side of the first container part (8) having the through hole (8c), a first chamber is defined in the first container part (8), a second chamber is defined in the second container part (10), the opening (8a) is sealed with a first sealing member (14), and one end of the second container part (10) is sealed with a second sealing member (12), and the mixing mechanism (20) may be fixed to the nozzle part (6) and include a piercing member (24) that pierces the first sealing member (14) and the second sealing member (12) as the nozzle part (6) is fitted. This allows the first container portion and the second container portion to be easily and reliably connected together by engaging the first sealing member with the second sealing member with the nozzle portion, making it possible to prepare a mixed liquid with a simple operation.

[0012] In the above-mentioned nasal drip instrument (2B), the container body (30) is provided with a first container part (36) having an opening (36a) and a through hole (36c) on the side opposite to the opening (36a), and a second container part (38) having one end open and joined to the side of the first container part (36) having the through hole (36c), the opening (36a) is sealed with a first sealing member (42), and one end of the second container part (38) is sealed with a first sealing member (42). The first side is sealed with a second sealing member (40), the nozzle portion (32) is provided with a protrusion (44) that breaks through the first sealing member (42) as the fitting operation is performed, and the mixing mechanism (34) may have a configuration in which the second sealing member (40) is peeled off by an increase in internal pressure caused by pressing either the first container portion (36) or the second container portion (38), thereby connecting the first container portion (36) and the second container portion (38). This can further facilitate the mixing operation.

[0013] In addition, in the above-mentioned nasal drip appliances (2A, 2B), the nozzle portion (6, 32) may have a bifurcated structure corresponding to both nostrils. This allows the serum to be administered to the mucous membranes of both nasal cavities at the same time, thereby further improving usability.

[0014] In the above-mentioned nasal drip appliance (2A, 2B), the nozzle portion (6, 32) may be configured to eject the mixed liquid (serum) in a direction intersecting with the extension direction of the nozzle. This allows the serum to be effectively administered to the mucous membrane of the nasal cavity from the entrance of the nostril.

[0015] In addition, in the above-mentioned nasal drip appliance (2A, 2B), the nozzle portion (6, 32) may be configured to be bendable and capable of maintaining the bent state. In this way, even if the amount of the mixed liquid is low, the nasal drip appliance can be turned upside down and used, so that the mixed liquid can be used up without being wasted.

[0016] The nasal drops of the present invention may be a nasal drop comprising the nasal drop device (2A, 2B) configured as described above, and a first liquid agent and a second liquid agent contained in the nasal drop device (2A, 2B), in which the first liquid agent is physiological saline (S) and the second liquid agent is stem cell supernatant (K). This allows a mixed liquid having a high cosmetic effect to be easily prepared and taken through the mucous membrane of the nasal cavity. Effect of the Invention

[0017] According to the present invention, the configuration can be simplified by not having a pump mechanism, and the device can be easily used with one hand, which can lead to expanded use in the beauty industry. [Brief description of the drawings]

[0018] [Figure 1] FIG. 1 is a front view of a nasal drip appliance according to a first embodiment of the present invention in a use state. [Diagram 2] FIG. 2 is an exploded cross-sectional view of the nasal drip appliance shown in FIG. 1. [Diagram 3] FIG. 3 is a schematic cross-sectional view taken along line X1-X1 in FIG. 2. [Figure 4] FIG. 2 is a diagram showing the shape of the main part of the nasal drop appliance shown in FIG. 1, where (a) is a bottom view of a first container part, and (b) is a top view of a second container part. [Diagram 5] FIG. 3 is a schematic cross-sectional view taken along line X2-X2 in FIG. 2. [Figure 6] 2 is a schematic cross-sectional view showing a state in which a first container portion and a second container portion of the nasal drip appliance shown in FIG. 1 are connected to each other. FIG. [Figure 7] 2 is a schematic cross-sectional view showing a method of using the nasal drip appliance shown in FIG. 1 when the amount of mixed liquid is low. FIG. [Figure 8] FIG. 11 is an exploded view showing a cross section of a nasal drip appliance according to a second embodiment. [Figure 9] FIG. 9 is a schematic cross-sectional view showing an integrated structure of a container body in the nasal drip appliance shown in FIG. 8 before use. [Figure 10] 10 is a schematic cross-sectional view showing a state in which the container body is turned upside down from the state shown in FIG. 9, the second container part is removed, and the auxiliary plug is substituted therefor. [Figure 11] FIG. 9 is a schematic cross-sectional view showing the nasal drip appliance shown in FIG. 8 in use. [Figure 12] 9 is a schematic cross-sectional view showing a method of using the nasal drip appliance shown in FIG. 8 when the amount of mixed liquid is low. [Figure 13] FIG. 11 is a schematic cross-sectional view showing a modified example of the nozzle portion. [Figure 14] FIG. 11 is a schematic cross-sectional view showing another modified example of the nozzle portion. [Figure 15] FIG. 11 is a schematic cross-sectional view showing still another modified example of the nozzle portion. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0019] Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings.

