Pharmaceutical compositions and methods of use thereof

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A pharmaceutical composition that forms a covalent bond with PI3K addresses the need for effective regulation of PI3Ks, offering therapeutic benefits in treating various diseases by inhibiting PI3K activity and reducing cell proliferation.

WO2025072796A1 Publication Date: 2025-04-03TOTUS MEDICINES INC

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Patent Information

Application Number: PCT/US2024/049020
Authority / Receiving Office: WO · WO
Patent Type: Applications
Current Assignee / Owner
Priority Date: 2023-09-27
Filing Date: 2024-09-27
Publication Date: 2025-04-03

Application Information

Patent Timeline

27 Sep 2023

Priority

27 Sep 2024

Application

PCT/US2024/049020

03 Apr 2025

Publication

WO2025072796A1

IPC: A61K31/5377; A61K9/20; A61P25/28; A61P35/00; A61P37/02

CPC: A61K31/5377; A61P37/02; A61P35/00; A61P25/28; A61K9/2054; A61K9/20; A61P37/00; A61P43/00

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Application Domain

Organic active ingredients Nervous disorder

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AI Technical Summary

Technical Problem

Current treatments lack effective methods for binding to and regulating phosphatidylinositol 3-kinases (PI3Ks) to address various diseases.

Method used

A pharmaceutical composition comprising a therapeutically effective amount of a compound that forms a covalent bond with a kinase or pseudokinase, specifically targeting PI3K, along with pharmaceutical excipients for immediate release.

Benefits of technology

The composition effectively inhibits PI3K activity, providing therapeutic benefits in treating cancer, neurodegenerative diseases, autoimmune disorders, and aging by reducing cell proliferation.

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Abstract

The present invention provides methods and compositions for treating cancer via use of a compound that forms a covalent bond with a kinase or pseudokinase, or a pharmaceutically acceptable salt thereof, and at least one pharmaceutical excipient.

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