Animal Cells TRIZ Cases
- Humanized Anti-DNAM-1 Antibody Balancing Binding and Immunogenicity
This case preserves mouse CDRs while humanizing framework regions to retain DNAM-1 binding and reduce immunogenicity.
- Modular HDR Donor Plasmids for Rapid Cell Line Development
Dual toxic-protein cassettes simplify donor cloning and selection, enabling modified cell lines in less than 10 days.
- CLD18A2-Targeted CAR Effector Cells to Reduce Off-Target Effects
A modular CAR combines CLD18A2 recognition with CD3ζ and co-stimulatory signaling to target tumors and limit off-target toxicity.
- Glutamine-Free CHO Media With Asparagine for Protein Titer
Asparagine-supplemented glutamine-free CHO media limits ammonia and supports protein titer.
- MHC-Binding Peptide Epitopes for Esophageal Cancer Immunotherapy
This case uses defined peptide epitopes to improve tumor recognition while seeking fewer side effects than broad cancer treatments.