Compound Screening TRIZ Cases

A biotinylated lipid micelle assay detects lipid-modifying enzyme activity using proximity effect-based methods.

A biomarker-based method identifies skin compositions that improve tissue quality through measurable biochemical changes.

Screen mutant EGFr polypeptides to select binding agents with tailored epitope affinity, resolving specificity and efficacy trade-offs in cancer therapy.

Modifying AKG analogue structures reduces cytotoxicity while maintaining demethylase inhibition efficacy for prostate cancer treatment.

An in vitro plasma-substrate system measures lipasaemic activity via optical density changes to evaluate glycosaminoglycan compounds.

An isolated polypeptide inhibits caspase-2-dependent tau cleavage, reducing pathogenic fragments that drive memory loss in tauopathy.

Domain-specific antibodies assess EGFR phosphorylation status to predict patient responses to inhibitor therapies amid heterogeneous tumor populations.

SV40 large T-antigen and hTERT expression immortalizes neuronal cells while preserving biochemical properties.

Segmenting reagents into discrete droplets eliminates diffusion and surface adsorption, enabling reliable enzyme quantification at minute scales.

Targeted inhibitors suppress mutant EZH2 activity to reduce cancer cell proliferation and induce apoptosis in lymphoma.

Peptide inhibitors bind the cyclin D binding groove to selectively constrain CDK4 activity.

Replacing enzymatic digestion with mechanical micro-dissection eliminates contamination risks while ensuring consistent cell population homogeneity.

Open reversed microwell device manages fluids via interference coupling to enable high-content biological sample analysis.

Intestinal epithelial monolayers use biosensors to detect inflammation signals, breaking the chronic positive feedback loop in inflammatory bowel disease.

Genetically modified mice expressing human APOE4 and mouse Trem2 p.R47H proteins enable preclinical screening.

Forward programming pluripotent stem cells with endothelial factor genes bypasses complex multi-stage differentiation protocols.

Stable isotope labeling kinetics quantifies alpha-synuclein metabolism to resolve insufficient protein measurement precision in neurological disease diagnosis.

A 3D printer creates magnified hair surface models from imaging data to visualize treatment effects.

Antibody 7C10-C5 detects carboxymethylated PP2Ac without cross-reactivity, resolving measurement precision issues.

Modified carrier cells express immunosuppressive factors to protect oncolytic viruses from immune elimination and enhance viral amplification at tumor sites.

Polymer-coated nanoparticles target hepatocellular carcinoma cells to enable high-resolution visualization through spatial frequency heterodyne imaging.

Stacking planar conductors on parallel planes with vertical vias increases reactance, enabling lower resonance frequencies and compact device integration.