Chemokines TRIZ Cases
- Permuted RBP and MBP Fusion Tags for Protein Solubility
Segmented Ribose Binding Protein tags improve protein expression levels while maintaining high solubility for difficult-to-express targets.
- Engineered Candida albicans Strains Expressing Cytokines
Engineered Candida albicans expressing IL-17A and CXCL chemokines prevent candidiasis by converting pathogenicity into protective immune recruitment.
- IP-10 Epitope Antibody Specificity for Disease Treatment
Targeting conserved IP-10 epitopes with specific antibodies suppresses harmful protein activity in autoimmune diseases.
- Apheresis Column Chemokine Receptor Binding Cancer Treatment
Immobilized chemokines capture regulatory T lymphocytes via receptor binding in an apheresis column, reducing immune suppression and metastasis.
- CXCL10 Mutant with Enhanced GAG Binding for T-Cell Mobilization
Mutated CXCL10 polypeptides enhance glycosaminoglycan binding affinity, resolving insufficient T-cell mobilization in inflammatory disorders.