[0020] [First embodiment] As shown in FIG. 1, the nasal drip device 2A according to this embodiment is made of a flexible synthetic resin and includes a container body 4 in which the nasal drops and the liquid are stored separately, a nozzle part 6 that is fitted and fixed to the opening side of the container body 4, and a mixing mechanism that mixes the nasal drops and the liquid by a predetermined operation. The container body 4 includes a first container part 8 located at the upper side in the figure and a second container part 10 located at the lower side. A first chamber that contains a first liquid such as physiological saline S described later is defined in the first container part 8, and a second chamber that contains a second liquid such as stem cell supernatant K described later is defined in the second container part 10. The term "flexibility" here refers to the degree to which the device can be easily deformed by pinching it with fingers and can return to its original shape due to its elasticity.

[0021] As shown in FIG. 2, the first container part 8 has an opening 8a, and a through hole 8c on the bottom surface 8b opposite the opening 8a. A storage recess 8d for closely storing the second container part 10 is connected to the bottom surface 8b. A male screw 8e into which the nozzle part 6 fits is formed on the outer surface of the opening 8a. A through hole 10b similar to the through hole 8c is formed and opened on one end (upper end) 10a of the second container part 10, and the stem cell supernatant liquid K as a nasal drop is stored and sealed (sealed) by the second sealing member 12 so as not to deteriorate over time. As shown in FIG. 3, the first container part 8 has an elliptical cross section, and the pressure inside the first container part 8 can be easily increased by pinching and pressing both sides with fingers. The same is true for the second container part 10.

[0022] FIG. 4(a) shows the bottom surface of the first container part 8, and FIG. 4(b) shows the top surface of the second container part 10. As shown in FIG. 2, when the upper end of the second container part 10 containing the stem cell supernatant K is closely accommodated in the accommodation recess 8d of the first container part 8 and bonded to the flange-shaped bottom surface 8b, the bottom surface 8b of the first container part 8 is sealed with the second container part 10. That is, one end side (upper end side) of the second container part 10 is joined to the side having the through hole 8c of the first container part 8. As a result, the first container part 8 and the second container part 10 are completely partitioned. In this state, physiological saline S as the first liquid agent is accommodated in the first container part 8, and then the upper end of the opening 8a is sealed (sealed) with the first sealing member 14. Aluminum foil or the like can be used as the first sealing member 14 and the second sealing member 12.

[0023] As shown in FIG. 2, the nozzle section 6 has a cylindrical fitting section 16 with a closed top surface, and a nozzle body 18 with multiple small holes 18a at the tip. The nozzle body 18 is made of a bendable material and has a configuration that allows it to maintain a bent state (described later). Multiple small holes 16a that communicate with the nozzle body 18 are formed on the top surface of the fitting section 16, and a female screw 16b that screws into the male screw 8e of the opening 8a of the first container section 8 is formed on the inner circumference. The nozzle section 6 is provided with a mixing mechanism 20 that mixes the stem cell supernatant liquid K and the physiological saline solution S to generate a mixed liquid by fitting the nozzle section 6 to the opening 8a of the container body 4 (a predetermined operation).

[0024] The mixing mechanism 20 includes a screw cylinder 22 integrally formed in the center of the inner upper surface of the fitting portion 16, and a piercing member 24 fixed to the nozzle portion 6 and piercing the first sealing member 14 and the second sealing member 12 as the nozzle portion 6 is fitted. The piercing member 24 includes a rod 26 and a thrust arrow 28 formed at the lower end of the rod 26. A male screw 26a is formed at the upper end of the rod 26 for fixing to the screw cylinder 22, and the thrust arrow 28 has a configuration in which a plurality of isosceles triangular arrow piles 28a (four in this example) are fixed radially so that the lower end side is pointed, as shown in FIG.

