Ahr modulator and use thereof
By designing and synthesizing AhR modulators with specific chemical structures, the problem of difficulty in developing new modulators for AhR in the prior art is solved, and effective regulation of AhR is achieved, and the effect of potential treatment of immune diseases is achieved.
WO2025066915A1 Publication Date: 2025-04-03DEMING YAOTAI BIOTECH (SHENZHEN) CO LTD
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Patent Information
- Application Number
- PCT/CN2024/118486
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2023-09-28
- Filing Date
- 2024-09-12
- Publication Date
- 2025-04-03
AI Technical Summary
Technical Problem
The prior art is difficult to effectively develop novel modulators against aromatic hydrocarbon receptors (AhRs) for the treatment of immune-related diseases.
Method used
An AhR modulator with a specific chemical structure formula (I) was designed and the compound was prepared by a synthesis process flow such as the steps described in Examples 1 and 2.
Benefits of technology
This AhR modulator can effectively activate or inhibit AhR, thereby regulating the expression of related genes, and has potential therapeutic value for immune diseases.
✦ Generated by Eureka AI based on patent content.
Abstract
Disclosed in the present invention is an AhR regulator, which has the following structural general formula (I), A is CR3 or N; Ar is a 3-14 membered carbocyclic or 3-14 membered heterocyclic ring, preferably a 3-10 membered alkyl ring, a 3-10 membered heteroalkyl ring, a 6-10 membered aromatic ring, a 3-10 membered heteroaromatic ring, a 10-14 membered polycyclic aromatic ring or a 9-14 membered heteroaromatic ring; n is a natural number between 0 to 5; Q is deuterium, halogen, C ≡ N, hydroxyl, unsubstituted or 1 to 6 R' substituted C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C10 cycloalkyl, C3-C10 cycloalkenyl, C1-C8 alkoxy, (C1-C8 alkyl)1-2 amino, C2-C8 alkenyloxy, C2-C8 alkynyloxy and C1-C8 alkoxycarbonyl, C1-C8 carboxyl, S(O)1～2R, N(R)2, 6-10 membered aryl or 3-10 membered heteroaryl. The AhR modulator of the present invention has good activity in a drug for treating cancer and obesity, or in immunoregulation, hematopoiesis, cell cycle, or intestinal barrier.
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