Composition for prophylaxis and / or treatment of infection and use thereof
A composition of specific antigen genes in a plasmid vector with BioCapZ nanoparticles provides a safe and effective solution for preventing and treating African swine fever, addressing the limitations of existing vaccines.
WO2025064936A1 Publication Date: 2025-03-27ASTRID PHARMA CORP
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Patent Information
- Application Number
- PCT/US2024/047840
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2023-09-22
- Filing Date
- 2024-09-20
- Publication Date
- 2025-03-27
AI Technical Summary
Technical Problem
Current vaccines for African swine fever (ASF) pose safety concerns and efficacy issues, with modified live attenuated vaccines risking reversion to virulent strains and inadequate protection against ASFV.
Method used
A composition comprising specific antigen genes (e.g., SEQ ID NO: 2, 4, 8, 12, 13, 21) inserted into a plasmid vector, combined with a pharmaceutical acceptable carrier like nanoparticle BioCapZ, for prophylaxis and treatment of ASF infections.
Benefits of technology
The composition demonstrates high protection efficacy against ASFV, is safe for use, and can effectively treat ASF-infected animals, preventing clinical manifestations and mortality.
✦ Generated by Eureka AI based on patent content.
Abstract
A composition for prophylaxis and / or treatment of an infection in an animal is provided, including al least one antigen gene selected from the group consisting of; SEQ ID NO: 1 (S273R), SEQ ID NO: 2 (EI83L), SEQ ID NO: 3 (K78R). SEQ ID NO: 4 (KP177R), SEQ ID NO: 5 (A104R), SEQ ID NO: 6 (A137R), SEQ ID NO: 7 (A151R), SEQ ID NO: 8 (B646R), SEQ ID NO: 9 (B438L), SEQ ID NO: 10 (B602L), SEQ ID NO: 11 (CP2475L), SEQ ID NO: 12 (CP204L), SEQ ID NO: 13 (CP530R), SEQ ID NO: 14 (O61R), SEQ ID NO: 15 (D1I7L), SEQ ID NO: 16 (H108R), SEQ ID NO: 17 (E199L), SEQ ID NO: 18 (E120R), SEQ ID NO: 19 (E248R), SEQ ID NO: 20 (MGF l 10-4L), SEQ ID NO: 21 (EP402R), SEQ ID NO: 22 (MGF 505-5R), SEQ ID NO: 23 (MGF 360-12L), SEQ ID NO: 24 (DP96R), SEQ ID NO: 25 (A224L), SEQ ID NO: 26 (A179L), SEQ ID NO: 27 (I329L), SEQ ID NO: 28 (I10L), SEQ ID NO: 29 (I215L), and SEQ ID NO: 30 (G1211R). Amethod of preventing and / or treating an infection by administering the above composition to an animal is also provided.
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