Novel double-stranded RNA based on periostin RNA sequence and use thereof
JPWO2025142999A1Pending Publication Date: 2025-07-03
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Patent Information
- Application Number
- JP2025567180
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Priority Date
- 2023-12-26
- Filing Date
- 2024-12-25
- Publication Date
- 2025-07-03
AI Technical Summary
Technical Problem
Existing cancer treatments, particularly those targeting periostin, face challenges with high costs and variability in quality, necessitating a more uniform and effective method to inhibit periostin-expressing cells.
Method used
Development of double-stranded RNA sequences specifically designed to target the signal peptide region of periostin, functioning as small interfering RNA (siRNA) to suppress periostin expression and inhibit cell proliferation, with additional sequences for enhanced stability and delivery.
Benefits of technology
The double-stranded RNA effectively inhibits the proliferation of periostin-expressing cells, including tumor cells, while minimizing off-target effects and maintaining stability, even at low concentrations.
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Abstract
Disclosed herein is a double-stranded RNA having a first strand and a second strand complementary to the first strand, wherein the first strand has a main sequence comprising 19-23 bases in which the 5'-terminal base is guanine (G) or cytosine (C), and an additional sequence comprising 2-4 bases added to the 3'-terminal side of the main sequence, wherein the main sequence is determined from among base sequences encoding a signal peptide region of periostin.
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