Compositions and methods for amplifying, detecting, or quantifying human cytomegalovirus

Amplification oligomers and kits for CMV UL56 gene detection enhance sensitivity and specificity, addressing the limitations of current diagnostic methods by enabling rapid and accurate CMV detection and quantification.

JP7770472B2Active Publication Date: 2025-11-14GEN PROBE INC
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Patent Information

Application Number
JP2024097981
Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
Priority Date
2018-08-21
Filing Date
2024-06-18
Publication Date
2025-11-14
Estimated Expiration
2039-08-21

AI Technical Summary

Technical Problem

Current diagnostic tests for human cytomegalovirus (CMV) are not sufficiently sensitive and specific, requiring multiple tests and often relying on symptomatic individuals, which complicates accurate detection and quantification, especially in immunocompromised patients and pregnant women.

Method used

The development of amplification oligomers, nucleic acids, and kits that include forward and reverse primers, promoter primers, probe oligomers, and target capture oligomers to amplify and detect CMV UL56 gene sequences, utilizing various nucleic acid amplification methods such as PCR and isothermal transcription-associated amplification.

Benefits of technology

Provides highly sensitive and specific detection and quantification of CMV, enabling rapid and accurate diagnosis in samples, particularly beneficial for managing CMV in transplant recipients and pregnant women.

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Abstract

To provide compositions and methods for amplifying, detecting or quantifying a human cytomegalovirus.SOLUTION: Oligomer nucleotides, compositions, methods, kits and uses are provided for detecting or quantifying a Human Cytomegalovirus virus 1 (CMV (human herpesvirus 5, HHV5)) nucleic acid, e.g., using nucleic acid amplification and hybridization assays. Multiphase amplification of a CMV target sequence is also described. The oligomer nucleotides, compositions, methods, kits and uses can be used to amplify and / or detect the UL56 gene of CMV.SELECTED DRAWING: None
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