Gas distribution apparatus and composition comprising gas distribution apparatus

Abstract

A gas distribution apparatus and a composition comprising the gas distribution apparatus. Gaseous substances released by a mouthpiece can be divided into two paths by means of a Tesla valve in the gas distribution apparatus without modifying the mouthpiece, one path of gaseous substances enters the oral cavity of a user from a mouth branch, and the other path of gaseous substances enters the nasal cavity of the user from a nose branch or is released near the nostrils of the user. Therefore, the use experience and medical effect of a medical atomizer can be improved; an electronic cigarette user can take in vapor from the same source through both the mouth and nose, to improve the vaping experience; a fan airflow and / or a filter unit can be used to reduce the harmful substances contained in the vapor from the electronic cigarette and the cigarette in the mouth branch and the nose branch, and the user can take in some beneficial additional intakes through both the mouth and the nose.

Description

A gas distribution device and a composition containing the same TECHNICAL FIELD

[0001] The present application relates to the field of medical devices and consumer products, in particular to a gas distribution device and a composition containing the same. BACKGROUND

[0002] Oral inhalation devices include medical nebulizers, non-medical electronic nebulizers, vapor electronic cigarettes, cannabidiol (CBD) electronic cigarettes, heat-not-burn electronic cigarettes (HNB), combustion-type cigarettes, and tobacco smoking tools, such as cigarettes, cigars, pipes, and hookahs. The smoke of non-medical electronic nebulizers and CBD electronic cigarettes without nicotine is also called aerosol.

[0003] Medical nebulizers treat upper respiratory diseases such as pharyngitis, laryngitis, and tonsillitis by allowing patients to inhale drug liquid aerosols. The advantages are that the drug liquid aerosols can be directly deposited in the oral cavity and nasal cavity without being metabolized by the digestive tract and liver. The disadvantages are that: 1) the medical nebulizer mask cannot accelerate the drug liquid aerosols in a targeted manner, resulting in the drug liquid aerosols floating in the mask, and the drug liquid aerosols become large after absorbing moisture in the high-humidity oral cavity and nostrils, which slows down the flow rate, and the nasal hair also hinders their deep penetration, so the drug liquid aerosols can only be deposited in the oral mucosa and nostrils, with less deposition in the throat, lungs, and deep nasal cavity, making it difficult to treat lower respiratory diseases such as trachea, bronchus, and alveoli; 2) although increasing the power of the medical nebulizer can reduce the particle size of the drug liquid aerosols and increase the flow rate, allowing the drug liquid aerosols to be deposited in the lower respiratory tract and deep nasal cavity, the increased motor noise makes the patient uncomfortable; 3) part of the drug liquid aerosols in the nebulizer mask flows back to the medical nebulizer, not only wasting the drug, but also damaging the medical nebulizer circuit; 4) the integrated mask covers the mouth, nose, and part of the cheeks, and the drug liquid aerosols deposited on the cheeks are not only wasted but also disliked by some users.

[0004] In addition to the nicotine and tobacco aroma substances that users want to intake, there are hundreds of harmful substances in cigarette smoke, including tar, carbon monoxide (CO), carbonyl compounds, nitrogen oxides (NOx), hydrogen cyanide (HCN), tobacco-specific nitrosamines (TSNAs), benzopyrene (BaP), heavy metals, and free radicals. Among them, the carbonyl compounds are mainly formaldehyde, acetaldehyde, acetone, acrolein, propionaldehyde, crotonaldehyde, 2-butanone, and butyraldehyde. The intermittent puffing airflow pause and the ash obstruction of the burning cone hinder the air exchange, causing the tobacco to smolder and pyrolyze in an oxygen-deficient environment, resulting in the CO and NOx in the sidestream smoke being 2-11 times higher than the corresponding harmful substances in the mainstream smoke. The sidestream smoke diffuses into the air, not only harming others, but also being inhaled by the user's nostrils and scalp pores, endangering the user's health. The drawbacks of current cigarette filters and other smoke filtering devices are: (1) they cannot reduce the harm of sidestream smoke to users; (2) they mainly use cellulose acetate and other physical adsorbents to adsorb the harmful substances in the mainstream smoke, with small adsorption capacity and easy desorption, so that the harmful substances in the smoke after eight puffs are much higher than those in the first few puffs; (3) when cellulose acetate and other physical adsorbents adsorb the harmful substances in the mainstream smoke, they also adsorb nicotine and tobacco aroma substances, but in order to meet the user's nicotine satisfaction efficiency and tobacco aroma, the filter and other smoke filtering devices can only reduce the adsorption rate of the smoke components, making it difficult for the harmful substances to be reduced by more than 50%; it is known that cigar smoke has more harmful substances than cigarette smoke, but in order to maintain the flavor, cigar does not even use a filter; undoubtedly, this compromise is not conducive to the user's health. (4) the lack of nicotine compensation in cigarette filters and other smoke filtering devices will cause users to increase the number of puffs to obtain the required nicotine, and instead intake more harmful substances in the smoke.

[0005] Electronic cigarettes are a kind of harm reduction tools that simulate the transmission of nicotine from cigarettes to the user's oral cavity, but many smokers do not like electronic cigarettes, and they complain that the nicotine satisfaction efficiency and tobacco aroma of electronic cigarettes are much worse than those of cigarettes. Moreover, studies have found that metal parts in electronic cigarettes can migrate metal ions into the smoke oil and mix into the smoke, and even the content of some heavy metals in each puff of electronic cigarette smoke is higher than that in each puff of cigarette smoke. Even if the intake of heavy metals per puff is less than 1 nanogram, heavy metals are difficult to excrete from the body, and will accumulate and cause poisoning over time.

[0006] SUMMARY

[0007] To solve or partially solve the above problems, the present application provides a gas distribution device, which comprises a gas receiving section connected to a mouthpiece, a mouth suction branch and a nose suction branch, at least one Tesla valve is arranged in the gas distribution device, and the gaseous substance released by the mouthpiece is distributed into two paths by the gas distribution device, one path of the gaseous substance enters the oral cavity of a user from the mouth suction branch, and the other path of the gaseous substance enters the nasal cavity of the user or is released beside the nostrils of the user, the gaseous substance includes but is not limited to a drug liquid atomized substance, an electronic cigarette smoke or aerosol, a cigarette smoke, but is not single air. The present application also provides a composition comprising the gas distribution device, and the composition comprises one or more of a cylinder provided with an air inlet hole and an air outlet hole, a battery, a fan, a cigarette, a match, and a cigarette butt bin. The mouthpiece in the present application includes but is not limited to a medical atomizer, a non-medical electronic atomizer, a steam electronic cigarette, a cannabidiol electronic cigarette, a heat-not-burn electronic cigarette, a combustion-type cigarette, a pipe, and a water pipe device. The combustion-type cigarette includes but is not limited to a cigarette, a cigar, and a cigarillo.

[0008] In some embodiments, the Tesla valve is arranged in one or more of the gas receiving section, the nose suction branch, and the mouth suction branch of the gas distribution device. The Tesla valve, also known as a passive check valve or a valve conduit, is a kind of one-way valve which accelerates the conduction of fluid in a positive direction in multiple stages and throttles the resistance of fluid in a reverse direction in multiple stages. The geometric shape of the Tesla valve includes but is not limited to an inclined path and a half-ring path.

[0009] In some embodiments, the Tesla valve is arranged in a sleeve to form a Tesla valve sleeve and is obtained by integral molding or separate combination, and the gap between the outer wall of the Tesla valve and the inner wall of the sleeve is air or other fillers. The port of the Tesla valve sleeve is provided with a thread or a gasket, so as to facilitate the airtight connection, disassembly or adjustment of the position of the Tesla valve in the gas distribution device.

[0010] In some embodiments, at least one filter unit is further arranged in the gas distribution device, and the filter unit is provided with a filter material or a filter material loaded on a carrier, which can trap harmful substances in the gaseous substance released by the mouthpiece. The solid carrier includes but is not limited to acetate fiber, polypropylene fiber, metal felt, porous ceramic microspheres, activated carbon, silica gel, zeolite, meerschaum, medical stone, molecular sieve, and aluminum oxide; the gel carrier includes but is not limited to gel, ion exchange resin; the liquid carrier includes but is not limited to ionic liquid, water, solution, suspension, turbid liquid, and tobacco tar. Preferably, the solid carrier and the gel carrier are porous carriers, which can physically adsorb certain harmful substances, such as tar in smoke, and some porous carriers can also trap certain harmful substances in smoke through ion exchange or complexation chemical reactions.

[0011] In some embodiments, the filter unit contains a carrier loaded with metal ions or modified with functional groups, which can trap nitrosamines and hydrogen cyanide in the smoke. The metal ions include but are not limited to Cu 2+ , Mg2+ Zn 2+ Fe 3+ Al 3+ The functional groups include, but are not limited to, amino, hydroxyl, or sulfydryl, etc. The carriers include, but are not limited to, zeolite, sepiolite, montmorillonite, medical stone, molecular sieve, activated carbon, ion exchange resin, and porous alumina, etc. The molecular sieve can be exemplified by NaY, NaA, HY, KA, NaZSM-5, HZSM-5, MCM-48, MCM-41, etc. For example, the zeolite is ultrasonically treated in Cu 2+ solution for 0.5 hours (h), and then the zeolite is filtered, calcined at high temperature, and solidified to obtain the zeolite loaded with Cu 2+ MCM-48 is mixed with 3-aminopropyltriethoxysilane and toluene, and then refluxed at 120°C for 20 h. After the temperature is decreased to room temperature, a proper amount of porous alumina particles is added and ultrasonically treated for 0.5 h. The porous alumina particles loaded with MCM-48-NH2 are obtained after filtration and drying.

[0012] In some embodiments, the filter unit contains biomass or biomass modified with functional groups or metal ions and carriers, which can trap carbonyl compounds and hydrogen cyanide in the flue gas. The biomass includes, but is not limited to, tea, chitosan and its derivatives, chitin and its derivatives, cyclodextrin, cellulose, catalase, glutathione, etc. For example, 2 g of chitosan is dissolved in 98 g of 1% hydrochloric acid. After the pH is adjusted to 4.8 by using 0.1% NaOH solution, 0.8 g of copper sulfate is added and stirred for 1 min. The amino in the chitosan is complexed with Cu 2+ to form chitosan-Cu 2+ After 10 g of medical stone particles are added and continuously stirred for 1 h, the medical stone particles are ultrasonically treated for 0.5 h. The medical stone particles filtered and washed with 95% alcohol are dried at 60°C to obtain the medical stone loaded with chitosan-Cu 2+ .

