New stable aromatic boronic esters
A novel aromatic boronic acid ester addresses stability and isolation issues, enabling effective purification and reactivity for Suzuki-Miyaura coupling and functional group transformations, enhancing its applicability in pharmaceutical and functional material synthesis.
Patent Information
- Application Number
- JP2023503795
- Authority / Receiving Office
- JP · JP
- Patent Type
- Patents
- Current Assignee / Owner
- Priority Date
- 2021-03-01
- Filing Date
- 2022-02-28
- Publication Date
- 2025-10-03
- Estimated Expiration
- 2042-02-28
AI Technical Summary
Aromatic boronic acid derivatives face issues such as instability during silica gel chromatography, low yields in isolation and purification, and difficulty in functional group transformations, which hinder their application in various reactions.
Development of a novel aromatic boronic acid ester represented by formula (I) that is stable during silica gel chromatography, allowing easy isolation and purification, and exhibits reactivity similar to aromatic boronic acid pinacol esters in Suzuki-Miyaura coupling reactions and functional group transformations.
The novel aromatic boronic acid ester maintains stability during chromatography, facilitates easy isolation and purification, and demonstrates reactivity suitable for Suzuki-Miyaura coupling and functional group conversions, making it useful for pharmaceutical and functional material synthesis.