Jellyfish polypeptide, preparation method, and use
Jellyfish polypeptides were prepared by liquid chromatography-mass spectrometry and enzymatic hydrolysis, which solved the safety problem in the extraction of active components from jellyfish, achieved significant inhibitory and immunomodulatory effects on tumors, and provided non-toxic active products for the treatment and prevention of tumors and immunomodulation.
Patent Information
- Application Number
- PCT/CN2025/096902
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2024-05-28
- Filing Date
- 2025-05-23
- Publication Date
- 2025-12-04
AI Technical Summary
Existing technologies pose safety risks when extracting active components from jellyfish, especially given the diverse toxic effects of jellyfish toxins, making it difficult to effectively develop non-toxic active products for the treatment or prevention of tumors and the preparation of immunomodulators.
Jellyfish extract was separated using liquid chromatography-mass spectrometry (LC-MS). Peptide fragments with 8–27 amino acid residues were obtained by enzymatic hydrolysis and filtration. These fragments were then hydrolyzed using alkaline protease and pepsin, followed by separation using LC-MS to prepare jellyfish peptides.
The prepared jellyfish polypeptide has a significant inhibitory effect on various tumors such as colorectal cancer, lung cancer and prostate cancer. It can kill tumor cells, reduce inflammation and organ lesions, and improve individual immunity. It has immunomodulatory function and is suitable for tumor treatment and prevention products and immunomodulators.