[0013] In some embodiments, the filter unit contains carriers loaded with one or more sub-valence metal ions, which can trap nitrogen oxides in the flue gas. The sub-valence metal ions include, but are not limited to, Cu + , Fe 2+ , Ni 2+ , Mn 2+ , Co 2+ . For example, 20 g of sepiolite is added to 500 ml of a solution containing 1 M Co 2+ and 1 M Mn 2+ , stirred for 2 h, filtered, washed with water, and dried, and then calcined in nitrogen (N2) for 3 h to obtain the sepiolite loaded with manganese suboxide-cobalt suboxide (MnO-CoO). NiSO4 and EDTA-2Na are respectively added to water and stirred to obtain Ni 2+EDTA aqueous solution. The stability of sub-valence metal ions can also be improved by using a cage carrier, including but not limited to NaY, NaX, 13X, HZSM, 3A, 4A, etc. molecular sieves, metal organic frameworks (MOFs), ion exchange resins, etc. For example, 50 g of NaY molecular sieve particles are added to 30 ml of 1 M copper chloride aqueous solution, heated at 100 °C and stirred for 4 h in a closed system, Cu 2+ is exchanged for Cu 2+ and reduced to Cu + , and cooled to room temperature in N2. Cu + -NaY molecular sieve. 1.16 g of Ni(NO3)2·6H2O, 0.33 g of terephthalic acid, 15 ml of N,N-dimethylformamide (DMF) are uniformly mixed, then the pH is adjusted to 4 with 10% hydrochloric acid, and stirred for 0.5 h before being transferred to a reaction kettle lined with polytetrafluoroethylene. After being heated at 120 °C in a closed system for 20 h, the supernatant is removed by centrifugation, and the precipitate is washed with DMF and ethanol for 3 times before being soaked in dichloromethane (CH2Cl2) for activation. After 3 days, the supernatant is removed by centrifugation, and the precipitate is dried at 150 °C under vacuum for 4 h to obtain Ni 2+ -MOFs nanoparticles; 2 g of oxalic acid is dissolved in 20 g of ethanol, 1 g of Ni 2+ -MOFs nanoparticles and 5 g of porous ceramic microspheres are stirred at room temperature until the ethanol is completely volatilized, and the solid is calcined at 300 °C in N2for 4 h to remove oxalic acid to obtain Ni 2+ -MOFs loaded porous ceramic microspheres. 20 g of porous resin particles and 100 ml of Fe(II)-EDTA-Na2SO3aqueous solution are added to a flask and stirred. In the aqueous solution, [Fe(II)-EDTA] 2- is ion exchanged with Cl - in the resin framework. After 3 h, the resin particles loaded with Fe(II)-EDTA are obtained by filtration, washing and drying.

[0014] In some embodiments, the carrier in the filtration unit is basic, such as sodium hydroxide aqueous solution, which can trap acidic hazardous substances such as HCN in flue gas.

[0015] In some embodiments, the filtration unit contains antioxidants and / or selenium elements, which can remove free radicals in flue gas. Antioxidants include but are not limited to tea polyphenols, carnosic acid, rosemary acid, squalene, tocopherol, astaxanthin, vitamins, anthocyanins, lutein; selenium elements include but are not limited to inorganic selenium, biological selenium, etc., such as selenium-rich yeast and selenium-rich plants, etc.

[0016] In some embodiments, the filter unit contains porphyrin or metalloporphyrin and a carrier, which can trap benzopyrene, N-nitrosamine, CO, NOx, HCN in the flue gas. For example, iron porphyrin or iron porphyrin-loaded activated carbon is prepared as follows: 50 ml of saturated ferrous nitrate ethanol solution is added to a 250 ml flask, which is protected by N2 and controlled at 60°C in a water bath. Then, 25 ml of ethanol solution containing 0.2 g of original porphyrin sodium is added, and stirred for 4 h. Then, 50 ml of chloroform is added, and the chloroform layer is separated. Then, 50 ml of 0.1 M sodium hydroxide is added to the chloroform layer, which is completely dissolved. Then, 20 vol% hydrochloric acid is added to adjust the pH of the solution to less than 5. A large amount of black-green precipitate is separated out, which is filtered and dried at 40°C under vacuum for 12 h to obtain iron porphyrin. Then, the iron porphyrin is dissolved in CH2Cl2, and activated carbon is added and adsorbed for 10 h. Then, the activated carbon is dried at 40°C under vacuum for 12 h to obtain iron porphyrin-loaded activated carbon.

[0017] In some embodiments, the filter unit contains a complexing agent, which can trap heavy metals in the flue gas. The complexing agent includes, but is not limited to, ethylenediaminetetraacetic acid (EDTA), disodium ethylenediaminetetraacetate (EDTA-2Na), cysteine, citric acid, dithiocarbamate, dithizone. The complexing agent is dissolved in a liquid carrier, or loaded on a solid carrier or a colloidal carrier.

[0018] In some embodiments, a small amount of color developing agent is dissolved in an ionic liquid or adsorbed on other filter materials, so that the color developing agent is arranged in the filter unit. The color developing agent is preferably highly sensitive to heavy metals, including but not limited to porphyrin, disazo reagent, methyl thymol blue color developing agent. Through the color change of the color developing agent, the user can perceive the heavy metals trapped in the filter unit. For easy observation, the shell of the gas distribution device corresponding to the filter unit is made of transparent material or embedded with a small piece of magnifying glass.

[0019] In some embodiments, the filter unit is set into the gas distribution device, and some additional intake substances are pre-adsorbed. The additional intake substances include, but are not limited to, aroma substances such as menthol, tobacco essence, and fruit essence; alkaloids such as nicotine, arecoline, and caffeine; and functional substances such as cannabidiol, nasal powder, rosemary, and herbal extract. In the mouth suction branch, throat-clearing and lung-moistening functional substances or flavorings such as cool, sour, and sweet are set; and in the nose suction branch, tobacco essence, fruit essence, or functional substances for clearing the nose are set to meet the needs of the human mouth, nose, and connected organs. For example, a proper amount of iron porphyrin and β-cyclodextrin are dissolved in a 50% ethanol aqueous solution, and then the solution is immersed in acetic acid fibers and ultrasonically treated for 0.5 h. After the acetic acid fibers are taken out, they are dried at 80°C in a ventilated oven to obtain acetic acid fibers loaded with iron porphyrin and β-cyclodextrin. Then, 0.1 g of menthol, nicotine, arecoline, caffeine, rosemary extract, momordica grosvenori extract, linalool, lily essential oil, pear extract, and pipa extract are weighed and mixed to form a 1 g mixture, which is slowly added to 99 g of the acetic acid fibers loaded with iron porphyrin and β-cyclodextrin to pre-adsorb the additional intake substances.

[0020] In some embodiments, after the filter unit is set into the gas distribution device, some additional intake substances can be adsorbed on site. For example, 0.05 g of tobacco essence, 0.05 g of nicotine, and 0.01 g of clove extract are dissolved in a mixture of 2.28 ml of polyethylene glycol-600 (PEG-600) and 5.72 ml of glyceryl triacetate, and then 0.1 g of β-cyclodextrin is added and stirred for 3 h to obtain a β-cyclodextrin suspension as a liquid filter material. The β-cyclodextrin in the suspension can not only adsorb harmful substances such as tar and nitrosamine in smoke, but also physically adsorb tobacco essence, nicotine, and clove on site and then release them into the mouth suction branch or the nose suction branch. The principle is that β-cyclodextrin has poor solubility in glyceryl triacetate, and a part of the β-cyclodextrin is dissolved in the mixture by the solubilizing agent PEG-600. The suspended β-cyclodextrin and the dissolved β-cyclodextrin dynamically alternate, and the dissolved β-cyclodextrin adsorbs tobacco essence, nicotine, and clove molecules dissolved in the mixture using its unique molecular hole structure, and then alternately suspends on the liquid surface and releases them.

[0021] In some embodiments, one carrier in the filtering unit can also be loaded on another carrier or carriers. For example, ionic liquid is loaded on a carrier such as silica gel; ionic liquid can also dissolve a variety of substances such as complexing agents, biomass, antioxidants, essences, alkaloids, etc. After more substances are dissolved in ionic liquid, the paste-like filtering material is then loaded on a solid carrier such as cellulose acetate. Ionic liquid is almost non-volatile. Ionic liquid includes but is not limited to coordination ionic liquid, amino acid ionic liquid, and composite ionic liquid, etc. Among them, amino acid ionic liquid can intercept HCN and aldehyde in flue gas. The principle is that amino can form Schiff base compound with aldehyde group, and amino can also undergo acid-base neutralization reaction with HCN. For example, choline-lysine ionic liquid with dissolved EDTA-2Na is loaded on other carriers. The preparation method is as follows: choline hydroxide and lysine are mixed at a molar ratio of 1:1.05, stirred at 3°C for 48h, then distilled at 55°C under reduced pressure to remove water, then mixed solvent of acetonitrile-methanol (volume ratio 9:1) is added to the remaining material, then stirred and extracted, then unreacted lysine is removed by filtration, then the filtrate is distilled at 40°C under reduced pressure to remove the solvent, then the remaining material is vacuum dried at 70°C for 48h to obtain choline-lysine ionic liquid ([Ch][Lys]); then 0.5g of EDTA-2Na is dissolved in 10g of [Ch][Lys] to obtain EDTA-[Ch][Lys] ionic liquid; then 5g of porous silica gel with a particle size of about 10 microns is kneaded for 1h to obtain porous silica gel loaded with EDTA-[Ch][Lys], or a proper amount of EDTA-[Ch][Lys] is dropped onto a porous polypropylene fiber carrier to obtain polypropylene fiber loaded with EDTA-[Ch][Lys] as a liquid-solid composite filtering material. 0.15g of β-cyclodextrin and 0.05g of cellulose are dissolved in 10g of NaOH aqueous solution with pH of 9, then 3g of porous silica gel loaded with EDTA-[Ch][Lys] and 46.8g of selenium-rich plant stems and leaves are added and stirred uniformly, then water is removed by mechanical hot pressing to obtain a cylindrical porous filter core containing 6wt% of porous silica gel loaded with EDTA-[Ch][Lys], 93.6wt% of selenium-rich plant stems and leaves, 0.3wt% of β-cyclodextrin, and 0.1wt% of cellulose, which is cut into 5mm in length as a filtering unit; the filtering unit is hung in a vial, 1ml of each of tobacco extract, xanthium extract, passion fruit extract, rose essential oil, lavender essential oil, jasmine flower essential oil, osmanthus essential oil, and magnolia flower essential oil are added to the bottom of the vial to form a mixed solution, the vial is closed and placed at 4°C for 10h, then taken out, and a variety of additional intake substances are pre-adsorbed on the filtering unit.

[0022] In some embodiments, a gas-permeable tube plug or a gas-permeable tube plug compounded with a liquid-repellent material is also provided in the gas distribution device. For example, 1 wt% of 1H, 1H, 2H, 2H tridecafluoro octyl triethoxysilane (FAS) or other fluoro silane is dissolved in anhydrous ethanol, 1 wt% of water is added, and the mixture is stirred for 5 h before being immersed in a cylindrical porous ceramic. The mixture is left to stand for 24 h to allow the fluoro silane molecules to be fully adsorbed on the framework of the porous ceramic. The porous ceramic is then removed and baked at 100 °C for 5 h to produce a gas-permeable tube plug with a liquid-repellent surface. The gas-permeable tube plug can be a regular mesh or a mesh coated with a liquid-repellent material. For example, a homogeneous emulsion of 30 wt% polytetrafluoroethylene (PTFE) microparticles with a particle size of less than 3 microns, 10 wt% polyvinyl acetate, 8 wt% polyvinyl alcohol, 2 wt% sodium dodecylbenzenesulfonate, and 50 wt% water is stirred and then uniformly sprayed onto a metal mesh with a pore size of 30-420 microns. The mesh is then baked at 350 °C for 0.5 h to produce a metal mesh compounded with PTFE. The gas-permeable tube plug can also be a plastic mesh or a plastic mesh attached to a liquid-repellent and gas-permeable membrane, such as a PTFE membrane and a polypropylene membrane. The gas-permeable tube plug compounded with a liquid-repellent material can prevent the leakage of liquid carriers in the gas distribution device but does not prevent the flow of gaseous substances in the gas distribution device.

