eye drop container

Abstract

This eye drop container (30) has a storage section (31) for storing eye drops, and the storage section (31) is made of a laminate having a layer containing a cyclic olefin copolymer and a layer containing a polyethylene resin provided outside the layer containing the cyclic olefin copolymer. The thickness of the layer containing the cyclic olefin copolymer is 50 to 1000 μm, and the thickness of the laminate is 300 to 2000 μm. This container can suppress sorption (adsorption, absorption) of eye drops, improve moisture resistance to suppress evaporation, and further reduce squeeze strength.

Description

[Technical Field]

[0001] The present invention relates to an eye drop container. This application claims priority based on Japanese Patent Application No. 2018-230193, filed on December 7, 2018, the contents of which are incorporated herein by reference. [Background technology]

[0002] Conventionally, containers made of resins such as polyethylene (PE), polypropylene (PP), and polyethylene terephthalate (PET) have been widely used as eye drop containers for containing eye drops. A typical eye drop container includes an eye drop container and a nozzle protruding from the container, and is configured so that the eye drops can be dispensed from the eye drop container by pointing the nozzle toward the eye and pressing the container with a finger.

[0003] On the other hand, in packaging containers such as packaging bags, cyclic olefin copolymers are known as resins that have excellent non-adsorption properties for content components (see, for example, Patent Documents 1 and 2). [Prior art documents] [Patent documents]

[0004] [Patent Document 1] International Publication No. 2003 / 043895 [Patent Document 2] International Publication No. 2004 / 080370 Summary of the Invention [Problem to be solved by the invention]

[0005] To prevent sorption (adsorption or absorption) of eye drops in the container, it is necessary to use a material that does not easily sorb the active ingredients of the eye drops. However, according to the studies of the present inventors, when a cyclic olefin copolymer is used in an eye drop container as a resin with excellent non-adsorption properties for the contents, a problem arises in that the squeeze strength required to press the container when administering eye drops is large because the cyclic olefin copolymer is harder than the above-mentioned resins such as PE, PP, and PET.

[0006] The present invention has been made in view of the above circumstances, and an object of the present invention is to provide an eye drop container that can suppress sorption (adsorption, absorption) of eye drops, improve moisture resistance to suppress evaporation, and further reduce squeeze strength. [Means for solving the problem]

[0007] In order to solve the above-mentioned problems, one aspect of the present invention is an eye drop container having a storage section for storing eye drops, wherein the storage section is made of a laminate having a layer containing a cyclic olefin copolymer and a layer containing a polyethylene resin provided outside the layer containing the cyclic olefin copolymer, and the layer containing the cyclic olefin copolymer has a thickness of 50 to 1000 μm, and the laminate has a thickness of 300 to 2000 μm.

[0008] The layer containing the cyclic olefin copolymer may constitute the innermost layer of the housing portion. The housing portion may have an innermost layer containing the polyethylene resin inside the layer containing the cyclic olefin copolymer. The innermost layer containing the polyethylene resin may have a thickness of 500 μm or less. The eye drop container may have a nozzle portion for injecting the eye drop contained in the container portion. The layer containing a cyclic olefin copolymer may contain at least one of COP (a copolymer of different cyclic olefins) and COC (a copolymer of a cyclic olefin and a non-cyclic olefin). [Effects of the Invention]

[0009] According to the eye drop container of the above embodiment, by laminating a layer containing a polyethylene resin on the outside of a layer containing a cyclic olefin copolymer (copolymer) having excellent non-sorption properties, it is possible to suppress sorption (adsorption, absorption) of the eye drop, improve moisture resistance to suppress evaporation, and further reduce the squeeze strength and improve squeezability. [Brief explanation of the drawings]

[0010] [Figure 1] FIG. 2 is a cross-sectional view showing the laminate of the first embodiment. [Figure 2] FIG. 4 is a cross-sectional view showing a laminate of a second embodiment. [Figure 3] FIG. 2 is a schematic diagram illustrating an example of an eye drop container. DETAILED DESCRIPTION OF THE INVENTION

[0011] The present invention will be described below based on preferred embodiments. The eye drop container of this embodiment has a storage section for storing eye drops, and the storage section is composed of a laminate having a layer containing a cyclic olefin copolymer. Furthermore, the laminate constituting the storage section has a layer containing a polyethylene resin at least outside the layer containing the cyclic olefin copolymer.

