Tomato ACS2 Gene Mutations Extend Shelf Life

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Solution Overview

Problem

Current tomato breeding techniques struggle to achieve a balance between fruit firmness post-harvest and consumer preferences for taste, texture, and color, primarily due to the limitations of fruit ripening processes which lead to short shelf life.

Innovation Solution

Introduction of Solanum lycopersicum plants with an acs2 allele containing specific mutations that result in a mutant acs2 protein with reduced activity, leading to lower ethylene production, slower fruit ripening, and a longer shelf life compared to wild-type plants.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Strength

If conventional tomato breeding techniques are used to maintain fruit firmness, then post-harvest firmness is improved, but consumer preferences for taste, texture and color are compromised

Engineering Contradiction:
Improvefruit firmnessVSAvoidconsumer preference satisfaction
Core Design Contradiction:
StrengthVSAdaptability or versatility

Solution Approach 1:

The invention changes the biochemical parameter of ethylene production by introducing mutations in the ACS2 gene, which encodes ACC synthase. This enzymatic parameter change leads to altered ripening kinetics, allowing fruits to maintain firmness longer while still developing acceptable taste, texture and color properties that satisfy consumer preferences

Inventive Principle:
Principle #35Parameter changes

2Adaptability or versatility

If fruit ripening is accelerated to meet consumer preferences for taste, texture and color, then consumer preference satisfaction is improved, but shelf life is reduced

Engineering Contradiction:
Improveconsumer preference satisfactionVSAvoidshelf life
Core Design Contradiction:
Adaptability or versatilityVSDuration of action of stationary object

Solution Approach 1:

The invention creates a dynamic ripening profile by modifying ACS2 gene function, resulting in fruits that ripen more slowly and controllably. This dynamic adjustment of ripening rate allows extension of shelf life while ensuring that when consumers do receive the fruit, it can still achieve acceptable sensory qualities

Inventive Principle:
Principle #15Dynamics

3Speed

If ethylene production is increased to promote ripening, then ripening speed is improved, but shelf life is reduced

Engineering Contradiction:
Improveripening speedVSAvoidshelf life
Core Design Contradiction:
SpeedVSDuration of action of stationary object

Solution Approach 1:

Instead of increasing ethylene production to accelerate ripening, the invention inverts the approach by reducing ethylene production through ACS2 gene mutations. This inverse strategy slows ripening speed, thereby extending shelf life while still allowing fruits to develop acceptable consumer qualities over the extended period

Inventive Principle:
Principle #13The other way round (Inversion)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The modified acs2 allele in tomato plants effectively delays fruit ripening and extends the shelf life, addressing the challenge of maintaining fruit firmness and meeting consumer preferences.

Implementation Method 1

ACC synthase (ACS) is an enzyme that catalyzes the synthesis of 1-aminocyclopropane-1-carboxylic acid (ACC) from S-Adenosyl methionine. ACC is then converted into ethylene catalyzed by ACO.

Methodology Applied
Scientific EffectEnzyme catalysis: Enzyme

Data Source

PatentEP2931026B1Solanum lycopersicum plants having non-transgenic alterations in the ACS2 gene
Publication Date: 2025.05.07 NUNHEMS BV
  • EP2931026B1 patent drawingFigure 1
  • EP2931026B1 patent drawingFigure 2
  • EP2931026B1 patent drawingFigure 3

AI summary

The present invention relates to cultivated plant of the species Solanum lycopersicum comprising a acs2 allele having one or more mutations, said mutations resulting in production of a mutant acs2 protein having loss-of-function acs2 protein or reduced function compared to wild type Acs2 protein.