[0023] In some embodiments, the framework of the gas-permeable tube plug can also be loaded with a filter material or an adsorbent for additional intake substances. For example, an appropriate amount of β-cyclodextrin and iron porphyrin as a filter material is dissolved in 30 ml of CH2Cl2 containing 0.2 g of carboxymethyl cellulose and 0.3 g of acrylamide. 0.05 g of initiator KPS and 0.1 ml of epichlorohydrin are then quickly added and stirred for 3 min before being immersed in a metal mesh. The metal mesh is left to stand for 1 h before being removed. After being ventilated for 48 h to completely remove CH2Cl2, a thin layer of gel containing β-cyclodextrin and iron porphyrin is loaded onto the metal mesh, which is then hung in a vial to adsorb additional intake substances such as nicotine and flavoring.

[0024] In some embodiments, a nosepiece or a universal tube and other accessories are also provided in the nose inhalation branch of the gas distribution device. A flow regulating valve is also provided in the nose inhalation branch. The user can adjust the valve area in the gas path to control the flow of gaseous substances in the nose inhalation branch, thereby preventing nasal irritation.

[0025] In some embodiments, the connection between the gas connection section of the gas distribution device and the outlet of the mouthpiece, or the connection between the gas connection section and the mouth inhalation branch or the nose inhalation branch, or the connection between the Tesla valve sleeve, the sleeve containing the filter unit, and the adapter tube in the gas distribution device, can be achieved by nesting or threaded connection.

[0026] In some embodiments, the angle between the gas connection section of the gas distribution device and the mouthpiece, the angle between the mouth inhalation branch and the user's face, and the angle between the nose inhalation branch and the mouth inhalation branch, can be adjusted between 0° and 180°.

[0027] In some embodiments, the distance between the end of the nasal inhalation branch of the gas distribution device and the user's nostrils is one of: (1) approximately the distance between the cigarette tip and the nostrils when the user directly inhales the cigarette; (2) close to but not in contact with the nostrils; (3) covering the nostrils through the nasal inhalation cover; and (4) directly inserted into one or both nostrils.

[0028] In some embodiments, the gas distribution device is also provided with openings and sealing plugs for replacing the filter unit and the filter material. The gas inlet of the gas distribution device and the ends of the nasal inhalation branch and the mouth inhalation branch are also provided with sealing covers to prevent the additional intake from escaping and to keep the interior of the gas distribution device clean when the gas distribution device is not in use.

[0029] In some embodiments, the gas distribution device is placed in the cavity of a cylinder provided with an air inlet and an air outlet, and forms a composition with the battery, fan, etc. in the cavity. The airflow generated by the fan can continuously blow the burning cone of the cigarette, not only blowing away the sidestream smoke from the user's nostrils and scalp pores, but also accelerating the airflow around the burning cone, supplementing fresh air in time during the burning process of the tobacco, reducing incomplete combustion, and thus reducing harmful substances such as tar, CO, NOx, etc. in the mainstream smoke.

[0030] The technical principle of the present application is that when the oral inhalation member is activated by the key to release gaseous substances, the Tesla valve in the gas distribution device can positively conduct the gaseous substances to enter the user's mouth and nose through the mouth inhalation branch and the nasal inhalation branch, respectively. When the oral inhalation member is triggered by the mouth inhalation airflow to release gaseous substances, the Tesla valve in the nasal inhalation branch can not only positively conduct gaseous substances, but also reversely inhibit external air from entering the gas distribution device, thereby maintaining negative pressure in the gas distribution device, and allowing the gaseous substances released by the oral inhalation member to enter the gas distribution device, one way through the mouth inhalation branch into the user's oral cavity, and the other way through the nasal inhalation branch into the user's nasal cavity or transmitted to the user's nostrils, achieving simultaneous intake of the gaseous substances released by the oral inhalation member into the mouth and nose.

[0031] Unexpectedly, when the gas outlet of the key-activated medical atomizer is combined with the gas distribution device, the end of the mouth inhalation branch of the gas distribution device can reach the throat of the user's mouth, and the end of the nasal inhalation branch can also be inserted into the patient's nostrils, so that the liquid atomized substance can avoid the high-humidity environment of the oral cavity and the blockage of nasal hair and penetrate deep into the throat, lungs, and nasal cavity, which is helpful for curing lower respiratory tract diseases such as trachea, bronchus, alveolus, and rhinitis.

[0032] Unexpectedly, by providing a Tesla valve in the gas distribution device, not only can the flow rate of gaseous substances be increased, but also the particle size of gaseous substances can be refined. The principle is that when the gaseous substances released by the oral inhalation member pass through the Tesla valve, the gaseous substances are expanded and then compressed in the valve, and the pressure difference changes cause the gaseous substances to rapidly impact the obstruction surface, and the gaseous substances are broken into smaller particles. Obviously, this is beneficial to improving the efficacy of medical atomizers and improving the smoking experience of electronic cigarettes and cigarettes.

[0033] Unexpectedly: when the user inhales the suction airflow from the end of the mouth suction branch of the gas distribution device, the smoke released by the electronic cigarette can be automatically distributed into two paths by the gas distribution device and enter the user's mouth and nose, which can simulate the scene that the user's mouth and nose simultaneously inhale mainstream smoke and sidestream smoke from the same cigarette during smoking. Due to the physiological characteristics of human organs connected to the mouth and nose and brain perception, nicotine transmission efficiency from the nose is higher than that from the mouth, and the brain "mirror" neural signal recognition efficiency of aroma substances transmitted from the nose is higher than that from the mouth. Therefore, whether the user places the end of the nose suction branch close to the nostrils, covers the nostrils with a nose suction cover, or directly inserts it into the nostrils, the nicotine satisfaction efficiency and smoke flavor of the electronic cigarette will be greatly improved.

[0034] Unexpectedly: the gas distribution device can also adjust the distribution ratio of gaseous substances released by the mouth suction piece in the mouth suction branch and the nose suction branch. For example: when the gas distribution device connected to the electronic cigarette or cigarette is only provided with a Tesla valve in the nose suction branch, or a baffle or fan is provided in the gas connection section, it can increase the smoke entering the nose suction branch and reduce the smoke entering the mouth suction branch, which has three benefits: (1) More smoke entering the nose can further improve the nicotine satisfaction efficiency and smoke flavor of the electronic cigarette or cigarette; (2) More smoke entering the nose can reduce the risk of some essences in the electronic cigarette smoke continuously depositing in the alveoli after entering the lungs through the mouth, and can also reduce the harm of cigarette smoke to the user's mouth and lungs; (3) The hair in the nostrils or the mucus in the nasal cavity will block the harmful substances such as tar in the smoke from deep into other organs of the human body, and also expel the trapped harmful substances out of the body in the form of nasal discharge.

[0035] Unexpectedly: the gaseous substances released by the mouth suction piece can act as a carrier gas to improve the volatilization speed and temperature of additional intake substances in the gas distribution device. The smoke released by cigarettes and electronic cigarettes is usually 40-60°C, which can directly heat these additional intake substances, improving the sensory experience of additional intake substances entering the user's mouth and nose, especially some aroma substances.

[0036] Unexpectedly: some color developing agents in the filter unit can themselves trap heavy metals in the smoke, and when accumulated to the microgram level, they can cause color changes visible to the human eye. Such color developing agents include but are not limited to: meso-tetra-(p-sulfophenyl) porphyrin, tetra(4-methoxy-4-sulfonic acid phenyl) porphyrin, tetra(4-methoxy-3-sulfonic acid phenyl) porphyrin, tetraphenylporphyrin, meso-tetra(4-chlorophenyl) porphyrin, meso-tetra(p-hydroxyphenyl) porphyrin, meso-tetra(4-nitrophenyl) porphyrin, 1-(2-pyridylazo)-2-naphthol, 4-(2-pyridylazo)resorcinol.

[0037] Unexpectedly: due to the high aromaticity of porphyrin compounds, when porphyrin compounds are used as filter materials and color developing agents in the filter unit, they can also increase the aroma that users feel when using the mouth suction piece.

[0038] Unexpectedly, the Tesla valve in the gas distribution device can prevent the backflow of gaseous substances released by the mouthpiece into the mouthpiece, thereby reducing the aerosol condensate at the outlet of the medical atomizer and the vapor electronic cigarette, and reducing the risk of corrosion of the circuit in the mouthpiece.

[0039] Unexpectedly, the mouth suction branch and the nose suction branch of the gas distribution device can also exchange positions. For example, the electronic cigarette rod is originally parallel to the mouth suction branch and perpendicular to the nose suction branch, and after exchanging positions, the mouth suction branch is perpendicular to the rod, and the user's face is almost parallel to the direction of the rod when inhaling the electronic cigarette.

[0040] The difference between the present application and the prior art is:

[0041] (1) The cigarette filter and other smoke filtration devices are difficult to reduce the main harmful substances in mainstream smoke by more than 50% without reducing nicotine satisfaction efficiency and smoke flavor, and cannot reduce the harm of sidestream smoke to users. The gas distribution device and the composition containing the gas distribution device of the present application can reduce the main harmful substances in the mouth suction branch smoke by more than 55% relative to the main harmful substances in the mainstream smoke of a cigarette, and reduce the main harmful substances in the nose suction branch smoke by more than 93% relative to the main harmful substances in the sidestream smoke of a cigarette, without reducing nicotine satisfaction efficiency and smoke flavor.

[0042] (2) Patents CN217509876U, CN218571414U, CN112450490A, CN112586805A, and CN214431833U respectively set Tesla valves in the bottom component of the electronic cigarette atomizer, the smoke intensification chamber, the electronic cigarette cartridge, the sealing structure of the electronic cigarette cartridge, and the airflow channel of the microphone. All of them set Tesla valves inside the electronic cigarette to improve the problems of oil leakage or sealing of the electronic cigarette. Not only do they need to modify the internal structure of the existing electronic cigarette, but also the Tesla valve placed in an electronic cigarette cannot be combined with other electronic cigarettes. The present application does not need to modify the mouthpiece, and the Tesla valve is set in the gas distribution device outside the mouthpiece. The gas distribution device containing the Tesla valve can be quickly combined with other mouthpieces after the Tesla valve is placed in a gas distribution device.

[0043] ⑥PCT / CN2021 / 124562 patent discloses an oral-nasal coordinated electronic cigarette, the electronic cigarette smoke can only enter the oral cavity but cannot enter the user's nasal cavity at the same time, and the electronic cigarette structure needs to be modified and the essence carrier needs to be added to make the nasal cavity simultaneously inhale the essence, so the oral inhalation material and the nasal inhalation material are from different sources, which cannot simulate the scene that the mainstream smoke and the sidestream smoke of the cigarette come from the same material, and in order to heat the nasal inhalation essence, a special heating device needs to be specially arranged in the nasal inhalation module. The gas distribution device of the present application can directly distribute the gaseous material released by the oral inhalation member into two paths and enter the user's mouth and nose without modifying the oral inhalation member; and when the oral inhalation member is an electronic cigarette or a cigarette, the temperature of the smoke in the nasal inhalation branch can reach 40-60 DEG C without a special heating device, which can also assist in heating some additional intake materials in the nasal inhalation branch.

[0044] ⑦Patent CN104248043B discloses a smoke flavor compensation device, an electronic cigarette and a filter for a cigarette holder, but only the smoke flavor can be compensated. The gas distribution device of the present application not only compensates the smoke flavor, but also compensates the nicotine and increases other additional intake materials.