[0012] FIG. 1 shows a laminate of a container according to a first embodiment. This laminate 10 has a moisture-proof innermost layer 11 and an outer layer 12. The innermost layer 11 is composed of a layer containing a cyclic olefin copolymer. The outer layer 12 is composed of a layer containing a polyethylene resin. The innermost layer 11 has an inner surface that can come into contact with the eye drops. The outer layer 12 may be the outermost layer of the laminate 10 (the layer that comes into contact with the outside air). The laminate 10 may have another layer outside the outer layer 12.

[0013] FIG. 2 shows a laminate of a container according to a second embodiment. This laminate 20 has an innermost layer 21, a moisture-proof intermediate layer 22, and an outer layer 23. The intermediate layer 22 is composed of a layer containing a cyclic olefin copolymer. The outer layer 23 is composed of a layer containing a polyethylene resin. The innermost layer 21 has an inner surface that can come into contact with the eye drops. The outer layer 23 may be the outermost layer of the laminate 20. The laminate 20 may have other layers outside the outer layer 23.

[0014] In the first or second embodiment, the laminate 10, 20 has a layer containing a cyclic olefin copolymer as a resin with excellent non-sorption (non-adsorption) and moisture-proof properties. The layer containing the cyclic olefin copolymer is the innermost layer 11 in the first embodiment, and the intermediate layer 22 in the second embodiment. The thickness of the innermost layer 11 or the intermediate layer 22 is preferably in the range of 50 to 1000 μm, more preferably in the range of 100 to 400 μm. Examples of cyclic olefin copolymers include COP (copolymers of different cyclic olefins) and COC (copolymers of cyclic olefins and acyclic olefins). This allows the contents to be sorbed into the laminate 10, 20, improves moisture resistance through the laminate 10, 20, and suppresses evaporation. By suppressing evaporation through the laminate 10, 20, moisture-induced deterioration or concentration changes of the active ingredient are suppressed, thereby extending the shelf life of the eye drops. The thickness of the layer containing the cyclic olefin copolymer may be, for example, 50 μm, 100 μm, 150 μm, 200 μm, 300 μm, 350 μm, 400 μm, 450 μm, 500 μm, 600 μm, 750 μm, or 1000 μm, or may be within a range (greater than or equal to A and less than or equal to B) with two numerical values ​​A and B selected from the above group of numerical values ​​as the lower and upper limits.

[0015] Examples of COP (copolymer of different cyclic olefins) include copolymers of two or more types of cyclic olefins, or hydrogenated products thereof. COP (copolymer of different cyclic olefins) is preferably an amorphous polymer, more preferably a ring-opening polymer of a cyclic olefin obtained by metathesis or the like, or a hydrogenated product thereof. COP (copolymer of different cyclic olefins) contains a higher proportion of alicyclic structures than COC (copolymer of a cyclic olefin and an acyclic olefin) and has excellent non-sorption (non-adsorption) properties.

[0016] Examples of COC (copolymer of cyclic olefin and acyclic olefin) include copolymers of at least one kind of cyclic olefin and at least one kind of acyclic olefin, or hydrogenated products thereof. COC (copolymer of cyclic olefin and acyclic olefin) is preferably an amorphous polymer, and more preferably a copolymer of cyclic olefin and ethylene, or hydrogenated products thereof.

[0017] The cyclic olefin used as a constituent monomer of the cyclic olefin copolymer is an unsaturated hydrocarbon (olefin) having at least one ring structure, such as at least one of vinylcycloalkanes having a cycloalkane of 3 to 20 carbon atoms and derivatives thereof, monocycloalkenes having 3 to 20 carbon atoms and derivatives thereof, and cyclic olefins having a norbornene skeleton (norbornene-based monomers).

[0018] Examples of norbornene-based monomers include bicyclo[2.2.1]-2-heptene (norbornene) and its derivatives. Examples of norbornene derivatives include compounds having a substituent such as an alkyl group, compounds having two or more unsaturated bonds such as norbornadiene, and compounds having three or more ring structures, two of which constitute a norbornene skeleton. Examples of norbornene-based monomers having three or more ring structures include tricyclo[5.2.1.0]-2-heptene (norbornene). 2,6]decene (dihydrodicyclopentadiene), compounds in which one or more molecules of cyclopentadiene are added to norbornene or dihydrodicyclopentadiene by the Diels-Alder reaction (e.g., tetracyclododecene, pentacyclopentadecene, hexacycloheptadecene, etc.), hydrogenated products of these, isomers with different double bond positions, alkyl-substituted products, etc.

