Carbon-Sulfur Lyases TRIZ Cases

Specific EgtD mutations at residue 70 raise catalytic activity and relieve the rate-limiting step in microbial ergothioneine production.

A modified polypeptide degrades DON in grains while improving thermal tolerance and avoiding the safety and quality issues of chemical detoxification.

An enzyme-based polypeptide degrades DON in grains without harsh chemical treatment, improving thermal stability and preserving grain quality.

A targeted stDCyD chemogenetic tool enables reversible subcellular pH and H2S control with real-time biosensing and minimal off-target effects.

Engineered ComF operons enable in vivo coenzyme M biosynthesis, avoiding oxidation-prone chemical supply and improving oxidative stress tolerance.

Targeted measurement of infection-responsive genes such as FGF21 improves H. pylori disease diagnosis, prognosis prediction, and treatment planning.

Engineered enzyme scaffolds organize localization and stoichiometry in host cells to raise cannabinoid yields with more consistent production.

An engineered Salmonella strain depletes methionine in tumors to inhibit EZH2, reducing cancer invasion and metastasis with low toxicity.

Engineered probiotics degrade gut methionine to avoid restrictive diets, improving long-term compliance and lowering treatment burden.

ATP-driven MccB adenylation activates TeCH-tagged polypeptide C-termini for high-yield thioester formation and precise bioconjugation.

Site-specific albumin linking addresses rapid therapeutic-protein clearance while preserving activity and extending drug action.

Engineered oxidases catalyze oxidative cyclization in cells to produce CBCA, CBDA, and THCA without lengthy plant purification.

An optimized reverse β-oxidation and Cannabis sativa enzyme platform boosts olivetolic acid and CBGA production from glucose.

Recombinant fermentation couples glutathione synthetase and glyoxalase to raise conversion and support batch production.

Bidirectional scaffolds organize enzyme position and orientation in recombinant cells, increasing cannabinoid pathway flux and yields.

Oral Escherichia coli JM109 releases recombinant methioninase in the gut to degrade methionine, avoiding injection discomfort and anaphylaxis risks.

Alternative methylglyoxal reductases replace high-expression YqhD to reduce metabolic burden while maintaining catalytic efficiency.

Guide RNA directs Cas9 endonuclease to specific plant genomic loci, resolving random transgene integration issues from traditional transformation methods.

Dual protein system catalyzes site-selective C-alpha and C-beta deuteration of amino acids through hydrogen-deuterium exchange.

Engineered OAC polypeptides resolve low biosynthetic efficiency by enhancing catalytic activity to achieve higher titers and purity levels.

Fluoro organothiol self-assembled monolayers form hydrophobic electrode surfaces for label-free electrochemical detection.

Genetically modified microalgae assemble complex polyketide-terpenoid pathways to produce olivetolic acid, bypassing low-yield plant extraction.

Engineered non-natural olivetolic acid cyclases increase catalytic activity and substrate affinity to produce hydroxylated benzoic acid precursors.

MEGL-expressing viral vector reduces intracellular methionine and inhibits EZH2 expression, suppressing tumor cell proliferation.

Reduced ACS2 activity slows ripening, extending shelf life while maintaining fruit firmness.

Modified primate cystathionine-gamma-lyase enzymes degrade L-cystine and L-cysteine to starve tumors.

CsOAS gene overexpression or silencing controls cannabinoid production levels in biological systems.

Freeze-thaw processing of white wine grape skins releases aromatic compounds to enhance beverage flavor profiles.