Photooxygenation catalyst compound having a phenothiazine skeleton and medicine containing the same
JP7652425B2Active Publication Date: 2025-03-27THE UNIV OF TOKYO
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Patent Information
- Application Number
- JP2021571222
- Authority / Receiving Office
- JP · JP
- Patent Type
- Patents
- Current Assignee / Owner
- Priority Date
- 2020-01-14
- Filing Date
- 2021-01-14
- Publication Date
- 2025-03-27
- Estimated Expiration
- 2041-01-14
Abstract
[Problem] The present invention addresses the problem of developing a photocatalyst compound that is capable of efficiently oxygenating amyloids in a low aggregation state and at a low concentration and that could reduce cytotoxicity under light irradiation, and, furthermore, the purpose of the present invention is to provide a prophylactic / therapeutic agent for amyloid-related diseases employing said novel photocatalyst compound. [Solution] It has been shown that it is possible to selectively oxygenate amyloids by means of light irradiation while suppressing stacking of catalyst molecules on each other and reducing cytotoxicity as a result of employing a photocatalyst compound having a mother skeleton in which a phenothiazine structure and a morpholine structure are joined and in which a side chain having a specific structure is also introduced. In addition, it has been shown that said compound is capable of efficiently oxygenating amyloids in a low aggregation state and at a low concentration.
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