[0025] When the nozzle part 6 is fitted into the opening 8a of the first container part 8 with the piercing member 24 fixed to the nozzle part 6, as shown in FIG. 6, the piercing arrow 28 of the piercing member 24 first breaks through the first sealing member 14 to communicate the first container part 8 with the nozzle part 6, and then breaks through the second sealing member 12. By breaking through the second sealing member 12, the first container part 8 and the second container part 10 communicate with each other, and the physiological saline solution S and the stem cell supernatant liquid K can be mixed. The length of the rod 26 is set so that the piercing arrow 28 stops midway through the thickness direction of the second sealing member 12 with the nozzle part 6 fitted into the opening 8a. If the container body 4 is shaken up and down in the state shown in FIG. 6, the first container part 8 and / or the second container part 10 are pinched, or the container body 4 is turned upside down, the mixing is promoted and a mixed liquid M is formed.

[0026] The shape of the thrust arrow 28 is not limited to the above, and may be, for example, a cylindrical shape with a pointed lower end and a plurality of liquid passage holes formed inside the cylinder that pass through in the vertical direction.

[0027] In the state of the posture shown in FIG. 6, when the tip of the nozzle body 18 is inserted into the nostril or brought close to the nostril, and the first container part 8 or the second container part 10 is pinched with the fingers to increase the internal pressure, the mixed liquid M rises and is discharged in the form of mist or droplets from the tip of the nozzle body 18, and is administered to the mucous membrane in the nasal cavity. In this embodiment, the material deformability of the container body 4 is used to replace part of the pump function. This allows the mixed liquid M to be easily administered to the mucous membrane of the nasal cavity with one hand like eye drops, and the usability can be greatly improved compared to conventional nasal drip devices. In addition, the stem cell supernatant liquid K is opened immediately before use and mixed with the physiological saline solution S, so that deterioration over time and loss of functions such as cytokines can be avoided, and the reduction in the beauty effect can be effectively suppressed.

[0028] Since the device does not have a pump mechanism, i.e., does not have a suction function, when the amount of the mixed liquid M decreases, it cannot be pushed out by just pinching the first container part 8 or the second container part 10. In order to solve this problem, the nozzle body 18 is made flexible as described above. When the amount of the mixed liquid M decreases, as shown in FIG. 7, the nozzle body 18 is bent and the nasal drip device 2A is used in an upside-down state. In this way, the administration operation can still be performed with one hand, and the mixed liquid M can be used up to the last. By appropriately bending the nozzle body 18, the nozzle body 18 can be inserted or brought close to the nostril without any hindrance without the container body 4 side touching the face. A bellows structure may be adopted as the bending structure of the nozzle body 18.

[0029] [Second embodiment] The second embodiment will be described with reference to Figures 8 to 12. The same parts as those in the first embodiment or parts that can be considered to be the same are indicated by the same reference numerals, and the explanations of the configurations and functions already given will be omitted as appropriate.

[0030] As shown in Fig. 8, the nasal drip appliance 2B according to this embodiment is made of a flexible synthetic resin and includes a container body 30 in which a first liquid agent and a second liquid agent are stored separately, a nozzle portion 32 that is fitted and fixed to the opening side of the container body 30, and a mixing mechanism 34 that mixes the first liquid agent and the second liquid agent by a predetermined operation to generate a mixed liquid. Fig. 8 shows the container body 30 in a state before being unitized.

[0031] The container body 30 includes a first container part 36 having an opening 36a and a through hole 36c as a screw hole in a thick bottom surface 36b opposite to the opening 36a, and a second container part 38 having one end opened and joined to the side of the first container part 36 having the through hole 36c. A male screw 36d into which the nozzle part 32 fits is formed on the outer surface of the opening 36a. An opening 38a is formed on one end of the second container part 38, and a male screw 38b that screws into the through hole 36c is formed on the outer surface of the opening 38a. The second container part 38 is joined to the first container part 36 in an airtight state by screwing the opening 38a into the through hole 36c. The second container part 38 contains a stem cell supernatant liquid K as a second liquid agent from the opening 38a, and one end side is sealed with a second sealing member 40.

[0032] The second container part 38, the upper end of the opening 38a of which is sealed with the second sealing member 40, is joined (screwed) to the first container part 36, whereby the first container part 36 and the second container part 38 are completely partitioned. In this state, physiological saline solution S is contained as the first liquid agent in the first container part 36, and then the upper end of the opening 36a is sealed with the first sealing member 42. As the first sealing member 42 and the second sealing member 40, aluminum foil or the like can be used.

