Biomarker-Based Skin Composition Formulation Method
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Solution Overview
Problem
Current skin care products lack scientific evidence on how they impact skin health, with many providing only temporary and superficial benefits, and there is a disconnect between skin science and product formulation, limiting effective improvement of skin tissues and cells.
Innovation Solution
A method using biomarker panels, specifically ceramides, to identify and evaluate test agents for their ability to improve skin health, enabling the formulation of personal care compositions that demonstrate statistically significant changes in skin biomarkers, correlating with objective measures of improved skin health.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Shape
If conventional skin care products are used to provide temporary moisturization and softening of the stratum corneum, then superficial skin appearance is improved, but actual skin health and tissue quality remain unchanged
Solution Approach 1:
The patent replaces subjective visual assessment with objective biomarker measurement systems. Instead of relying on mechanical observation of skin appearance, the invention uses biochemical markers (cytokines, growth factors, DNA damage markers) to objectively measure actual skin health changes, thereby substituting superficial assessment with reliable biological measurement
Solution Approach 2:
The patent implements feedback mechanisms by measuring biomarker levels before and after product application. This allows for quantitative assessment of whether a product actually improves skin health, creating a closed-loop system where product efficacy is verified through biological feedback rather than assumed based on formulation
2Reliability
If biomarker panels are used to identify compositions that improve skin health, then scientific evidence of skin health improvement is obtained, but product development complexity and evaluation time increase
Solution Approach 1:
The patent segments the complex task of evaluating skin health into distinct biomarker categories (inflammation markers, growth factors, DNA damage markers). This segmentation allows for targeted measurement of specific biological pathways, reducing the complexity of comprehensive skin health assessment by breaking it into manageable, measurable components
Solution Approach 2:
The patent changes the measurement parameters from subjective visual scales to objective biochemical concentrations. By measuring specific biomarker levels (e.g., cytokine concentrations, growth factor levels) rather than subjective appearance ratings, the invention transforms complex quality assessment into quantifiable parameter changes that can be statistically analyzed
3Quantity of substance
If existing products are formulated based on laboratory-tested active properties, then antioxidant and antiinflammatory effects are claimed, but actual cellular and physiological effects on consumer skin are lacking
Solution Approach 1:
The patent introduces biomarkers as intermediary indicators that connect active ingredient application to actual cellular effects. Rather than directly measuring complex cellular responses, the invention uses biomarker levels (such as inflammatory cytokines or growth factors) as intermediary measurements that reliably indicate whether actives are producing the intended cellular and physiological effects
Solution Approach 2:
The patent replaces in-vitro laboratory testing with in-vivo biomarker measurement. Instead of relying on mechanical or chemical assays that show theoretical activity, the invention substitutes these with direct measurement of biological responses in human skin through biomarker panels, providing evidence of actual physiological effects rather than predicted activity
Data Source
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AI summary
In various embodiments, provided are methods for selecting and formulating compositions for treating and maintaining the quality of skin, wherein a composition is selected for use in a personal care product based on its demonstrated biological effect to improve skin quality as evidenced by one or more biomarker changes (e.g. lipids such as ceramides and fatty acids; natural moisturizing factors such as trans-urocanic acid, citrulline, glycine, histidine, ornithine, proline, 2-pyrrolidone-5 acid, serine) that correlate with improvement as evidenced by one or more objective measurements of skin health.