Component Separation TRIZ Cases

A disposable sampling module and reusable detection module measure saliva stress biomarkers for early, low-complexity health warnings.

This GC guide holds a winged column nut and provides inlet and detector markings to reduce unstable grips and depth errors.

Continuous affinity chromatography cuts cycle time and protects biomolecule quality.

An encoder-decoder model predicts peptide retention times, building a library that narrows candidates before mass-spectrometry analysis.

The detachable discharge member stabilizes pressure through added flow resistance and enables replacement when clogging disrupts gas flow.

Compare chromatographic results with known component behavior to characterize real apparatus parameters for transfer and diagnostics.

This chromatography case uses polyphosphonic acids to reduce non-specific binding and system loss during oligonucleotide separation.

Large pores improve mass transfer in poly-amide HILIC phases, reducing aggregation and resolving protein and peptide glycoforms.

Dual detectors and controller logic verify continuous liquid segments, preventing transfer-line gaps from compromising analysis.

Dimethylamine-based reagents release and label O-glycans in one pot for high-throughput UV, MS, and fluorescence analysis.

An inert-gas ball mill, cryogenic trap, chromatography, and mass spectrometry preserve trapped-gas composition during analysis.

A universal lockstep protocol coordinates multiple nucleic acid assays, reducing resource contention and supporting higher throughput.

This case uses breath VOC concentrations to distinguish IPF from controls and other interstitial lung diseases without biopsy.

Chromatography and immunoassays analyze postoperative CSF steroids or proteins to identify high-risk brain-injured patients early.

Elastic plastic column tubes use hoop tension around interference-fit flow distributors to reduce dead zones and simplify cleaning.

A channelled flow guide evens liquid arrival and velocity across adsorbent media, improving resolution and reducing buffer use.

Controlled LED wavelengths induce measurable genetic damage for comet-assay cancer diagnosis without multiple costly examinations.

Thermal interfaces stabilize column heating in removable chromatography cartridges.

A flow-path switching valve supports chip and packed columns, reducing replacement work and helping suppress chromatogram peak broadening.

This case compares protein and aggregate Raman intensities to select relevant bands and improve suspension concentration prediction.

This case uses multiple m/z windows, HPLC, and SPE to quantify IGF-2 variants altered by polymorphisms.

This kidney evaluation approach uses D-amino acid reabsorption and excretion to monitor disease with simpler blood and urine testing.

This case separates mobile phase and elution solvent recovery by timed valve switching, avoiding variable ratios in collected solutions.

Processor-controlled valves, sensor feedback, and stationarity analysis improve data collection for fluid-solid experiments.

Multi-port valves, capture columns, and reaction coils automate sterile sample preparation for faster real-time CQA analysis.

This case integrates two chromatography columns on one substrate with heating to reduce dead volumes and condensation.

A manifold mixer uses varied transfer-channel volumes to homogenize fluids and control peak shape, pressure, and qualification time.

Replace slow conventional hydrolysis with Brachyspira β-glucuronidase to improve recovery of opioids and benzodiazepines.

A needle sensor distinguishes liquid from air, stopping suction at depletion to prevent column-damaging air injection and sample waste.

An inorganic-organic hybrid coating masks reactive metal sites in liquid chromatography frits, limiting adsorption and analyte degradation.

A switchable sample gas path enables direct ion mobility screening or GC pre-separation, balancing detection speed and discrimination.

Extenders, spacers, and end caps simplify column connections while maintaining loading force and fluid-tight seals.

A pH 10–14 alkaline solution regenerates HIC media, reducing residual load without chaotropic agents or organic solvents.

Pressurized solvent sources, divert valves, and sensors automate priming to reduce air entrapment and stabilize chromatography flow.