Bacteria TRIZ Cases

Roseburia strains modulate gut microbiota to improve glucose tolerance and insulin sensitivity, bypassing the side effects of conventional drug therapies.

Segmenting cellulose production at low pH from melanin formation at neutral pH resolves the contradiction between high yield and pigment synthesis.

Bacillus mojavensis H12 produces pullulanase to convert high-molecular-weight pullulan into low-molecular-weight forms.

Transferring O-antigen biosynthetic gene clusters to E. coli eliminates co-expressed polysaccharides that cause fermentation viscosity.

Composite oil displacement agent eliminates alkaline corrosion and pump scaling while maintaining ultralow interfacial tension for enhanced oil recovery.

Engineered microorganism produces mixed PHA polymers to resolve slow crystallization speed and improve productivity.

Mutant polyhydroxyalkanoate synthetase introduces specific amino acid substitutions to produce copolymers with high 3-hydroxyhexanoate ratios.

A microbial agent degrades volatile organic compounds and fatty acids in painting booths.

Engineered nitrile hydratase bacterium with amidase gene knockout reduces acrylic acid by-product formation and improves acrylamide yield.

Inoculating cotton seeds with specific endophytic bacteria strains stimulates germination and enhances root growth through synergistic microbial colonization.

Specific Lactobacillus and Bifidobacterium strain combinations overcome single-strain limitations to enhance survival through gastric transit and colonization.

Engineered glucose dehydrogenase polypeptides catalyze imine reduction to secondary amines.

Cyanobacteria express a codon-optimized synthase to produce beta-phellandrene, avoiding cellular toxicity and labor-intensive plant extraction.

Modular RNA aptamer riboswitches enable scalable microbial consortia by resolving the trade-off between functional diversity and system stability.

Disrupting the CPC-operon reduces phycobilisome antenna size in cyanobacteria to increase biomass accumulation under high light conditions.

Engineered diazotrophic microbes excrete nitrogenous compounds, replacing energy-intensive Haber-Bosch ammonia production with biological fixation.

Engineered bacterial cells produce autoinducing peptide analogs to antagonize the agr quorum sensing system in Staphylococcus aureus.

Engineered microbial host cells replace endogenous NAD+ biosynthesis genes with heterologous enzymes to enhance temperature tolerance.

Deleting ubiCA in E. coli limits aerobic respiration, conserving carbon lost during complete oxidation while maintaining sufficient ATP supply for fermentation.

Adsorption chromatography isolates Omicsynins, resolving severe purification conditions while maintaining broad-spectrum antiviral efficacy.

Codon optimization and fusion tags resolve the contradiction between high protein yield and low solubility during recombinant manufacturing.

Silent mutations in the sinR gene reduce repressor concentration, resolving low expression levels in recombinant strains.

Engineered microorganisms overexpress alpha-ketoglutarate synthase to boost L-glutamic acid yields.

Culturing Lactobacillus plantarum with unsaturated fatty acid esters until the end of the logarithmic growth phase increases the IL-10/IL-12 production ratio.

Attenuated E. coli strains secrete heterologous proteins into fermentation media via modified metabolic pathways.

Selective enrichment media incorporating efflux pump inhibitors to suppress background microflora while allowing Salmonella growth.

Inactivating pha genes eliminates polyhydroxybutyrate interference, improving diutan filterability while maintaining high yield.

A salt-free buffer containing glucose or oligosaccharides maintains prokaryotic cell viability during extended storage at -20°C.

A micro-aerobic cultivation method boosts fatty acid yields through genetic modifications and oxygen control.

Microbial kinases phosphorylate recombinant caseins to restore native functional properties, solving the yield and attribute trade-off in industrial production.

A Sphingomonas sp. MD2 strain decomposes methane and odor compounds within a biocover system.

Targeted amino acid substitutions in modified DAAO boost stability and activity, resolving low conversion rates in L-glufosinate production.

Recombinant microorganism redirects metabolic flux to butanol via gene expression control, resolving yield and productivity trade-offs.

Sub-toxic antibiotics increase cyanobacteria lipid yield by altering cell membrane permeability.

D-tagaturonate epimerase catalyzes non-phosphorylated hexose conversion into rare sugar epimers like tagatose.

Attenuated Salmonella expressing VEGFR-2 targets tumor cells via antigen presentation.

An integrated wet-mill method processes corn kernels to simultaneously produce ethanol and single cell protein.

Genetically modified methanotrophs produce 1,4-butanediol from methane, bypassing petrochemical dependence and natural pathway absence.

Deleting the cAMP receptor protein gene removes catabolic repression, enabling simultaneous xylose and glucose uptake to maximize chemical productivity.

Engineered Clostridium autoethanogenum converts waste carbon monoxide into ethanol while minimizing acetate byproduct formation.

Acetyl transferase enzymes modify carotenoid profiles to enhance compound accumulation, resolving poor economic efficiency in biotechnological production.

Stabilized probiotic coating on elastomeric gloves restores microbiological equilibrium, reducing dermatitis and infection risks from hygiene protocols.

Engineered microorganisms produce polyhydroxyalkanoate copolymers with high 3HH content using vegetable oil carbon sources.

A recombinant acetogenic cell converts syngas into 1,4-butanediol via the Wood-Ljungdahl pathway.

A fluorescence reporter plasmid system enables Bacillus strains to emit distinct colors in dormant and active states.

Complexing semiconductor particles with photosynthetic organisms creates artificial light harvesting structures that reduce artificial light energy consumption.

Phase-controlled bacterial culture and chromatography isolate monophosphoryl lipid A from lipid A impurities.

Manganese carbonate-supported ferrihydrite accelerates biogenic manganese oxide formation to remove arsenic and antibiotics from wastewater.