[0019] Examples of acyclic olefins used as constituent monomers of COC (copolymers of cyclic olefins and acyclic olefins) include α-olefins such as ethylene, propylene, 1-butene, 1-pentene, 1-hexene, 1-heptene, and 1-octene, and alkenes such as 3-decene and 3-dodecene.

[0020] The resin component constituting the moisture-proof innermost layer 11 or intermediate layer 22 may be at least one type of cyclic olefin copolymer, or may be a mixture of a cyclic olefin copolymer with other resins. The proportion of the cyclic olefin copolymer in the innermost layer 11 or intermediate layer 22 is, for example, 50 to 100% by weight. Examples of other resins that can be blended into the moisture-proof innermost layer 11 or intermediate layer 22 include polyolefin resins such as polyethylene resins, and thermoplastic elastomers such as styrene-based elastomers.

[0021] In the first or second embodiment, the outer layer 12, 23 is composed of a layer containing a polyethylene resin. This reduces the squeeze strength of a laminate having a layer containing a cyclic olefin copolymer, improving squeezability. The thickness of the outer layer 12, 23 may be, for example, 150 μm, 200 μm, 300 μm, 350 μm, 400 μm, 450 μm, 500 μm, 600 μm, 750 μm, 1000 μm, 1200 μm, or 1400 μm, or may be within a range (greater than or equal to A and less than or equal to B) with two numerical values ​​A and B selected from the above numerical group as the lower and upper limits. The thickness range of the outer layer 12 of the laminate 10 may be different from the thickness range of the outer layer 23 of the laminate 20.

[0022] Examples of polyethylene resins that can be used to form the outer layers 12, 23 include ethylene homopolymers, linear low-density polyethylene (C4-LLDPE) copolymerized with ethylene and an α-olefin having four carbon atoms (1-butene, etc.), linear low-density polyethylene (C6-LLDPE) copolymerized with ethylene and an α-olefin having six carbon atoms (1-hexene, etc.), linear low-density polyethylene (C8-LLDPE) copolymerized with ethylene and an α-olefin having eight carbon atoms (1-octene, etc.), ethylene-vinyl acetate copolymer (EVA), and ethylene-vinyl alcohol copolymer (EVOH).

[0023] The resin component constituting the outer layers 12, 23 may be at least one type of polyethylene resin alone, or may be a mixture of polyethylene resin with other resins, etc. The proportion of polyethylene resin in the outer layers 12, 23 is, for example, 50 to 100% by weight. Other resins that can be blended into the outer layers 12, 23 include polyolefin resins such as polypropylene resin, and thermoplastic elastomers such as styrene-based elastomers.

[0024] Another layer may be provided between the innermost layer 11 and the outer layer 12 in the first embodiment, and between the intermediate layer 22 and the outer layer 23 in the second embodiment. If there is no problem with the adhesion between the resin layers, the innermost layer 11 or the intermediate layer 22 may be laminated so as to be in direct contact with the outer layers 12, 23. When another layer is interposed between the innermost layer 11 or the intermediate layer 22 and the outer layers 12, 23, the thickness thereof is preferably, for example, 150 μm or less.

[0025] In the second embodiment, the innermost layer 21 may be a layer that does not contain a cyclic olefin copolymer and may be a layer that contains a thermoplastic resin such as a polyethylene resin or a polyester resin. When the innermost layer 21 is made of a polyethylene resin, the polyethylene resin of the innermost layer 21 may be the same type of polyethylene resin as that of the outer layer 23, or may be a polyethylene resin different from that of the outer layer 23. The thickness of the innermost layer 21 is not particularly limited, but is, for example, 600 μm or less, and preferably 50 to 500 μm. Specific examples of the thickness of the innermost layer 21 include 50 μm, 100 μm, 150 μm, 200 μm, 300 μm, 400 μm, 500 μm, and 600 μm, or may be within a range in which two numerical values ​​A and B selected from the above numerical group are the lower and upper limits (A or greater and B or less). The innermost layer 21 and the intermediate layer 22 may be laminated in direct contact with each other, or another layer may be provided between the innermost layer 21 and the intermediate layer 22.

[0026] The thickness of the laminates 10, 20 is preferably in the range of 300 to 2000 μm, more preferably in the range of 500 to 1500 μm, and examples thereof include 300 μm, 400 μm, 500 μm, 600 μm, 700 μm, 800 μm, 1000 μm, 1200 μm, 1500 μm, 1800 μm, and 2000 μm, or a range (greater than or equal to A and less than or equal to B) having two numerical values ​​A and B selected from the above group of numerical values ​​as the lower and upper limits. Here, the thickness of the laminates 10, 20 refers to the total thickness including the thickness of each layer that is laminated and molded in close contact with each other over the entire surface of the storage section, and does not include the thickness of layers that are partially attached to the storage section, such as labels, stickers, etc., or the thickness of layers that are overlapped without being in close contact with each other, such as shrink film, etc.