[0045] The beneficial effects of the present application are: the present application points out a gas distribution device and a composition containing the same, without modifying the oral inhalation member, the gaseous material released by the oral inhalation member is automatically distributed into two paths by the Tesla valve in the gas distribution device, one path of gaseous material enters the user's oral cavity from the mouth inhalation branch, and the other path of gaseous material enters the user's nasal cavity or is released beside the user's nostrils, so that: the use experience and medical effect of the medical atomizer can be improved; the same source of smoke can be inhaled by the user's mouth and nose at the same time to improve the smoking experience; and the fan airflow and / or the filtering unit can be used to reduce the harmful substances contained in the smoke in the mouth inhalation branch and the nasal inhalation branch of the electronic cigarette or the cigarette, and on the premise that the nicotine meets the efficiency and the smoke flavor is not reduced, the harm reduction of the electronic cigarette and the cigarette exceeds that of the prior art, and some additional intake materials can be inhaled by the user's mouth and nose respectively. BRIEF DESCRIPTION OF DRAWINGS

[0046] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed in the embodiment description are briefly introduced as follows. Obviously, the drawings in the following description are only some embodiments of the present application, and for those skilled in the art, other drawings can be obtained from these drawings without creative labor.

[0047] Fig. 1 is a forward conduction schematic diagram of a Tesla valve.

[0048] Fig. 2 is a reverse suppression schematic diagram of a Tesla valve.

[0049] Fig. 3 is a structure diagram of the composition containing the gas distribution device in embodiment 1.

[0050] Fig. 4 is a structural view of the gas distribution device in Example 2.

[0051] Fig. 5 is a structural view of the composition containing the gas distribution device in Example 3.

[0052] Fig. 6 is a structural view of the composition containing the gas distribution device in Example 4.

[0053] Fig. 7 is a structural view of the composition containing the gas distribution device in Example 5.

[0054] Fig. 8 is a structural view of the suction system 61.

[0055] Fig. 9 is a structural view of the suction system 62.

[0056] Fig. 10 is a structural view of the suction system 63.

[0057] Fig. 11 is a structural view of the suction system 64.

[0058] Fig. 12 is a structural view of the suction system 71.

[0059] Fig. 13 is a structural view of the suction system 72.

[0060] Fig. 14 is a structural view of the suction system 73.

[0061] Fig. 15 is a structural view of the suction system 74.

[0062] Fig. 16 is a structural view of the suction system 81.

[0063] Fig. 17 is a structural view of the suction system 82. DETAILED DESCRIPTION

[0064] The technical solutions in the embodiments of the present application will be described clearly and completely below. Obviously, the described embodiments are only a part of the embodiments of the present application, but not all the embodiments. Based on the embodiments in the present application, all the other embodiments obtained by those skilled in the art without creative work, belong to the protection scope of the present application.

[0065] Please refer to Figs. 1-17, the embodiments of the present application include:

[0066] Comparative Example 1

[0067] Five patients were found in a hospital who were using a medical nebulizer, their diseases were pharyngitis, laryngitis, tonsillitis, etc. upper respiratory tract infection and chronic bronchitis, cough, etc. lower respiratory tract infection, the medical nebulizer included an integrated mask covering the nose, mouth and part of the cheeks, the patient had to keep the mouth open and inhale for about 10 minutes, so that the drug liquid mist could be deposited in the oral cavity and nasal cavity. Among the 5 patients, 1 young woman complained that the drug liquid mist was deposited on her face, 1 boy could not insist on long-term mouth opening and inhalation, 1 old man complained that the mouth opening and inhalation made him uncomfortable, and 2 young men complained that the symptoms of chronic bronchitis and cough did not improve after using the nebulizer for several days.

[0068] Comparative Example 2

[0069] A solid cartridge of an HNB electronic cigarette contains nicotine, tobacco flavor and smoke generating agent, etc. in an effort to make the amount of nicotine in each puff of the HNB electronic cigarette and each puff of the cigarette almost the same. The comprehensive evaluation of 10 smokers is that the nicotine satisfaction efficiency and smoke flavor of the HNB electronic cigarette are worse than those of the cigarette.

[0070] Comparative Example 3

[0071] A cylindrical porous ceramic atomizing core of a CBD electronic cigarette contains a nichrome heating wire, and the periphery of the ceramic atomizing core is a metal cover connected to a metal aerosol channel. The CBD atomizing liquid directly contacts these metal parts when stored at room temperature and heated and atomized. After adding the CBD atomizing liquid to the CBD electronic cigarette for 10 days, the content of nickel ions, chromium ions and lead ions in each puff of aerosol when the CBD electronic cigarette is smoked is detected by the suction system 63.

[0072] Comparative Example 4

[0073] A tobacco-flavored steam electronic cigarette, its oil contains 30wt% ethylene glycol, 50wt% glycerol and 20wt% tobacco extract. The temperature range of the porous ceramic atomizing core and the metal thick film printing layer is 200-310℃. After adding the oil for 10 days, the content of nicotine in each puff of smoke when the electronic cigarette is smoked is detected by the suction system 61; the content of nickel ions, chromium ions, lead ions, formaldehyde, acetaldehyde, propylene aldehyde and diacetyl in each puff of smoke when the electronic cigarette is smoked is detected by the suction system 63.

[0074] Comparative Example 5

[0075] A popular cigarette with filter is chosen from the market. The content of TSNAs and BaP in the sidestream smoke and in the mainstream smoke of each cigarette is detected by using the smoking system 71 ; the content of tar, nicotine, CO and HCN in the sidestream smoke and in the mainstream smoke of each cigarette is detected by using the smoking system 73; the content of carbonyl compounds in the sidestream smoke and in the mainstream smoke of each cigarette is detected by removing the gas bag of the smoking system 73; the number of free radicals in the sidestream smoke and in the mainstream smoke of each cigarette is detected by removing the trap and the gas bag of the smoking system 73; the content of nickel, chromium and lead in the sidestream smoke and in the mainstream smoke of each cigarette is detected by removing the gas bag of the smoking system 73 and replacing the trap with an electrostatic trap tube; the content of NOx in the sidestream smoke and in the mainstream smoke of each cigarette is detected by using the smoking system 81.

[0076] Example 1

[0077] The Tesla valve comprises an inlet pipe 01, a plurality of intermediate pipe units 02 connected in series, and an outlet pipe 03. The intermediate pipe unit comprises an inclined branch pipe 021, an inlet connecting pipe 022 arranged on one side of the inclined branch pipe, and an outlet connecting pipe 023 arranged on the other side of the inclined branch pipe. The inclined branch pipe is connected in parallel with a ring-shaped branch pipe 024. The inlet connecting pipe 022 is connected with the inlet pipe 01, and the outlet connecting pipe 023 is connected with the outlet pipe 03. The Tesla valve can accelerate the forward fluid in multiple stages and throttle the reverse fluid in multiple stages. After the mask of the comparative example 1 medical atomizer is removed, the gas outlet of the medical atomizer is combined with the gas connection section 102 of the gas distribution device 101, the first gasket 103 is adhered to the inner side of the gas connection port of the gas connection section, and the first Tesla valve 104 is arranged in the gas connection section. The gas connection section is horizontally connected with the first gas distribution pipe 105, the first gas distribution pipe is connected with the first sleeve pipe 107 containing the second Tesla valve 106, the second gasket 108 is fixed on the gas inlet housing of the first sleeve pipe, and the first gas distribution pipe and the first sleeve pipe form a mouth suction branch. The gas connection section is also vertically connected with the second gas distribution pipe 109, the second gas distribution pipe is connected with the second sleeve pipe 111 containing the third Tesla valve 110, the third gasket 112 is fixed on the gas inlet housing of the second sleeve pipe, and the gas outlet of the second sleeve pipe is connected with the air pipe in the nasal suction mask 113, which communicates with two gas holes 114 aligned with the nostrils of the user. The nasal suction mask is made of soft silica gel and can be attached to the nose. The fixing belts 115 on both sides of the nasal suction mask are connected with each other and are wrapped around the head of the user. The second gas distribution pipe, the second sleeve pipe, and the nasal suction mask form a nasal suction branch. The medical atomizer is filled with liquid medicine and started, and the liquid medicine aerosol released from the gas outlet is divided into two paths by the gas distribution device. One path enters the oral cavity of the patient from the mouth suction branch, and the other path enters the nasal cavity of the patient through the nasal suction branch. After the medical atomizer used by the five patients in the comparative example 1 is combined with the gas distribution device, the young woman no longer complains that the liquid medicine aerosol is deposited on her face, the boy and the old man are willing to insert the first sleeve pipe deep into their oral cavities or even close to their throats, and the young man feels that more liquid medicine aerosol is deposited in his lower respiratory tract. After several days of continuous use, the symptoms of bronchitis and cough are significantly improved. In addition, a disposable mouthpiece sleeve can be connected to the end of the first sleeve pipe, and a hose can be added between the second sleeve pipe and the nasal suction mask to improve the flexibility of the nasal suction mask.

[0078] Example 2

[0079] The solid cartridge mouthpiece of the HNB electronic cigarette in Comparative Example 2 was inserted into the gas connection port 203 in the gas connection section 202 of the gas distributor 201. The first internal thread joint 204 in the gas connection section connected the first external thread joint 206 in the mouth suction pipe 205 to form the mouth suction branch; the second internal thread joint 207 in the gas connection section connected the second external thread joint 210 in the sleeve 209 containing the Tesla valve 208 to form the nose suction branch. After the HNB electronic cigarette was started, the solid cartridge was heated. When the user used the mouth to generate a suction airflow at the end of the mouth suction pipe, the suction airflow was throttled and blocked by the Tesla valve in the nose suction branch, so that the gas connection section maintained a negative pressure. The suction airflow made the smoke released by the solid cartridge enter the gas distributor and be divided into two paths. One path of the smoke entered the user's oral cavity from the mouth suction branch. At the same time, the other path of the smoke entered the nose suction branch and was accelerated and conducted by the first Tesla valve. The gas outlet of the nose suction branch was close to the user's nostrils, and the user's nasal cavity could inhale the smoke. The comprehensive evaluation of 10 taste testers was that: due to the fact that the smoke could be inhaled by the mouth and nose at the same time, the nicotine satisfaction efficiency and the smoke aroma of the HNB electronic cigarette were very close to those of a cigarette. In addition, the mouthpieces of the electronic atomizer, the steam electronic cigarette, the CBD electronic cigarette, the combustion type cigarette, the tobacco pipe, the water pipe and other mouth suction pieces were respectively inserted into the gas connection port 203 of the gas distributor. The gas distributor could also divide the smoke released by these mouth suction pieces into two paths to enter the user's oral cavity and nasal cavity, thereby improving the suction experience of these mouth suction pieces.

