High-surface-area and virtual-sphere microcarrier for cell culture and formation method therefor
Biocompatible microcarriers with irregular, smooth surfaces and concave structures made from edible polymers address the limitations of traditional cell culture methods by enabling high cell recovery and efficient production, suitable for large-scale applications like plant-based meat production.
Patent Information
- Application Number
- PCT/CN2024/119559
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2023-09-21
- Filing Date
- 2024-09-19
- Publication Date
- 2025-03-27
AI Technical Summary
Traditional two-dimensional cell culture methods fail to mimic in vivo environments, limiting cell growth and interaction, and existing three-dimensional microcarriers made from cross-linked dextran require complex and costly processes for cell separation and have low cell recovery rates, which is not suitable for large-scale production and plant-based meat production.
Development of biocompatible, high-molecular-weight microcarriers with irregular, smooth surface features and concave structures, made from edible polymers like konjac glucomannan, which allow for high cell attachment and growth without the need for cell separation from the microcarrier, achieving nearly 100% cell recovery.
The microcarriers provide a favorable environment for cell growth and attachment, enabling high cell recovery rates and efficient production, suitable for large-scale applications including plant-based meat production, with enhanced mechanical stability and biodegradability.