[0027] The laminates 10 and 20 may have one or more of a reinforcing layer, a gas barrier layer, an ultraviolet absorbing layer, and a printed layer. Examples of lamination methods for the layers constituting the laminates 10 and 20 include dry lamination, extrusion lamination, coextrusion, and coating, and can be appropriately selected depending on the materials and combinations of each layer. The laminates 10 and 20 may be entirely colorless and transparent, or may be partially or entirely colored in the thickness direction or surface direction. The container molding method is not particularly limited, but examples include blow molding. The type of container is not particularly limited, but examples include bottle containers.

[0028] The gas barrier layer can be composed of, for example, an inorganic material or a gas barrier resin. Examples of inorganic materials include a metal vapor deposition layer and metal oxides such as alumina. Examples of gas barrier resins include ethylene-vinyl alcohol copolymer (EVOH), vinylidene chloride, and fluororesins (PCTFE, PTFE, PFA). However, unlike packaging bags, the storage section of an eye drop container is subjected to repeated pressure during administration, resulting in a large load. For this reason, it is preferable that the laminates 10 and 20 do not include a gas barrier layer composed of different materials such as inorganic materials or halogen-containing resins, and that the storage section be composed of a polyethylene resin and a cyclic olefin copolymer, which are a combination that has excellent mutual adhesion.

[0029] The laminates 10 and 20 may have a layer containing an oxygen absorber. Examples of oxygen absorbers include conjugated diene polymers, conjugated diene polymer cyclized products obtained by cyclizing conjugated diene polymers, and transition metal salts. Examples of conjugated diene polymers include polyterpenes such as poly(α-pinene), poly(β-pinene), and poly(dipentene). Examples of transition metal salts include cobalt(II) oleate, cobalt(II) naphthenate, cobalt(II) 2-ethylhexanoate, cobalt(II) stearate, and cobalt(II) neodecanoate. The layer containing the oxygen absorber may be the above-mentioned resin layer, i.e., the moisture-proof innermost layer 11, the innermost layer 21, the intermediate layer 22, or the outer layer 12 or 23, or another layer.

[0030] 3 is a schematic diagram showing an example of an eye drop container. Eye drop container 30 of this embodiment has a storage section 31 that stores liquid or other eye drops, and a nozzle section 33 for dispensing the eye drops stored in storage section 31. A stepwise tapered section 32 may be provided between storage section 31 and nozzle section 33. At least storage section 31 is preferably composed of laminates 10, 20 having a layer containing the above-mentioned cyclic olefin copolymer and a layer containing a polyethylene resin.

[0031] The storage section 31 and the reduced diameter section 32 may be integrally formed from the laminates 10, 20. When the storage section 31 and the reduced diameter section 32 are integrally formed, the nozzle section 33 may have a portion that fits into the reduced diameter section 32. When the storage section 31 and the reduced diameter section 32 are formed as separate bodies, the nozzle section 33 may be integrally formed with the reduced diameter section 32, and the reduced diameter section 32 may have a portion that fits into the upper part of the storage section 31.

[0032] Eye drop container 30 may have cap 34 to protect nozzle portion 33. Cap 34 is preferably connected to at least one of storage portion 31, reduced diameter portion 32, and nozzle portion 33 in an openable / closable or detachable manner. The capacity of storage portion 31 is not particularly limited, but may be, for example, 50 ml or less, and may be 1 ml, 2.5 ml, 3 ml, 5 ml, 10 ml, 15 ml, 20 ml, 25 ml, 30 ml, 40 ml, etc., or may be within a range (greater than or equal to A and less than or equal to B) with two numerical values ​​A and B selected from the above numerical group as the lower and upper limits. Examples of eye drops include aqueous eye drops, oil-based eye drops, eye drops that are dissolved before use, and suspension eye drops. The eye drops may contain, in addition to the active ingredient, one or more of a solubilizing agent, a stabilizer, an isotonicity agent, a buffer, a pH adjuster, a preservative, and a thickening agent.

