ABCB5-targeted stem cell reprogramming and Anti-aging strategies
Targeting ABCB5+ stem cells with specific gene modulation techniques addresses the indiscriminate reprogramming issue, enhancing their rejuvenation and therapeutic efficacy.
WO2026128591A1PCT designated stage Publication Date: 2026-06-18CHILDRENS MEDICAL CENT CORP +1
Patent Information
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- CHILDRENS MEDICAL CENT CORP
- Filing Date
- 2025-12-10
- Publication Date
- 2026-06-18
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Figure US2025058979_18062026_PF_FP_ABST
Abstract
Methods and compositions for rejuvenating and reprogramming stem cells are disclosed. The methods involve administering to a subject an ABCB5 targeted composition comprising an anti-ABCB5 antibody conjugated to a therapeutic payload comprised of an upregulation factor or downregulation factor, or a nucleic acid encoding an upregulation factor or downregulation factor in an effective amount to reprogram and rejuvenate ABCB5+ stem cells in the subject. The compositions include anti-ABCB5 antibody conjugated to a therapeutic payload comprising an upregulation factor or downregulation factor, or a nucleic acid encoding an upregulation factor or downregulation factor. Compositions and methods for expressing extracellular matrix proteins in ABCB5+ stem cells are also disclosed.
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