Connective Tissue Peptides TRIZ Cases
- Radioprotectants Targeting TSP-1 and CD47 Interaction
Inhibiting the interaction between thrombospondin-1 and CD47 protects non-target tissues from radiation damage, allowing higher doses to enhance tumor ablation.
- Mechanochemical Collagen Assembly via Extensional Strain
Applying controlled extensional and shear strains to prefibrillar solutions overcomes poor collagen organization in seeded cell methods.
- Cthrc1 Inhibition for Cardiac Perfusion and Vascular Remodeling
Inhibiting Cthrc1 expression improves cardiac perfusion by promoting outward vascular remodeling without increasing myocardial oxygen demand.
- Integrin α9β1 Inhibitors for Ischemic Stroke Reperfusion Injury
Isolated anti-integrin α9 inhibitors block integrin α9β1 activity to limit brain damage following reperfusion after ischemic stroke.
- Biotinylated Antibody Targeting for Cartilage Lesions
Biotinylated antibodies recruit reparative cells to damaged cartilage via avidin bridges, preventing systemic side effects from non-specific drug delivery.