[0080] Example 3

[0081] The mouthpiece of the CBD electronic cigarette in Comparative Example 3 was inserted into the gas inlet 303 in the gas connection section 302 of the gas distribution device 301. The first internal threaded joint 304 in the gas connection section was connected to the first external threaded joint 306 in the first sleeve 305, which contained a cylindrical first filter unit 307, a gas-permeable tube plug 308, and a gas-permeable tube plug 309. The first filter unit contained polypropylene fibers loaded with EDTA-[Ch][Lys] as filter material, and the ionic liquid [Ch][Lys] contained a small amount of meso-tetra-(p-sulfonatophenyl) porphyrin as a color developing agent. The second internal threaded joint 310 in the first sleeve was connected to the second external threaded joint 312 in the second sleeve 311, which contained a first Tesla valve 313. The first sleeve and the second sleeve formed a mouth suction branch. The third internal threaded joint 314 in the gas connection section was connected to the third external threaded joint 316 in the third sleeve 315, which contained a second Tesla valve 317. The fourth internal threaded joint 318 in the third sleeve was connected to the fourth external threaded joint 320 in the fourth sleeve 319, which contained a second filter unit 321, a gas-permeable tube plug 322, and a gas-permeable tube plug 323. The second filter unit was also polypropylene fibers loaded with EDTA-[Ch][Lys], and the ionic liquid [Ch][Lys] contained a small amount of 1-(2-pyridylazo)-2-naphthol as a color developing agent. The third sleeve and the fourth sleeve formed a nose suction branch. When the user used the mouth to generate a suction airflow at the end of the second sleeve, the suction airflow was blocked by the second Tesla valve in the nose suction branch, so that the suction airflow formed a negative pressure environment with the aerosol channel of the CBD electronic cigarette, thereby activating the airflow sensing switch in the electronic cigarette, starting to heat the CBD atomizing liquid and releasing aerosol. The aerosol was divided into two paths in the gas connection section, one path of the aerosol entered the user's oral cavity from the mouth suction branch, and the other path of the aerosol entered the user's nasal cavity from the nose suction branch. The comprehensive evaluation of six CBD users was that they could benefit from the simultaneous intake of CBD aerosol into the mouth and nose, and could relax their body and mind with fewer puffs. In addition, an inclined baffle 324 could be provided in the gas connection section, which could increase the aerosol entering the nose suction branch and reduce the aerosol entering the mouth suction branch. In addition, the mouth suction branch and the nose suction branch could also exchange positions. When the mouth suction branch changed from parallel to the electronic cigarette rod to perpendicular to the electronic cigarette rod, the nose suction branch changed from perpendicular to the electronic cigarette rod to parallel to the electronic cigarette rod. At this time, the user's face was almost parallel to the rod, which could also make the CBD aerosol enter the user's oral cavity and nasal cavity at the same time. Using the suction system 64, the sum of the contents of nickel ions, chromium ions, and lead ions in the aerosol was detected during each puff of the CBD electronic cigarette. The contents of nickel ions, chromium ions, and lead ions in the aerosol during each puff of the CBD electronic cigarette in Comparative Example 3 and Example 3 were compared, and the results are shown in Table 1:

[0082] Table 1

[0083] Example 4

[0084] The mouthpiece of the steam electronic cigarette in Comparative Example 4 was inserted into the gas connection port 403 in the gas connection section 402 of the gas distribution device 401. The first gas distribution pipe 404 in the gas connection section was connected to the first sleeve pipe 405, the outer wall of the air inlet of the first sleeve pipe was provided with the first gasket 406, and the first Tesla valve 407 was arranged in the first sleeve pipe. The air outlet of the first sleeve pipe was connected to the second sleeve pipe 408, and the second sleeve pipe was provided with the second gasket 409, the air pipe plug 410, the first filter unit 411 and the air pipe plug 412. The first filter unit was filled with four kinds of particles with a particle size of 0.1mm-3mm as filter material, and the proportion of each kind of particle was 25wt%. Specifically, the four kinds of particles were sepiolite, MCM-41 molecular sieve, chitosan-Cu 2+meals, iron porphyrin loaded activated carbon, wherein the surface of the meales adsorbs a small amount of color developing agent meso-tetra (4-nitrophenyl) porphyrin. The gas outlet of the second sleeve is connected to the third sleeve 413, the outer wall of the gas inlet of the third sleeve is provided with a third gasket 414, the third sleeve is provided with a gas permeable tube plug 415, a second filter unit 416 and a gas permeable tube plug 417, the second filter unit is EDTA-[Ch][Lys] loaded polypropylene fiber and is suspended in a vial containing 2 grams of nicotine for 0.5h to pre-adsorb a small amount of nicotine. The first gas branch, the first sleeve, the second sleeve and the third sleeve form the mouth suction branch. The second gas branch in the gas connection section is at an angle of about 150° with the tobacco rod, the second gas branch is connected to the fourth sleeve 419, the outer wall of the gas inlet of the fourth sleeve is provided with a fourth gasket 420, and the fourth sleeve is provided with a second Tesla valve 421. The gas outlet of the fourth sleeve is connected to the fifth sleeve 422, the fifth sleeve is sequentially provided with a fifth gasket 423, a gas permeable tube plug 424, a third filter unit 425 and a gas permeable tube plug 426, the third filter unit is filled with the same filtering material as the first filter unit, wherein the surface of the MCM-41 molecular sieve adsorbs a small amount of color developing agent 4-(2-pyridine azo) resorcinol. The gas outlet of the fifth sleeve is connected to the sixth sleeve 427, the outer wall of the gas inlet of the sixth sleeve is provided with a sixth gasket 428, the sixth sleeve is provided with a gas permeable tube plug 429, a fourth filter unit 430 and a gas permeable tube plug 431, the fourth filter unit is also EDTA-[Ch][Lys] loaded polypropylene fiber and pre-adsorbs a small amount of nicotine, the gas permeable tube plug 431 is a metal grid loaded with a thin layer of β-cyclodextrin and iron porphyrin gel and pre-adsorbs a small amount of nicotine and essence. The second gas branch, the fourth sleeve, the fifth sleeve and the sixth sleeve form the nose suction branch. When the user generates a suction airflow at the end of the mouth suction branch, the electronic cigarette smoke enters the gas distribution device and is divided into two paths, one path of smoke enters the user's oral cavity from the mouth suction branch, and the other path of smoke enters the nose suction branch and is released beside the user's nostrils. The comprehensive evaluation of eight electronic cigarette users is: due to the simultaneous intake of electronic cigarette smoke into the mouth and nose, the electronic cigarette can satisfy the nicotine requirement with fewer puffs and richer smoke flavor. In addition, a fan 432 can be provided in the cavity of the gas connection section, the fan blade has a "V" excavated bucket shape, the upper part 433 of the fan blade has an opening, and the thickness of the upper part to the bottom 434 of the fan blade gradually decreases. The suction airflow of the mouth suction branch and the smoke released by the electronic cigarette can make the fan blade rotate and increase the amount of smoke entering the nose suction branch, or the fan blade is rotated by the battery and mechanical pressing force. The suction system 62 detects the sum of the nicotine content in the smoke of the mouth suction branch and the nose suction branch when the electronic cigarette is smoked; the suction system 64 detects the sum of the nickel ion, chromium ion, lead ion, formaldehyde, acetaldehyde, propylene aldehyde and diacetyl in the smoke of the mouth suction branch and the nose suction branch when the electronic cigarette is smoked.The contents of nickel ions, chromium ions, lead ions, formaldehyde, acetaldehyde, propylene aldehyde, diacetyl and nicotine in the smoke when the electronic cigarette was puffed in Comparative Example 4 and Example 4 are shown in Table 2.

[0085] Table 2

[0086] Example 5

[0087] In Comparative Example 5, the filter of the cigarette was inserted into the gas connection port 503 in the gas connection section 502 of the gas distribution device 501, and the filter with a small diameter was inserted into the inner tube 504. The first gas distribution tube 505 in the gas connection section was connected to the first sleeve tube 506, and the first Tesla valve 507 was arranged in the first sleeve tube. The gas outlet of the first sleeve tube was connected to the first U-shaped tube 508, the other end of the first U-shaped tube was connected to the second sleeve tube 509, and the gas permeable tube plug 510, the first filter unit 511 and the gas permeable tube plug 512 were arranged in the second sleeve tube. The first filter unit was filled with eight kinds of particles with a particle size of 0.1mm-3mm and an occupancy of 12.5wt%, and the specific particles were as follows: zeolite loaded with Cu 2+ , porous alumina particles loaded with MCM-48-NH2, rhyolite loaded with chitosan-Cu 2+ , sepiolite loaded with MnO-CoO, Cu + -NaY molecular sieve, porous ceramic microspheres loaded with Ni 2+ -MOFs, and porous ceramic microspheres loaded with Fe 2+- Resin particles of EDTA, activated carbon loaded with iron porphyrin. The outlet of the second sleeve is connected to a second U-shaped tube 513, the other end of the second U-shaped tube is connected to a third sleeve 514, and the third sleeve is provided with a gas-permeable tube plug 515 compounded with fluorosilane, a fixing frame 516, a gas guide tube 517, a second filter unit 518, a sealing plug 519 of a liquid injection port, a fixing frame 520, a gas guide tube 521, a gas-permeable tube plug 522 compounded with fluorosilane, a third filter unit 523, a gas-permeable tube plug 524, wherein the second filter unit is a 0.5wt% NaOH aqueous solution in which eight kinds of filter materials are dissolved, and the concentration of each of the eight kinds of filter materials is 0.1wt%, specifically: EDTA-2Na, Ni(II)-EDTA, cellulose, tea polyphenol, cannabigerol, vitamin E, selenium-rich yeast, and β-cyclodextrin. In addition, the aqueous solution also contains a small amount of antibacterial agent. The third filter unit is acetic acid fiber loaded with iron porphyrin and β-cyclodextrin, and then adsorbs ten additional intakes, specifically: menthol, nicotine, arecoline, caffeine, rosemary, monk fruit extract, linalool, lily essential oil, pear extract, and pipa extract. The first gas branch pipe, the first sleeve, the first U-shaped tube, the second sleeve, the second U-shaped tube, and the third sleeve form a mouth suction branch. The second gas branch pipe 525 in the gas connection section is connected to the fourth sleeve 526, and the fourth sleeve is provided with a second Tesla valve 527. The outlet of the fourth sleeve is connected to a third U-shaped tube 528, the other end of the third U-shaped tube is connected to a fifth sleeve 529, and the fifth sleeve is provided with a gas-permeable tube plug 530, a fourth filter unit 531, and a gas-permeable tube plug 532 compounded with PTFE, and the fourth filter unit is filled with the same adsorbent material as the first filter unit. The outlet of the fifth sleeve is connected to a fourth U-shaped tube 533, and the fourth U-shaped tube is provided with a fifth filter unit 534, which is a suspension of β-cyclodextrin containing 2.28ml of PEG-600, 5.72ml of triacetin, 0.05g of tobacco essence, 0.05g of nicotine, 0.01g of clove extract, and 0.1g of β-cyclodextrin. The fifth filter unit also has a sealing plug 535 of a liquid injection port. The other end of the fourth U-shaped tube is connected to a sixth sleeve 536, and the sixth sleeve is provided with a gas-permeable tube plug 537 compounded with PTFE, a sixth filter unit 538, and a gas-permeable tube plug 539. The sixth filter unit is a cylindrical porous filter core with a length of 5mm, and its composition is: 6wt% of porous silica gel loaded with EDTA-[Ch][Lys], 93.6wt% of selenium-rich plant stems and leaves, 0.3wt% of β-cyclodextrin, and 0.1wt% of cellulose, and it is pre-adsorbed with volatile substances in tobacco extract, xanthium extract, passion fruit extract, rose essential oil, lavender essential oil, jasmine essential oil, osmanthus essential oil, and lily magnolia essential oil. The second gas branch pipe, the fourth sleeve, the third U-shaped tube, the fifth sleeve, the fourth U-shaped tube, and the sixth sleeve form a nasal suction branch.The air distribution device is fixed in a cavity 541 of a cylinder 540, which is made of two halves connected by a snap joint, and includes two openable cavity covers. A battery 542 and its charging port are also provided in the cavity, and wires 543 connect the battery to a controller 544, while wires 545 connect the controller to a motor 548 through a fan base 546 and a fan shaft 547. The motor drives the rotation of fan blades 549, and the fan airflow flows out of multiple air outlets 551 in a front cover 550 of the cavity, while a rear cover 552 of the cavity is also provided with multiple air inlets 553. The fan airflow can continuously blow the burning cone of a cigarette, not only blowing the sidestream smoke away from the user's nostrils and scalp pores, but also accelerating the air flow around the burning cone, reducing the smoldering of the cigarette in an oxygen-deficient environment, and thus reducing the harmful substances such as CO and NOx in mainstream smoke. In the air distribution device composition, the front end of the air inlet, the end of the mouth suction branch, the end of the nose suction branch, the fan controller knob, and the battery charging port are all provided outside the cavity of the cylinder, which is convenient for users to operate. When the user generates suction airflow at the end of the mouth suction branch, the mainstream smoke of the cigarette enters the air distribution device, and one-way smoke enters the user's oral cavity through the mouth suction branch, while the other way smoke reaches the user's nostrils through the nose suction branch. Five smokers used the air distribution device composition to smoke five cigarettes, and the nicotine satisfaction was higher than that of eight cigarettes smoked in the conventional way, and the smoke flavor was stronger and more full-bodied. The surface of the cylinder is also provided with a circular cigarette storage 554, which is arranged and stacked with some medium-diameter cigarettes 555 and smaller-diameter cigarettes 556, and the cigarette storage cover 557 is provided with corresponding cigarette outlets 558 and 559 and a movable sealing cover. The inside of the cylinder is also provided with a sundry storage 561 for storing matches 560 and the like, and the rear cover 552 is provided with a corresponding cover 562. The inside of the cylinder is also provided with a cigarette butt storage 565 for storing medium-diameter cigarette butts 563, smaller-diameter cigarette butts 564, and ash, and the rear cover 552 is provided with a corresponding cover 566. The rear cover is also provided with a steel sheet 567 that can ignite a match by friction. In addition, the cigarette storage 554 is provided with independent sub-storages for each cigarette, and the cigarette storage cover 557 is provided with corresponding cigarette outlets. The cigarettes can be naturally slid out of the cigarette outlets or taken out with the help of tweezers 568 and the like.The contents of TSNAs and BaP in the smoke of each cigarette in the nose suction branch and in the mouth suction branch were detected by using the suction system 72; the contents of tar, nicotine, CO and HCN in the smoke of each cigarette in the nose suction branch and in the mouth suction branch were detected by using the suction system 74; after removing the gas bag from the suction system 74, the contents of carbonyl compounds in the smoke of each cigarette in the nose suction branch and in the mouth suction branch were detected; after removing the trap and the gas bag from the suction system 74, the number of free radicals in the smoke of each cigarette in the nose suction branch and in the mouth suction branch was detected; after removing the gas bag from the suction system 74 and replacing the trap with an electrostatic capture tube, the contents of nickel, chromium and lead in the smoke of each cigarette in the nose suction branch and in the mouth suction branch were detected; and the content of NOx in the smoke of each cigarette in the nose suction branch and in the mouth suction branch was detected by using the suction system 82. In Comparative Example 5 and Example 5, the contents of tar, nicotine, CO, carbonyl compounds, NOx, HCN, TSNAs, BaP, nickel, chromium, lead and free radicals in the smoke of the smoked cigarettes were compared, and the results are shown in Table 3.

