Small molecule regulators of apj
Small molecule APJ agonists address the lack of brain-targeting ligands by modulating the APJ receptor, offering therapeutic effects for metabolic syndrome, stroke, vascular dementia, and addiction.
WO2026128137A1PCT designated stage Publication Date: 2026-06-18RES TRIANGLE INST
Patent Information
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- RES TRIANGLE INST
- Filing Date
- 2025-11-07
- Publication Date
- 2026-06-18
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Figure US2025054543_18062026_PF_FP_ABST
Abstract
The present disclosure relates to compounds of Formula (I), as well as salts thereof, and pharmaceutical compositions comprising the compounds, which modulate the activity of the apelin receptor (APJ). These compounds that bind to APJ may act as APJ agonists, which are useful in the treatment of APJ-mediated disorders. In particular, the compounds of the present disclosure have been demonstrated to regulate APJ in the brain, thereby offering potential therapeutic effect in one or more of metabolic syndrome, stroke, vascular dementia, post-traumatic stress disorder, pain, and addiction.
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