[0033] A cylindrical protrusion 44 is provided at the center of the upper end of the fitting portion 16 of the nozzle part 32, which breaks through the first sealing member 42 as the fitting operation proceeds. The protrusion 44 has a shape in which the lower end is cut obliquely, and its inner hole 44a communicates with the nozzle body 18. In this embodiment, no small hole 16a is formed in the upper surface of the fitting portion 16.

[0034] The mixing mechanism 34 has a configuration in which the second sealing member 40 is peeled off or broken by the internal pressure increase caused by pressing the second container part 38, and the first container part 36 and the second container part 38 are connected. That is, the mixing mechanism 34 is equipped with the second container part 38 and the second sealing member 40 that can be pinched and deformed. When the second sealing member 40 is peeled off or broken, as shown in FIG. 9, the stem cell supernatant liquid K contained in the second container part 38 flows into the first container part 36 and is mixed with the physiological saline solution S contained in the first container part 36. Thereafter, as shown in FIG. 10, the container body 30 is turned upside down to remove the second container part 38, and the auxiliary plug 46 is screwed into the through hole 36c to close it. Of course, the second container part 38 may be left as it is without being removed, but by replacing it with the auxiliary plug 46, the shape of the container in use thereafter becomes compact and not bulky.

[0035] As shown in FIG. 11, when the nozzle part 32 is fitted (screwed) into the opening 36a of the first container part 36 containing the mixed liquid M, the projection 44 breaks through the first sealing member 42 with the fitting operation, and the first container part 36 and the nozzle part 32 communicate with each other. In the state shown in FIG. 11, when the tip of the nozzle body 18 is inserted into the nostril and the first container part 36 is pinched with the fingers to increase the internal pressure, the mixed liquid M rises and is discharged from the tip of the nozzle body 18 and administered to the mucous membrane in the nasal cavity. When the amount of the mixed liquid M decreases, as shown in FIG. 12, the nozzle body 18 is bent as in the first embodiment to use the nasal drip tool 2B in an upside-down state. In this embodiment, the second container part 38 is pinched to peel off or destroy the second sealing member 40, but the first container part 36 may be pinched to peel off or destroy the second sealing member 40. In this case, the adhesive strength of the first sealing member 42 is set to be greater than the adhesive strength of the second sealing member 40.

[0036] FIG. 13 shows a modified nozzle section 32. The tip of the nozzle body 18A of the nozzle section 32 has a bifurcated structure corresponding to both nostrils. That is, the tip of the nozzle body 18A is divided into two branches 18b and 18c, and each of the tips 18b and 18c has a small hole 18a. In this way, the mixed liquid M can be simultaneously administered to the mucous membranes of both nasal cavities, and the efficiency of use can be improved. The same can be implemented in the nozzle section 6 of the first embodiment. Also, a bifurcated structure and a single structure nozzle section 32 may be prepared in advance, and they may be selectively replaced.

[0037] FIG. 14 shows another modified example of the nozzle part 32. The nozzle body 18B of the nozzle part 32 has a configuration for ejecting the mixed liquid M in a direction intersecting (orthogonal) with the extension direction of the nozzle. That is, the fine holes 18a are formed on both sides, not at the tip. In this way, the mixed liquid M can be effectively administered to the mucous membrane of the nasal cavity from the entrance of the nostril. This can also be implemented in the nozzle part 6 of the first embodiment. In this example, the nozzle part 32 of the tip ejection type and the side ejection type may be prepared in a set and selectively replaced.

[0038] FIG. 15 shows yet another modified example of the nozzle part 32. The tip of the nozzle body 18B of the nozzle part 32 may be spherical as shown in FIG. 15, and multiple fine holes 18a may be provided radially in the upper half of the tip. If the nozzle body 18B in the embodiment shown in FIG. 15 is adopted, the tip (spherical part) of the nozzle body 18B is placed directly under the entrance of the nasal cavity, and the mixed liquid M is discharged in this state, so that the mixed liquid M discharged upward from the multiple fine holes 18a is administered to the mucous membrane in the nasal cavity. This makes it possible to administer the mixed liquid M to the mucous membrane in the nasal cavity without inserting the tip of the nozzle body 18B into the nasal cavity.

[0039] As described above, in each embodiment, the deformation function of the container body made of a flexible synthetic resin replaces part of the pump function, which simplifies the configuration and reduces manufacturing costs, and allows the product to be easily used with one hand in the same way as eye drops, improving usability, which can contribute to expanding use in the beauty industry.