[0033] Specific examples of active ingredients used in eye drops include, but are not limited to, prostaglandin-related drugs such as isopropyl unoprostone, latanoprost, travoprost, tafluprost, and bimatoprost; non-steroidal anti-inflammatory drugs such as diclofenac sodium, pranoprofen, bromfenac sodium hydrate, and nepafenac; vitamin B preparations such as cyanocobalamin and flavin adenine dinucleotide sodium; antiallergic ingredients such as ashitazanolast hydrate, amlexanox, ibudilast, epinastine hydrochloride, olopatadine hydrochloride, cromoglycate sodium, ketotifen fumarate, tranilast, pemirolast potassium, and levocabastine hydrochloride; immunosuppressants such as cyclosporine and tacrolimus hydrate; and beta-blockers such as carteolol. Hydrochloride, timolol maleate, nipradilol, betaxolol hydrochloride, levobunolol hydrochloride; alpha-1 blockers such as bunazosin hydrochloride; alpha-2 agonists such as brimonidine tartrate; parasympathomimetic agents such as pilocarpine hydrochloride; sympathomimetic agents such as dipivefrine hydrochloride; cholinesterase inhibitors such as distigmine bromide; anti-cataract drugs such as glutathione and pirenoxine; antibacterial agents such as gatifloxacin hydrate, dibekacin sulfate, tosufloxacin tosilate hydrate, tobramycin, vancomycin hydrochloride, moxifloxacin hydrochloride, levofloxacin hydrate, lomefloxacin hydrochloride, ofloxacin, chloramphenicol, and norfloxacin; beta-blocker / carbonic anhydrase inhibitor combination drugs such as dorzolamide hydrochloride and brinzolamide. One or more of these may be contained.

[0034] The present invention has been described above based on preferred embodiments, but the present invention is not limited to the above-described embodiments, and various modifications are possible within the scope of the gist of the present invention. The packaging container made of the laminate of this embodiment is not limited to the storage portion of an eye drop container, but can also be used as a container for storing other contents, such as nasal drops, ear drops, and other medicines that are administered by dripping a medicinal solution onto the affected area. In a layer containing a cyclic olefin copolymer, it is also possible to blend a cyclic olefin homopolymer or a hydrogenated product thereof in place of or together with the cyclic olefin copolymer. [Example]

[0035] The present invention will be specifically described below with reference to examples.

[0036] (Measurement of squeeze strength and water vapor transmission rate of eye drop containers) The storage part of an eye drop container was formed into a bottle shape by blow molding using the layer structure shown in Table 1. The storage part was cylindrical (round) with a diameter of 20 mm and a height of approximately 27 mm, with a bottom at the bottom and a mouth at the top to which a nozzle was attached. In the "Thickness [μm]" column of Table 1, when the material and thickness of one layer overlaps the "Outer layer" and "Intermediate layer" columns, it means that the layer is the outer layer of the first embodiment in which the intermediate layer is omitted. Also, when the material and thickness of one layer overlaps the "Outer layer," "Intermediate layer," and "Innermost layer" columns, it means that the material is a single layer. "PE1" is a polyethylene resin (density 931 [Kg / m 3 ], MFR1.1[g / 10min]), "PE3" is a polyethylene resin (density 922[Kg / m 3 ], MFR 0.6 [g / 10 min]), "PE4" is polyethylene resin (density 931 [Kg / m 3 ], MFR 1.1 [g / 10 min]). "C1" is a cyclic olefin copolymer (density 1010 [Kg / m 3 ], MFR 9.0 (230℃) [g / 10min]), "C2" is a cyclic olefin copolymer (density 1010 [Kg / m 3 ], MFR 20.0 (280℃) [g / 10min]). "CE" is a composite of "C1" and a styrene-based elastomer (density 1000 [Kg / m 3], MFR 8.3 (230°C) [g / 10 min]. The total thickness shown in Table 1 means the thickness of the laminate, but because each is an average value, the total thickness of each layer may not match the thickness of the laminate (with an error of ±1 μm or less).

[0037] The squeeze strength (N) was measured by applying a metal ball with a diameter of 10 mm to the center of the bottle at a speed of 100 mm / min (a rate of 1.2 seconds for 2 mm of compression), and measuring the maximum load at which the bottle wall was compressed by 3 mm. The ball was applied to the bottle in four directions: up, right, down, and left, and measurements were carried out with n=5 evaluations for each direction, and the average value was calculated.