[0088] Table 3

[0089] Detection experiment

[0090] 1. Device and method for quantitatively detecting multiple components in electronic cigarette smoke

[0091] According to GB 41700-2022 Electronic Cigarettes, GB / T 41701-2022 Determination of Nicotine, Propylene Glycol and Glycerol in Electronic Cigarette Liquid by Gas Chromatography, and Migration of Heavy Metals in Metal Parts for Electronic Cigarettes, Tobacco Science, 2019, etc.

[0092] 1.1 Suction system

[0093] The suction system 61 is: inserting the mouthpiece of the electronic cigarette 601 into the holder 602, and connecting the smoke outlet of the electronic cigarette with the trap 603 containing a filter and the smoke machine 604 containing a vacuum pump.

[0094] The suction system 62 is: based on the suction system 61, adding a gas distribution device 605 and a Y-shaped tube 606.

[0095] The suction system 63 is: based on the suction system 61, adding two absorption bottles 608 containing absorption liquid 607, and the absorption liquid is 15 ml of 20 vol% nitric acid solution.

[0096] The suction system 64 is: based on the suction system 63, adding a gas distribution device 605 and a Y-shaped tube 606.

[0097] The parameters of the electronic cigarette smoking machine when detecting the following items are: 200 puffs of continuous smoking of the vapor electronic cigarette and the CBD electronic cigarette, 4 cartridges of continuous smoking of the HNB electronic cigarette, 3 seconds of interval after each puff, 30 seconds of interval, 55 ml of puffing capacity, and replacement of the filter pad every 20 puffs.

[0098] 1.2 Detection of nicotine

[0099] According to the puffing system 61 or the puffing system 62, nicotine adsorbed by the filter pad of the trap is extracted with an isopropyl alcohol solution containing 0.3 mg / ml of n-heptadecane, and detected by gas chromatography. According to the standard working curve, the content of nicotine in the smoke of each puff of the electronic cigarette is calculated.

[0100] 1.3 Detection of carbonyl compounds

[0101] According to the puffing system 63 or the puffing system 64, 1 gram of 2,4-dinitrophenylhydrazine hydrochloride, 500 ml of acetonitrile, 4.8 ml of 85 wt% phosphoric acid, and 535.2 ml of water are mixed to prepare a derivatization reagent, 25 ml of the derivatization reagent is transferred to two absorption bottles as absorption liquid, the carbonyl compounds in the smoke are derivatized by the absorption liquid, 5 ml of solution is transferred from each absorption bottle to a 20 ml volumetric flask, 0.5 ml of pyridine is added, and the volume is made up with acetonitrile, filtered with a filter membrane with a pore size of 0.45 microns, and then detected by high performance liquid chromatography. According to the standard working curve of formaldehyde, acetaldehyde, propylene aldehyde, and diacetyl, the content of these carbonyl compounds in the smoke of each puff of the electronic cigarette is calculated.

[0102] 1.4 Detection of chromium, nickel, and lead

[0103] According to the puffing system 63 or the puffing system 64, a 20 vol% nitric acid solution is used as absorption liquid, and ICP-MS instrument is used for detection, and according to the standard working curve of chromium ions, nickel ions, and lead ions, the content of chromium ions, nickel ions, and lead ions in the smoke of each puff of the electronic cigarette is calculated.

[0104] 2. Puffing system and method for quantitatively detecting a plurality of components in mainstream smoke and sidestream smoke of a cigarette

[0105] According to GB / T 16450-2004, Definition and Standard Conditions for Smoking Machines for Routine Analysis, GB / T 19609-2004, Determination of Total Particulate Matter and Tar in Cigarettes by Smoking Machine for Routine Analysis, YC / T 185-2004, Determination of Tar and Nicotine in Cigarette Sidestream Smoke, GB / T 21130-2007, Determination of Benzo[a]pyrene in Total Particulate Matter of Cigarettes / Smoke, YC / T 246-2008, Determination of Nicotine in Tobacco and Tobacco Products by Gas Chromatography, YC / T 254-2008, Determination of Main Carbonyl Compounds in Mainstream Smoke of Cigarettes by High Performance Liquid Chromatography, GB / T 23228-2008, Determination of Tobacco-Specific N-Nitrosamines in Total Particulate Matter of Mainstream Smoke of Cigarettes by Gas Chromatography-Thermal Energy Analysis, YC / T 348-2010, Determination of Nitrogen Oxides in Mainstream Smoke of Cigarettes by Ion Chromatography, YC / T 350-2010, Determination of Hydrogen Cyanide in Cigarette Sidestream Smoke by Continuous Flow Method, YC / T 378-2010, Determination of Carbonyl Compounds in Cigarette Sidestream Smoke by High Performance Liquid Chromatography, YC / T 379-2010, Determination of Chromium, Nickel, Arsenic, Selenium, Cadmium and Lead in Mainstream Smoke of Cigarettes by Inductively Coupled Plasma Mass Spectrometry, GB / T 27525-2011, Determination of Benzo[a]pyrene in Cigarettes / Sidestream Smoke by Gas Chromatography-Mass Spectrometry, GB / T 28971-2012, Determination of Tobacco-Specific N-Nitrosamines in Cigarette Sidestream Smoke by Gas Chromatography-Thermal Energy Analyzer, GB / T 23203.1-2013, Determination of Moisture in Total Particulate Matter of Cigarettes - Part 1: Gas Chromatographic Method, DB45 / T 1495-2017, Determination of Solid Phase Free Radical Content in Mainstream Smoke of Cigarettes by Electron Spin Resonance Spectrometry, YC / T 253-2019, Determination of Hydrogen Cyanide in Mainstream Smoke of Cigarettes by Continuous Flow Method, etc.

[0106] 2.1 Smoking system

[0107] The same brand of cigarettes with filters were pretreated at 22℃ and relative humidity 60% for 48h, and then the cigarettes with proper suction resistance, length and weight were selected for the following smoke component detection.

[0108] The smoking system 71 is: inserting the filter of the cigarette 701 into the trap 702 containing filter, connecting the flow meter and flow regulating valve 703, the smoking machine 704 containing vacuum pump and the exhaust passage 705 for trapping mainstream smoke; and setting the fish tail cover 706, the trap 707 containing filter, the flow meter and flow regulating valve 708, the vacuum pump 709 and the exhaust passage 710 for trapping sidestream smoke.

[0109] The smoking system 72 is: based on the smoking system 71, adding the gas distribution device composition 711.

[0110] Suction system 73 is: based on suction system 71, 2 absorption bottles 713 containing absorption liquid 712 and gas collection bag 714 are added to trap mainstream smoke, 2 absorption bottles 716 containing absorption liquid 715 and gas collection bag 717 are added to trap sidestream smoke.

[0111] Suction system 74 is: based on suction system 73, gas distribution device composition 711 is added.

[0112] Suction system 81 is: the filter of cigarette 801 is inserted into holder 802 containing filter, piston pump 803 of smoking machine, double bulb glass tube 804 filled with chromium trioxide-quartz sand, 2 absorption bottles 806 containing absorption liquid 805, exhaust passage 807 are connected to trap mainstream smoke; fish tail cover 808, holder 809 containing filter, piston pump 810 of smoking machine, double bulb glass tube 811 filled with chromium trioxide-quartz sand, 2 absorption bottles 813 containing absorption liquid 812, exhaust passage 814 are also set up to trap sidestream smoke.

[0113] Suction system 82 is: based on suction system 81, gas distribution device composition 815 is added.

[0114] Cigarette smoking machine parameters: after lighting the cigarette, interval 5.5 seconds after 2 seconds of each puff, each puff capacity 35 ml, replace the next cigarette after 8 puffs, and replace the filter during the period.

[0115] 2.2 Detection of TSNAs in smoke

[0116] Using suction system 71 or suction system 72, the filter in the trap and the fish tail cover are pretreated with ascorbic acid, and after 20 cigarettes are smoked, the filter in the trap is extracted with CH2Cl2 and the inner wall of the fish tail cover is cleaned. The extract of the filter in the mainstream smoke trap is used as the mainstream smoke sample, and the extract of the filter in the sidestream smoke trap and the cleaning liquid of the fish tail cover are combined to form the sidestream smoke sample. The two samples are concentrated by rotary evaporator and then purified by basic alumina chromatographic column, and the content of TSNAs in each sample is determined by gas chromatography-thermal energy analysis instrument. According to the standard working curve, the content of TSNAs in each cigarette sidestream smoke and each mainstream smoke is calculated respectively.

