Cell Receptors/Surface-Antigens/Surface-Determinants TRIZ Cases

See how a recombinant chimeric protein combining CD46, CD55, and CD59 domains enables sustained

See how a chimeric protein combining CD46, CD55, and CD59 enables gene therapy delivery to redu

See how a chimeric protein combining CD46, CD55, and CD59 domains with GPI anchor removal enabl

See how a recombinant chimeric protein combining CD46, CD55, and CD59 domains enables single-do

Receptor response data guides substance emission control to reproduce target scents or tastes without trial-and-error blending.

Multiple HVEM-based adapters and modified HSV glycoproteins improve cancer-cell targeting and viral propagation while limiting normal-cell infection.

Specific CD155 amino acid changes tune TIGIT, CD226, and CD96 binding to modulate T cell signaling for cancer and immune disorders.

F11R/JAM-A inhibitors curb smooth muscle proliferation and migration to prevent restenosis after angioplasty without stent-related risks.

A truncated mini-PCDH15 transgene fits single AAV vectors, enabling expression in inner ear and eye cells for Usher 1F treatment.

Machine learning and split luciferase assays predict G12/13 GPCR coupling with higher sensitivity and quantitative consistency.

Targeted CD163 SRCR5, PSTII, and interdomain mutations disrupt PRRSV entry and sharply reduce cell susceptibility to genotype 2 infection.

TGFβR1/TGFβR2 ratio screening predicts and boosts MSC chondrogenic potential without lengthy donor cell culturing and histology.

Modified HSV paired with checkpoint inhibitors improves tumor targeting, including uninjected metastatic sites, while limiting harm to normal cells.

Detergent solubilization and chromatography replace ultracentrifugation to scale membrane protein production while preserving yield and purity.

A cationic peptide with 6-10 arginine or lysine residues boosts Lck activity, raising IL-2 and cytokine output while reducing T-cell exhaustion.

Antibody polypeptides bind active LPAR1 to improve selectivity over small molecules, reduce toxicity, and suppress fibrotic signaling.

Specific anti-CD8α antibodies rapidly deplete CD8α-expressing cells, then allow controlled repopulation to balance treatment and immune recovery.

Engineered CHO cells shift recombinant serum proteins to human-like bi-antennary glycosylation, reducing immune risk and plasma dependence.

Cardiac iron imaging with MRI, PET, or SPECT helps detect hypertension-induced myocardial microbleeds and guide iron-targeted treatment.

By removing irradiation, this humanized NSG mouse model improves CD34+ stem cell engraftment and supports non-HLA matched PDX testing.

CTLA-4-binding polypeptides tune affinity and epitope targeting to reduce immune suppression while limiting adverse effects in cancer therapy.

LOX-1 captures LAB in blood samples to enable direct, objective Kawasaki disease diagnosis and reduce subjectivity from clinical exclusion.

GABRR1 agonists drive megakaryocyte progenitor differentiation to raise platelet levels and reduce reliance on repeated transfusions.

A modified Fc-P2X7R fusion protein detects CAR T cells in patient samples while reducing Fc receptor binding that could trigger unwanted immune activation.

Compact PD-L1 binding polypeptides preserve affinity while improving tissue penetration beyond bulky antibodies for cancer therapy and diagnosis.

Defined CD4+/CD8+ CAR-T dosing ratios and timing improve antigen-targeted response in relapsed or refractory non-Hodgkin lymphoma.

Cell-free insertion into hybrid lipid bilayers preserves membrane protein orientation and mobility without detergent-driven membrane disruption.

AAV-delivered CaV3.2 inhibitory peptides target DRG neurons to reduce chronic pain while limiting off-target side effects.

Phage and yeast display plus xenograft selection speed GRP78-targeting antibody discovery for cancer imaging and growth inhibition.

Genetic immunodeficiency enables CD34+ stem cell and non-HLA matched PDX engraftment without irradiation, preserving mouse health for preclinical testing.

