Pyrido[2,3-b][1,4]oxazines or tetrahydropyrido[2,3-b][1,4]oxazepines as IAP antagonists
JP7652794B2Active Publication Date: 2025-03-27BEIGENE SWITZERLAND GMBH
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Patent Information
- Application Number
- JP2022558442
- Authority / Receiving Office
- JP · JP
- Patent Type
- Patents
- Current Assignee / Owner
- Priority Date
- 2020-12-08
- Filing Date
- 2021-06-03
- Publication Date
- 2025-03-27
- Estimated Expiration
- 2041-06-03
Abstract
Disclosed herein are novel 2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine or 1,2,3,4-tetrahydropyrido[2,3-b][1,4]oxazepine derivatives for use as antagonists of IAPs (inhibitor of apoptosis proteins), also known as Smac mimetics. Also disclosed herein are the use of these antagonists to induce or sensitize cells to induction of apoptotic cell death, and the use of such compounds to treat proliferative diseases such as cancer. [Formula 1] JPEG2023527505000739.jpg84165
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