[0038] The water vapor transmission rate was measured as follows: (1) weigh the empty bottle; (2) fill the bottle with 5.0 ml of distilled water and then cap it with an aluminum film; (3) measure the weight of the filled bottle and store it at 40°C and 25% RH; (4) measure the weight of the bottle after a specified number of days; and (5) calculate the water vapor transmission rate [%]. Measurements were performed with n = 5 evaluations, and the average was calculated. The water vapor transmission rate in this test was calculated as the percentage of weight loss, similar to Method 1 of the water vapor transmission rate test in the Japanese Pharmacopoeia, but under higher temperature and lower humidity conditions. The aluminum film has significantly lower water vapor transmission rate than the bottle, so water vapor transmission through the lid is considered negligible.

[0039] [Table 1]

[0040] As shown in Table 1, it was confirmed that the eye drop containers of Examples 1 to 15 exhibited squeeze strength comparable to that of the conventional product (Comparative Example 1), and also exhibited water vapor permeability superior to that of the conventional product (Comparative Example 1) over a long period of time.

[0041] (Adsorption test of eye drop containers) The eye drop container of Example 16 had an innermost sealant layer made of cyclic olefin, and a polyethylene (PE) layer on the outside. The shape, dimensions, manufacturing method, etc. of the eye drop container used in the adsorption test were the same as those of the eye drop container used in the above-mentioned measurements of squeeze strength and water vapor transmission rate. The "Thickness [μm]" column in Table 2 lists the layer structure in the same way as in Table 1.

[0042] The adsorption test was carried out by measuring the remaining concentration of the active ingredient after storing the eye drop container containing the eye drop under predetermined conditions. The eye drops were prepared by dissolving 50 mg of the active ingredient latanoprost (reagent) in a mixed solvent (5% acetonitrile, distilled water, polysorbate 20) to approximately 500 ppm, and then adjusting the latanoprost concentration to approximately 0.005% by volume. Approximately 5 ml of this eye drop solution was placed in a bag-shaped eye drop container using a whole pipetter and stored at 40°C in a dry environment. The residual concentration of the eye drop solution in the container was measured after 28 or 60 days of storage from the time of sealing. 28 days corresponds to 672 hours, and 60 days corresponds to 1440 hours. The residual concentration was measured by liquid chromatography using a column (ODS column, C18 column, 4.6 mm x 250 mm, 5 μm) at a retention time of approximately 18 minutes, from the absorbance value, with a mobile phase of a 48:52 mixture of 0.2% aqueous acetic acid and acetonitrile, a flow rate of 1.0 ml / min, an absorbance measurement wavelength of 210 nm, and a column temperature of 40°C.

[0043] The storage period of the eye drops before being sealed in the eye drop container was set to 0 weeks, and the remaining concentration at that time was defined as the initial concentration. The measured initial concentration was 68.9 ppm. The remaining rate (%) was calculated as the ratio of the remaining concentration to the initial concentration using the following formula: Residual rate (%) = [Residual concentration (ppm)] / [Initial concentration (ppm)] × 100 (%)

[0044] [Table 2]

[0045] As shown in Table 2, the eye drop container of Example 16 exhibited high non-adsorption of the active ingredient. [Industrial Applicability]

[0046] As described above, the eye drop container of the present invention can suppress sorption (adsorption, absorption) of eye drops, improve moisture resistance to suppress evaporation, and further reduce squeeze strength to improve squeezability, and therefore the present invention is industrially applicable. [Explanation of symbols]

[0047] 10, 20... laminate, 11... moisture-proof innermost layer, 12, 23... outer layer, 21... innermost layer, 22... middle layer, 30... eye drop container, 31... storage section, 32...reduced diameter portion, 33...nozzle portion, 34...cap.

Claims

1. An eye drop container having a storage portion for storing eye drops, the storage section is composed of a laminate having a layer containing a cyclic olefin copolymer and an outer layer containing a polyethylene resin provided outside the layer containing the cyclic olefin copolymer, the thickness of the layer containing the cyclic olefin copolymer is 63 to 116 μm, the thickness of the outer layer containing the polyethylene resin is 480 to 597 μm, and the thickness of the laminate is 543 to 669 μm; An eye drop container, wherein the layer containing the cyclic olefin copolymer constitutes the innermost layer of the container portion.

2. 2. The eye drop container according to claim 1, wherein the eye drop container has a nozzle portion for injecting the eye drop contained in the container portion.

3. The eye drop container according to claim 1 or 2, wherein the layer containing a cyclic olefin copolymer contains at least one of COP (a copolymer of different cyclic olefins) and COC (a copolymer of a cyclic olefin and a non-cyclic olefin).

Images