[0040] Although the embodiments of the present invention have been described above, the present invention is not limited to the above embodiments, and various modifications are possible within the scope of the claims and the technical ideas described in the specification and drawings. For example, in each of the above embodiments, a two-liquid mixing configuration in which two types of liquid agents are mixed is exemplified, but a configuration in which three or more types of liquid agents (liquids) are mixed is also possible.

[0041] In the above embodiment, the first liquid agent contained in the first chamber of the first container unit 8 is physiological saline solution S, and the second liquid agent contained in the second chamber of the second container unit 10 is stem cell supernatant solution K. However, the first liquid agent and the second liquid agent are not limited to these and may be other liquid agents. In other words, the mixed liquid and the liquid agent before the mixture administered to the mucous membrane of the nasal cavity or the like by the spot cosmetic device of the present invention may be a cosmetic liquid, a beauty serum, or a medicinal liquid such as a drug.

[0042] In the first embodiment, the second container unit 10 may contain a powdered agent. In this case, the mixing mechanism 20 can mix the powdered agent in the second container unit 10 with the liquid agent in the first container unit 8 and dissolve it in the liquid agent. In the above embodiments, the mucous membrane of the nasal cavity is the target of administration, but the ear canal or the like may also be the target of administration. [Explanation of symbols]

[0043] 2A, 2B Nasal drop device 4, 30 Container body 6, 32 Nozzle section 8, 36 First container part (first chamber) 8a, 36a opening 8c, 36c through hole 10, 38 Second container part (second chamber) 12, 40 Second sealing member 14, 42 First sealing member 20, 34 Mixing mechanism 24 Piercing member 44 Protrusion K Stem cell supernatant as nasal drops (second liquid) S. Physiological saline as the liquid agent (first liquid agent)

Claims

1. a container body formed of a flexible synthetic resin and capable of storing a first liquid agent and a second liquid agent which are different from each other in a separated state in a first chamber and a second chamber, respectively; a mixing mechanism for mixing the first liquid agent in the first chamber and the second liquid agent in the second chamber by a predetermined operation to generate a mixed liquid; a nozzle portion that is fitted and fixed to the opening side of the container body and sprays the mixed liquid generated by the mixing mechanism, the container body includes a first container portion having the opening and a through hole on the opposite side to the opening, and a second container portion having an open end and joined to the side of the first container portion having the through hole, the first chamber is defined within the first container portion, and the second chamber is defined within the second container portion; the opening is sealed with a first sealing member, The one end side of the second container portion is sealed with a second sealing member, A nasal drip device characterized in that the mixing mechanism is fixed to the nozzle portion and is equipped with a piercing member that pierces the first sealing member and the second sealing member in response to the fitting operation of the nozzle portion.

2. a container body formed of a flexible synthetic resin and capable of storing a first liquid agent and a second liquid agent which are different from each other in a separated state in a first chamber and a second chamber, respectively; a mixing mechanism for mixing the first liquid agent in the first chamber and the second liquid agent in the second chamber by a predetermined operation to generate a mixed liquid; a nozzle portion that is fitted and fixed to the opening side of the container body and sprays the mixed liquid generated by the mixing mechanism, the container body includes a first container portion having the opening and a through hole on the opposite side to the opening, and a second container portion having an open end and joined to the side of the first container portion having the through hole, the first chamber is defined within the first container portion, and the second chamber is defined within the second container portion; the opening is sealed with a first sealing member, The one end side of the second container portion is sealed with a second sealing member, The nozzle portion is provided with a protrusion that breaks through the first sealing member during a fitting operation, The mixing mechanism is configured such that an internal pressure increase caused by pressing either the first container portion or the second container portion causes the second sealing member to peel off, thereby connecting the first container portion and the second container portion.

3. 3. The nasal drip device according to claim 1, wherein the nozzle portion has a bifurcated structure corresponding to both nostrils.

4. 3. The nasal drip apparatus according to claim 1, wherein the nozzle portion is configured to eject the mixed liquid in a direction intersecting with an extension direction of the nozzle.

5. 3. The nasal drip apparatus according to claim 1, wherein the nozzle portion is bendable and can maintain the bent state.

6. A nasal drop comprising the nasal drop device according to claim 1 or 2, and the first liquid preparation and the second liquid preparation contained in the nasal drop device, A nasal drop, characterized in that the first liquid agent is physiological saline and the second liquid agent is stem cell supernatant.

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