Continuous process for manufacturing preparing aminodicarboxylic acid-n,n-diacetic acids
A continuous process for manufacturing aminodicarboxylic acid-N,N-diacetic acids, like GLDA, addresses yield and purity issues by using a controlled reaction and hydrolysis method, achieving high enantiomeric purity and reduced impurities, enhancing efficiency and cost-effectiveness.
Patent Information
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- BASF SE
- Filing Date
- 2025-12-03
- Publication Date
- 2026-06-18
AI Technical Summary
Existing processes for manufacturing aminodicarboxylic acid-N,N-diacetic acids, such as L-glutamic acid N,N-diacetic acid (GLDA), suffer from low yields, high impurity content, lack of enantiomeric purity, and inefficiencies in batch or semi-batch processes, which are not easily scalable or cost-effective.
A continuous process involving the reaction of aminodicarboxylic acid with formaldehyde and hydrocyanic acid under controlled conditions, followed by hydrolysis, allows for the production of GLDA with high enantiomeric excess and low impurity levels, utilizing a continuous setup with controlled pH and temperature to minimize racemization and improve throughput.
The process achieves high yields of enantiomerically pure GLDA with reduced impurities, offering improved efficiency, cost-effectiveness, and better heat integration compared to traditional batch methods.
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