Method for high-throughput preparation and screening of bioconjugate drug and system thereof
By employing a high-throughput method for preparing and screening bioconjugates, utilizing enzyme catalysis equipment and patient-derived models, the limitations of traditional methods, such as the limited number of candidate drugs and model heterogeneity, have been overcome, enabling efficient screening of drug molecules with preclinical potential.
WO2026124560A1PCT designated stage Publication Date: 2026-06-18GENEQUANTUM HEALTHCARE (SUZHOU) CO LTD +1
Patent Information
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- GENEQUANTUM HEALTHCARE (SUZHOU) CO LTD
- Filing Date
- 2025-12-10
- Publication Date
- 2026-06-18
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Figure CN2025141582_18062026_PF_FP_ABST
Abstract
Provided are a method for high-throughput preparation and screening of a bioconjugate drug, and a system thereof. The method for high-throughput preparation and screening of a bioconjugate comprises the following steps: step 1, performing the high-throughput preparation of bioconjugates to obtain bioconjugate library A; step 2, performing primary screening on molecules in the bioconjugate library A by means of cell or organoid assays to obtain bioconjugate library B; step 3, performing secondary screening on molecules in the bioconjugate library B by means of patient-derived tissue xenograft animal model assays to obtain bioconjugate library C; and optionally step 4, performing pharmacological and toxicological studies on molecules in the bioconjugate library C to obtain a pre-clinical candidate compound.
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