Recombinant algae having high biomass and lipid productivity
By genetically modifying an algal strain to disrupt a cryptochrome/photolyase FAD-binding domain gene, the organism's biomass and lipid productivity are significantly increased, addressing the economic viability issues of current biofuel-producing algal strains.
WO2025064430A1 Publication Date: 2025-03-27VIRIDOS INC
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Patent Information
- Application Number
- PCT/US2024/047105
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2023-09-18
- Filing Date
- 2024-09-17
- Publication Date
- 2025-03-27
AI Technical Summary
Technical Problem
Current algal strains used for biofuel production have insufficient lipid and biomass productivity, making them economically unviable for large-scale biofuel development.
Method used
A recombinant photosynthetic organism is genetically modified to have a deletion, disruption, or inactivation of a gene encoding a cryptochrome/photolyase FAD-binding domain, resulting in significantly higher biomass and lipid productivity.
Benefits of technology
The modified organism exhibits at least 35% higher biomass productivity and 20% higher lipid productivity compared to unmodified control organisms, enhancing the potential for economically viable biofuel production.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention provides a recombinant photosynthetic organism that has been genetically modified in a gene encoding a protein kinase-like protein. The recombinant organism exhibits higher biomass productivity and higher lipid productivity versus a corresponding control algal organism not having the genetic modification. The recombinant organism is therefore useful in applications requiring biomass and / or lipid productivity, e.g., in the production of biofuels or other lipidic matter. Methods of using the organism and biomass containing or produced by the organism are also provided.
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