[0117] 2.3 Detection of BaP in smoke

[0118] After 20 cigarettes were smoked by using suction system 71 or suction system 72, BaP in the filter of the trap was extracted by cyclohexane. The smoke condensate on the fish tail was washed by methanol and then cyclohexane was extracted after the methanol was volatilized. The extract of the filter of the mainstream smoke trap was used as the sample of the mainstream smoke, and the extract of the filter of the sidestream smoke trap and the extract of the inner wall of the fish tail were combined and used as the sample of the sidestream smoke. The two samples were concentrated by a rotary evaporator and purified by a solid phase extraction column, and the content of BaP was quantitatively determined by a gas chromatograph-mass spectrometer. According to the standard working curve, the content of BaP in each sidestream smoke and in each puff of mainstream smoke was calculated.

[0119] 2.4 Detection of tar, nicotine and CO in smoke

[0120] After 24 cigarettes were smoked by using suction system 73 or suction system 74, nicotine in the mainstream smoke was the sum of nicotine in the filter of the mainstream smoke trap and in the absorption bottle, and tar in the mainstream smoke was the remaining part of the total particulate matter in the filter of the mainstream smoke trap minus water and nicotine. CO in the mainstream smoke was collected by the gas bag 714. Nicotine in the sidestream smoke was the sum of nicotine in the filter of the sidestream smoke trap, in the absorption bottle and on the inner wall of the fish tail, and tar in the sidestream smoke was the remaining part of the total particulate matter in the filter of the sidestream smoke trap minus water and nicotine, plus tar on the inner wall of the fish tail. CO in the sidestream smoke was collected by the gas bag 717. A solution of n-heptadecane in isopropanol with a concentration of 0.3 mg / ml was used as the extractant for the total particulate matter on the filter of the trap, the absorbent in the absorption bottle and the cleaning agent for the inner wall of the fish tail. After smoking, the total particulate matter in the filter of the mainstream smoke trap and in the filter of the sidestream smoke trap was determined by gravimetric method, the water and nicotine in the filter of the sidestream smoke trap, nicotine on the inner wall of the fish tail and in the absorption bottle, and water and nicotine in the filter of the mainstream smoke trap and in the absorption bottle were determined by gas chromatography, and tar in the cleaning agent for the inner wall of the fish tail was calculated by ultraviolet absorption spectroscopy, and CO in the two gas bags was determined by a non-dispersive infrared analyzer. According to the respective standard working curve, the content of tar, nicotine and CO in each sidestream smoke and in each puff of mainstream smoke was calculated.

[0121] 2.5 Detection of HCN in smoke

[0122] The filter in the trap is pre-treated with NaOH-ethanol / water solution using suction system 73 or 74 without a bag, 5 cigarettes are smoked, the HCN in the mainstream smoke is the sum of the HCN in the mainstream smoke trap and the absorption solution, and the HCN in the sidestream smoke is the sum of the HCN in the inner wall of the fish tail, the filter in the sidestream smoke trap and the absorption solution. The 0.1 M NaOH aqueous solution is used as the extractant for the filter in the trap, the absorbent in the absorption bottle and the cleaning agent for the inner wall of the fish tail. The extractant for the filter in the mainstream smoke trap and the absorption solution for the mainstream smoke are combined to form a mainstream smoke sample, and the cleaning solution for the inner wall of the fish tail, the extractant for the filter in the sidestream smoke trap and the absorption solution for the sidestream smoke are combined to form a sidestream smoke sample. Under slightly acidic conditions, the cyanide ion and chloramine T in the two samples react to form cyanogen chloride, which reacts with isonicotinic acid to form pentenedialdehyde by hydrolysis, which then reacts with 1,3-dimethylbarbituric acid to form a blue compound, and the absorbance is detected at 600 nm. According to the standard working curve, the content of HCN in each sidestream smoke and each mainstream smoke is calculated.

[0123] 2.6 Detection of carbonyl compounds in smoke

[0124] 1.5 g of 2,4-dinitrophenylhydrazine is dissolved in 80 ml of acetonitrile, 200 μl of perchloric acid is added, and the volume is made up to 100 ml with acetonitrile to prepare a derivatization reagent. 2.5 g of 2,4-dinitrophenylhydrazine is dissolved in 800 ml of acetonitrile, 2 ml of perchloric acid is added, and the volume is made up to 1000 ml with acetonitrile to prepare an absorbent for the absorption bottle. 1 ml of the derivatization reagent is added to the filter in the trap, and 2 cigarettes are smoked using suction system 73 or 74 without a bag. A 2 vol% pyridine-acetonitrile solution is used as the extractant, and the extractant after the filter in the mainstream smoke trap is soaked is combined with the absorption solution in the absorption bottle to form a mainstream smoke sample. The cleaning solution after the inner wall of the fish tail is cleaned with the absorbent, the extractant after the filter in the trap is soaked and the absorption solution in the absorption bottle are combined to form a sidestream smoke sample. The two samples are filtered through a filter membrane with a pore size of 0.45 μm and then concentrated using a rotary evaporator. The content of the carbonyl compounds is determined by high performance liquid chromatography, and the total content of the 8 carbonyl compounds, i.e. formaldehyde, acetaldehyde, acetone, propylene aldehyde, propyl aldehyde, croton aldehyde, 2-butanone and butyl aldehyde, in each sidestream smoke and each mainstream smoke is calculated according to the standard working curve.

[0125] 2.7 Detection of free radicals in smoke

[0126] The free radicals were quantitatively detected by using the suction system 73 or 74 without the trap and the bag, and four absorption bottles were respectively filled with 20 ml of N-tert-butyl-α-phenyl nitrone tetrachloromethane solution (PBN-CCl4) with a concentration of 0.02 M as the absorbent. After one cigarette was smoked, the inner wall of the fume fish tail cover was immediately washed with tetrachloromethane, and the absorption liquid in two absorption bottles was combined and diluted to 100 ml as the sidestream smoke sample. The absorption liquid in the other two absorption bottles was combined and diluted to 100 ml as the mainstream smoke sample. The number of free radicals in the sidestream smoke of each cigarette and in the mainstream smoke of each puff was respectively calculated by using an electron spin resonance spectrometer (ESR).

[0127] 2.8 Detection of heavy metals in smoke

[0128] The absorbent in the absorption bottle was 20 ml of 10 vol% nitric acid. The bag was removed from the suction system 73 or 74, and the trap was replaced by the electrostatic collection tube. After 10 cigarettes were smoked, the washing liquid for washing the inner wall of the electrostatic collection tube of the mainstream smoke and the absorption liquid in the absorption bottle of the mainstream smoke were both added to a digestion tank. After methanol and other organic impurities were evaporated, an appropriate amount of nitric acid and hydrogen peroxide was added for microwave digestion, transfer and constant volume to obtain the mainstream smoke sample. The washing liquid for washing the inner wall of the fume fish tail cover and the inner wall of the electrostatic collection tube of the sidestream smoke, and the absorption liquid in the absorption bottle of the sidestream smoke were all added to another digestion tank. After methanol and other organic impurities were evaporated, an appropriate amount of nitric acid and hydrogen peroxide was added for microwave digestion, transfer and constant volume to obtain the sidestream smoke sample. Nitric acid solutions of chromium, nickel and lead with different concentrations were prepared in advance as standard working solutions. The standard working curve was prepared by using the quantitative relationship between mass-to-charge ratio intensity and element concentration by inductively coupled plasma mass spectrometry. The content of chromium, nickel and lead in the sidestream smoke of each cigarette and in the mainstream smoke of each puff was respectively calculated.

[0129] 2.9 Detection of NOx in smoke

[0130] The suction system 81 or 82 was used to smoke 3 cigarettes. The mainstream smoke and the sidestream smoke passed through the filter holder, the double bulb glass tube and the absorption bottle respectively. The chromium trioxide-quartz sand in the double bulb glass tube oxidized NO in the gas phase to NO2, which was then absorbed by the triethanolamine solution in the absorption bottle to be converted into NO2 - and NO3 - . After ion exchange separation, the NOx content in the sidestream smoke of each cigarette and in the mainstream smoke of each puff was respectively calculated by using the conductive detector according to the standard working curve.

[0131] In 2.2-2.9 above, the plurality of components in the cigarette smoke in Comparative Example 5 were detected using suction system 71, suction system 73 and suction system 81. When the plurality of components in the cigarette smoke in Example 5 were detected using suction system 72, suction system 74 and suction system 82, the mainstream smoke was equivalent to the mouth suction branch smoke, and the sidestream smoke was equivalent to the nose suction branch smoke.

[0132] The technical effects of the above examples are:

[0133] Compared with Comparative Example 1, Example 1 uses the gas distribution device to divide the gaseous substances released by the medical atomizer into two paths, and then accelerates them through the Tesla valve and respectively enters the patient's oral cavity and nasal cavity, which helps the medical atomizer to treat lower respiratory tract diseases and improves the user experience.

[0134] Compared with Comparative Example 2, in Example 2, the user inhales the same smoke released by the HNB at the same time, simulates the user inhaling the mainstream smoke and sidestream smoke at the same time when smoking cigarettes, and narrows the gap between the smoking experience of electronic cigarettes and cigarettes.

[0135] Compared with Comparative Example 3, in Example 3, two polypropylene fiber filter units of EDTA-[Ch][Lys] are set, and the reduction of three heavy metal ions in the CBD electronic cigarette aerosol is 45.08%-51.32% per puff.

[0136] Compared with Comparative Example 4, in Example 4, four filter units are set, and the reduction of three heavy metal ions in the electronic cigarette smoke is 57.52%-64% per puff, and the reduction of four carbonyl compounds is 48.36%-52.99%.

[0137] The reduction of the main harmful substances in the mouth suction branch smoke of Example 5 per puff is 56.57%-100% compared with the main harmful substances in the cigarette mainstream smoke of Comparative Example 5 per puff, and the reduction of the main harmful substances in the nose suction branch smoke of Example 5 per cigarette is 93.38%-99.23% compared with the sidestream smoke of Comparative Example 5 per cigarette. The harm reduction effect of the gas distribution device composition on the user's intake of cigarette smoke exceeds the prior art. The main reasons are: (1) the fan airflow in the gas distribution device composition can timely blow the cigarette sidestream smoke away from the user's nostrils and scalp pores, and can also accelerate the airflow around the burning cone, thereby reducing the harmful substances such as tar, CO, NOx in the mainstream smoke. (2) The mouth suction branch smoke or the nose suction branch smoke is a branch of the mainstream smoke of each cigarette. (3) The six filter units in the gas distribution device composition contain a plurality of adsorbent materials, which can selectively intercept the harmful substances in the smoke by physical adsorption and chemical reaction, and the specific interception is:

[0138] Cu-loaded 2+Zeolite ZSM-5 can intercept nitrosamines in flue gas. The principle is that the oxygen in the N-N=O functional group of nitrosamines with a flat structure is negatively charged by structural resonance, and is strongly attracted by the cylindrical electrostatic field formed by the movement of cations in the zeolite channel, causing the N-N=O functional group of nitrosamines to insert into the zeolite channel. In addition, Cu 2+ "induction" not only promotes the above interception, but also catalyzes the degradation of nitrosamines.

[0139] Porous alumina particles loaded with MCM-48-NH2 can intercept HCN in flue gas. The principle is that the amino group in MCM-48-NH2 can form a covalent bond with HCN.

[0140] Chitosan-Cu 2+ loaded with MCM-48-NH2 can intercept HCN in flue gas. The principle is that the amino group in MCM-48-NH2 can form a covalent bond with HCN. 2+ The lone pair of electrons in Cu

[0141] MnO-CoO loaded sepiolite and Fe(II)-EDTA loaded resin can intercept NOx in flue gas. The principle is that the metal ions in the substate can catalyze the reduction of NOx to N2; Fe 2+ in Fe(II)-EDTA can complex NOx.