Recombinant Bt toxin receptors reveal binding pathways for engineering more specific toxins and slowing insect resistance.

Pre-procedure suPAR screening identifies patients at high AKI risk so targeted antagonists can block suPAR signaling and protect kidney function.

NOTCH3 agonists activate receptor signaling to prevent mural cell loss and vascular leakage in small vessel disease.

Targeting LRP1 in oligodendrocytes lifts myelin-debris inhibition of OPC differentiation, enabling faster remyelination in MS.

Collecting cultured cells when specific activity reaches 1.2 or higher preserves sensor protein function while improving chemical sensor production.

Protease-deficient yeast and tuned vectors enable scalable expression of full-length difficult proteins while preserving folding and activity.

A closed 4-day dendritic cell process uses MPLA, IFN-γ, and mRNA electroporation to raise yield while preserving IL-12 and antigen presentation.

Engineered Notch ligands on suspension beads replace hard-to-scale stromal culture, enabling clinically relevant progenitor T-cell generation.

Pre-edited mammalian cells lower immunogenic genes and modify CD47 expression to survive hostile transplant conditions and reduce rejection.

Cationic liposomes deliver H3 K27M epitope RNA to boost central memory T cells and immune response in diffuse intrinsic pontine glioma.

BRET-tagged ion channels enable long-term neural activity readout without external light, reducing phototoxicity while improving spatial resolution.

Directed evolution of mixed poxvirus strains boosts tumor-selective killing, EEV secretion, and resistance to antibody neutralization.

Stage-specific secretin receptor modulation reduces fibrosis in early PBC and supports bile duct recovery in late PBC.

Notch inhibition directs early cardiomyocytes toward atrial fate, while CD151-based enrichment improves subtype purity and yield.

Notch ligands on suspension microbeads replace complex stromal or plate cultures to scale clinically relevant T-lineage cell production.

Mimetic peptides modeled on the Cx46 C-terminus block c-Src interaction, reduce Akt activation, and suppress cancer stem cell traits.

Viral delivery of Ikzf1 and Ikzf4 reprograms Müller glia into cone photoreceptors, avoiding poor retinal integration from cell transplantation.

Modified ADAM-12 disintegrin peptides use non-natural amino acid substitutions to improve plasma stability and inhibit cancer invasion and metastasis.

Selective C6 peptide inhibition of hHv1 reduces neutrophil ROS release upstream, helping mitigate inflammatory damage in ARDS.

A PD-L1 analog Fc vaccine primes dogs to produce endogenous anti-PD-L1 antibodies, reducing treatment cost and repeat dosing.

Targeting the photoreceptor-specific CRB1-B isoform helps preserve outer limiting membrane integrity and reduce photoreceptor death.

Soluble CD163 levels in follicular fluid or serum provide an objective way to select embryos with higher implantation and pregnancy potential.

GJA1-20k peptide or gene therapy mitigates mitochondrial stress to protect tissue during ischemia-reperfusion when cooling is impractical.

AAV packaging limits are addressed by ABCA4 minigene vectors for ocular delivery, supporting photoreceptor expression and improved autofluorescence.

Hydroxypropyl-β-cyclodextrin and succinic acid stabilize high-concentration TACI-Fc liquid formulations without surfactants or lyophilization.

Specific CAR domains target pathologic T cells for elimination, addressing side effects from broad immune suppression in autoimmune disease.

Fc-binding protein separates antibodies by sugar chain differences for disease detection.

GJA1-20k reduces basal oxygen consumption and oxidative stress during ischemia/reperfusion injury.

Gene therapy produces SIRPα-Fc fusion proteins at the tumor site to block CD47 and redirect macrophages, reducing systemic toxicity.

Recombinant SNAMPXIN substrate undergoes FRET signal change upon cleavage by active Clostridium neurotoxins.

Surface-displayed mutated Oncostatin M on small extracellular vesicles reduces cardiomyocyte hypertrophy and fibrosis while preventing protein degradation.