[0142] Chitosan and EDTA can intercept heavy metal ions in flue gas. The principle is that the amino and hydroxyl groups in the chitosan molecule can complex heavy metal ions; the two nitrogen atoms and four hydroxyl oxygen atoms on the carboxyl groups in the EDTA molecule can complex heavy metal ions, especially in the liquid phase, which can completely intercept heavy metal ions.

[0143] Cu + -NaY molecular sieve and porous ceramic microspheres loaded with Ni 2+ -MOFs can intercept CO in flue gas. The principle is that Cu + or Ni 2+ can form metal carbonyl complexes with CO, which belong to π-bond complex adsorption.

[0144] Basic carriers can intercept acidic harmful substances such as HCN in flue gas. The principle is that the acid-base neutralization reaction.

[0145] A suspension of β-cyclodextrin can intercept tar, nitrosamines and carbonyl compounds in flue gas. The principle is that the glucose hydroxyl groups on the surface of β-cyclodextrin bind tar, nitrosamines and carbonyl compounds by hydrogen bonds.

[0146] The activated carbon loaded with iron porphyrin can intercept benzopyrene, CO, HCN, NOx, nitrosamine, carbonyl compound and tar in the smoke. The principle is that the molecule of porphyrin compound has rigid structure and large surface, and can have strong π-π interaction with polycyclic aromatic hydrocarbon such as benzopyrene. The iron ion in the iron porphyrin can form complex with the coordination group of CO, NOx, CN - and the like.

[0147] The antioxidants such as tea polyphenol, carnosol, vitamin E and selenium-rich yeast can remove free radicals in the smoke. The principle is that the antioxidants neutralize the lone pair of electrons in the free radicals with electrons to make them lose activity; the selenium element has aggregation effect on the free radicals and forms selenium-addition free radicals which decay easily, thus shortening the survival time of the free radicals. In addition, the free radicals in the smoke pass through the gas separation device, and the mouth suction branch and the nose suction branch are tortuous, thus prolonging the time for the free radicals to reach the mouth and nose, and also making part of the free radicals self-quench.

[0148] The filter unit not only can intercept the harmful substances in the smoke, but also can release the additional intake substances which are pre-adsorbed or adsorbed on site. The principle is that (1) the airflow of the mouth suction member promotes the desorption of the additional intake substances; (2) the adsorption heat generated when the filter unit adsorbs the harmful substances in the smoke promotes the desorption of the additional intake substances; (3) the filter unit adsorbs the additional intake substances mainly by intermolecular force, and the adsorption force is usually smaller than the chemical bond force when the filter unit selectively adsorbs the harmful substances in the smoke, so the adsorption sites in the filter unit will be gradually occupied by the harmful substances in the smoke, causing the desorption of the additional intake substances. The desorbed additional intake substances not only can compensate for part of the nicotine and aroma substances lost due to the adsorption of the filter unit, but also can increase other substances which are lacking in the smoke.

[0149] In Example 5, the acetate fiber loaded with iron porphyrin and β-cyclodextrin in the third filter unit not only can intercept the harmful substances in the smoke, but also can release the pre-adsorbed additional intake substances. For example, menthol, nicotine, arecoline, caffeine, rosemary, momordica grosvenori extract, linalool, and the volatile substances of lily essential oil, pear extract and pipa extract which are beneficial to the lungs are released into the mouth suction branch smoke. The suspension of β-cyclodextrin in the fifth filter unit can release the on-site adsorbed tobacco essence, nicotine and clove into the nose suction branch smoke. The porous filter core in the sixth filter unit can release the volatile substances of tobacco extract, passion fruit extract, rose essential oil, lavender essential oil, jasmine flower essential oil and osmanthus essential oil which are beneficial to the nose into the nose suction branch smoke.

[0150] In Example 1, the ratio of gaseous substances released by the medical nebulizer in the mouth suction branch and the nose suction branch is about 1:1. In Example 5, although the second filtering unit similar to the structure of the hookah increases the airflow resistance of the mouth suction branch, the suction airflow at the end of the mouth suction branch still makes more cigarette smoke enter the user's oral cavity from the mouth suction branch. According to the data of Example 5, the distribution ratio of cigarette mainstream smoke in the mouth suction branch and the nose suction branch is about 85:15.

[0151] In Example 2, only a Tesla valve is arranged in the nose suction branch, in Example 3, a baffle is arranged in the air connection section, and in Example 4, a fan is arranged in the air connection section. These three methods can increase the proportion of gaseous substances released by the mouth suction piece entering the nose suction branch and reduce the proportion entering the mouth suction branch, which is beneficial to improving the nicotine satisfaction efficiency of HNB electronic cigarettes, CBD electronic cigarettes and vapor electronic cigarettes, and reducing harmful substances in smoke entering the lungs.

[0152] In Example 5, the fan airflow blows the cigarette sidestream smoke away, not only improving the air flow around the cigarette burning cone and reducing harmful substances such as CO and NOx in the cigarette mainstream smoke, but also reducing the harm of sidestream smoke to users. The nose suction branch smoke is only about 15% of the cigarette mainstream smoke, and the reduction of the main harmful substances in the sidestream smoke is 93.38%-99.23%. Therefore, in addition to releasing the nose suction branch smoke beside the nostrils, users can also directly inhale the nose suction branch smoke through the nose suction cover or inserting into the nostrils, and the hair in the nostrils and the nasal mucosa can also continue to filter the harmful substances in the smoke entering the nostrils through the nose suction branch.

[0153] The gas distribution device and the composition containing the same can also compensate for the nicotine adsorbed by the filtering unit. For example, in Example 4, the filtering unit pre-adsorbs nicotine, so that the total amount of nicotine in the mouth suction branch and the nose suction branch per puff increases by 5.56% compared with Example 4. In Example 5, the nicotine in the mouth suction branch per puff increases by 25% compared with Example 5, although the nicotine in the nose suction branch smoke per cigarette is reduced by 84.49% compared with the sidestream smoke of the cigarette, but the adsorption unit in the nose suction branch can also release the pre-adsorbed nicotine to the user's nasal cavity.

[0154] In the above embodiments, the main components of the gas distribution device are: the gas connection section connected to the mouthpiece, the mouth suction branch and the nose suction branch, and at least one Tesla valve is arranged in the gas distribution device. The objects combined with the gas distribution device are: the nose suction cover, the filter material, the color developing agent, the additional intake object, the air permeable tube plug, the cylinder provided with the air inlet hole and the air outlet hole, the battery, the fan, the cigarette, the match, the cigarette butt bin, etc. In addition, the composition containing the gas distribution device can also include other objects that can improve the user's smoking experience, dopamine secretion or convenience, including but not limited to: display, heating device, music, 40 Hz gamma wave or flashing stimulation, whistle, lighter, flashlight, breath freshener, etc. After appropriately enlarging the cylinder cavity space, these objects can be placed in the composition of the gas distribution device.

[0155] In addition, the end of the nose suction branch and the mouth suction branch can also be made of antibacterial material or hydrophobic coating, etc.

[0156] In addition, the gas distribution device and the composition containing the gas distribution device can also be partially or entirely in other shapes. For example: when combined with a medical atomizer, cartoon, animal, plant, etc. shapes can improve the fun of use for children patients; when combined with tobacco and electronic cigarettes, etc. mouthpiece, the trademark or harm reduction logo, etc. shape can improve the publicity.

[0157] The above is only an embodiment of the present application, and does not limit the patent scope of the present application. Any equivalent structure or equivalent process transformation using the content of the present application specification, or direct or indirect application in other related technical fields, are also included in the patent protection scope of the present application.

Claims

1. A gas distribution apparatus, characterized by, The gas distribution device comprises a gas connection section connected to a mouthpiece, a mouth suction branch and a nose suction branch, at least one Tesla valve is arranged in the gas distribution device, the gaseous substances released by the mouthpiece are divided into two paths by the gas distribution device, one path of gaseous substances enters the user's oral cavity from the mouth suction branch, and the other path of gaseous substances enters the user's nasal cavity or is released beside the user's nostrils.

2. The gas distribution device of claim 1, wherein The mouthpiece is one of a medical atomizer, a non-medical electronic atomizer, a steam electronic cigarette, a cannabidiol electronic cigarette, a heat-not-burn electronic cigarette, a combustion cigarette, a pipe, and a water pipe.

3. The gas distribution device of claim 1, wherein At least one filter unit is arranged in the gas distribution device, and one or more of a filter material, an additional intake, and a color developing agent are arranged in the filter unit.

4. The gas distribution device of claim 3, wherein The filter material is at least one of a combination of polypropylene fibers loaded with ethylenediaminetetraacetic acid-choline-lysine ionic liquid, sepiolite, MCM-41 molecular sieve, rhyolite loaded with chitosan-copper ions, activated carbon loaded with iron porphyrin, zeolite loaded with copper ions, porous alumina particles loaded with MCM-48-NH2, sepiolite loaded with manganous oxide-cobalt oxide, NaY molecular sieve loaded with cuprous ions, porous ceramic microspheres loaded with nickelous ions-metal organic framework, resin particles loaded with ferrous ions-ethylenediaminetetraacetic acid, 0.5wt% sodium hydroxide aqueous solution dissolved with ethylenediaminetetraacetic acid disodium, nickelous ions-ethylenediaminetetraacetic acid disodium, cellulose, tea polyphenol, salvia phenol, vitamin E, selenium-rich yeast, and β-cyclodextrin, acetic acid fibers loaded with iron porphyrin and β-cyclodextrin, a cylindrical porous filter element composed of porous silica gel loaded with ethylenediaminetetraacetic acid-choline-lysine ionic liquid, selenium-rich plant stems and leaves, β-cyclodextrin, and cellulose, and a suspension of β-cyclodextrin.

5. The gas distribution device of claim 3, wherein The additional intake is at least one of a combination of menthol, nicotine, arecoline, caffeine, rosemary, monk fruit extract, linalool, lily essential oil, pear extract, pipa extract, tobacco essence, clove extract, tobacco extract, hawksbeard extract, passion fruit extract, rose essential oil, lavender essential oil, jasmine essential oil, osmanthus essential oil, and magnolia flower essential oil.

6. The gas distribution device of claim 3, wherein The color developing agent is at least one of a combination of meso-tetra-(p-sulfophenyl) porphyrin, tetra(4-methoxy-4-sulfonic acid phenyl) porphyrin, tetra(4-methoxy-3-sulfonic acid phenyl) porphyrin, tetraphenyl porphyrin, meso-tetra(4-chlorophenyl) porphyrin, meso-tetra(p-hydroxyphenyl) porphyrin, meso-tetra(4-nitrophenyl) porphyrin, 1-(2-pyridylazo)-2-naphthol, and 4-(2-pyridylazo)resorcinol.

7. The gas distribution device of claim 1, wherein At least one gas-permeable tube plug is arranged in the gas distribution device.

8. The gas distribution device of claim 7, wherein The gas-permeable tube plug is combined with a liquid-repellent material, and the liquid-repellent material is at least one of a combination of fluorosilane, polytetrafluoroethylene, and polypropylene.

9. A composition comprising a gas-dispensing device, characterized in that, The composition is provided with the gas distribution device of any one of claims 1-8.

10. The composition containing a gas dividing device according to claim 9, characterized by, The composition further comprises one or more of a cylinder provided with an air inlet hole and an air outlet hole, a battery, a fan, a cigarette, a match, and a cigarette butt bin.

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